{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T19:25:15Z","timestamp":1789759515487,"version":"4.0.1"},"reference-count":108,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Br Dent J"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1038\/sj.bdj.2014.905","type":"journal-article","created":{"date-parts":[[2014,10,24]],"date-time":"2014-10-24T07:08:16Z","timestamp":1414134496000},"page":"411-419","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Drugs, medications and periodontal disease"],"prefix":"10.1038","volume":"217","author":[{"given":"P. A.","family":"Heasman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. J.","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,10,24]]},"reference":[{"key":"BFsjbdj2014905_CR1","unstructured":"Biobank UK. Available at: http:\/\/www.ukbiobank.ac.uk\/ (accessed September 2014)."},{"key":"BFsjbdj2014905_CR2","unstructured":"UK National Statistics. Theme: Population. Available at: http:\/\/www.statistics.gov.uk\/hub\/population\/ (accessed September 2014)."},{"key":"BFsjbdj2014905_CR3","unstructured":"Cracknell R . The ageing population. Key issues for the New Parliament 2010. Available at: http:\/\/www.parliament.uk\/documents\/commons\/lib\/research\/key_issues\/Key-Issues-The-ageing-population2007.pdf (accessed September 2014)."},{"key":"BFsjbdj2014905_CR4","unstructured":"Banks J, Breeze E, Lessof C, Nazroo J (eds). Living in the 21st century: older people in England. The 2006 English longitudinal study of ageing (wave 3). London: The Institute for Fiscal Studies, 2008."},{"key":"BFsjbdj2014905_CR5","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/S0140-6736(12)60240-2","volume":"380","author":"K Barnett","year":"2012","unstructured":"Barnett K, Mercer S, Norbury M, Watt G, Wyke S, Guthrie B . Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study. Lancet 2012; 380: 37\u201343.","journal-title":"Lancet"},{"key":"BFsjbdj2014905_CR6","unstructured":"Melzer D, Tavakoly B, Winder R, Richards S, Gericke C, Lang I . Health care quality for an active later life. Improving quality of prevention and treatment through information: England 2005 to 2012. A report from the Peninsula College of Medicine and Dentistry Ageing Research Group for Age UK. Exeter: Peninsula College of Medicine and Dentistry, University of Exeter. Available at: http:\/\/medicine.exeter.ac.uk\/media\/universityofexeter\/medicalschool\/pdfs\/Health_Care_Quality_for_an_Active_Later_Life_UpdatedAug2013.pdf ."},{"key":"BFsjbdj2014905_CR7","unstructured":"Prescription Cost Analysis, England (2013). Health and Social Care Information Centre. Available at: http:\/\/www.hscic.gov.uk\/catalogue\/PUB13887 (accessed September 2014)."},{"key":"BFsjbdj2014905_CR8","unstructured":"Organ Donation and Transplants. Parliamentary Office of Science and Technology. Epost@parliament.uk. Number 441, September 2013."},{"key":"BFsjbdj2014905_CR9","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1177\/10454411910020010201","volume":"2","author":"TM Hassell","year":"1991","unstructured":"Hassell T M, Hefti A F . Drug-induced gingival overgrowth: old problem, new problem. Crit Rev Oral Pathol Med 1991; 2: 103\u2013137.","journal-title":"Crit Rev Oral Pathol Med"},{"key":"BFsjbdj2014905_CR10","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1111\/j.1600-0765.1990.tb00895.x","volume":"25","author":"BD Johnson","year":"1990","unstructured":"Johnson B D, Narayanan A S, Preters H P, Page R C . The effect of cell donor age on the synthetic properties of fibroblasts obtained from phenytoin-induced hyperplasia. J Periodontol Res 1990; 25: 74\u201380.","journal-title":"J Periodontol Res"},{"key":"BFsjbdj2014905_CR11","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1111\/j.1600-0765.1990.tb00902.x","volume":"25","author":"T Mod\u00e9er","year":"1990","unstructured":"Mod\u00e9er T, Mendez C, Dahll\u00f6f G, Auduren I, Andersson G . Effect of phenytoin medication on the metabolism of epidermal growth factor receptor in cultured gingival fibroblasts. J Periodontol Res 1990; 25: 120\u2013127.","journal-title":"J Periodontol Res"},{"key":"BFsjbdj2014905_CR12","doi-asserted-by":"publisher","first-page":"253","DOI":"10.3181\/00379727-142-36999","volume":"42","author":"TZ Liu","year":"1973","unstructured":"Liu T Z, Bhatnegar R S . Inhibition of protocollagen prolive hydroxylases by Dilantin\u00ae. Proc Soc Exp Biol Med 1973; 42: 253\u2013255.","journal-title":"Proc Soc Exp Biol Med"},{"key":"BFsjbdj2014905_CR13","first-page":"79","volume":"121","author":"LS Moy","year":"1985","unstructured":"Moy L S, Tan E M L, Holness R, Uitte J . Phenytoin modulates connective tissue metabolism and cell proliferation in human skin fibroblasts culture. Dermatology 1985; 121: 79\u201383.","journal-title":"Dermatology"},{"key":"BFsjbdj2014905_CR14","doi-asserted-by":"publisher","first-page":"1811","DOI":"10.1097\/00007890-199457120-00022","volume":"57","author":"HE Pernu","year":"1994","unstructured":"Pernu H E, Knuuttila M L E, Huttenen K R H, Tiilikainen A S K . Drug-induced gingival overgrowth and class II major histocompatibility antigens. Transplantation 1994; 57: 1811\u20131813.","journal-title":"Transplantation"},{"key":"BFsjbdj2014905_CR15","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1902\/jop.1994.65.10.895","volume":"65","author":"MS Williamson","year":"1994","unstructured":"Williamson M S, Miller E K, Plemons J, Rees T, Iacopino A M . Cyclosporine A upregulates interleukin6 gene expression in human gingiva: Possible mechanism for gingival overgrowth. J Periodontol 1994; 65: 895\u2013903.","journal-title":"J Periodontol"},{"key":"BFsjbdj2014905_CR16","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1902\/jop.1997.68.1.73","volume":"68","author":"AM Iacopino","year":"1997","unstructured":"Iacopino A M, Doxey D, Cutler C W et al. Phenytoin and cyclosporine A specifically regulate macrophage and expression of platelet-derived growth factor and interleukin1 in vitro and in vivo: possible mechanism of drug-induced overgrowth. J Periodontol 1997; 68: 73\u201383.","journal-title":"J Periodontol"},{"key":"BFsjbdj2014905_CR17","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1002\/jcb.240460209","volume":"46","author":"DA Tipton","year":"1991","unstructured":"Tipton D A, Stricklin G P, Dabbous M K . Fibroblast heterogeneity of collagenolytic response to cyclosporine. J Cell Biochem 1991; 46: 152\u2013165.","journal-title":"J Cell Biochem"},{"key":"BFsjbdj2014905_CR18","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1002\/(SICI)1097-4652(200003)182:3<351::AID-JCP5>3.0.CO;2-U","volume":"182","author":"M Kataoka","year":"2000","unstructured":"Kataoka M, Shimizu Y, Kunikiyo K et al. Cyclosporin A decreases the degradation of type I collagen in rat gingival overgrowth. J Cell Physiol 2000; 182: 351\u2013358.","journal-title":"J Cell Physiol"},{"key":"BFsjbdj2014905_CR19","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1111\/j.1600-051X.1992.tb00650.x","volume":"19","author":"S Barclay","year":"1992","unstructured":"Barclay S, Thomason J M, Idle J R, Seymour R A . The incidence and severity of nifedipine-induced gingival overgrowth. J Clin Periodontol 1992; 19: 311\u2013314.","journal-title":"J Clin Periodontol"},{"key":"BFsjbdj2014905_CR20","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1902\/jop.1985.56.4.211","volume":"56","author":"RM Lucas","year":"1985","unstructured":"Lucas R M, Howell L P, Wall B A . Nifedipine-induced gingival hyperplasia. A histochemical and ultrastructural study. J Periodontol 1985; 56: 211\u2013215.","journal-title":"J Periodontol"},{"key":"BFsjbdj2014905_CR21","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/S0014-2999(01)00810-X","volume":"415","author":"Y Fujimori","year":"2001","unstructured":"Fujimori Y, Maeda S, Saeki M, Morisake I, Kamisaki Y . Inhibition by nifedipine of adherenceand activated macrophage-induced death of human gingival fibroblasts. Eur J Pharmacol 2001; 415: 95\u2013103.","journal-title":"Eur J Pharmacol"},{"key":"BFsjbdj2014905_CR22","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1902\/jop.1995.66.7.572","volume":"66","author":"EB Nery","year":"1995","unstructured":"Nery E B, Edson R G, Lee K K, Pruthi V J, Watson J . Prevalence of nifedipine-induced gingival hyperplasia. J Periodontol 1995; 66: 572\u2013578.","journal-title":"J Periodontol"},{"key":"BFsjbdj2014905_CR23","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/0030-4220(85)90212-9","volume":"60","author":"EE van der Wall","year":"1985","unstructured":"van der Wall E E, Tuinzing D B, Hes J . Gingival hyperplasia induced by nifedipine, an arterial vasodilating drug. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1985; 60: 38\u201340.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"BFsjbdj2014905_CR24","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1902\/jop.1996.67.1.21","volume":"67","author":"G Mariani","year":"1996","unstructured":"Mariani G, Calastrini C, Carinci F, Bergamini L, Calastrini F, Stabellini G . Ultrastructural and histochemical features of the ground substance in cyclosporine Ainduced gingival overgrowth. J Periodontol 1996; 67: 21\u201327.","journal-title":"J Periodontol"},{"key":"BFsjbdj2014905_CR25","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1111\/j.1600-0757.1999.tb00175.x","volume":"21","author":"WW Hallmon","year":"1999","unstructured":"Hallmon W W, Rossman J A . The role of drugs in the pathogenesis of gingival overgrowth. A collective review of current concepts. Periodontol 2000 1999; 21: 176\u2013196.","journal-title":"Periodontol 2000"},{"key":"BFsjbdj2014905_CR26","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1902\/jop.1991.62.1.30","volume":"62","author":"S Nishikawa","year":"1991","unstructured":"Nishikawa S, Taha H, Hamasaki A et al. Nifedipine-induced gingival hyperplasia: a clinical and in vitro study. J Periodontol 1991; 62: 30\u201335.","journal-title":"J Periodontol"},{"key":"BFsjbdj2014905_CR27","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1111\/j.1834-7819.1999.tb00224.x","volume":"44","author":"RI Marshall","year":"1999","unstructured":"Marshall R I, Bartold P M . A clinical review of drug-induced gingival overgrowth. Aust Dent J 1999; 44: 219\u2013232.","journal-title":"Aust Dent J"},{"key":"BFsjbdj2014905_CR28","first-page":"116","volume":"21","author":"LH Silverstein","year":"1995","unstructured":"Silverstein L H, Kock J I, Lefkove M D, Garnick J J, Singh B, Steflik D E . Nifedipine-induced gingival enlargement around dental implants: a clinical report. J Oral Implant 1995; 21: 116\u2013120.","journal-title":"J Oral Implant"},{"key":"BFsjbdj2014905_CR29","doi-asserted-by":"publisher","first-page":"61","DOI":"10.14219\/jada.archive.1992.0190","volume":"123","author":"GW Bredfeldt","year":"1992","unstructured":"Bredfeldt G W . Phenytoin-induced hyperplasia found in edentulous patients. J Am Dent Assoc 1992; 123: 61\u201364.","journal-title":"J Am Dent Assoc"},{"key":"BFsjbdj2014905_CR30","doi-asserted-by":"crossref","unstructured":"Informational Paper. Drug-associated gingival enlargement. J Periodontol 2004; 75: 1424\u20131431.","DOI":"10.1902\/jop.2004.75.10.1424"},{"key":"BFsjbdj2014905_CR31","doi-asserted-by":"publisher","first-page":"2909","DOI":"10.1073\/pnas.73.8.2909","volume":"73","author":"TM Hassell","year":"1976","unstructured":"Hassell T M, Page R C, Narayanan A S, Cooper C G . Diphenylhydantoin (Dilantin) gingival hyperplasia: Drug-induced abnormality of connective tissue. Proc Natl Acad Sci 1976; 73: 2909\u20132912.","journal-title":"Proc Natl Acad Sci"},{"key":"BFsjbdj2014905_CR32","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1001\/jama.1939.02800130028009","volume":"112","author":"O Kimball","year":"1939","unstructured":"Kimball O . The treatment of epilepsy with sodium diphenylhydantoinate. J Am Med Assoc 1939; 112: 1244\u20131245.","journal-title":"J Am Med Assoc"},{"key":"BFsjbdj2014905_CR33","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1097\/00000658-198209000-00012","volume":"196","author":"RY Calne","year":"1982","unstructured":"Calne R Y, White D J . The use of cyclosporin A in clinical organ grafting. Ann Surg 1982; 196: 330\u2013337.","journal-title":"Ann Surg"},{"key":"BFsjbdj2014905_CR34","first-page":"17","volume":"151","author":"TE Starzl","year":"1980","unstructured":"Starzl T E, Weil R, Iwatsuki S et al. The use of cyclosporin A and prednisolone in cadaver kidney transplantation. Surg Gynecol Obstet 1980; 151: 17\u201326.","journal-title":"Surg Gynecol Obstet"},{"key":"BFsjbdj2014905_CR35","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1902\/jop.1996.67.11.1201","volume":"67","author":"I Cebeci","year":"1996","unstructured":"Cebeci I, Kantarci A, Firatli E, Carin M, Tuncer\u00f6 . The effect of verapamil on the prevalence and severity of cyclosporin-induced gingival overgrowth in renal allograft recipients. J Periodontol 1996; 67: 1201\u20131205.","journal-title":"J Periodontol"},{"key":"BFsjbdj2014905_CR36","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/0030-4220(84)90283-4","volume":"57","author":"D Lederman","year":"1984","unstructured":"Lederman D, Lumerman H, Reuben S, Freedman P D . Gingival hyperplasia associated with nifedipine therapy. Report of a case. Oral Surg Oral Med Oral Pathol 1984; 57: 620\u2013622.","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"BFsjbdj2014905_CR37","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1902\/jop.1999.70.1.63","volume":"70","author":"JS Ellis","year":"1999","unstructured":"Ellis J S, Seymour R A, Steele J G, Robertson P, Butler T J, Thomason J M . Prevalence of Gingival Overgrowth Induced by Calcium Channel Blockers: A Community-Based Study. J Periodontol 1999; 70: 63\u201367.","journal-title":"J Periodontol"},{"key":"BFsjbdj2014905_CR38","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1902\/jop.1999.70.9.967","volume":"70","author":"T Ilgenli","year":"1999","unstructured":"Ilgenli T, Atilla G, Baylas H . Effectiveness of periodontal therapy in patients with drug-induced gingival overgrowth. Long-term results. J Periodontol 1999; 70: 967\u2013972.","journal-title":"J Periodontol"},{"key":"BFsjbdj2014905_CR39","first-page":"139","volume":"15","author":"G Dahll\u00f6f","year":"1991","unstructured":"Dahll\u00f6f G, Axio E, Mod\u00e9er T . Regression of phenytoin-induced gingival overgrowth after withdrawal of medication. Swed Dent J 1991; 15: 139\u2013143.","journal-title":"Swed Dent J"},{"key":"BFsjbdj2014905_CR40","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1111\/j.1600-051X.1986.tb02241.x","volume":"13","author":"G Dahll\u00f6f","year":"1986","unstructured":"Dahll\u00f6f G, Mod\u00e9er T . The effect of a plaque control programme on the development of phenytoin-induced gingival overgrowth. A 2year longitudinal study. J Clin Periodontol 1986; 13: 845\u2013849.","journal-title":"J Clin Periodontol"},{"key":"BFsjbdj2014905_CR41","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1902\/jop.1997.68.11.1140","volume":"68","author":"A Khocht","year":"1997","unstructured":"Khocht A, Schneider L C . Periodontal management of gingival overgrowth I the heart transplant patient. A case report. J Periodontol 1997; 68: 1140\u20131146.","journal-title":"J Periodontol"},{"key":"BFsjbdj2014905_CR42","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.1902\/jop.2000.71.10.1630","volume":"71","author":"G Hern\u00e1ndez","year":"2000","unstructured":"Hern\u00e1ndez G, Arriba L, Lucas M, de Andr\u00e9s A . Reduction of severe gingival overgrowth in a kidney transplant patient by replacing cyclosporin A with tacrolimus. J Periodontol 2000; 71: 1630\u20131636.","journal-title":"J Periodontol"},{"key":"BFsjbdj2014905_CR43","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1902\/jop.2012.110467","volume":"84","author":"B Cetinkaya","year":"2013","unstructured":"Cetinkaya B, Guzeldemir E, Ogus E, Bulut S . Proinflammatory and anti-inflammatory cytokines in gingival crevicular fluid and serum of patients with rheumatoid arthritis and patients with chronic periodontitis. J Periodontol 2013; 84: 84\u201393.","journal-title":"J Periodontol"},{"issue":"Suppl 6","key":"BFsjbdj2014905_CR44","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1111\/j.1600-051X.2005.00785.x","volume":"32","author":"GE Salvi","year":"2005","unstructured":"Salvi G E, Lang N P . Host response modulation in the management of periodontal diseases. J Clin Periodontol 2005; 32 Suppl 6: 108\u2013129.","journal-title":"J Clin Periodontol"},{"key":"BFsjbdj2014905_CR45","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1111\/j.1600-051X.2010.01671.x","volume":"38","author":"PM Preshaw","year":"2011","unstructured":"Preshaw P M, Taylor J J . How has research into cytokine interactions impacted our understanding of periodontitis? J Clin Periodontol 2011; 38: 60\u201384.","journal-title":"J Clin Periodontol"},{"issue":"Suppl 8","key":"BFsjbdj2014905_CR46","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1902\/jop.2008.080233","volume":"79","author":"DL Cochran","year":"2008","unstructured":"Cochran D L . Inflammation and bone loss in periodontal disease. J Periodontol 2008; 79 Suppl 8: 1569\u20131576.","journal-title":"J Periodontol"},{"key":"BFsjbdj2014905_CR47","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1111\/j.1600-051X.1984.tb00903.x","volume":"11","author":"B Safkan","year":"1984","unstructured":"Safkan B, Knuuttila M . Corticosteroid therapy and periodontal disease. J Clin Periodontol 1984; 11: 515\u2013522.","journal-title":"J Clin Periodontol"},{"key":"BFsjbdj2014905_CR48","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1902\/jop.1958.29.4.300","volume":"29","author":"S Krohn","year":"1958","unstructured":"Krohn S . Effect of the administration of steroid hormones on the gingival tissues. J Periodontol 1958; 29: 300\u2013306.","journal-title":"J Periodontol"},{"key":"BFsjbdj2014905_CR49","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1111\/j.1600-0765.1981.tb00953.x","volume":"16","author":"IM Waite","year":"1981","unstructured":"Waite I M, Saxton C A, Young A, Wagg B J, Corbett M . The periodontal status of subjects receiving non-steroidal anti-inflammatory drugs. J Periodontol Res 1981; 16: 100\u2013108.","journal-title":"J Periodontol Res"},{"key":"BFsjbdj2014905_CR50","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1111\/j.1600-051X.1983.tb02201.x","volume":"10","author":"RS Feldman","year":"1983","unstructured":"Feldman R S, Szeto B, Cauncey H H, Goldhaber P . Non-steroidal anti-inflammatory drugs in the reduction of alveolar bone loss. J Clin Periodontol 1983; 10: 131\u2013136.","journal-title":"J Clin Periodontol"},{"key":"BFsjbdj2014905_CR51","doi-asserted-by":"publisher","first-page":"1757","DOI":"10.2174\/1381612053764878","volume":"11","author":"GE Salvi","year":"2005","unstructured":"Salvi G E, Lang N P . The effects of non-steroidal anti-inflammatory drugs (selective and non-selective) on the treatment of periodontal diseases. Curr Pharm Des 2005; 11: 1757\u20131169.","journal-title":"Curr Pharm Des"},{"key":"BFsjbdj2014905_CR52","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1902\/jop.1998.69.7.777","volume":"69","author":"PM Preshaw","year":"1998","unstructured":"Preshaw P M, Lauffart B, Brown P, Zak E, Heasman P A . Effects of ketorolac tromethamine Mouthrinse (0.1%) on crevicular fluid prostaglandin E2 concentrations in untreated chronic periodontitis. J Clin Periodontol 1998; 69: 777\u2013783.","journal-title":"J Clin Periodontol"},{"key":"BFsjbdj2014905_CR53","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1111\/j.1600-051X.1993.tb00389.x","volume":"20","author":"PA Heasman","year":"1993","unstructured":"Heasman P A, Benn D, Kelly P J, Seymour R A, Aitken D . The use of topical flurbiprofen as an adjunct to non-surgical management of periodontal disease. J Clin Periodontol 1993; 20: 457\u2013464.","journal-title":"J Clin Periodontol"},{"issue":"Suppl.11","key":"BFsjbdj2014905_CR54","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1111\/j.1600-051X.2010.01669.x","volume":"38","author":"S Culshaw","year":"2011","unstructured":"Culshaw S, McInnes I B, Liew F Y . What can the periodontal community learn from the pathophysiology of rheumatoid arthritis? J Clin Periodontol 2011; 38 Suppl.11: 106\u2013113.","journal-title":"J Clin Periodontol"},{"key":"BFsjbdj2014905_CR55","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/j.1365-2249.2006.03260.x","volume":"147","author":"GP Garlet","year":"2007","unstructured":"Garlet G P, Cardoso C R B, Campanelli A P et al. The dual role of p55 tumour necrosis factor\u03b1 receptor in Actinobacillus actinomycetemcomitans-induced experimental periodontitis: host protection and tissue destruction. Clin Exp Immunol 2007; 147: 128\u2013138.","journal-title":"Clin Exp Immunol"},{"key":"BFsjbdj2014905_CR56","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1902\/jop.2004.75.1.162","volume":"75","author":"V Lima","year":"2004","unstructured":"Lima V, Vidal F D P, Rocha F A C, Brito G A C . Effects of tumour necrosis factor\u03b1 inhibitors pentoxifylline and thalidomide on alveolar bone loss in short-term experimental periodontal disease in rats. J Periodontol 2004; 75: 162\u2013168.","journal-title":"J Periodontol"},{"key":"BFsjbdj2014905_CR57","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1902\/jop.1998.69.12.1419","volume":"69","author":"DT Graves","year":"1998","unstructured":"Graves D T, Delima A J, Assuma R, Amar S, Oates T, Cochran D . Interleukin1 and tumour necrosis factor antagonists inhibit the progression of inflammatory cell infiltration toward alveolar bone in experimental periodontitis. J Periodontol 1998; 69: 1419\u20131425.","journal-title":"J Periodontol"},{"key":"BFsjbdj2014905_CR58","doi-asserted-by":"publisher","first-page":"1645","DOI":"10.1902\/jop.2008.070616","volume":"79","author":"JO Pers","year":"2008","unstructured":"Pers JO, Saraux A, Pierre R, Youinou P . Anti-TNF-\u03b1 immunotherapy is associated with increased gingival inflammation without clinical attachment loss in subjects with rheumatoid arthritis. J Periodontol 2008; 79: 1645\u20131651.","journal-title":"J Periodontol"},{"key":"BFsjbdj2014905_CR59","first-page":"10201030","volume":"52","author":"JS Smolen","year":"2005","unstructured":"Smolen J S, Han C, Bala M, Maini R M et al. Evidence of radiographic benefit of treatment with infliximab plus methotrexate in rheumatoid arthritis patients who had no clinical improvement. A detailed sub analysis of data from the anti-tumour necrosis factor trial in rheumatoid arthritis with concomitant therapy study. Arthritis Rheum 2005; 52: 10201030.","journal-title":"Arthritis Rheum"},{"key":"BFsjbdj2014905_CR60","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.1902\/jop.2009.090015","volume":"80","author":"Y Mayar","year":"2009","unstructured":"Mayar Y, Balbir-Gurman A, Machtei E E . Anti-tumour necrosis factor\u03b1 therapy and periodontal parameters in patients with rheumatoid arthritis. J Periodontol 2009; 80: 1414\u20131420.","journal-title":"J Periodontol"},{"key":"BFsjbdj2014905_CR61","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1902\/jop.2012.120009","volume":"84","author":"Y Mayar","year":"2013","unstructured":"Mayar Y, Elimelech R, Balbir-Gurman A, Braun-Moscovici, Machtei E E . Periodontal condition of patients with autoimmune diseases and the effect of anti-tumour necrosis factor\u03b1 therapy. J Periodontol 2013; 84: 136\u2013142.","journal-title":"J Periodontol"},{"key":"BFsjbdj2014905_CR62","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1111\/j.1600-0757.2005.00137.x","volume":"40","author":"RA Seymour","year":"2006","unstructured":"Seymour R A . Effects of medications on the periodontal tissues in health and disease. Periodontol 2000 2006; 40: 120\u2013129.","journal-title":"Periodontol 2000"},{"key":"BFsjbdj2014905_CR63","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1034\/j.1600-051X.2003.00055.x","volume":"30","author":"P Mascarenhas","year":"2003","unstructured":"Mascarenhas P, Gapski R, Al-Shammari, Wang HL . Influence of sex hormones on the periodontium. J Clin Periodontol 2003; 30: 671\u2013681.","journal-title":"J Clin Periodontol"},{"key":"BFsjbdj2014905_CR64","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/0030-4220(49)90365-5","volume":"2","author":"AW Maier","year":"1949","unstructured":"Maier A W, Oban B . Gingivitis in pregnancy. Oral Surg 1949; 2: 334\u2013373.","journal-title":"Oral Surg"},{"key":"BFsjbdj2014905_CR65","first-page":"51","volume":"22","author":"D Plancak","year":"1998","unstructured":"Plancak D, Vizner B, Jorgic-Srdjak K, Slaj M . Endocrinological status of patients with periodontal disease. Collegium Antrolpol 1998; 22: 51\u201355.","journal-title":"Collegium Antrolpol"},{"key":"BFsjbdj2014905_CR66","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1111\/jcpe.12053","volume":"40","author":"E Figuero","year":"2003","unstructured":"Figuero E, CarrillodeAlbornoz A, Mart\u00edn C, Tob\u00edas A, Herrera D . Effect of pregnancy on gingival inflammation in systemically healthy women: a systematic review. J Clin Periodontol 2003; 40: 457\u2013473.","journal-title":"J Clin Periodontol"},{"key":"BFsjbdj2014905_CR67","unstructured":"Office for National Statistics. Contraception and sexual health 2008\u20132009. 2009."},{"key":"BFsjbdj2014905_CR68","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1034\/j.1600-051x.2000.027010753.x","volume":"27","author":"A Tilakaratne","year":"2000","unstructured":"Tilakaratne A, Soory M, Ranasinghe A W, Corea S M X, De Silva M . Effects of hormonal contraceptives on the periodontium, in a population of Sri Lankan women. J Clin Periodontol 2000; 27: 753\u2013757.","journal-title":"J Clin Periodontol"},{"key":"BFsjbdj2014905_CR69","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1111\/j.1600-051X.2005.00842.x","volume":"32","author":"G Ficarra","year":"2005","unstructured":"Ficarra G, Beninati F, Rubino I et al. Osteonecrosis of the jaws in periodontal patients with a history of bisphosphonates treatment. J Clin Periodontol 2005; 32: 1123\u20131128.","journal-title":"J Clin Periodontol"},{"key":"BFsjbdj2014905_CR70","doi-asserted-by":"publisher","first-page":"1799","DOI":"10.1056\/NEJMoa074941","volume":"357","author":"KW Lyles","year":"2007","unstructured":"Lyles K W, Col\u00f3n-Emeric C S, Magaziner J S et al. Zolendronic acid in reducing clinical fracture and mortality after hip fracture. N Engl J Med 2007: 357; 1799\u20131809.","journal-title":"N Engl J Med"},{"key":"BFsjbdj2014905_CR71","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1902\/cap.2011.110073","volume":"2","author":"MS Reddy","year":"2012","unstructured":"Reddy M S, Geisinger M L, Liu PR, Holmes C M, Vassilopoulos P J, Geurs N C . Intravenous bisphosphonates for osteoporosis and implant placement. Clin Adv Periodontics 2012; 2: 42\u201347.","journal-title":"Clin Adv Periodontics"},{"key":"BFsjbdj2014905_CR72","unstructured":"Scottish Dental Clinical Effectiveness Programme. Oral health management of patients prescribed bisphosphonates. Dental Clinical Guidance, April 2011. Available at: http:\/\/www.sdcep.org.uk\/index.aspx?o=3017 (accessed 30 September 2014)."},{"key":"BFsjbdj2014905_CR73","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.joms.2007.09.019","volume":"66","author":"B Grant","year":"2008","unstructured":"Grant B, Amenedo C, Freeman K, Kraut R . Outcomes of placing dental implants in patients taking oral bisphosphonates: a review of 115 cases. J Oral Maxillofac Surg 2008; 66: 223\u2013230.","journal-title":"J Oral Maxillofac Surg"},{"key":"BFsjbdj2014905_CR74","first-page":"349","volume":"21","author":"M Jeffcoat","year":"2006","unstructured":"Jeffcoat M, Safety of oral bisphosphonates: controlled studies on alveolar bone. Int J Oral Maxillofac Implants 2006; 21: 349\u2013353.","journal-title":"Int J Oral Maxillofac Implants"},{"key":"BFsjbdj2014905_CR75","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1111\/j.1600-051X.2012.01854.x","volume":"39","author":"JK Yip","year":"2013","unstructured":"Yip J K, Borrell L N, Cho SC, Francisco H, Tarnow D P . Association between oral bisphosphonate use and dental implant failure among middle-aged women. J Clin Periodontol 2013; 39: 408\u2013414.","journal-title":"J Clin Periodontol"},{"key":"BFsjbdj2014905_CR76","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1016\/j.joms.2009.09.017","volume":"68","author":"TS Lazarovici","year":"2010","unstructured":"Lazarovici T S, Yahalom R, Taicher S, Schwartz-Arad D, Peleg O, Yarom N . Bisphosphonate-related osteonecrosis of the jaw associated with dental implants. J Oral Maxillofac Surg 2010; 68: 790\u2013796.","journal-title":"J Oral Maxillofac Surg"},{"key":"BFsjbdj2014905_CR77","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1902\/jop.2009.090587","volume":"81","author":"F Javad","year":"2010","unstructured":"Javad F, Almas K . Osseointegration of dental implants in patients undergoing bisphosphonate treatment: A literature review. J Periodontol 2010; 81: 479\u2013484.","journal-title":"J Periodontol"},{"key":"BFsjbdj2014905_CR78","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1902\/jop.2006.77.1.1","volume":"77","author":"JA Goya","year":"2006","unstructured":"Goya J A, Paez H A, Mandalunis P M . Effect of topical administration of monosodium olpadronate on experimental periodontitis in rats. J Periodontol 2006; 77: 1\u20136.","journal-title":"J Periodontol"},{"key":"BFsjbdj2014905_CR79","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1902\/jop.2002.73.5.479","volume":"73","author":"T Mitsuta","year":"2002","unstructured":"Mitsuta T, Horiuchi H, Shinoda H . Effects of topical administration of clodronate on alveolar bone resorption in rats with experimental periodontitis. J Periodontol 2002; 73: 479\u2013486.","journal-title":"J Periodontol"},{"key":"BFsjbdj2014905_CR80","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1902\/jop.1992.63.10.825","volume":"63","author":"MA Brunsvold","year":"1992","unstructured":"Brunsvold M A, Chaves E S, Kornman K S, Aufdemorte T B, Wood R . Effects of a bisphosphonate on experimental periodontitis in monkeys. J Periodontol 1992; 63: 825\u2013830.","journal-title":"J Periodontol"},{"key":"BFsjbdj2014905_CR81","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1902\/jop.2010.100608","volume":"82","author":"SJ Lee","year":"2011","unstructured":"Lee SJ, Oh TJ, Bae TS et al. Effect of bisphosphonates on anodized and heat-treated titanium surfaces: an animal experimental study. J Periodontol 2011; 82: 1035\u20131042.","journal-title":"J Periodontol"},{"key":"BFsjbdj2014905_CR82","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1902\/jop.2005.76.7.1113","volume":"76","author":"N Lane","year":"2005","unstructured":"Lane N, Armitage C G, Loomer P et al. Bisphosphonate therapy improves the outcome of conventional periodontal treatment: results of a 12-month, randomized, placebo-controlled study. J Periodontol 2005; 76: 1113\u20131122.","journal-title":"J Periodontol"},{"key":"BFsjbdj2014905_CR83","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1177\/147323000303100614","volume":"31","author":"Y Takaishi","year":"2003","unstructured":"Takaishi Y, Ikeo T, Miki T, Nishizawa Y, Morri H . Suppression of alveolar bone resorption by etidronate treatment for periodontal disease: 4 to 5 year follow-up of four patients. J Int Med Res 2003; 31: 575\u2013584.","journal-title":"J Int Med Res"},{"key":"BFsjbdj2014905_CR84","first-page":"173","volume":"13","author":"Y Takaishi","year":"2003","unstructured":"Takaishi Y . Treatment of periodontal disease, prevention and bisphosphonate. Clin Calcium 2003; 13: 173\u2013176.","journal-title":"Clin Calcium"},{"key":"BFsjbdj2014905_CR85","first-page":"5","volume":"5","author":"UM El-Shinnawi","year":"2003","unstructured":"El-Shinnawi U M, El-Tantawy S I . The effect of alendronate sodium on alveolar bone loss in periodontitis (clinical trial). J Int Acad Periodontol 2003; 5: 5\u201310.","journal-title":"J Int Acad Periodontol"},{"key":"BFsjbdj2014905_CR86","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1111\/j.1600-051X.2009.01388.x","volume":"36","author":"F Graziani","year":"2009","unstructured":"Graziani F, Cei S, Guerrero A et al. Lack of short-term adjunctive effect of systemic neridronate in non-surgical periodontal therapy of advanced generalized chronic periodontitis: an open-label randomized clinical trial. J Clin Periodontol 2009; 36: 419\u2013427.","journal-title":"J Clin Periodontol"},{"key":"BFsjbdj2014905_CR87","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1111\/j.1600-051X.1997.tb00480.x","volume":"24","author":"JM Thomason","year":"1997","unstructured":"Thomason J M, Seymour R A, Murphy P, Brigham K M, Jones P . Aspirin-induced post-gingivectomy haemorrhage: a timely reminder. J Clin Periodontol 1997; 24: 136\u2013138.","journal-title":"J Clin Periodontol"},{"key":"BFsjbdj2014905_CR88","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1111\/j.1600-051X.2008.01206.x","volume":"35","author":"S Elad","year":"2008","unstructured":"Elad S, Chackartchi T, Shapira L, Findler M . A critically severe gingival bleeding following non-surgical periodontal treatment in patients medicated with anti-platelet. J Clin Periodontol 2008: 35; 342\u2013345.","journal-title":"J Clin Periodontol"},{"key":"BFsjbdj2014905_CR89","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/S0140-6736(04)16721-4","volume":"364","author":"HC Diener","year":"2004","unstructured":"Diener H C, Bogousslavsky J, Brass L M et al. Aspirin and clopidogrel compared with clopidogrel gel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomized, double-blind, placebo-controlled trial. Lancet 2004; 364: 331\u2013337.","journal-title":"Lancet"},{"key":"BFsjbdj2014905_CR90","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1111\/jcpe.12203","volume":"41","author":"LS Coimbra","year":"2014","unstructured":"Coimbra L S, Steffens J P, Rossa Jr C, Graves D T, Spolidorio L C . Clopidogrel enhances periodontal repair in rats through decreased inflammation. J Clin Periodontol 2014; 41: 295\u2013302.","journal-title":"J Clin Periodontol"},{"key":"BFsjbdj2014905_CR91","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1902\/jop.2010.100555","volume":"82","author":"LS Coimbra","year":"2011","unstructured":"Coimbra L S, Rossa Jr C, Guimar\u0227es M R et al. Influence of anti-platelet drugs in the pathogenesis of experimental periodontitis and periodontal repair in rats. J Periodontol 2011; 82: 767\u2013777.","journal-title":"J Periodontol"},{"key":"BFsjbdj2014905_CR92","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1034\/j.1600-051x.2001.280106.x","volume":"28","author":"A Drouganis","year":"2001","unstructured":"Drouganis A, Hirsch R . Low-dose aspirin therapy and periodontal attachment loss in ex- and non-smokers. J Clin Periodontol 2001; 28: 38\u201345.","journal-title":"J Clin Periodontol"},{"key":"BFsjbdj2014905_CR93","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1111\/j.1601-0825.2005.01172.x","volume":"12","author":"N Horiuchi","year":"2006","unstructured":"Horiuchi N, Maeda T . Statins and bone metabolism. Oral Dis 2006; 12: 85\u2013101.","journal-title":"Oral Dis"},{"key":"BFsjbdj2014905_CR94","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1111\/j.1600-051X.2006.01046.x","volume":"34","author":"BG Saver","year":"2007","unstructured":"Saver B G, Hujoel P P, Cunha-Cruz J, Maupome G . Are statins associated with decreased tooth loss in chronic periodontitis? J Clin Periodontol 2007; 34: 214\u2013219.","journal-title":"J Clin Periodontol"},{"key":"BFsjbdj2014905_CR95","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/1472-6831-8-16","volume":"8","author":"O Lindy","year":"2008","unstructured":"Lindy O, Suomalainen K, Makela M, Lindy S . Statin use is associated with fewer periodontal lesions: a retrospective study. BMC Oral Health 2008; 8: 16.","journal-title":"BMC Oral Health"},{"key":"BFsjbdj2014905_CR96","doi-asserted-by":"publisher","first-page":"e160","DOI":"10.1902\/jop.2013.130456","volume":"85","author":"P Meisel","year":"2014","unstructured":"Meisel P, Kroemer H K, Nauck M, Holtfreter B, Kocher T . Tooth loss, periodontitis, and statins in a population-based follow-up study. J Periodontol 2014; 85: e160\u2013168.","journal-title":"J Periodontol"},{"key":"BFsjbdj2014905_CR97","doi-asserted-by":"publisher","first-page":"391","DOI":"10.4103\/0253-7613.115017","volume":"45","author":"S Suresh","year":"2013","unstructured":"Suresh S, Narayana S, Jayakumar P, Sudhakar U, Pramod V . Evaluation of anti-inflammatory effect of statins in chronic periodontitis. Indian J Pharmacol 2013; 45: 391\u2013394.","journal-title":"Indian J Pharmacol"},{"key":"BFsjbdj2014905_CR98","first-page":"2","volume":"16","author":"CA Nassar","year":"2014","unstructured":"Nassar C A, Battistetti G D, Nahsan F P et al. Evaluation of the effect of simvastatin on the progression of alveolar bone loss in experimental periodontitisan animal study. J Int Acad Periodontol 2014; 16: 2\u20137.","journal-title":"J Int Acad Periodontol"},{"key":"BFsjbdj2014905_CR99","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1177\/0022034513516980","volume":"93","author":"J Jin","year":"2014","unstructured":"Jin J, Machado E R, Yu H et al. Simvastatin inhibits LPS-induced alveolar bone loss during metabolic syndrome. J Dent Res 2014; 93: 294\u2013299.","journal-title":"J Dent Res"},{"key":"BFsjbdj2014905_CR100","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1111\/adj.12042","volume":"58","author":"NS Rao","year":"2013","unstructured":"Rao N S, Pradeep A R, Bajaj P, Kumari M, Naik S B . Simvastatin local drug delivery in smokers with chronic periodontitis: a randomized controlled clinical trial. Aust Dent J 2013; 58: 156\u2013162.","journal-title":"Aust Dent J"},{"key":"BFsjbdj2014905_CR101","doi-asserted-by":"publisher","first-page":"2382","DOI":"10.1016\/j.jacc.2013.08.1627","volume":"62","author":"S Subramanian","year":"2013","unstructured":"Subramanian S, Emami H, Vucic E et al. High-dose atorvastatin reduces periodontal inflammation: a novel pleiotropic effect of statins. J Am Coll Cardiol 2013; 62: 2382\u20132391.","journal-title":"J Am Coll Cardiol"},{"key":"BFsjbdj2014905_CR102","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1111\/j.1600-051X.2010.01619.x","volume":"37","author":"ME Fajardo","year":"2010","unstructured":"Fajardo M E, Rocha M L, Sanchez-Marin F J, Espinosa-Chavez E J . Effect of atorvastatin on chronic periodontitis: a randomized pilot study. J Clin Periodontol 2010; 37: 1016\u20131022.","journal-title":"J Clin Periodontol"},{"key":"BFsjbdj2014905_CR103","doi-asserted-by":"publisher","first-page":"400","DOI":"10.3322\/caac.21157","volume":"62","author":"JB Epstein","year":"2012","unstructured":"Epstein J B, Thariat J, Bensadoun R J et al. Oral complications of cancer and cancer therapy: from cancer treatment to survivorship. CA Cancer J Clin 2012; 62: 400\u2013422.","journal-title":"CA Cancer J Clin"},{"key":"BFsjbdj2014905_CR104","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/S1368-8375(01)00025-2","volume":"37","author":"JB Epstein","year":"2001","unstructured":"Epstein J B, Stevenson-Moore P . Periodontal disease and periodontal management in patients with cancer. Oral Oncol 2001; 37: 613\u2013619.","journal-title":"Oral Oncol"},{"key":"BFsjbdj2014905_CR105","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1177\/0022034513507956","volume":"93","author":"E Hajishengallis","year":"2014","unstructured":"Hajishengallis E, Hajishengallis G . Neutrophil homeostasis and periodontal health in children and adults. J Dent Res 2014; 93: 231\u2013237.","journal-title":"J Dent Res"},{"key":"BFsjbdj2014905_CR106","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/s10549-012-2217-z","volume":"137","author":"LS Taichman","year":"2013","unstructured":"Taichman L S, Havens A M, Van Poznak C H . Potential implications of adjuvant endocrine therapy for the oral health of postmenopausal women with breast cancer. Breast Cancer Res Treat 2013; 137: 23\u201332.","journal-title":"Breast Cancer Res Treat"},{"key":"BFsjbdj2014905_CR107","unstructured":"MHRA Regulating Medicines and Medical Devices. Safety information. Available at: http:\/\/www.mhra.gov.uk\/Safetyinformation\/index.htm (accessed September 2014)."},{"key":"BFsjbdj2014905_CR108","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1111\/j.1601-5037.2012.00550.x","volume":"11","author":"CA Gurgan","year":"2013","unstructured":"Gurgan C A, Ozcan M, Karakus O et al. Periodontal status and post-transplantation complications following intensive periodontal treatment in patients underwent allogenic hematopoietic stem cell transplantation conditioned with myeloablative regimen. Int J Dent Hyg 2013; 11: 84\u201390.","journal-title":"Int J Dent Hyg"}],"container-title":["British Dental Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/sj.bdj.2014.905.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/sj.bdj.2014.905","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/sj.bdj.2014.905.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T22:50:39Z","timestamp":1684623039000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/sj.bdj.2014.905"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":108,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["BFsjbdj2014905"],"URL":"https:\/\/doi.org\/10.1038\/sj.bdj.2014.905","relation":{},"ISSN":["0007-0610","1476-5373"],"issn-type":[{"value":"0007-0610","type":"print"},{"value":"1476-5373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"8 August 2014","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 October 2014","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}