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The influence of epigenetic mechanisms, particularly RNA-mediated post-transcriptional regulation of host immune responses has been proven vital following infections by different pathogens, and bacteria can modulated host miRNAs. Global miRNA expression analysis from macrophages infected <jats:italic>in vitro<\/jats:italic> with different strains of <jats:italic>Leptospira<\/jats:italic> spp was performed using miRNA 4.1 microarray strips. Leptospirosis is a bacterial zoonosis of global importance, responsible for significant morbidity and mortality worldwide. Despite considerable advances, much is yet to be discovered about disease pathogenicity, particularly in regards to host-pathogen interactions. We present here a high-quality dataset examining the microtranscriptome of murine macrophages J774A.1 following 8h of infection with virulent, attenuated and saprophyte strains of <jats:italic>Leptospira<\/jats:italic>. Metadata files were submitted to the Gene Expression Omnibus (GEO) repository.<\/jats:p>","DOI":"10.1038\/sdata.2018.171","type":"journal-article","created":{"date-parts":[[2018,8,21]],"date-time":"2018-08-21T13:04:27Z","timestamp":1534856667000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["microRNA profile datasets of murine macrophages infected with different strains of Leptospira spp"],"prefix":"10.1038","volume":"5","author":[{"given":"Leandro E.","family":"Garcia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erivelto C. 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