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We therefore investigated whether Rett syndrome (RTT), that represents the first cause of severe intellectual disability in girls, might benefit from NPC-based therapy. Using in vitro co-cultures, we demonstrate that, by sensing the pathological context, NPC-secreted factors induce the recovery of morphological and synaptic defects typical of\n                    <jats:italic>Mecp2<\/jats:italic>\n                    deficient neurons. In vivo, we prove that intracerebral transplantation of NPCs in RTT mice significantly ameliorates neurological functions. To uncover the molecular mechanisms underpinning the mediated benefic effects, we analyzed the transcriptional profile of the cerebellum of transplanted animals, disclosing the possible involvement of the Interferon \u03b3 (IFN\u03b3) pathway. Accordingly, we report the capacity of IFN\u03b3 to rescue synaptic defects, as well as motor and cognitive alterations in\n                    <jats:italic>Mecp2<\/jats:italic>\n                    deficient models, thereby suggesting this molecular pathway as a potential therapeutic target for RTT.\n                  <\/jats:p>","DOI":"10.1038\/s44321-024-00144-9","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T05:21:24Z","timestamp":1727155284000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Neural precursor cells rescue symptoms of Rett syndrome by activation of the Interferon \u03b3 pathway"],"prefix":"10.1038","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0963-9789","authenticated-orcid":false,"given":"Angelisa","family":"Frasca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7081-8161","authenticated-orcid":false,"given":"Federica","family":"Miramondi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Butti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzia","family":"Indrigo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9792-6824","authenticated-orcid":false,"given":"Maria","family":"Balbontin Arenas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca M","family":"Postogna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianna","family":"Piffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Bedogni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Pizzamiglio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Cambria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9812-579X","authenticated-orcid":false,"given":"Ugo","family":"Borello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0198-4529","authenticated-orcid":false,"given":"Flavia","family":"Antonucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianvito","family":"Martino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0820-3155","authenticated-orcid":false,"given":"Nicoletta","family":"Landsberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,20]]},"reference":[{"issue":"3","key":"144_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.109296","volume":"27","author":"E Albizzati","year":"2024","unstructured":"Albizzati E, Breccia M, Florio E, Cabasino C, Postogna FM, Grassi R, Boda E, Battaglia C, De Palma C, De Quattro C et al (2024) Mecp2 knock-out astrocytes affect synaptogenesis by interleukin 6 dependent mechanisms. iScience 27(3):109296","journal-title":"iScience"},{"key":"144_CR2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.823060","volume":"16","author":"E Albizzati","year":"2022","unstructured":"Albizzati E, Florio E, Miramondi F, Sormonta I, Landsberger N, Frasca A (2022) Identification of region-specific cytoskeletal and molecular alterations in astrocytes of Mecp2 deficient animals. 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