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There are no effective therapies to prevent or treat pNFs. Drug discovery efforts are slowed by the \u2018benign\u2019 nature of the Schwann cells that are the progenitor cells of pNF. In this work we characterize a set of pNF-derived cell lines at the genomic level (via SNP Arrays, RNAseq, and Whole Exome- Sequencing), and carry out dose response-based quantitative high-throughput screening (qHTS) with a collection of 1,912 oncology-focused compounds in a 1536-well microplate cell proliferation assays. Through the characterization and screening of <jats:italic>NF1<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup>, <jats:italic>NF1<\/jats:italic><jats:sup>+\/+<\/jats:sup> and <jats:italic>NF1<\/jats:italic><jats:sup>+\/\u2212<\/jats:sup> Schwann cell lines, this resource introduces novel therapeutic avenues for the development for <jats:italic>NF1<\/jats:italic> associated pNF as well as all solid tumors with <jats:italic>NF1<\/jats:italic> somatic mutations. The integrated data sets are openly available for further analysis at <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.synapse.org\/pnfCellCulture\">http:\/\/www.synapse.org\/pnfCellCulture<\/jats:ext-link>.<\/jats:p>","DOI":"10.1038\/sdata.2018.106","type":"journal-article","created":{"date-parts":[[2018,6,12]],"date-time":"2018-06-12T13:04:10Z","timestamp":1528808650000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Pharmacological and genomic profiling of neurofibromatosis type 1 plexiform neurofibroma-derived schwann cells"],"prefix":"10.1038","volume":"5","author":[{"given":"Marc","family":"Ferrer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6534-4774","authenticated-orcid":false,"given":"Sara J. 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