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Correlating intratumoral androgens, instead of circulating androgens, and their downstream transcriptome, a measure of free unbound androgen function, may offer a direct assessment of androgen action in BC. Intratumoral androgen androstenedione (A4) levels in BC specimens correlated with 1388 genes, which classified patients into low, intermediate, and high A4 levels. This A4-high patients\u2019 transcriptome was associated with lower tumor cell proliferation, earlier stage and grade, and longer survival, while A4-low patients\u2019 transcriptome was associated with the triple-negative subtype. We developed a 90-gene A4-associated transcriptional classifier that captures intratumoral A4-associated biology. The signature requires independent validation. snRNAseq analysis indicated that high A4 specimens were enriched for favorable cell lineage, while low A4 specimens were enriched for aggressive cell lineage and cancer hallmarks. 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