{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T10:54:03Z","timestamp":1785840843320,"version":"3.56.0"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2016,10,18]],"date-time":"2016-10-18T00:00:00Z","timestamp":1476748800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Spinal Cord"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1038\/sc.2016.143","type":"journal-article","created":{"date-parts":[[2016,10,18]],"date-time":"2016-10-18T09:24:51Z","timestamp":1476782691000},"page":"213-215","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Ankylosing spondylitis does not increase the risk of neurogenic heterotopic ossification in patients with a spinal cord injury: a retrospective cohort study"],"prefix":"10.1038","volume":"55","author":[{"given":"M","family":"Ohlmeier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Karras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E M","family":"Suero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Grasm\u00fccke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Aach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Meindl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T A","family":"Schildhauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Citak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,10,18]]},"reference":[{"key":"BFsc2016143_CR1","doi-asserted-by":"publisher","first-page":"1953","DOI":"10.1097\/BRS.0b013e31825ee81b","volume":"37","author":"M Citak","year":"2012","unstructured":"Citak M, Suero EM, Backhaus M, Aach M, Godry H, Meindl R et al. Risk factors for heterotopic ossification in patients with spinal cord injury: a case-control study of 264 patients. Spine 2012; 37: 1953\u20131957.","journal-title":"Spine"},{"key":"BFsc2016143_CR2","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1302\/0301-620X.74B2.1544955","volume":"74","author":"RH Wittenberg","year":"1992","unstructured":"Wittenberg RH, Peschke U, Botel U . Heterotopic ossification after spinal cord injury. Epidemiology and risk factors. J Bone Joint Surg Br 1992; 74: 215\u2013218.","journal-title":"J Bone Joint Surg Br"},{"key":"BFsc2016143_CR3","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1080\/10790268.2004.11752233","volume":"27","author":"IM Estrores","year":"2004","unstructured":"Estrores IM, Harrington A, Banovac K . C-reactive protein and erythrocyte sedimentation rate in patients with heterotopic ossification after spinal cord injury. J Spinal Cord Med 2004; 27: 434\u2013437.","journal-title":"J Spinal Cord Med"},{"key":"BFsc2016143_CR4","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1007\/s00402-015-2277-8","volume":"135","author":"F Zhang","year":"2015","unstructured":"Zhang F, Chen W, Zhang Q, Liu S, Zhang Y . Incidence and risk factors for heterotopic ossification after total hip arthroplasty: a meta-analysis. Arch Orthop Trauma Surg 2015; 135: 1307\u20131314.","journal-title":"Arch Orthop Trauma Surg"},{"key":"BFsc2016143_CR5","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1093\/rheumatology\/20.4.193","volume":"20","author":"JM Larson","year":"1981","unstructured":"Larson JM, Michalski JP, Collacott EA, Eltorai D, McCombs CC, Madorsky JB . Increased prevalence of HLA-B27 in patients with ectopic ossification following traumatic spinal cord injury. Rheumat Rehabil 1981; 20: 193\u2013197.","journal-title":"Rheumat Rehabil"},{"key":"BFsc2016143_CR6","first-page":"531","volume":"65","author":"DE Garland","year":"1984","unstructured":"Garland DE, Alday B, Venos KG . Heterotopic ossification and HLA antigens. Arch Phys Med Rehabil 1984; 65: 531\u2013532.","journal-title":"Arch Phys Med Rehabil"},{"key":"BFsc2016143_CR7","first-page":"266","volume":"35","author":"FM Maynard Jr.","year":"1997","unstructured":"Maynard FM Jr., Bracken MB, Creasey G, Ditunno JF Jr., Donovan WH, Ducker TB et al. International Standards for Neurological and Functional Classification of. Spinal Cord Injury. American Spinal Injury Association. Spinal Cord 1997; 35: 266\u2013274.","journal-title":"Spinal Cord Injury. American Spinal Injury Association. Spinal Cord"},{"key":"BFsc2016143_CR8","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1177\/1536867X0900900201","volume":"9","author":"P Cummings","year":"2009","unstructured":"Cummings P . Methods for estimating adjusted risk ratios. Stata J 2009; 9: 175\u2013196.","journal-title":"Stata J"},{"key":"BFsc2016143_CR9","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1093\/aje\/kwg074","volume":"157","author":"L-A McNutt","year":"2003","unstructured":"McNutt L-A . Estimating the Relative Risk in Cohort Studies and Clinical Trials of Common Outcomes. Am J Epidemiol. 2003; 157: 940\u2013943.","journal-title":"Am J Epidemiol."},{"key":"BFsc2016143_CR10","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1093\/biomet\/68.3.589","volume":"68","author":"B Efron","year":"1981","unstructured":"Efron B . Nonparametric estimates of standard error: The jackknife, the bootstrap and other methods. Biometrika 1981; 68: 589\u2013599.","journal-title":"Biometrika"},{"key":"BFsc2016143_CR11","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-3462-1","volume-title":"Regression Modeling Strategies","author":"FE Harrell","year":"2001","unstructured":"Harrell FE . Regression Modeling Strategies, 1st edn. Springer-Verlag New York, Inc: Secaucus, NJ, USA. 2001; ISBN: 0387952322."},{"key":"BFsc2016143_CR12","first-page":"511","volume":"146","author":"J Stausberg","year":"2009","unstructured":"Stausberg J, Kiefer E . Classification of pressure ulcers: a systematic literature review. Stud Health Technol Inform. 2009; 146: 511\u2013515.","journal-title":"Stud Health Technol Inform."},{"key":"BFsc2016143_CR13","doi-asserted-by":"publisher","first-page":"2304","DOI":"10.1016\/j.arth.2015.06.013","volume":"30","author":"J Thilak","year":"2015","unstructured":"Thilak J, Panakkal JJ, Kim TY, Goodman SM, Lee SS, Salvati EA . Risk Factors of Heterotopic Ossification Following Total Hip Arthroplasty in Patients With Ankylosing Spondylitis. J Arthroplasty 2015; 30: 2304\u20132307.","journal-title":"J Arthroplasty"},{"key":"BFsc2016143_CR14","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1007\/s00402-015-2277-8","volume":"135","author":"Y Zhu","year":"2015","unstructured":"Zhu Y, Zhang F, Chen W, Zhang Q, Liu S, Zhang Y . Incidence and risk factors for heterotopic ossification after total hip arthroplasty: a meta-analysis. Arch Orthop Trauma Surg 2015; 135: 1307\u20131314.","journal-title":"Arch Orthop Trauma Surg"},{"key":"BFsc2016143_CR15","doi-asserted-by":"publisher","first-page":"483","DOI":"10.2174\/1874325001509010483","volume":"30","author":"SE Putnis","year":"2015","unstructured":"Putnis SE, Wartemberg GK, Khan WS, Agarwal S . A Literature Review of Total Hip Arthroplasty in Patients with Ankylosing Spondylitis: Perioperative Considerations and Outcome. Open Orthop J 2015; 30: 483\u2013488.","journal-title":"Open Orthop J"},{"key":"BFsc2016143_CR16","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1177\/014107680609900814","volume":"99","author":"T Treasure","year":"2006","unstructured":"Treasure T . Hypertrophic pulmonary osteoarthropathy and the vagus nerve: an historical note. J R Soc Med 2006; 99: 388\u2013390.","journal-title":"J R Soc Med"},{"key":"BFsc2016143_CR17","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1016\/j.jaad.2005.01.006","volume":"52","author":"KE Spicknall","year":"2005","unstructured":"Spicknall KE, Zirwas MJ, English JC . III. Clubbing: an update on diagnosis, differential diagnosis, athophysiology, and clinical relevance. J Am Acad Dermatol 2005; 52: 1020\u20131028.","journal-title":"J Am Acad Dermatol"},{"key":"BFsc2016143_CR18","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/ncprheum0252","volume":"2","author":"KR Kozak","year":"2006","unstructured":"Kozak KR, Milne GL, Morrow JD, Cuiffo BP . Hypertrophic osteoarthropathy pathogenesis: a case highlighting the potential role for cyclo-oxygenase-2-derived prostaglandin E2. Nat Clin Pract Rheumatol 2006; 2: 452\u2013456.","journal-title":"Nat Clin Pract Rheumatol"},{"key":"BFsc2016143_CR19","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1002\/path.1565","volume":"203","author":"S Atkinson","year":"2004","unstructured":"Atkinson S, Fox SB . Vascular endothelial growth factor (VEGF)-A and platelet-derived growth factor (PDGF) play a central role in the pathogenesis of digital clubbing. J Pathol 2004; 203: 721\u2013728.","journal-title":"J Pathol"}],"container-title":["Spinal Cord"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/sc2016143.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/sc2016143","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/sc2016143.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T22:30:46Z","timestamp":1684621846000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/sc2016143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,18]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["BFsc2016143"],"URL":"https:\/\/doi.org\/10.1038\/sc.2016.143","relation":{},"ISSN":["1362-4393","1476-5624"],"issn-type":[{"value":"1362-4393","type":"print"},{"value":"1476-5624","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,18]]},"assertion":[{"value":"10 June 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 September 2016","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 September 2016","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 October 2016","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}