{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:36:24Z","timestamp":1787740584924,"version":"build-2784847793"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Br Dent J"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1038\/sj.bdj.2015.812","type":"journal-article","created":{"date-parts":[[2015,10,23]],"date-time":"2015-10-23T07:21:06Z","timestamp":1445584866000},"page":"385-390","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Effective anaesthesia of the acutely inflamed pulp: part 1. The acutely inflamed pulp"],"prefix":"10.1038","volume":"219","author":[{"given":"S. S.","family":"Virdee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Seymour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Bhakta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,10,23]]},"reference":[{"key":"BFsjbdj2015812_CR1","first-page":"138","volume":"51","author":"R Bahl","year":"2004","unstructured":"Bahl R . Local anaesthesia in dentistry. Anesth Prog 2004; 51: 138\u2013142.","journal-title":"Anesth Prog"},{"key":"BFsjbdj2015812_CR2","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/sj.bdj.4800006","volume":"186","author":"JG Meechan","year":"1999","unstructured":"Meechan J G . How to overcome failed local anaesthesia. Br Dent J 1999; 186: 15\u201320.","journal-title":"Br Dent J"},{"key":"BFsjbdj2015812_CR3","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1034\/j.1601-1546.2002.10103.x","volume":"1","author":"KM Hargreaves","year":"2002","unstructured":"Hargreaves K M, Keiser K . Local anaesthetic failures in endodontics. Endod Topics 2002; 1: 26\u201339.","journal-title":"Endod Topics"},{"key":"BFsjbdj2015812_CR4","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1097\/01.DON.0000125317.21892.8F","volume":"30","author":"E Claffey","year":"2004","unstructured":"Claffey E, Reader A, Nusstein J, Beck M, Weaver J . Anaesthetic efficacy of articaine for inferior alveolar nerve blocks in patients with irreversible pulpitis. J Endod 2004; 30: 568\u2013571.","journal-title":"J Endod"},{"key":"BFsjbdj2015812_CR5","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1016\/j.joen.2009.04.012","volume":"35","author":"V Aggarwal","year":"2009","unstructured":"Aggarwal V, Jain A, Kabi D . Anaesthetic efficacy of supplemental buccal and lingual infiltrations of articaine and lidocaine after an inferior alveolar nerve block in patients with irreversible pulpitis. J Endod 2009; 35: 925\u2013929.","journal-title":"J Endod"},{"key":"BFsjbdj2015812_CR6","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/S0099-2399(98)80053-8","volume":"24","author":"J Nusstein","year":"1998","unstructured":"Nusstein J, Reader A, Nist R, Beck M, Meyers W J . Anaesthetic efficacy of the supplemental intraosseous injection of 2% lidocaine with 1: 100, 000 epinephrine in irreversible pulpitis. J Endod 1998; 24: 487\u2013491.","journal-title":"J Endod"},{"key":"BFsjbdj2015812_CR7","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/S0099-2399(06)81366-X","volume":"19","author":"H Cohen","year":"1993","unstructured":"Cohen H, Cha B, Sp\u00e5ngberg L . Endodontic anaesthesia in mandibular molars: a clinical study. J Endod 1993; 19: 370\u2013373.","journal-title":"J Endod"},{"key":"BFsjbdj2015812_CR8","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1097\/00004770-200310000-00004","volume":"29","author":"S Kennedy","year":"2003","unstructured":"Kennedy S, Reader A, Nusstein J, Beck M, Weaver J . The significance of needle deflection in success of the inferior alveolar nerve block in patients with irreversible pulpitis. J Endod 2003; 29: 630\u2013633.","journal-title":"J Endod"},{"key":"BFsjbdj2015812_CR9","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1016\/S1079-2104(97)90372-3","volume":"84","author":"D Reisman","year":"1997","unstructured":"Reisman D, Reader A, Nist R, Beck M, Weaver J . Anaesthetic efficacy of the supplemental intraosseous injection of 3% mepivacaine in irreversible pulpitis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1997; 84: 676\u2013682.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"BFsjbdj2015812_CR10","doi-asserted-by":"publisher","first-page":"103","DOI":"10.4103\/0975-7406.113307","volume":"5","author":"T Boopathi","year":"2013","unstructured":"Boopathi T, Sebeena M, Sivakumar K, Harikaran J, Karthick K, Raj A . Supplemental pulpal anaesthesia for mandibular teeth. J Pharm Bioallied Sci 2013; 5: 103\u2013108.","journal-title":"J Pharm Bioallied Sci"},{"key":"BFsjbdj2015812_CR11","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.1016\/j.joen.2009.09.035","volume":"35","author":"GN Glickman","year":"2009","unstructured":"Glickman G N . AAE consensus conference recommended diagnostic terminology. J Endod 2009; 35: 1634.","journal-title":"J Endod"},{"key":"BFsjbdj2015812_CR12","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1111\/j.1365-2591.2008.01375.x","volume":"41","author":"J Lin","year":"2008","unstructured":"Lin J, Chandler N P . Electric pulp testing: a review. Int Endod J 2008; 41: 365\u2013374.","journal-title":"Int Endod J"},{"key":"BFsjbdj2015812_CR13","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1177\/002203458506400411","volume":"64","author":"MV Narhi","year":"1985","unstructured":"Narhi M V . The characteristics of intradental sensory units and their responses to stimulation. J Dent Rest 1985; 64: 564\u2013571.","journal-title":"J Dent Rest"},{"key":"BFsjbdj2015812_CR14","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1111\/j.1600-9657.1999.tb00769.x","volume":"15","author":"K Petersson","year":"1999","unstructured":"Petersson K, Soderstrom C, Kiani-Anaraki M, Levy G . Evaluation of the ability of thermal and electrical tests to register pulp vitality. Endod Dent Traumatol 1999; 15: 127\u2013131.","journal-title":"Endod Dent Traumatol"},{"key":"BFsjbdj2015812_CR15","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1016\/j.joen.2013.04.019","volume":"39","author":"CE Villa-Ch\u00e1vez","year":"2013","unstructured":"Villa-Ch\u00e1vez C E, Pati\u00f1o-Mar\u00edn N, Loyola-Rodr\u00edguez J P, Zavala-Alonso N V, Mart\u00ednez-Casta\u00f1\u00f3n G A, Medina-Sol\u00eds C E. Predictive values of thermal and electrical dental pulp tests: a clinical study. J Endod 2013; 39: 965\u2013969.","journal-title":"J Endod"},{"key":"BFsjbdj2015812_CR16","doi-asserted-by":"publisher","first-page":"S17","DOI":"10.1111\/j.1834-7819.2007.tb00522.x","volume":"52","author":"PV Abbott","year":"2007","unstructured":"Abbott P V, Yu C . A clinical classification of the status of the pulp and the root canal system. Aust Dent J 2007; 52: S17\u2013S31.","journal-title":"Aust Dent J"},{"key":"BFsjbdj2015812_CR17","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1034\/j.1601-1546.2002.30109.x","volume":"3","author":"K Keiser","year":"2002","unstructured":"Keiser K, Hargreaves K M . Building effective strategies for the management of endodontic pain. Endod Top 2002; 3: 93\u2013105.","journal-title":"Endod Top"},{"key":"BFsjbdj2015812_CR18","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1111\/j.1834-7819.2007.tb00525.x","volume":"52","author":"C Yu","year":"2007","unstructured":"Yu C, Abbott P V . An overview of the dental pulp: its functions and responses to injury. Aust Dent J 2007; 52: 4\u201316.","journal-title":"Aust Dent J"},{"key":"BFsjbdj2015812_CR19","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/S0099-2399(85)80219-3","volume":"11","author":"S Kim","year":"1985","unstructured":"Kim S . Microcirculation of the dental pulp in health and disease. J Endod 1985; 11: 465\u2013471.","journal-title":"J Endod"},{"key":"BFsjbdj2015812_CR20","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/S0099-2399(81)80242-7","volume":"7","author":"HO Trowbridge","year":"1981","unstructured":"Trowbridge H O . Pathogenesis of pulpitis resulting from dental caries. J Endod 1981; 7: 52\u201360.","journal-title":"J Endod"},{"key":"BFsjbdj2015812_CR21","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/S0099-2399(89)80091-3","volume":"15","author":"D Vreeland","year":"1989","unstructured":"Vreeland D, Reader A, Beck M, Meyers W, Weaver J . An evaluation of volumes and concentrations of lidocaine in human inferior alveolar nerve block. J Endod 1989; 15: 6\u201312.","journal-title":"J Endod"},{"key":"BFsjbdj2015812_CR22","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/S0099-2399(06)80510-8","volume":"19","author":"C McLean","year":"1993","unstructured":"McLean C, Reader A, Beck M, Meryers W J . An evaluation of 4% prilocaine and 3% mepivacaine compared with 2% lidocaine (1:100,000 epinephrine) for inferior alveolar nerve block. J Endod 1993; 19: 146\u2013150.","journal-title":"J Endod"},{"key":"BFsjbdj2015812_CR23","first-page":"84","volume":"38","author":"SA Hinkley","year":"1991","unstructured":"Hinkley S A, Reader A, Beck M, Meyers W J . An evaluation of 4% prilocaine with 1:200,000 epinephrine and 2% mepivacaine with 1:20,000 levonordefrin compared with 2% lidocaine with 1:100,000 epinephrine for inferior alveolar nerve block. Anesth Prog 1991; 38: 84\u201389.","journal-title":"Anesth Prog"},{"key":"BFsjbdj2015812_CR24","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1016\/S1079-2104(99)70156-3","volume":"87","author":"L Hannan","year":"1999","unstructured":"Hannan L, Reader A, Nist R, Beck M, Meyers W J . The use of ultrasound for guiding needle placement for inferior alveolar nerve blocks. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1999; 87: 658\u2013665.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"BFsjbdj2015812_CR25","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1097\/01.don.0000167395.61075.38","volume":"31","author":"C Fernandez","year":"2005","unstructured":"Fernandez C, Reader A, Beck M, Nusstein J . A prospective, randomized, double-blind comparison of bupivacaine and lidocaine for inferior alveolar nerve blocks. J Endod 2005; 31: 499\u2013503.","journal-title":"J Endod"},{"key":"BFsjbdj2015812_CR26","first-page":"372","volume":"50","author":"J Nusstein","year":"2002","unstructured":"Nusstein J, Reader A, Beck M . Anaesthetic efficacy of different volumes of lidocaine with epinephrine for inferior alveolar nerve blocks. Gen Dent 2002; 50: 372\u2013375.","journal-title":"Gen Dent"},{"key":"BFsjbdj2015812_CR27","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.14219\/jada.archive.2006.0114","volume":"137","author":"G Steinkruger","year":"2006","unstructured":"Steinkruger G, Nusstein J, Reader A, Beck M, Weaver J . The significance of needle bevel orientation in achieving a successful inferior alveolar nerve block. J Am Dent Assoc 2006; 137: 1685\u20131691.","journal-title":"J Am Dent Assoc"},{"key":"BFsjbdj2015812_CR28","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1016\/S1079-2104(99)70133-2","volume":"87","author":"S Clark","year":"1999","unstructured":"Clark S, Reader A, Beck M, Meyers W J . Anaesthetic efficacy of the mylohyoid nerve block and combination inferior alveolar nerve block\/mylohyoid nerve block. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1999; 87: 557\u2013563.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"BFsjbdj2015812_CR29","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1067\/moe.2001.115720","volume":"92","author":"T Yonchak","year":"2001","unstructured":"Yonchak T, Reader A, Beck M, Meyers W J . Anaesthetic efficacy of unilateral and bilateral inferior alveolar nerve blocks to determine cross innervation in anterior teeth. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001; 92: 132\u2013135.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"BFsjbdj2015812_CR30","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1097\/01.don.0000140576.36513.cb","volume":"31","author":"P Mikesell","year":"2005","unstructured":"Mikesell P, Nusstein J, Reader A, Beck M, Weaver J . A comparison of articaine and lidocaine for inferior alveolar nerve blocks. J Endod 2005; 31: 265\u2013270.","journal-title":"J Endod"},{"key":"BFsjbdj2015812_CR31","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/j.joen.2006.12.009","volume":"33","author":"GW Hsiao-Wu","year":"2007","unstructured":"Hsiao-Wu G W, Susarla S M, White R R . Use of the cold test as a measure of pulpal anaesthesia during endodontic therapy: a randomized, blinded, placebo-controlled clinical trial. J Endod 2007; 33: 406\u2013410.","journal-title":"J Endod"},{"key":"BFsjbdj2015812_CR32","unstructured":"Dale M M, Rang H P . Rang and Dale's Pharmacology. 6th ed. Edinburgh: Churchill Livingstone, 2007."},{"key":"BFsjbdj2015812_CR33","unstructured":"Norton, N S, Netter F H . Netter's head and neck anatomy for dentistry. Philadelphia: Saunders Elsevier; 2007."},{"key":"BFsjbdj2015812_CR34","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1111\/j.1747-4477.2001.tb00470.x","volume":"27","author":"S Bennett","year":"2001","unstructured":"Bennett S, Townsend G . Distribution of the mylohyoid nerve: anatomical variability and clinical implications. Aust Endod J 2001; 27: 109\u2013111.","journal-title":"Aust Endod J"},{"key":"BFsjbdj2015812_CR35","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1002\/ca.20479","volume":"20","author":"P Stein","year":"2007","unstructured":"Stein P, Brueckner J, Milliner M . Sensory innervation of mandibular teeth by the nerve to the mylohyoid: implications in local anaesthesia. Clin Anat 2007; 20: 591\u2013595.","journal-title":"Clin Anat"},{"key":"BFsjbdj2015812_CR36","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/0030-4220(85)90095-7","volume":"59","author":"J Wallace","year":"1985","unstructured":"Wallace J, Michanowicz A, Mundell R, Wilson E G . A pilot study of the clinical problem of regionally anaesthetizing the pulp of an acutely inflamed mandibular molar. Oral Surg Oral Med Oral Pathol 1985; 59: 517\u2013521.","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"BFsjbdj2015812_CR37","first-page":"232","volume-title":"Handbook of local anaesthesia","author":"SF Malamed","year":"1997","unstructured":"Malamed S F . Local anaesthetic considerations in dental specialties. In: Duncan L L (ed). Handbook of local anaesthesia. 4th ed. pp 232. St. Louis: Mosby Year Book Inc., 1997."},{"key":"BFsjbdj2015812_CR38","first-page":"210","volume":"11","author":"AA Fleury","year":"1990","unstructured":"Fleury A A . Local anaesthetic failure in endodontic therapy: the acute inflammation factor. Comp Cont Educ Dent 1990; 11: 210\u2013216.","journal-title":"Comp Cont Educ Dent"},{"key":"BFsjbdj2015812_CR39","doi-asserted-by":"publisher","first-page":"69","DOI":"10.14219\/jada.archive.1992.0004","volume":"123","author":"MKS Wong","year":"1992","unstructured":"Wong M K S, Jacobsen P L . Reasons for local anaesthesia failures. J Am Dent Assoc 1992; 123: 69\u201367.","journal-title":"J Am Dent Assoc"},{"key":"BFsjbdj2015812_CR40","unstructured":"Vandermeulen E . Pain perception, mechanisms of action of local anaesthetics and possible causes of failure. Rev Belge Med Dent 2000; 55: 29\u201340."},{"key":"BFsjbdj2015812_CR41","first-page":"83","volume":"27","author":"KM Hargreaves","year":"2001","unstructured":"Hargreaves K M, Dryden J, Schwarze M, Gracia N, Martin W, Flores C M . Development of a model to evaluate phenotypic plasticity in human nociceptors. Soc Neursci 2001; 27: 83.","journal-title":"Soc Neursci"},{"key":"BFsjbdj2015812_CR42","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/S0304-3959(99)00251-1","volume":"85","author":"K Coward","year":"2000","unstructured":"Coward K, Plumpton C, Facer P, et al. Immunolocalization of SNS\/PN3 and NaN\/SNS2 sodium channels in human pain states. Pain 2000; 85: 41\u201350.","journal-title":"Pain"},{"key":"BFsjbdj2015812_CR43","first-page":"1688","volume":"59","author":"N Ogata","year":"2001","unstructured":"Ogata N, Yamamoto M, Maruyama H . The role of tetrodotoxin-resistant sodium channels in pain sensation studied on sns-knockout mice. Nihon Rinsho 2001; 59: 1688\u20131697.","journal-title":"Nihon Rinsho"},{"key":"BFsjbdj2015812_CR44","doi-asserted-by":"publisher","first-page":"2104","DOI":"10.1523\/JNEUROSCI.12-06-02104.1992","volume":"12","author":"ML Roy","year":"1992","unstructured":"Roy M L, Narahashi T . Differential properties of tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels in rat dorsal root ganglion neurons. Soc Neursci 1992; 12: 2104\u20132111.","journal-title":"Soc Neursci"},{"key":"BFsjbdj2015812_CR45","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1073\/pnas.93.3.1108","volume":"93","author":"M Gold","year":"1996","unstructured":"Gold M, Reichling D, Shuster M, Levine J . Hyperalgesic agents increase a tetrodotoxin-resistant Na\u00b9 current in nociceptors. Proc Natl Acad Sci USA 1996; 93: 1108\u20131112.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFsjbdj2015812_CR46","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/S0099-2399(06)81568-2","volume":"16","author":"MR Byers","year":"1990","unstructured":"Byers M R, Taylor P E, Khayat B G, Kimberly C L . Effects of injury and inflammation on pulpal and periapical nerves. J Endod 1990; 16: 78\u201384.","journal-title":"J Endod"},{"key":"BFsjbdj2015812_CR47","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.joen.2008.01.014","volume":"34","author":"J Modaresi","year":"2008","unstructured":"Modaresi J, Dianat O, Soluti A . Effect of pulp inflammation on nerve impulse quality with or without anaesthesia. J Endod 2008; 34: 438\u2013441.","journal-title":"J Endod"},{"key":"BFsjbdj2015812_CR48","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/0007-117X(81)90023-8","volume":"19","author":"JP Rood","year":"1981","unstructured":"Rood J P, Pateromichelakis S . Inflammation and peripheral nerve sensitisation. Br J Oral Surg 1981; 19: 67\u201372.","journal-title":"Br J Oral Surg"},{"key":"BFsjbdj2015812_CR49","first-page":"287","volume":"30","author":"H Sorensen","year":"2004","unstructured":"Sorensen H, Skidmore L, Rzasa R, Kleier S, Levinson S, Hendry M . Comparison of pulpal sodium channel density in normal teeth to diseased teeth with severe spontaneous pain. J Endod 2004; 30: 287.","journal-title":"J Endod"},{"key":"BFsjbdj2015812_CR50","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.pain.2010.09.030","volume":"152","author":"CJ Woolf","year":"2011","unstructured":"Woolf C J . Central sensitization: implications for the diagnosis and treatment of pain. Pain. 2011; 152: 2\u201315.","journal-title":"Pain."},{"key":"BFsjbdj2015812_CR51","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/S0099-2399(75)80246-9","volume":"1","author":"J Birchfield","year":"1975","unstructured":"Birchfield J, Rosenberg P . Role of the anaesthetic solution in intrapulpal anaesthesia. J Endod 1975; 1: 26\u201327.","journal-title":"J Endod"},{"key":"BFsjbdj2015812_CR52","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/S1079-2104(97)90088-3","volume":"83","author":"J VanGheluwe","year":"1997","unstructured":"VanGheluwe J, Walton R . Intrapulpal injection\u2014factors related to effectiveness. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1997; 83: 38\u201340.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"BFsjbdj2015812_CR53","doi-asserted-by":"publisher","first-page":"97","DOI":"10.14219\/jada.archive.1992.0133","volume":"123","author":"RE Walton","year":"1992","unstructured":"Walton R E, Torabinejad M . Managing local anaesthesia problems in the endodontic patient. J Am Dent Assoc 1992; 123: 97\u2013102.","journal-title":"J Am Dent Assoc"},{"key":"BFsjbdj2015812_CR54","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1093\/bja\/61.2.154","volume":"61","author":"A Punnia-Moorthy","year":"1988","unstructured":"Punnia-Moorthy A . Buffering capacity of normal and inflamed tissues following the injection of local anaesthetic solutions. Br J Anaesth 1988; 61: 154\u2013159.","journal-title":"Br J Anaesth"},{"key":"BFsjbdj2015812_CR55","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1016\/j.joen.2013.01.008","volume":"39","author":"P Hobeich","year":"2013","unstructured":"Hobeich P, Simon S, Schneiderman E, He J . A prospective, randomized, double-blind comparison of the injection pain and anaesthetic onset of 2% lidocaine with 1:100,000 epinephrine buffered with 5% and 10% sodium bicarbonate in maxillary infiltrations. J Endod 2013; 39: 597\u2013599.","journal-title":"J Endod"},{"key":"BFsjbdj2015812_CR56","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/S0099-2399(97)80271-3","volume":"23","author":"F Dagher","year":"1997","unstructured":"Dagher F, Yared G, Machtou P . An evaluation of 2% lidocaine with different concentrations of epinephrine for inferior alveolar nerve block. J Endod 1997; 23: 178\u2013180.","journal-title":"J Endod"},{"key":"BFsjbdj2015812_CR57","doi-asserted-by":"publisher","first-page":"1746","DOI":"10.1152\/jn.1998.79.4.1746","volume":"79","author":"A Scholz","year":"1998","unstructured":"Scholz A, Kuboyama N, Haempelmann G, Vogel W . Complex blockade of TTX-resistant Na+ currents by lidocaine and bupivacaine reduce firing frequency in DRG neurons. J Neurophysiol 1998; 79: 1746\u20131754.","journal-title":"J Neurophysiol"},{"key":"BFsjbdj2015812_CR58","doi-asserted-by":"publisher","first-page":"97","DOI":"10.14219\/jada.archive.1992.0133","volume":"123","author":"RE Walton","year":"1992","unstructured":"Walton R E, Torabinejad M . Managing local anaesthesia problems in the endodontic patient. J Am Dent Assoc 1992; 123: 97\u2013102.","journal-title":"J Am Dent Assoc"},{"key":"BFsjbdj2015812_CR59","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1038\/sj.bdj.2014.497","volume":"216","author":"A Al-Namankany","year":"2014","unstructured":"Al-Namankany A, Petrie A, Ashley P . Video modelling and reducing anxiety related to dental injections- a randomised clinical trial. Br Dent J. 2014; 216: 675\u2013679.","journal-title":"Br Dent J."}],"container-title":["British Dental Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/sj.bdj.2015.812.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/sj.bdj.2015.812","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/sj.bdj.2015.812.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T22:58:06Z","timestamp":1684623486000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/sj.bdj.2015.812"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":59,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["BFsjbdj2015812"],"URL":"https:\/\/doi.org\/10.1038\/sj.bdj.2015.812","relation":{},"ISSN":["0007-0610","1476-5373"],"issn-type":[{"value":"0007-0610","type":"print"},{"value":"1476-5373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"14 September 2015","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 October 2015","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}