{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T03:14:31Z","timestamp":1789528471987,"version":"build-2803163510"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2014,9,2]],"date-time":"2014-09-02T00:00:00Z","timestamp":1409616000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Spinal Cord"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1038\/sc.2014.144","type":"journal-article","created":{"date-parts":[[2014,9,2]],"date-time":"2014-09-02T09:18:58Z","timestamp":1409649538000},"page":"809-816","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Role of local application of autologous platelet-rich plasma in the management of pressure ulcers in spinal cord injury patients"],"prefix":"10.1038","volume":"52","author":[{"given":"R","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R K","family":"Rohilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R K","family":"Dhayal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Sen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P K","family":"Sehgal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,9,2]]},"reference":[{"key":"BFsc2014144_CR1","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1097\/MRR.0b013e3282fb7d25","volume":"31","author":"R Singh","year":"2008","unstructured":"Singh R, Dhankar SS, Rohilla R . Quality of life of people with spinal cord injury in northern India. Int J Rehabli Res 2008; 31: 247\u2013251.","journal-title":"Int J Rehabli Res"},{"key":"BFsc2014144_CR2","first-page":"877","volume":"42","author":"N Drigotaite","year":"2006","unstructured":"Drigotaite N, Krisciunas A . Complications after spinal cord injuries and their influence on the effectiveness of rehabilitation. Medicina (Kaunas) 2006; 42: 877\u2013880.","journal-title":"Medicina (Kaunas)"},{"key":"BFsc2014144_CR3","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1179\/107902610X12923394765616","volume":"34","author":"SA Sell","year":"2011","unstructured":"Sell SA, Ericksen JJ, Reis TW, Droste LR, Bhuiyan MB, Gater DR . A case report on the use of sustained release platelet rich plasma for the treatment for chronic pressure ulcers. J Spinal Cord Med 2011; 34: 122\u2013127.","journal-title":"J Spinal Cord Med"},{"issue":"12 Suppl","key":"BFsc2014144_CR4","doi-asserted-by":"publisher","first-page":"S122","DOI":"10.1097\/00005373-199012001-00025","volume":"30","author":"TK Hunt","year":"1990","unstructured":"Hunt TK . Basic principles of wound healing. J Trauma 1990; 30 (12 Suppl): S122\u2013S128.","journal-title":"J Trauma"},{"key":"BFsc2014144_CR5","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1111\/j.1742-481X.2011.00770.x","volume":"8","author":"LM Rappl","year":"2011","unstructured":"Rappl LM . Effect of platelet rich plasma gel in a physiologically relevant platelet concentration on wounds in persons with spinal cord injury. Int Wound J 2011; 8: 187\u2013195.","journal-title":"Int Wound J"},{"key":"BFsc2014144_CR6","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1111\/j.1524-475X.2006.00175.x","volume":"14","author":"J Whitney","year":"2006","unstructured":"Whitney J, Phillips L, Aslam R, Barbul A, Gottrup F, Gould L et al. Guidelines for the treatment of pressure ulcers. Wound Repair Regen 2006; 14: 663\u2013679.","journal-title":"Wound Repair Regen"},{"key":"BFsc2014144_CR7","doi-asserted-by":"crossref","unstructured":"Reese RJ . Autologous platelet rich plasma (PRP): what do we know? Important concepts relevant to hair restoration surgery. Hair Transplant Forum Int 2010, 14\u201317.","DOI":"10.33589\/20.1.0014"},{"key":"BFsc2014144_CR8","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1056\/NEJM198907133210209","volume":"321","author":"T Hunt","year":"1989","unstructured":"Hunt T, Van FL . Enhancement of wound healing by growth factors. New Engl J Med 1989; 321: 11\u201312.","journal-title":"New Engl J Med"},{"key":"BFsc2014144_CR9","doi-asserted-by":"publisher","first-page":"147e","DOI":"10.1097\/01.prs.0000239606.92676.cf","volume":"118","author":"BL Eppley","year":"2006","unstructured":"Eppley BL, Pietrzak WS, Blanton M . Platelet-rich plasma: a review of biology and applications in plastic surgery. Plast Reconstr Surg 2006; 118: 147e\u2013159e.","journal-title":"Plast Reconstr Surg"},{"key":"BFsc2014144_CR10","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1002\/jbm.b.30886","volume":"84","author":"E Anitua","year":"2008","unstructured":"Anitua E, Aguirre JJ, Algorta J, Ayerdi E, Cabezas AI, Orive G et al. Effectiveness of autologous preparation rich in growth factors for the treatment of chronic cutaneous ulcers. J Biomed Mater Res B Appl Biomater 2008; 84: 415\u2013421.","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"BFsc2014144_CR11","first-page":"36","volume":"56","author":"RG Frykberg","year":"2010","unstructured":"Frykberg RG, Driver VR, Carman D, Lucero B, Borris-Hale C, Fylling CP et al. Chronic wounds treated with a physiologically relevant concentration of platelet-rich plasma gel: a prospective case series. Ostomy Wound Manage 2010; 56: 36\u201344.","journal-title":"Ostomy Wound Manage"},{"key":"BFsc2014144_CR12","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1111\/j.1537-2995.2004.03366.x","volume":"44","author":"L Mazzucco","year":"2004","unstructured":"Mazzucco L, Medici D, Serra M, Panizza R, Rivara G, Orecchia S et al. The use of autologous platelet gel to treat difficult- to-heal wounds: a pilot study. Transfusion 2004; 44: 1013\u20131018.","journal-title":"Transfusion"},{"key":"BFsc2014144_CR13","first-page":"5","volume":"8","author":"M Gurgen","year":"2008","unstructured":"Gurgen M . Treatment of chronic wounds with autologous platelet-rich plasma. EWMA J 2008; 8: 5\u201311.","journal-title":"EWMA J"},{"key":"BFsc2014144_CR14","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1111\/j.1742-481X.2010.00671.x","volume":"7","author":"S Scevola","year":"2010","unstructured":"Scevola S, Nicoletti G, Brenta F, Isernia P, Maestri M, Faga A . Allogenic platelet gel in the treatment of pressure sores: a pilot study. Int Wound J 2010; 7: 184\u2013190.","journal-title":"Int Wound J"},{"key":"BFsc2014144_CR15","unstructured":"European Pressure Ulcer Advisory Panel. Pressure Ulcer Treatment Guidelines. EPUAP www.EPUAP.org 1999."},{"key":"BFsc2014144_CR16","unstructured":"Pressure Ulcer Scale for Healing (PUSH) PUSH Tool Version 3.0:9\/15\/98 \u00a9National Pressure Ulcer Advisory Panel http:\/\/www.npuap.org ."},{"key":"BFsc2014144_CR17","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1051\/ject\/200638260","volume":"38","author":"RL Knox","year":"2006","unstructured":"Knox RL, Hunt AR, Collins JC, DeSmet M, Barnes S . Platelet-rich plasma combined with skin substitute for chronic wound healing: a case report. J Extra Corpor Technol 2006; 38: 260\u2013264.","journal-title":"J Extra Corpor Technol"},{"key":"BFsc2014144_CR18","first-page":"280","volume":"21","author":"T Yuan","year":"2009","unstructured":"Yuan T, Zhang CQ, Tang MJ, Guo SC, Zeng BF . Autologous platelet-rich plasma enhances healing of chronic wounds. Wounds 2009; 21: 280\u2013285.","journal-title":"Wounds"},{"key":"BFsc2014144_CR19","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.transci.2004.01.004","volume":"30","author":"G Crovetti","year":"2004","unstructured":"Crovetti G, Martinelli G, Issi M, Barone M, Guizzardi M, Campanati B et al. Platelet gel for healing cutaneous chronic wounds. Transfus Apher Sci 2004; 30: 145\u2013151.","journal-title":"Transfus Apher Sci"},{"key":"BFsc2014144_CR20","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1093\/gerona\/60.1.93","volume":"60","author":"SE Gardner","year":"2005","unstructured":"Gardner SE, Frantz RA, Bergquist S, Shin CD . A prospective study of the Pressure Ulcer Scale for Healing (PUSH). J Gerontol Med Sci 2005; 60: 93\u201397.","journal-title":"J Gerontol Med Sci"},{"key":"BFsc2014144_CR21","first-page":"26","volume":"56","author":"J Hon","year":"2010","unstructured":"Hon J, Lagden K, McLaren A, O'Sullivan D, Orr L, Houghton PE et al. A prospective, multicenter study to validate use of the pressure ulcer scale for healing (PUSH) in patients withdiabetic, venous, and pressure ulcers. Ostomy Wound Manage 2010; 56: 26\u201336.","journal-title":"Ostomy Wound Manage"},{"key":"BFsc2014144_CR22","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1152\/physrev.2003.83.3.835","volume":"83","author":"S Werner","year":"2003","unstructured":"Werner S, Grose R . Regulation of wound healing by growth factors and cytokines. Physiol Rev 2003; 83: 835\u2013870.","journal-title":"Physiol Rev"},{"key":"BFsc2014144_CR23","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1111\/j.1743-6109.2006.00164.x","volume":"14","author":"G Pietramaggiori","year":"2006","unstructured":"Pietramaggiori G, Kaipainen A, Czeczuga JM, Wagner CT, Orgill DP . Freeze-dried platelet-rich plasma shows beneficial healing properties in chronic wounds. Wound Repair Regen 2006; 14: 573\u2013580.","journal-title":"Wound Repair Regen"},{"key":"BFsc2014144_CR24","doi-asserted-by":"publisher","first-page":"7696","DOI":"10.1073\/pnas.84.21.7696","volume":"84","author":"SE Lynch","year":"1987","unstructured":"Lynch SE, Nixon JC, Colvin RB, Antoniades HN . Role of platelet-derived growth factor in wound healing: synergistic effects with other growth factors. ProcNatl Acad Sci USA 1987; 84: 7696\u20137700.","journal-title":"ProcNatl Acad Sci USA"},{"key":"BFsc2014144_CR25","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1080\/10790268.2010.11689718","volume":"33","author":"R Singh","year":"2010","unstructured":"Singh R, Singh R, Rohilla RK, Siwach R, Verma V, Kaur K . Surgery for pressure ulcers improves general health and quality of life in patients with spinal cord injury. J Spinal Cord Med 2010; 33: 396\u2013400.","journal-title":"J Spinal Cord Med"},{"key":"BFsc2014144_CR26","doi-asserted-by":"publisher","first-page":"58 60","DOI":"10.1038\/sj.sc.3100340","volume":"35","author":"U Fuoco","year":"1997","unstructured":"Fuoco U, Scivoletto G, Pace A, Vona VU, Castellano V . Anaemia and serum protein alteration in patients with pressure ulcers. Spinal Cord 1997; 35: 58 60.","journal-title":"Spinal Cord"}],"container-title":["Spinal Cord"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/sc2014144.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/sc2014144","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/sc2014144.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,2]],"date-time":"2024-06-02T05:07:21Z","timestamp":1717304841000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/sc2014144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,2]]},"references-count":26,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["BFsc2014144"],"URL":"https:\/\/doi.org\/10.1038\/sc.2014.144","relation":{},"ISSN":["1362-4393","1476-5624"],"issn-type":[{"value":"1362-4393","type":"print"},{"value":"1476-5624","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,2]]},"assertion":[{"value":"14 August 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 July 2014","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 July 2014","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 September 2014","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}