{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T15:56:19Z","timestamp":1785858979051,"version":"3.56.0"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T00:00:00Z","timestamp":1722297600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T00:00:00Z","timestamp":1722297600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"MOST | National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32170543"],"award-info":[{"award-number":["32170543"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Young Elite Scientists Sponsorship Program by CAST","award":["2022QNRC001"],"award-info":[{"award-number":["2022QNRC001"]}]},{"DOI":"10.13039\/100007847","name":"\u5409 \u6797 \u7701 \u79d1 \u5b66 \u6280 \u672f \u5385 | Natural Science Foundation of Jilin Province","doi-asserted-by":"publisher","award":["20230101154JC"],"award-info":[{"award-number":["20230101154JC"]}],"id":[{"id":"10.13039\/100007847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO Mol Med"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cerebral palsy (CP) is a prevalent neurological disorder that imposes a significant burden on children, families, and society worldwide. Recently, the RhoB p.S73F mutation was identified as a de novo mutation associated with CP. However, the mechanism by which the RhoB p.S73F mutation causes CP is currently unclear. In this study, rabbit models were generated to mimic the human RhoB p.S73F mutation using the SpG-BE4max system, and exhibited the typical symptoms of human CP, such as periventricular leukomalacia and spastic-dystonic diplegia. Further investigation revealed that the RhoB p.S73F mutation could activate ACAT1 through the LYN pathway, and the subsequently altered lipid levels may lead to neuronal and white matter damage resulting in the development of CP. This study presented the first mammalian model of genetic CP that accurately replicates the RhoB p.S73F mutation in humans, provided further insights between RhoB and lipid metabolism, and novel therapeutic targets for human CP.<\/jats:p>","DOI":"10.1038\/s44321-024-00113-2","type":"journal-article","created":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T14:32:34Z","timestamp":1722349954000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The RhoB p.S73F mutation leads to cerebral palsy through dysregulation of lipid homeostasis"],"prefix":"10.1038","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4720-0402","authenticated-orcid":false,"given":"Xinyu","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruonan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongtian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqiang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1049-9127","authenticated-orcid":false,"given":"Shoutang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5256-6802","authenticated-orcid":false,"given":"Liangxue","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3649-962X","authenticated-orcid":false,"given":"Yuning","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6914-8589","authenticated-orcid":false,"given":"Zhanjun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,30]]},"reference":[{"key":"113_CR1","doi-asserted-by":"publisher","first-page":"1602","DOI":"10.1001\/jama.296.13.1602","volume":"296","author":"M Bax","year":"2006","unstructured":"Bax M, Tydeman C, Flodmark O (2006) Clinical and MRI correlates of cerebral palsy: the European Cerebral Palsy Study. JAMA 296:1602\u20131608","journal-title":"JAMA"},{"key":"113_CR2","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/S0005-2728(88)80086-0","volume":"972","author":"I Binderman","year":"1988","unstructured":"Binderman I, Harel S, Earon Y, Tomer A, Weisman Y, Kaye AM, S\u00f6mjen D (1988) Acute stimulation of creatine kinase activity by vitamin D metabolites in the developing cerebellum. Biochim Biophys Acta 972:9","journal-title":"Biochim Biophys Acta"},{"key":"113_CR3","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1152\/physiol.00054.2018","volume":"34","author":"JE Brandenburg","year":"2019","unstructured":"Brandenburg JE, Fogarty MJ, Sieck GC (2019) A critical evaluation of current concepts in cerebral palsy. Physiology 34:216\u2013229","journal-title":"Physiology"},{"key":"113_CR4","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1152\/jn.00186.2018","volume":"120","author":"JE Brandenburg","year":"2018","unstructured":"Brandenburg JE, Gransee HM, Fogarty MJ, Sieck GC (2018) Differences in lumbar motor neuron pruning in an animal model of early onset spasticity. J Neurophysiol 120:601\u2013609","journal-title":"J Neurophysiol"},{"key":"113_CR5","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1152\/jn.00233.2019","volume":"122","author":"CF Cavarsan","year":"2019","unstructured":"Cavarsan CF, Gorassini MA, Quinlan KA (2019) Animal models of developmental motor disorders: Parallels to human motor dysfunction in cerebral palsy. J Neurophysiol 122:1238\u20131253","journal-title":"J Neurophysiol"},{"key":"113_CR6","doi-asserted-by":"publisher","first-page":"17974","DOI":"10.1074\/jbc.C000145200","volume":"275","author":"Z Chen","year":"2000","unstructured":"Chen Z, Sun J, Pradines A, Favre G, Adnane J, Sebti SM (2000) Both farnesylated and geranylgeranylated RhoB inhibit malignant transformation and suppress human tumor growth in nude mice. J Biol Chem 275:17974\u201317978","journal-title":"J Biol Chem"},{"key":"113_CR7","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1067\/mob.2003.204","volume":"188","author":"SL Clark","year":"2003","unstructured":"Clark SL, Hankins G (2003) Temporal and demographic trends in cerebral palsy\u2014Fact and fiction. Am J Obstet Gynecol 188:628\u2013633","journal-title":"Am J Obstet Gynecol"},{"key":"113_CR8","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1097\/GRF.0b013e3181870994","volume":"51","author":"SM Clark","year":"2008","unstructured":"Clark SM, Ghulmiyyah LM, Hankins G (2008) Antenatal antecedents and the impact of obstetric care in the etiology of cerebral palsy. Clin Obstet Gynecol 51:775\u2013786","journal-title":"Clin Obstet Gynecol"},{"key":"113_CR9","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1111\/j.1469-8749.1994.tb11863.x","volume":"36","author":"AP Cosgrove","year":"1994","unstructured":"Cosgrove AP, Graham HK (1994) Botulinum toxin A prevents the development of contractures in the hereditary spastic mouse. Dev Med Child Neurol 36:379\u2013385","journal-title":"Dev Med Child Neurol"},{"key":"113_CR10","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1161\/01.STR.0000251445.94697.64","volume":"38","author":"M Derrick","year":"2007","unstructured":"Derrick M, Drobyshevsky A, Ji X, Tan S (2007) A model of cerebral palsy from fetal hypoxia-ischemia. Stroke 38:731\u2013735","journal-title":"Stroke"},{"key":"113_CR11","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1002\/ana.24115","volume":"75","author":"A Drobyshevsky","year":"2014","unstructured":"Drobyshevsky A, Jiang R, Lin L, Derrick M, Luo K, Back SA, Tan S (2014) Unmyelinated axon loss with postnatal hypertonia after fetal hypoxia. Ann Neurol 75:533\u2013541","journal-title":"Ann Neurol"},{"key":"113_CR12","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.neuroscience.2016.10.068","volume":"340","author":"LE Dur\u00e1n-Carabali","year":"2017","unstructured":"Dur\u00e1n-Carabali LE, Sanches EF, Marques MR, Aristimunha D, Pagnussat A, Netto CA (2017) Longer hypoxia-ischemia periods to neonatal rats causes motor impairments and muscular changes. Neuroscience 340:291\u2013298","journal-title":"Neuroscience"},{"key":"113_CR13","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1016\/j.molcel.2016.10.014","volume":"64","author":"J Fan","year":"2016","unstructured":"Fan J, Lin R, Xia S, Chen D, Elf SE, Liu S, Pan Y, Xu H, Qian Z, Wang M et al (2016) Tetrameric acetyl-CoA acetyltransferase 1 is important for tumor growth. Mol Cell 64:859\u2013874","journal-title":"Mol Cell"},{"key":"113_CR14","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1126\/science.282.5392.1321","volume":"282","author":"G Feng","year":"1998","unstructured":"Feng G, Tintrup H, Kirsch J, Nichol MC, Kuhse J, Betz H, Sanes JR (1998) Dual requirement for gephyrin in glycine receptor clustering and molybdoenzyme activity. Science 282:1321\u20131324","journal-title":"Science"},{"key":"113_CR15","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1111\/j.1469-8749.2010.03618.x","volume":"52","author":"CY Fong","year":"2010","unstructured":"Fong CY, Mumford AD, Likeman MJ, Jardine PE (2010) Cerebral palsy in siblings caused by compound heterozygous mutations in the gene encoding protein C. Dev Med Child Neurol 52:489\u2013493","journal-title":"Dev Med Child Neurol"},{"key":"113_CR16","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.ajog.2008.06.094","volume":"199","author":"EM Graham","year":"2008","unstructured":"Graham EM, Ruis KA, Hartman AL, Northington FJ, Fox HE (2008) A systematic review of the role of intrapartum hypoxia-ischemia in the causation of neonatal encephalopathy. Am J Obstet Gynecol 199:587\u2013595","journal-title":"Am J Obstet Gynecol"},{"key":"113_CR17","doi-asserted-by":"publisher","first-page":"15082","DOI":"10.1038\/nrdp.2015.82","volume":"2","author":"HK Graham","year":"2016","unstructured":"Graham HK, Rosenbaum P, Paneth N, Dan B, Lin J-P, Damiano DL, Becher JG, Gaebler-Spira D, Colver A, Reddihough D et al (2016) Cerebral palsy. Nat Rev Dis Prim 2:15082","journal-title":"Nat Rev Dis Prim"},{"key":"113_CR18","doi-asserted-by":"publisher","first-page":"2372","DOI":"10.1523\/JNEUROSCI.1756-17.2018","volume":"38","author":"KN Hood","year":"2018","unstructured":"Hood KN, Zhao J, Redell JB, Hylin MJ, Harris B, Perez A, Moore AN, Dash PK (2018) Endoplasmic reticulum stress contributes to the loss of newborn hippocampal neurons after traumatic brain injury. J Neurosci 38:2372\u20132384","journal-title":"J Neurosci"},{"key":"113_CR19","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1016\/j.cell.2020.06.027","volume":"182","author":"W Huang","year":"2020","unstructured":"Huang W, Bhaduri A, Velmeshev D, Wang S, Wang L, Rottkamp CA, Alvarez-Buylla A, Rowitch DH, Kriegstein AR (2020) Origins and proliferative states of human oligodendrocyte precursor cells. Cell 182:594\u2013608.e11","journal-title":"Cell"},{"key":"113_CR20","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/S0896-6273(01)00297-5","volume":"30","author":"CA Huebner","year":"2001","unstructured":"Huebner CA, Stein V, Hermans-Borgmeyer I, Meyer T, Ballanyi K, Jentsch TJ (2001) Disruption of KCC2 reveals an essential role of K-CI cotransport already in early synaptic inhibition. Neuron 30:515\u2013524","journal-title":"Neuron"},{"key":"113_CR21","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-018-0705-9","volume":"17","author":"P Jin","year":"2018","unstructured":"Jin P, Pan Y, Pan Z, Xu J, Lin M, Sun Z, Chen M, Xu M (2018) Alzheimer-like brain metabolic and structural features in cholesterol-fed rabbit detected by magnetic resonance imaging. Lipids Health Dis 17:61","journal-title":"Lipids Health Dis"},{"key":"113_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41588-020-0695-1","volume":"52","author":"SC Jin","year":"2020","unstructured":"Jin SC, Lewis SA, Bakhtiari S, Zeng X, Kruer MC (2020) Mutations disrupting neuritogenesis genes confer risk for cerebral palsy. Nat Genet 52:1\u201311","journal-title":"Nat Genet"},{"key":"113_CR23","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.1161\/CIRCULATIONAHA.106.649566","volume":"115","author":"H Kajimoto","year":"2007","unstructured":"Kajimoto H, Hashimoto K, Bonnet SN, Haromy A, Harry G, Moudgil R, Nakanishi T, Rebeyka I, Thebaud B, Michelakis ED (2007) Oxygen activates the Rho\/Rho-kinase pathway and induces RhoB and ROCK-1 expression in human and rabbit ductus arteriosus by increasing mitochondria-derived reactive oxygen species: a newly recognized mechanism for sustaining ductal constriction. Circulation 115:1777","journal-title":"Circulation"},{"key":"113_CR24","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1074\/jbc.275.1.423","volume":"275","author":"T Kwon","year":"2000","unstructured":"Kwon T, Kwon DY, Chun J, Kim JH, Kang SS (2000) Akt protein kinase inhibits Rac1-GTP binding through phosphorylation at serine 71 of Rac1. J Biol Chem 275:423\u2013428","journal-title":"J Biol Chem"},{"key":"113_CR25","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1158\/1541-7786.MCR-12-0173","volume":"10","author":"HL Lehman","year":"2012","unstructured":"Lehman HL, Van Laere SJ, van Golen CM, Vermeulen PB, Dirix LY, van Golen KL (2012) Regulation of inflammatory breast cancer cell invasion through Akt1\/PKB\u03b1 phosphorylation of RhoC GTPase. Mol Cancer Res 10:1306\u20131318","journal-title":"Mol Cancer Res"},{"key":"113_CR26","doi-asserted-by":"crossref","unstructured":"Li N, Zhou P, Tang H, He L, Hu H (2021) In-depth analysis reveals complex molecular etiology of idiopathic cerebral palsy. Brain 145:119\u2013141","DOI":"10.1093\/brain\/awab209"},{"key":"113_CR27","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.ajhg.2013.12.015","volume":"94","author":"SC Lim","year":"2014","unstructured":"Lim SC, Smith KR, Stroud DA, Compton AG, Tucker EJ, Dasvarma A, Gandolfo LC, Marum JE, McKenzie M, Peters HL et al (2014) A founder mutation in PET100 causes isolated complex IV deficiency in Lebanese individuals with Leigh syndrome. Am J Hum Genet 94:209\u2013222","journal-title":"Am J Hum Genet"},{"key":"113_CR28","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1097\/00003086-196600460-00002","volume":"3","author":"WJ Little","year":"1966","unstructured":"Little WJ (1966) On the influence of abnormal parturition, difficult labours, premature birth, and asphyxia neonatorum, on the mental and physical condition of the child, especially in relation to deformities. Clin Orthop Relat Res 3:7\u201322","journal-title":"Clin Orthop Relat Res"},{"key":"113_CR29","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1038\/s41419-020-02833-y","volume":"11","author":"H Liu","year":"2020","unstructured":"Liu H, Xu Y, Yao B, Sui T, Lai L, Li Z (2020) A novel N6-methyladenosine (m6A)-dependent fate decision for the lncRNA THOR. Cell Death Dis 11:613\u2013613","journal-title":"Cell Death Dis"},{"key":"113_CR30","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05232-2","volume":"9","author":"Z Liu","year":"2018","unstructured":"Liu Z, Chen M, Chen S, Deng J, Song Y, Lai L, Li Z (2018) Highly efficient RNA-guided base editing in rabbit. Nat Commun 9:2717","journal-title":"Nat Commun"},{"key":"113_CR31","doi-asserted-by":"publisher","first-page":"1850","DOI":"10.3390\/pharmaceutics13111850","volume":"13","author":"X-F Lou","year":"2021","unstructured":"Lou X-F, Wang C, Zhang J-C, Du Y-Z, Xu X-L (2021) A melanin-like nanoenzyme for acute lung injury therapy via suppressing oxidative and endoplasmic reticulum stress response. Pharmaceutics 13:1850","journal-title":"Pharmaceutics"},{"key":"113_CR32","doi-asserted-by":"publisher","first-page":"2976","DOI":"10.1182\/blood-2016-07-727321","volume":"128","author":"F Lupo","year":"2016","unstructured":"Lupo F, Tibaldi E, Matte A, Sharma AK, Brunati AM, Alper SL, Zancanaro C, Benati D, Siciliano A, Bertoldi M et al (2016) A new molecular link between defective autophagy and erythroid abnormalities in chorea-acanthocytosis. Blood 128:2976\u20132987","journal-title":"Blood"},{"key":"113_CR33","doi-asserted-by":"publisher","first-page":"15463","DOI":"10.1073\/pnas.93.26.15463","volume":"93","author":"S Marret","year":"1996","unstructured":"Marret S, Gressens P, Evrard P (1996) Arrest of neuronal migration by excitatory amino acids in hamster developing brain. Proc Natl Acad Sci USA 93:15463\u201315468","journal-title":"Proc Natl Acad Sci USA"},{"key":"113_CR34","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1111\/dmcn.14028","volume":"61","author":"PG Mcphee","year":"2018","unstructured":"Mcphee PG, Claridge EA, Noorduyn SG, Gorter JW (2018) Cardiovascular disease and related risk factors in adults with cerebral palsy: a systematic review. Dev Med Child Neurol 61:915\u2013923","journal-title":"Dev Med Child Neurol"},{"key":"113_CR35","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1177\/08830738050200080801","volume":"20","author":"MA Montenegro","year":"2005","unstructured":"Montenegro MA, Cendes F, Saito H, Serra JG, Guerreiro MM (2005) Intrapartum complications associated with malformations of cortical development. J Child Neurol 20:675\u2013678","journal-title":"J Child Neurol"},{"key":"113_CR36","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/B978-0-444-63916-5.00020-3","volume":"159","author":"P Morgan","year":"2018","unstructured":"Morgan P, McGinley JL (2018) Cerebral palsy. Handb Clin Neurol 159:323\u2013336","journal-title":"Handb Clin Neurol"},{"key":"113_CR37","doi-asserted-by":"publisher","first-page":"e67418","DOI":"10.1371\/journal.pone.0067418","volume":"8","author":"E Mu\u00f1oz-Moreno","year":"2013","unstructured":"Mu\u00f1oz-Moreno E, Arbat-Plana A, Batalle D, Soria G, Illa M, Prats-Galino A, Eixarch E, Gratacos E (2013) A magnetic resonance image based atlas of the rabbit brain for automatic parcellation. PLoS ONE 8:e67418","journal-title":"PLoS ONE"},{"key":"113_CR38","first-page":"21","volume":"26","author":"RE Myers","year":"1975","unstructured":"Myers RE (1975) Fetal asphyxia due to umbilical cord compression. Metabolic and brain pathologic consequences. Biol Neonate 26:21","journal-title":"Biol Neonate"},{"key":"113_CR39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0166-4328(03)00219-5","volume":"150","author":"BP Nathan","year":"2004","unstructured":"Nathan BP, Yost J, Litherland MT, Struble RG, Switzer PV (2004) Olfactory function in apoE knockout mice. Behav Brain Res 150:1\u20137","journal-title":"Behav Brain Res"},{"key":"113_CR40","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1097\/GRF.0b013e318187087c","volume":"51","author":"KB Nelson","year":"2008","unstructured":"Nelson KB (2008) Causative factors in cerebral palsy. Clin Obstet Gynecol 51:749\u2013762","journal-title":"Clin Obstet Gynecol"},{"key":"113_CR41","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1001\/jamapediatrics.2017.1689","volume":"171","author":"I Novak","year":"2017","unstructured":"Novak I, Morgan C, Adde L, Blackman J, Boyd RN, Brunstrom-Hernandez J, Cioni G, Damiano D, Darrah J, Eliasson A-C et al (2017) Early, accurate diagnosis and early intervention in cerebral palsy: advances in diagnosis and treatment. JAMA Pediatrics 171:897\u2013907","journal-title":"JAMA Pediatrics"},{"key":"113_CR42","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1111\/j.1469-8749.2007.tb12610.x","volume":"49","author":"P Rosenbaum","year":"2007","unstructured":"Rosenbaum P, Paneth N, Leviton A, Goldstein M, Bo J (2007) A report: the definition and classification of cerebral palsy April 2006. Dev Med Child Neurol Suppl 49:8\u201314","journal-title":"Dev Med Child Neurol Suppl"},{"key":"113_CR43","doi-asserted-by":"publisher","first-page":"1995","DOI":"10.1016\/j.ridd.2014.03.051","volume":"35","author":"JM Ryan","year":"2014","unstructured":"Ryan JM, Crowley VE, Hensey O, Broderick JM, Gormley J (2014) Habitual physical activity and cardiometabolic risk factors in adults with cerebral palsy. Res Dev Disabil 35:1995\u20132002","journal-title":"Res Dev Disabil"},{"key":"113_CR44","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1161\/01.RES.0000090998.08629.60","volume":"93","author":"S Sakurada","year":"2003","unstructured":"Sakurada S (2003) Ca2+-dependent activation of rho and rho kinase in membrane depolarization\u2013induced and receptor stimulation\u2013induced vascular smooth muscle contraction. Circulation Res 93:548\u2013556","journal-title":"Circulation Res"},{"key":"113_CR45","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1016\/j.devcel.2004.09.019","volume":"7","author":"E Sandilands","year":"2004","unstructured":"Sandilands E, Cans C, Fincham VJ, Brunton VG, Mellor H, Prendergast GC, Norman JC, Superti-Furga G, Frame MC (2004) RhoB and actin polymerization coordinate Src activation with endosome-mediated delivery to the membrane. Dev Cell 7:855\u2013869","journal-title":"Dev Cell"},{"key":"113_CR46","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1038\/emboj.2011.361","volume":"31","author":"M Schuster","year":"2012","unstructured":"Schuster M, Treitschke S, Kilaru S, Molloy J, Harmer NJ, Steinberg G (2012) Myosin-5, kinesin-1 and myosin-17 cooperate in secretion of fungal chitin synthase: Myosin-5, kinesin-1 and myosin-17 in CHS secretion. EMBO J 31:214\u2013227","journal-title":"EMBO J"},{"key":"113_CR47","doi-asserted-by":"publisher","first-page":"11486","DOI":"10.1073\/pnas.96.20.11486","volume":"96","author":"DC Shields","year":"1999","unstructured":"Shields DC, Schaecher KE, Saido TC, Banik NL (1999) A putative mechanism of demyelination in multiple sclerosis by a proteolytic enzyme, calpain. Proc Natl Acad Sci USA 96:11486\u201311491","journal-title":"Proc Natl Acad Sci USA"},{"key":"113_CR48","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1126\/science.1133427","volume":"314","author":"T Sj\u00f6blom","year":"2006","unstructured":"Sj\u00f6blom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N et al (2006) Consensus coding sequences of human breast and colorectal cancers. Science 314:268\u2013274","journal-title":"Science"},{"key":"113_CR49","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.clp.2018.05.011","volume":"45","author":"AJ Spittle","year":"2018","unstructured":"Spittle AJ, Morgan C, Olsen JE, Novak I, Cheong JLY (2018) Early diagnosis and treatment of cerebral palsy in children with a history of preterm birth. Clin Perinatol 45:409\u2013420","journal-title":"Clin Perinatol"},{"key":"113_CR50","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1111\/dmcn.14463","volume":"62","author":"K Stadskleiv","year":"2020","unstructured":"Stadskleiv K (2020) Cognitive functioning in children with cerebral palsy. Dev Med Child Neurol 62:283\u2013289","journal-title":"Dev Med Child Neurol"},{"key":"113_CR51","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1126\/science.1062023","volume":"294","author":"IR Vetter","year":"2001","unstructured":"Vetter IR, Wittinghofer A (2001) The guanine nucleotide-binding switch in three dimensions. Science 294:1299\u20131304","journal-title":"Science"},{"key":"113_CR52","doi-asserted-by":"publisher","first-page":"113643","DOI":"10.1016\/j.expneurol.2021.113643","volume":"340","author":"DB Visco","year":"2021","unstructured":"Visco DB, Toscano AE, Ju\u00e1rez PAR, Gouveia HJCB, Guzman-Quevedo O, Torner L, Manh\u00e3es-de-Castro R (2021) A systematic review of neurogenesis in animal models of early brain damage: Implications for cerebral palsy. Exp Neurol 340:113643","journal-title":"Exp Neurol"},{"key":"113_CR53","doi-asserted-by":"publisher","first-page":"864426","DOI":"10.3389\/fncel.2022.864426","volume":"16","author":"L Wang","year":"2022","unstructured":"Wang L, Liu Y, Zhang X, Ye Y, Xiong X, Zhang S, Gu L, Jian Z, Wang H (2022) Endoplasmic reticulum stress and the unfolded protein response in cerebral ischemia\/reperfusion injury. Front Cell Neurosci 16:864426","journal-title":"Front Cell Neurosci"},{"key":"113_CR54","doi-asserted-by":"publisher","first-page":"926791","DOI":"10.3389\/fnmol.2022.926791","volume":"15","author":"XK Wang","year":"2022","unstructured":"Wang XK, Gao C, Zhong HQ, Kong XY, Qiao R, Zhang HC, Chen BY, Gao Y, Li B (2022) TNAP\u2014a potential cytokine in the cerebral inflammation in spastic cerebral palsy. Front Mol Neurosci 15:926791","journal-title":"Front Mol Neurosci"},{"key":"113_CR55","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.3390\/ijms20051148","volume":"20","author":"CC Yang","year":"2019","unstructured":"Yang CC, Wang WY, Lin FH, Hou CH (2019) Rare-earth-doped calcium carbonate exposed to X-ray irradiation to induce reactive oxygen species for tumor treatment. Int J Mol Sci 20:1148","journal-title":"Int J Mol Sci"},{"key":"113_CR56","first-page":"jrm00195","volume":"53","author":"S Yang","year":"2021","unstructured":"Yang S, Xia J, Gao J, Wang L (2021) Increasing prevalence of cerebral palsy among children and adolescents in China 1988-2020: a systematic review and meta-analysis. J Rehab Med 53:jrm00195","journal-title":"J Rehab Med"},{"key":"113_CR57","doi-asserted-by":"publisher","first-page":"8960","DOI":"10.3390\/ijms23168960","volume":"23","author":"Z Yang","year":"2022","unstructured":"Yang Z, Arja RD, Zhu T, Sarkis GA, Patterson RL, Romo P, Rathore DS, Moghieb A, Abbatiello S, Robertson CS et al (2022) Characterization of calpain and caspase-6-generated glial fibrillary acidic protein breakdown products following traumatic brain injury and astroglial cell injury. Int J Mol Sci 23:8960","journal-title":"Int J Mol Sci"},{"key":"113_CR58","doi-asserted-by":"publisher","first-page":"e0175438","DOI":"10.1371\/journal.pone.0175438","volume":"12","author":"N Zaghloul","year":"2017","unstructured":"Zaghloul N, Patel H, Ahmed MN (2017) A model of periventricular leukomalacia (PVL) in neonate mice with histopathological and neurodevelopmental outcomes mimicking human PVL in neonates. PLoS ONE 12:e0175438","journal-title":"PLoS ONE"},{"key":"113_CR59","doi-asserted-by":"publisher","first-page":"e023540","DOI":"10.1161\/JAHA.121.023540","volume":"11","author":"C Zhang","year":"2022","unstructured":"Zhang C, Zhang B, Zhang X, Wang M, Sun X, Sun G (2022) Panax notoginseng saponin protects against diabetic cardiomyopathy through lipid metabolism modulation. J Am Heart Assoc 11:e023540","journal-title":"J Am Heart Assoc"},{"key":"113_CR60","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.molcel.2019.10.015","volume":"77","author":"Y Zhu","year":"2020","unstructured":"Zhu Y, Gu L, Lin X, Liu C, Lu B, Cui K, Zhou F, Zhao Q, Prochownik EV, Fan C (2020) Dynamic regulation of ME1 phosphorylation and acetylation affects lipid metabolism and colorectal tumorigenesis. Mol Cell 77:138\u2013149.e5","journal-title":"Mol Cell"}],"container-title":["EMBO Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1038\/s44321-024-00113-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1038\/s44321-024-00113-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1038\/s44321-024-00113-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T15:02:49Z","timestamp":1785855769000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1038\/s44321-024-00113-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,30]]},"references-count":60,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2024,9,12]]}},"alternative-id":["113"],"URL":"https:\/\/doi.org\/10.1038\/s44321-024-00113-2","relation":{},"ISSN":["1757-4684"],"issn-type":[{"value":"1757-4684","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,30]]},"assertion":[{"value":"22 December 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 July 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 July 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosure and competing interests statement"}}],"article-number":"3"}}