{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T04:36:22Z","timestamp":1776832582789,"version":"3.51.2"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2016,6,28]],"date-time":"2016-06-28T00:00:00Z","timestamp":1467072000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Spinal Cord"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1038\/sc.2016.55","type":"journal-article","created":{"date-parts":[[2016,6,28]],"date-time":"2016-06-28T18:02:36Z","timestamp":1467136956000},"page":"1088-1095","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Chondroitinase administration and pcDNA3.1-BDNF-BMSC transplantation promote motor functional recovery associated with NGF expression in spinal cord-transected rat"],"prefix":"10.1038","volume":"54","author":[{"given":"L-L","family":"Xiong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F-F","family":"Shang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S-W","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S-M","family":"Ju","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H-L","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T-H","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C-Z","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X-Y","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,6,28]]},"reference":[{"key":"BFsc201655_CR1","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1159\/000279335","volume":"34","author":"ME van den Berg","year":"2010","unstructured":"van den Berg ME, Castellote JM, Mahillo-Fernandez I, de Pedro-Cuesta J . Incidence of spinal cord injury worldwide: a systematic review. Neuroepidemiology 2010; 34: 184\u2013192 discussion 92.","journal-title":"Neuroepidemiology"},{"key":"BFsc201655_CR2","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1006\/exnr.1999.7184","volume":"160","author":"ML Lemons","year":"1999","unstructured":"Lemons ML, Howland DR, Anderson DK . Chondroitin sulfate proteoglycan immunoreactivity increases following spinal cord injury and transplantation. Exp Neurol 1999; 160: 51\u201365.","journal-title":"Exp Neurol"},{"key":"BFsc201655_CR3","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1006\/exnr.1998.6951","volume":"154","author":"J Zuo","year":"1998","unstructured":"Zuo J, Neubauer D, Dyess K, Ferguson TA, Muir D . Degradation of chondroitin sulfate proteoglycan enhances the neurite-promoting potential of spinal cord tissue. Exp Neurol 1998; 154: 654\u2013662.","journal-title":"Exp Neurol"},{"key":"BFsc201655_CR4","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1038\/416636a","volume":"416","author":"EJ Bradbury","year":"2002","unstructured":"Bradbury EJ, Moon LD, Popat RJ, King VR, Bennett GS, Patel PN et al. Chondroitinase ABC promotes functional recovery after spinal cord injury. Nature 2002; 416: 636\u2013640.","journal-title":"Nature"},{"key":"BFsc201655_CR5","doi-asserted-by":"publisher","first-page":"7405","DOI":"10.1523\/JNEUROSCI.1166-06.2006","volume":"26","author":"JD Houle","year":"2006","unstructured":"Houle JD, Tom VJ, Mayes D, Wagoner G, Phillips N, Silver J . Combining an autologous peripheral nervous system \"bridge\" and matrix modification by chondroitinase allows robust, functional regeneration beyond a hemisection lesion of the adult rat spinal cord. J Neurosci 2006; 26: 7405\u20137415.","journal-title":"J Neurosci"},{"key":"BFsc201655_CR6","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.expneurol.2007.07.019","volume":"209","author":"NJ Tester","year":"2008","unstructured":"Tester NJ, Howland DR . Chondroitinase ABC improves basic and skilled locomotion in spinal cord injured cats. Exp Neurol 2008; 209: 483\u2013496.","journal-title":"Exp Neurol"},{"key":"BFsc201655_CR7","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1089\/154732804323099208","volume":"13","author":"J Sammons","year":"2004","unstructured":"Sammons J, Ahmed N, El-Sheemy M, Hassan HT . The role of BMP-6, IL-6, and BMP-4 in mesenchymal stem cell-dependent bone development: effects on osteoblastic differentiation induced by parathyroid hormone and vitamin D(3). Stem Cells Dev 2004; 13: 273\u2013280.","journal-title":"Stem Cells Dev"},{"key":"BFsc201655_CR8","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1177\/0141076809701003","volume":"97","author":"HT Hassan","year":"2004","unstructured":"Hassan HT, El-Sheemy M . Adult bone-marrow stem cells and their potential in medicine. J R Soc Med 2004; 97: 465\u2013471.","journal-title":"J R Soc Med"},{"key":"BFsc201655_CR9","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.bbrc.2005.12.182","volume":"341","author":"H Li","year":"2006","unstructured":"Li H, Yu B, Zhang Y, Pan Z, Xu W, Li H . Jagged1 protein enhances the differentiation of mesenchymal stem cells into cardiomyocytes. Biochem Biophys Res Commun 2006; 341: 320\u2013325.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFsc201655_CR10","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1007\/s10571-006-9093-1","volume":"26","author":"D Cizkova","year":"2006","unstructured":"Cizkova D, Rosocha J, Vanicky I, Jergova S, Cizek M . Transplants of human mesenchymal stem cells improve functional recovery after spinal cord injury in the rat. Cell Mol Neurobiol 2006; 26: 1167\u20131180.","journal-title":"Cell Mol Neurobiol"},{"key":"BFsc201655_CR11","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1002\/j.1460-2075.1982.tb01207.x","volume":"1","author":"YA Barde","year":"1982","unstructured":"Barde YA, Edgar D, Thoenen H . Purification of a new neurotrophic factor from mammalian brain. EMBO J 1982; 1: 549\u2013553.","journal-title":"EMBO J"},{"key":"BFsc201655_CR12","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1089\/089771504322972112","volume":"21","author":"M Koda","year":"2004","unstructured":"Koda M, Hashimoto M, Murakami M, Yoshinaga K, Ikeda O, Yamazaki M et al. Adenovirus vector-mediated in vivo gene transfer of brain-derived neurotrophic factor (BDNF) promotes rubrospinal axonal regeneration and functional recovery after complete transection of the adult rat spinal cord. J Neurotrauma 2004; 21: 329\u2013337.","journal-title":"J Neurotrauma"},{"key":"BFsc201655_CR13","doi-asserted-by":"publisher","first-page":"483","DOI":"10.3171\/jns.1997.86.3.0483","volume":"86","author":"CH Tator","year":"1997","unstructured":"Tator CH, Koyanagi I . Vascular mechanisms in the pathophysiology of human spinal cord injury. J Neurosurg 1997; 86: 483\u2013492.","journal-title":"J Neurosurg"},{"key":"BFsc201655_CR14","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.neuroscience.2007.04.040","volume":"147","author":"GJ Wu","year":"2007","unstructured":"Wu GJ, Chen WF, Sung CS, Jean YH, Shih CM, Shyu CY et al. Preventive effects of intrathecal methylprednisolone administration on spinal cord ischemia in rats: the role of excitatory amino acid metabolizing systems. Neuroscience 2007; 147: 294\u2013303.","journal-title":"Neuroscience"},{"key":"BFsc201655_CR15","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1089\/neu.2005.22.226","volume":"22","author":"AO Caggiano","year":"2005","unstructured":"Caggiano AO, Zimber MP, Ganguly A, Blight AR, Gruskin EA . Chondroitinase ABCI improves locomotion and bladder function following contusion injury of the rat spinal cord. J Neurotrauma 2005; 22: 226\u2013239.","journal-title":"J Neurotrauma"},{"key":"BFsc201655_CR16","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1126\/science.290.5497.1775","volume":"290","author":"TR Brazelton","year":"2000","unstructured":"Brazelton TR, Rossi FM, Keshet GI, Blau HM . From marrow to brain: expression of neuronal phenotypes in adult mice. Science (New York, NY) 2000; 290: 1775\u20131779.","journal-title":"Science (New York, NY)"},{"key":"BFsc201655_CR17","first-page":"982","volume":"24","author":"J Lin","year":"2010","unstructured":"Lin J, Wang C, Wu Z . [Preliminary study on effects of human brain-derived neurotrophic factor gene-modified bone marrow mesenchymal stem cells by intravenous transplantation on structure and function of rat injured spinal cord]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2010; 24: 982\u2013987.","journal-title":"Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi"},{"key":"BFsc201655_CR18","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/S0014-4886(02)00052-3","volume":"182","author":"LW Yick","year":"2003","unstructured":"Yick LW, Cheung PT, So KF, Wu W . Axonal regeneration of Clarke's neurons beyond the spinal cord injury scar after treatment with chondroitinase ABC. Exp Neurol 2003; 182: 160\u2013168.","journal-title":"Exp Neurol"},{"key":"BFsc201655_CR19","first-page":"506","volume":"69","author":"A Goto","year":"1995","unstructured":"Goto A, Furukawa S . [Experimental changes in BDNF- and NT-3-like immunoreactivities in the spinal cord following its transection]. Nihon Seikeigeka Gakkai Zasshi 1995; 69: 506\u2013516.","journal-title":"Nihon Seikeigeka Gakkai Zasshi"},{"key":"BFsc201655_CR20","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/S0014-4886(03)00394-7","volume":"184","author":"CA Tobias","year":"2003","unstructured":"Tobias CA, Shumsky JS, Shibata M, Tuszynski MH, Fischer I, Tessler A et al. Delayed grafting of BDNF and NT-3 producing fibroblasts into the injured spinal cord stimulates sprouting, partially rescues axotomized red nucleus neurons from loss and atrophy, and provides limited regeneration. Exp Neurol 2003; 184: 97\u2013113.","journal-title":"Exp Neurol"},{"key":"BFsc201655_CR21","first-page":"724","volume":"39","author":"K Yu","year":"2001","unstructured":"Yu K, Ye X, Qu S . Intraspinal implantation of genetically modified myoblasts with brain-derived neurotrophic factor gene in treating spinal cord injury in rats: neurophysiological study. Zhonghua Wai Ke Za Zhi 2001; 39: 724\u2013727.","journal-title":"Zhonghua Wai Ke Za Zhi"},{"key":"BFsc201655_CR22","first-page":"1533","volume":"118","author":"YB Deng","year":"2005","unstructured":"Deng YB, Yuan QT, Liu XG, Liu XL, Liu Y, Liu ZG et al. Functional recovery after rhesus monkey spinal cord injury by transplantation of bone marrow mesenchymal-stem cell-derived neurons. Chin Med J 2005; 118: 1533\u20131541.","journal-title":"Chin Med J"},{"key":"BFsc201655_CR23","doi-asserted-by":"publisher","first-page":"14932","DOI":"10.1523\/JNEUROSCI.2769-09.2009","volume":"29","author":"M Sasaki","year":"2009","unstructured":"Sasaki M, Radtke C, Tan AM, Zhao P, Hamada H, Houkin K et al. BDNF-hypersecreting human mesenchymal stem cells promote functional recovery, axonal sprouting, and protection of corticospinal neurons after spinal cord injury. J Neurosc 2009; 29: 14932\u201314941.","journal-title":"J Neurosc"},{"key":"BFsc201655_CR24","doi-asserted-by":"publisher","first-page":"11","DOI":"10.5717\/jenb.2015.19.1.11","volume":"19","author":"YP Hong","year":"2015","unstructured":"Hong YP, Lee HC, Kim HT . Treadmill exercise after social isolation increases the levels of NGF, BDNF, and synapsin I to induce survival of neurons in the hippocampus, and improves depression-like behavior. J Exerc Nutrition Biochem 2015; 19: 11\u201318.","journal-title":"J Exerc Nutrition Biochem"},{"key":"BFsc201655_CR25","first-page":"292","volume":"18","author":"S Saeednia","year":"2015","unstructured":"Saeednia S, Bahadoran H, Amidi F, Asadi MH, Naji M, Fallahi P, Nejad NA . Nerve growth factor in human semen: Effect of nerve growth factor on the normozoospermic men during cryopreservation process. Iran J Basic Med Sci 2015; 18: 292\u2013299.","journal-title":"Iran J Basic Med Sci"}],"container-title":["Spinal Cord"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/sc201655.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/sc201655","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/sc201655.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T22:31:40Z","timestamp":1684621900000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/sc201655"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,28]]},"references-count":25,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["BFsc201655"],"URL":"https:\/\/doi.org\/10.1038\/sc.2016.55","relation":{},"ISSN":["1362-4393","1476-5624"],"issn-type":[{"value":"1362-4393","type":"print"},{"value":"1476-5624","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,28]]},"assertion":[{"value":"15 December 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 January 2016","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 March 2016","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 June 2016","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}