{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T13:54:06Z","timestamp":1794491646576,"version":"4.9.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"18","license":[{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000884","name":"Cancer Research Institute","doi-asserted-by":"publisher","award":["CRI3516"],"award-info":[{"award-number":["CRI3516"]}],"id":[{"id":"10.13039\/100000884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["135926"],"award-info":[{"award-number":["135926"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100003287","name":"Rally Foundation","doi-asserted-by":"publisher","award":["22YIC53"],"award-info":[{"award-number":["22YIC53"]}],"id":[{"id":"10.13039\/100003287","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015170","name":"Yale Cancer Center | Yale SPORE in Lung Cancer","doi-asserted-by":"publisher","award":["CA121974"],"award-info":[{"award-number":["CA121974"]}],"id":[{"id":"10.13039\/100015170","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"HHS | NIH | National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM138299"],"award-info":[{"award-number":["GM138299"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"HHS | NIH | National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["CA294038"],"award-info":[{"award-number":["CA294038"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"HHS | NIH | National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["EB037112"],"award-info":[{"award-number":["EB037112"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"HHS | NIH | National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM149299"],"award-info":[{"award-number":["GM149299"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"HHS | NIH | National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["CA258993"],"award-info":[{"award-number":["CA258993"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"HHS | NIH | National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["CA016086"],"award-info":[{"award-number":["CA016086"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"HHS | NIH | National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["AG083424"],"award-info":[{"award-number":["AG083424"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007316","name":"HHS | NIH | NCI | Division of Cancer Prevention, National Cancer Institute","doi-asserted-by":"publisher","award":["CA286364"],"award-info":[{"award-number":["CA286364"]}],"id":[{"id":"10.13039\/100007316","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000854","name":"Human Frontier Science Program","doi-asserted-by":"publisher","award":["RGY0088\/2021"],"award-info":[{"award-number":["RGY0088\/2021"]}],"id":[{"id":"10.13039\/501100000854","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009680","name":"Yale | YSM | Yale Liver Center","doi-asserted-by":"publisher","award":["DK034989"],"award-info":[{"award-number":["DK034989"]}],"id":[{"id":"10.13039\/100009680","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP21H05051"],"award-info":[{"award-number":["JP21H05051"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Yale Cancer Center Pilot Award"},{"name":"Yale DeLuca Pilot Award"},{"name":"Gabrielle's Angel Foundation Medical Research Award"},{"name":"Pershing Square Sohn Prize for Young Investigators in Cancer research"},{"name":"Yale Lion Heart Pilot Grant"},{"name":"Leslie Warner Postdoctoral Fellowship"},{"name":"Daiichi Sankyo Foundation of Life Science Fellowship"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO Rep"],"published-print":{"date-parts":[[2025,9,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Phospholipase C gamma 1 (\n                    <jats:italic>PLCG1<\/jats:italic>\n                    ) has been identified as the most frequently mutated gene in adult T-cell leukemia\/lymphoma, suggesting a critical function of PLCG1 in driving T cell activation. However, it remains unclear how these mutations regulate T cell physiology and pathology. Here, we investigate three common leukemia\/lymphoma-associated mutations (R48W, S345F, and D1165H). We discover that these mutations induce hyperactive T cell signaling and cause pro-survival phenotypes. PLCG1 mutants enhance LAT condensation, calcium influx, and ERK activation. They also promote T cell proliferation, upregulate cell adhesion molecules, induce cell aggregation, and confer resistance to Vorinostat, an FDA-approved drug for cutaneous T-cell lymphoma. The resistance depends on ERK signaling and can be reversed with an ERK inhibitor. Interestingly, PLCG1 mutants also induce bystander drug resistance in nearby cells expressing wild-type PLCG1. Mechanistically, alpha smooth muscle actin, which is specifically induced by PLCG1 mutants, directly binds PLCG1 to promote its activation. These results demonstrate that hyperactive PLCG1 promotes T cell survival and drug resistance by inducing non-canonical signaling.\n                  <\/jats:p>","DOI":"10.1038\/s44319-025-00546-x","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T10:18:54Z","timestamp":1754993934000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Hyperactive PLCG1 induces cell-autonomous and bystander T cell activation and drug resistance"],"prefix":"10.1038","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2761-5570","authenticated-orcid":false,"given":"Longhui","family":"Zeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwei","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8516-292X","authenticated-orcid":false,"given":"Kazuki","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Hajicek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1158-5131","authenticated-orcid":false,"given":"Yasunori","family":"Kogure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Kataoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seishi","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Sondek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8696-7922","authenticated-orcid":false,"given":"Xiaolei","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,12]]},"reference":[{"key":"546_CR1","doi-asserted-by":"crossref","first-page":"3568","DOI":"10.1074\/jbc.M109705200","volume":"277","author":"B Ananthanarayanan","year":"2002","unstructured":"Ananthanarayanan B, Das S, Rhee SG, Murray D, Cho W (2002) Membrane targeting of C2 domains of phospholipase C-delta isoforms. J Biol Chem 277:3568\u20133575","journal-title":"J Biol Chem"},{"key":"546_CR2","doi-asserted-by":"crossref","first-page":"26422","DOI":"10.1074\/jbc.R115.665869","volume":"290","author":"L Balagopalan","year":"2015","unstructured":"Balagopalan L, Kortum RL, Coussens NP, Barr VA, Samelson LE (2015) The linker for activation of T cells (LAT) signaling hub: from signaling complexes to microclusters. J Biol Chem 290:26422\u201326429","journal-title":"J Biol Chem"},{"key":"546_CR3","doi-asserted-by":"crossref","first-page":"e5430","DOI":"10.1371\/journal.pone.0005430","volume":"4","author":"RR Bartelt","year":"2009","unstructured":"Bartelt RR, Cruz-Orcutt N, Collins M, Houtman JC (2009) Comparison of T cell receptor-induced proximal signaling and downstream functions in immortalized and primary T cells. PLoS ONE 4:e5430","journal-title":"PLoS ONE"},{"key":"546_CR4","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/ng.2921","volume":"46","author":"S Behjati","year":"2014","unstructured":"Behjati S, Tarpey PS, Sheldon H, Martincorena I, Van Loo P, Gundem G, Wedge DC, Ramakrishna M, Cooke SL, Pillay N et al (2014) Recurrent PTPRB and PLCG1 mutations in angiosarcoma. Nat Genet 46:376\u2013379","journal-title":"Nat Genet"},{"key":"546_CR5","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.673446","volume":"9","author":"C Cassioli","year":"2021","unstructured":"Cassioli C, Balint S, Compeer EB, Felce JH, Gamberucci A, Della Bella C, Felce SL, Brunetti J, Valvo S, Pende D et al (2021) Increasing LFA-1 expression enhances immune synapse architecture and T cell receptor signaling in Jurkat E6.1 cells. Front Cell Dev Biol 9:673446","journal-title":"Front Cell Dev Biol"},{"key":"546_CR6","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1016\/j.jid.2018.06.176","volume":"138","author":"LW Chang","year":"2018","unstructured":"Chang LW, Patrone CC, Yang W, Rabionet R, Gallardo F, Espinet B, Sharma MK, Girardi M, Tensen CP, Vermeer M et al (2018) An integrated data resource for genomic analysis of cutaneous T-cell lymphoma. J Invest Dermatol 138:2681\u20132683","journal-title":"J Invest Dermatol"},{"key":"546_CR7","doi-asserted-by":"crossref","first-page":"eabc6612","DOI":"10.1126\/scisignal.abc6612","volume":"14","author":"D Chen","year":"2021","unstructured":"Chen D, Simons M (2021) Emerging roles of PLCgamma1 in endothelial biology. Sci Signal 14:eabc6612","journal-title":"Sci Signal"},{"key":"546_CR8","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.tibs.2017.11.008","volume":"43","author":"AH Courtney","year":"2018","unstructured":"Courtney AH, Lo WL, Weiss A (2018) TCR signaling: mechanisms of initiation and propagation. Trends Biochem Sci 43:108\u2013123","journal-title":"Trends Biochem Sci"},{"key":"546_CR9","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1139\/y97-108","volume":"75","author":"JS Drew","year":"1997","unstructured":"Drew JS, Murphy RA (1997) Actin isoform expression, cellular heterogeneity, and contractile function in smooth muscle. Can J Physiol Pharm 75:869\u2013877","journal-title":"Can J Physiol Pharm"},{"key":"546_CR10","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1093\/emboj\/17.2.414","volume":"17","author":"M Falasca","year":"1998","unstructured":"Falasca M, Logan SK, Lehto VP, Baccante G, Lemmon MA, Schlessinger J (1998) Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting. EMBO J 17:414\u2013422","journal-title":"EMBO J"},{"key":"546_CR11","doi-asserted-by":"crossref","first-page":"35836","DOI":"10.1074\/jbc.M110.166512","volume":"285","author":"A Gresset","year":"2010","unstructured":"Gresset A, Hicks SN, Harden TK, Sondek J (2010) Mechanism of phosphorylation-induced activation of phospholipase C-gamma isozymes. J Biol Chem 285:35836\u201335847","journal-title":"J Biol Chem"},{"key":"546_CR12","doi-asserted-by":"crossref","first-page":"e51700","DOI":"10.7554\/eLife.51700","volume":"8","author":"N Hajicek","year":"2019","unstructured":"Hajicek N, Keith NC, Siraliev-Perez E, Temple BR, Huang W, Zhang Q, Harden TK, Sondek J (2019) Structural basis for the activation of PLC-gamma isozymes by phosphorylation and cancer-associated mutations. eLife 8:e51700","journal-title":"eLife"},{"key":"546_CR13","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1126\/science.aau5721","volume":"363","author":"WYC Huang","year":"2019","unstructured":"Huang WYC, Alvarez S, Kondo Y, Lee YK, Chung JK, Lam HYM, Biswas KH, Kuriyan J, Groves JT (2019) A molecular assembly phase transition and kinetic proofreading modulate Ras activation by SOS. Science 363:1098\u20131103","journal-title":"Science"},{"key":"546_CR14","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1038\/ng.3415","volume":"47","author":"K Kataoka","year":"2015","unstructured":"Kataoka K, Nagata Y, Kitanaka A, Shiraishi Y, Shimamura T, Yasunaga J, Totoki Y, Chiba K, Sato-Otsubo A, Nagae G et al (2015) Integrated molecular analysis of adult T cell leukemia\/lymphoma. Nat Genet 47:1304\u20131315","journal-title":"Nat Genet"},{"key":"546_CR15","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1182\/blood.2021013568","volume":"139","author":"Y Kogure","year":"2022","unstructured":"Kogure Y, Kameda T, Koya J, Yoshimitsu M, Nosaka K, Yasunaga JI, Imaizumi Y, Watanabe M, Saito Y, Ito Y et al (2022) Whole-genome landscape of adult T-cell leukemia\/lymphoma. Blood 139:967\u2013982","journal-title":"Blood"},{"key":"546_CR16","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","volume":"30","author":"Y Liao","year":"2014","unstructured":"Liao Y, Smyth GK, Shi W (2014) featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. Bioinformatics 30:923\u2013930","journal-title":"Bioinformatics"},{"key":"546_CR17","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1021\/bi201252f","volume":"51","author":"JW Lomasney","year":"2012","unstructured":"Lomasney JW, Cheng HF, Kobayashi M, King K (2012) Structural basis for calcium and phosphatidylserine regulation of phospholipase C delta1. Biochemistry 51:2246\u20132257","journal-title":"Biochemistry"},{"key":"546_CR18","volume":"15","author":"MI Love","year":"2014","unstructured":"Love MI, Huber W, Anders S (2014) Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol 15:550","journal-title":"Genome Biol"},{"key":"546_CR19","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1182\/blood-2014-11-611194","volume":"126","author":"LY McGirt","year":"2015","unstructured":"McGirt LY, Jia P, Baerenwald DA, Duszynski RJ, Dahlman KB, Zic JA, Zwerner JP, Hucks D, Dave U, Zhao Z et al (2015) Whole-genome sequencing reveals oncogenic mutations in mycosis fungoides. Blood 126:508\u2013519","journal-title":"Blood"},{"key":"546_CR20","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.4049\/jimmunol.180.5.2903","volume":"180","author":"T Owaki","year":"2008","unstructured":"Owaki T, Asakawa M, Morishima N, Mizoguchi I, Fukai F, Takeda K, Mizuguchi J, Yoshimoto T (2008) STAT3 is indispensable to IL-27-mediated cell proliferation but not to IL-27-induced Th1 differentiation and suppression of proinflammatory cytokine production. J Immunol 180:2903\u20132911","journal-title":"J Immunol"},{"key":"546_CR21","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1182\/blood-2017-02-768234","volume":"130","author":"J Park","year":"2017","unstructured":"Park J, Yang J, Wenzel AT, Ramachandran A, Lee WJ, Daniels JC, Kim J, Martinez-Escala E, Amankulor N, Pro B et al (2017) Genomic analysis of 220 CTCLs identifies a novel recurrent gain-of-function alteration in RLTPR (p.Q575E). Blood 130:1430\u20131440","journal-title":"Blood"},{"key":"546_CR22","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.jid.2019.07.693","volume":"140","author":"VM Patel","year":"2020","unstructured":"Patel VM, Flanagan CE, Martins M, Jones CL, Butler RM, Woollard WJ, Bakr FS, Yoxall A, Begum N, Katan M et al (2020) Frequent and persistent PLCG1 mutations in Sezary cells directly enhance PLCgamma1 activity and stimulate NFkappaB, AP-1, and NFAT signaling. J Invest Dermatol 140:380\u2013389.e384","journal-title":"J Invest Dermatol"},{"key":"546_CR23","first-page":"pe39","volume":"2007","author":"Q Qi","year":"2007","unstructured":"Qi Q, August A (2007) Keeping the (kinase) party going: SLP-76 and ITK dance to the beat. Sci STKE 2007:pe39","journal-title":"Sci STKE"},{"key":"546_CR24","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.4049\/jimmunol.1800537","volume":"201","author":"A Sharma","year":"2018","unstructured":"Sharma A, Lawry SM, Klein BS, Wang X, Sherer NM, Zumwalde NA, Gumperz JE (2018) LFA-1 ligation by high-density ICAM-1 is sufficient to activate IFN-gamma release by innate T lymphocytes. J Immunol 201:2452\u20132461","journal-title":"J Immunol"},{"key":"546_CR25","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1126\/science.aad9964","volume":"352","author":"X Su","year":"2016","unstructured":"Su X, Ditlev JA, Hui E, Xing W, Banjade S, Okrut J, King DS, Taunton J, Rosen MK, Vale RD (2016) Phase separation of signaling molecules promotes T cell receptor signal transduction. Science 352:595\u2013599","journal-title":"Science"},{"key":"546_CR26","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/978-1-4939-6881-7_5","volume":"1584","author":"X Su","year":"2017","unstructured":"Su X, Ditlev JA, Rosen MK, Vale RD (2017) Reconstitution of TCR signaling using supported lipid bilayers. Methods Mol Biol 1584:65\u201376","journal-title":"Methods Mol Biol"},{"key":"546_CR27","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/j.jaci.2023.06.020","volume":"152","author":"P Tao","year":"2023","unstructured":"Tao P, Han X, Wang Q, Wang S, Zhang J, Liu L, Fan X, Liu C, Liu M, Guo L et al (2023) A gain-of-function variation in PLCG1 causes a new immune dysregulation disease. J Allergy Clin Immunol 152:1292\u20131302","journal-title":"J Allergy Clin Immunol"},{"key":"546_CR28","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1182\/blood-2013-05-504308","volume":"123","author":"JP Vaque","year":"2014","unstructured":"Vaque JP, Gomez-Lopez G, Monsalvez V, Varela I, Martinez N, Perez C, Dominguez O, Grana O, Rodriguez-Peralto JL, Rodriguez-Pinilla SM et al (2014) PLCG1 mutations in cutaneous T-cell lymphomas. Blood 123:2034\u20132043","journal-title":"Blood"},{"key":"546_CR29","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.101680","volume":"298","author":"J Wada","year":"2022","unstructured":"Wada J, Rathnayake U, Jenkins LM, Singh A, Mohammadi M, Appella E, Randazzo PA, Samelson LE (2022) In vitro reconstitution reveals cooperative mechanisms of adapter protein-mediated activation of phospholipase C-gamma1 in T cells. J Biol Chem 298:101680","journal-title":"J Biol Chem"},{"key":"546_CR30","doi-asserted-by":"crossref","first-page":"17763","DOI":"10.18632\/oncotarget.14846","volume":"8","author":"M Wang","year":"2017","unstructured":"Wang M, Zhang S, Chuang SS, Ashton-Key M, Ochoa E, Bolli N, Vassiliou G, Gao Z, Du MQ (2017) Angioimmunoblastic T cell lymphoma: novel molecular insights by mutation profiling. Oncotarget 8:17763\u201317770","journal-title":"Oncotarget"},{"key":"546_CR31","doi-asserted-by":"crossref","first-page":"10064","DOI":"10.18632\/oncotarget.7134","volume":"7","author":"Q Wang","year":"2016","unstructured":"Wang Q, Tan R, Zhu X, Zhang Y, Tan Z, Su B, Li Y (2016) Oncogenic K-ras confers SAHA resistance by up-regulating HDAC6 and c-myc expression. Oncotarget 7:10064\u201310072","journal-title":"Oncotarget"},{"key":"546_CR32","doi-asserted-by":"crossref","first-page":"e202009154","DOI":"10.1083\/jcb.202009154","volume":"220","author":"L Zeng","year":"2021","unstructured":"Zeng L, Palaia I, Saric A, Su X (2021) PLCgamma1 promotes phase separation of T cell signaling components. J Cell Biol 220:e202009154","journal-title":"J Cell Biol"},{"key":"546_CR33","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/978-1-0716-3393-9_20","volume":"2705","author":"L Zeng","year":"2023","unstructured":"Zeng L, Su X (2023) Biomolecular condensation of SH2 domain-containing proteins on membranes. Methods Mol Biol 2705:371\u2013379","journal-title":"Methods Mol Biol"},{"key":"546_CR34","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0092-8674(00)80901-0","volume":"92","author":"W Zhang","year":"1998","unstructured":"Zhang W, Sloan-Lancaster J, Kitchen J, Trible RP, Samelson LE (1998) LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell 92:83\u201392","journal-title":"Cell"},{"key":"546_CR35","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.critrevonc.2015.12.018","volume":"99","author":"PL Zinzani","year":"2016","unstructured":"Zinzani PL, Bonthapally V, Huebner D, Lutes R, Chi A, Pileri S (2016) Panoptic clinical review of the current and future treatment of relapsed\/refractory T-cell lymphomas: cutaneous T-cell lymphomas. Crit Rev Oncol Hematol 99:228\u2013240","journal-title":"Crit Rev Oncol Hematol"}],"container-title":["EMBO Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1038\/s44319-025-00546-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1038\/s44319-025-00546-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1038\/s44319-025-00546-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:48:23Z","timestamp":1786981703000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1038\/s44319-025-00546-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,12]]},"references-count":35,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2025,9,23]]}},"alternative-id":["546"],"URL":"https:\/\/doi.org\/10.1038\/s44319-025-00546-x","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.12.17.628879","asserted-by":"object"}]},"ISSN":["1469-221X","1469-3178"],"issn-type":[{"value":"1469-221X","type":"print"},{"value":"1469-3178","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,12]]},"assertion":[{"value":"29 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 August 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosure and competing interests statement"}}],"article-number":"13"}}