{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T11:43:27Z","timestamp":1789731807148,"version":"4.0.1"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,11,19]],"date-time":"2013-11-19T00:00:00Z","timestamp":1384819200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Spinal Cord"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1038\/sc.2013.131","type":"journal-article","created":{"date-parts":[[2013,11,19]],"date-time":"2013-11-19T10:20:24Z","timestamp":1384856424000},"page":"61-64","source":"Crossref","is-referenced-by-count":29,"title":["The prevalence of small intestinal bacterial overgrowth and methane production in patients with myelomeningocele and constipation"],"prefix":"10.1038","volume":"52","author":[{"given":"V","family":"Ojetti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Bruno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Paolucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Triarico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"D'aversa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Ausili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Gasbarrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Rendeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,11,19]]},"reference":[{"key":"BFsc2013131_CR1","doi-asserted-by":"publisher","first-page":"S31","DOI":"10.4103\/1817-1745.85707","volume":"6","author":"NK Venkataramana","year":"2011","unstructured":"Venkataramana NK . Spinal dysraphism. J Pediatr Neurosci 2011; 6 (Suppl 1): S31\u2013S40.","journal-title":"J Pediatr Neurosci"},{"key":"BFsc2013131_CR2","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1046\/j.1528-1157.44.s3.2.x","volume":"44","author":"L Frey","year":"2003","unstructured":"Frey L, Hauser WA . Epidemiology of neural tube defects. Epilepsia 2003; 44 (Suppl 3): 4\u201313.","journal-title":"Epilepsia"},{"key":"BFsc2013131_CR3","first-page":"313","volume":"30","author":"H Northrup","year":"2000","unstructured":"Northrup H, Volcik KA . Spina bifida and other neural tube defects. Curr Probl Pediatr 2000; 30: 313\u2013332.","journal-title":"Curr Probl Pediatr"},{"key":"BFsc2013131_CR4","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1111\/j.1365-2036.2006.02872.x","volume":"23","author":"C Rendeli","year":"2006","unstructured":"Rendeli C, Ausili E, Tabacco F, Focarelli B, Pantanella A, Di Rocco C et al. Polyethylene glycol 4000 vs lactulose for the treatment of neurogenic constipation in myelomeningocele children: a randomized-controlled clinical trial. Aliment Pharmacol Ther 2006; 23: 1259\u20131265.","journal-title":"Aliment Pharmacol Ther"},{"key":"BFsc2013131_CR5","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1038\/sc.2009.186","volume":"48","author":"E Ausili","year":"2010","unstructured":"Ausili E, Focarelli B, Tabacco F, Murolo D, Sigismondi M, Gasbarrini A et al. Transanal irrigation in myelomeningocele children: an alternative, safe and valid approach for neurogenic constipation. Spinal Cord 2010; 48: 560\u2013565.","journal-title":"Spinal Cord"},{"key":"BFsc2013131_CR6","first-page":"181","volume":"35","author":"W Roma\u0144czuk","year":"1993","unstructured":"Roma\u0144czuk W, Korczawski R . Chronic constipation: a cause of recurrent urinary tract infections. Turk J Pediatr 1993; 35: 181\u2013188.","journal-title":"Turk J Pediatr"},{"key":"BFsc2013131_CR7","doi-asserted-by":"publisher","first-page":"2978","DOI":"10.3748\/wjg.v16.i24.2978","volume":"16","author":"J Bures","year":"2010","unstructured":"Bures J, Cyrany J, Kohoutova D, F\u00f6rstl M, Rejchrt S, Kvetina J et al. Small intestinal bacterial overgrowth syndrome. World J Gastroenterol 2010; 16: 2978\u20132990.","journal-title":"World J Gastroenterol"},{"key":"BFsc2013131_CR8","first-page":"412","volume":"98","author":"M Pimentel","year":"2003","unstructured":"Pimentel M, Chow EJ, Lin HC . Normalization of lactulose breath testing correlates with symptom improvement in irritable bowel syndrome. a double-blind, randomized, placebo-controlled study. Am J Gastroenterol 2003; 98: 412\u2013419.","journal-title":"Am J Gastroenterol"},{"key":"BFsc2013131_CR9","doi-asserted-by":"publisher","first-page":"3213","DOI":"10.1007\/s10620-012-2197-1","volume":"57","author":"G Kim","year":"2012","unstructured":"Kim G, Deepinder F, Morales W, Hwang L, Weitsman S, Chang C et al. Methanobrevibacter smithii is the predominant methanogen in patients with constipation-predominant IBS and methane on breath. Dig Dis Sci 2012; 57: 3213\u20133218.","journal-title":"Dig Dis Sci"},{"key":"BFsc2013131_CR10","doi-asserted-by":"publisher","first-page":"G1089","DOI":"10.1152\/ajpgi.00574.2004","volume":"290","author":"M Pimentel","year":"2006","unstructured":"Pimentel M, Lin HC, Enayati P, van den Burg B, Lee HR, Chen JH et al. Methane, a gas produced by enteric bacteria, slows intestinal transit and augments small intestinal contractile activity. Am J Physiol Gastrointest Liver Physiol 2006; 290: G1089\u2013G1095.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"BFsc2013131_CR11","doi-asserted-by":"publisher","first-page":"1612","DOI":"10.1007\/s10620-011-1590-5","volume":"56","author":"D Kunkel","year":"2011","unstructured":"Kunkel D, Basseri RJ, Makhani MD, Chong K, Chang C, Pimentel M . Methane on breath testing is associated with constipation: a systematic review and meta-analysis. Dig Dis Sci 2011; 56: 1612\u20131618.","journal-title":"Dig Dis Sci"},{"key":"BFsc2013131_CR12","first-page":"419","volume":"13","author":"V Ojetti","year":"2009","unstructured":"Ojetti V, Pitocco D, Scarpellini E, Zaccardi F, Scaldaferri F, Gigante G et al. Small bowel bacterial overgrowth and type 1 diabetes. Eur Rev Med Pharmacol Sci 2009; 13: 419\u2013423.","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"BFsc2013131_CR13","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1111\/j.1440-1746.2009.06015.x","volume":"25","author":"H Koh","year":"2010","unstructured":"Koh H, Lee MJ, Kim MJ, Shin JI, Chung KS . Simple diagnostic approach to childhood fecal retention using the Leech score and Bristol stool form scale in medical practice. J Gastroenterol Hepatol 2010; 25: 334\u2013338.","journal-title":"J Gastroenterol Hepatol"},{"key":"BFsc2013131_CR14","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1016\/j.jpeds.2009.10.043","volume":"156","author":"A Leiby","year":"2010","unstructured":"Leiby A, Mehta D, Gopalareddy V, Jackson-Walker S, Horvath K . Bacterial overgrowth and methane production in children with encopresis. J Pediatr 2010; 156: 766\u2013770.","journal-title":"J Pediatr"},{"key":"BFsc2013131_CR15","doi-asserted-by":"publisher","first-page":"5035","DOI":"10.3748\/wjg.v17.i46.5035","volume":"17","author":"RA Awad","year":"2011","unstructured":"Awad RA . Neurogenic bowel dysfunction in patients with spinal cord injury, myelomeningocele, multiple sclerosis and Parkinson\u2019s disease. World J Gastroenterol 2011; 17: 5035\u20135048.","journal-title":"World J Gastroenterol"},{"key":"BFsc2013131_CR16","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/j.jpeds.2009.03.033","volume":"155","author":"E Scarpellini","year":"2009","unstructured":"Scarpellini E, Giorgio V, Gabrielli M, Lauritano EC, Pantanella A, Fundar\u00f2 C et al. Prevalence of small intestinal bacterial overgrowth in children with irritable bowel syndrome: a case-control study. J Pediatr 2009; 155: 416\u2013420.","journal-title":"J Pediatr"},{"key":"BFsc2013131_CR17","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1097\/MEG.0b013e32835eb916","volume":"25","author":"KM Lee","year":"2013","unstructured":"Lee KM, Paik CN, Chung WC, Yang JM, Choi MG . Breath methane positivity is more common and higher in patients with objectively proven delayed transit constipation. Eur J Gastroenterol Hepatol 2013; 25: 726\u2013732.","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"BFsc2013131_CR18","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1038\/ajg.2009.744","volume":"105","author":"D Roccarina","year":"2010","unstructured":"Roccarina D, Lauritano EC, Gabrielli M, Franceschi F, Ojetti V, Gasbarrini A . The role of methane in intestinal diseases. Am J Gastroenterol 2010; 105: 1250\u20131256.","journal-title":"Am J Gastroenterol"},{"key":"BFsc2013131_CR19","doi-asserted-by":"publisher","first-page":"40","DOI":"10.5056\/jnm.2010.16.1.40","volume":"16","author":"UC Ghoshal","year":"2010","unstructured":"Ghoshal UC, Kumar S, Mehrotra M, Lakshmi C, Misra A . Frequency of small intestinal bacterial overgrowth in patients with irritable bowel syndrome and chronic non-specific diarrhea. J Neurogastroenterol Motil 2010; 16: 40\u201346.","journal-title":"J Neurogastroenterol Motil"},{"key":"BFsc2013131_CR20","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1097\/01.mcg.0000165665.94777.bd","volume":"39","author":"AC Soares","year":"2005","unstructured":"Soares AC, Lederman HM, Fagundes-Neto U, de Morais MB . Breath methane associated with slow colonic transit time in children with chronic constipation. J Clin Gastroenterol 2005; 39: 512\u2013515.","journal-title":"J Clin Gastroenterol"}],"container-title":["Spinal Cord"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/sc2013131.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/sc2013131","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/sc2013131.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T22:23:58Z","timestamp":1684621438000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/sc2013131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,19]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["BFsc2013131"],"URL":"https:\/\/doi.org\/10.1038\/sc.2013.131","relation":{},"ISSN":["1362-4393","1476-5624"],"issn-type":[{"value":"1362-4393","type":"print"},{"value":"1476-5624","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,19]]}}}