{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:40:16Z","timestamp":1791322816902,"version":"4.3.1"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2003,3,1]],"date-time":"2003-03-01T00:00:00Z","timestamp":1046476800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Dent J"],"published-print":{"date-parts":[[2003,3]]},"DOI":"10.1038\/sj.bdj.4809925","type":"journal-article","created":{"date-parts":[[2003,3,25]],"date-time":"2003-03-25T18:50:05Z","timestamp":1048618205000},"page":"245-251","source":"Crossref","is-referenced-by-count":184,"title":["The interdisciplinary management of hypodontia: background and role of paediatric dentistry"],"prefix":"10.1038","volume":"194","author":[{"given":"J H","family":"Nunn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N E","family":"Carter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T J","family":"Gillgrass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R S","family":"Hobson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N J","family":"Jepson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J G","family":"Meechan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F S","family":"Nohl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2003,3,8]]},"reference":[{"key":"BF4809925_CR1","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/sj.bdj.4808606","volume":"177","author":"JA Hobkirk","year":"1994","unstructured":"Hobkirk JA, Goodman JR, Jones SP Presenting complaints and findings in a group of patients attending a hypodontia clinic. Br Dent J 1994; 177: 337\u2013339.","journal-title":"Br Dent J"},{"key":"BF4809925_CR2","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/ejo\/18.1.119","volume":"18","author":"B Bergendal","year":"1996","unstructured":"Bergendal B, Bergendal T, Hallonsten A-L, Koch G, Kurol J, Kvint S A multidisciplinary approach to oral rehabilitation with osseointegrated implants in children and adolescents with multiple aplasia. Eur J Orthod 1996; 18: 119\u2013129.","journal-title":"Eur J Orthod"},{"key":"BF4809925_CR3","first-page":"121","volume":"16","author":"R Meon","year":"1992","unstructured":"Meon R Hypodontia of the primary and permanent dentition. J Clin Paed Dent 1992; 16: 121\u2013123.","journal-title":"J Clin Paed Dent"},{"key":"BF4809925_CR4","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1177\/00220345740530040201","volume":"53","author":"BK Suarez","year":"1974","unstructured":"Suarez BK, Spence MA The genetics of hypodontia. J Dent Res 1974; 53: 781\u2013785.","journal-title":"J Dent Res"},{"key":"BF4809925_CR5","first-page":"1","volume":"109","author":"PM Butler","year":"1939","unstructured":"Butler PM Studies of the mammalian dentition. Differentiation of the post-canine dentition. Proc Zoo Soc (Lond) 1939; 109: 1\u201336.","journal-title":"Proc Zoo Soc (Lond)"},{"key":"BF4809925_CR6","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/0003-9969(95)00143-3","volume":"41","author":"Y Schalk-vander Weide","year":"1996","unstructured":"Schalk-vander Weide Y, Bosman F Tooth size in relatives of individuals with oligodontia. Arch Oral Biol 1996; 41: 469\u2013472.","journal-title":"Arch Oral Biol"},{"key":"BF4809925_CR7","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1177\/00220345960750100601","volume":"75","author":"S Pirinen","year":"1996","unstructured":"Pirinen S, Arte S, Apajalahti S Palatal displacement of canine is genetic and related to congenital absence of teeth. J Dent Res 1996; 75: 1742\u20131746.","journal-title":"J Dent Res"},{"key":"BF4809925_CR8","first-page":"471","volume":"68","author":"T Baccetti","year":"1998","unstructured":"Baccetti T Tooth rotation associated with aplasia of nonadjacent teeth. Angle Orthod 1998; 68: 471\u2013474.","journal-title":"Angle Orthod"},{"key":"BF4809925_CR9","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1177\/00220345960750060401","volume":"75","author":"S Arte","year":"1996","unstructured":"Arte S, Nieminen P, Pirinen S, Thesleff I, Peltonen L Gene defect in hypodontia: exclusion of EGF, EGFR and FGR-3 as candidate genes. J Dent Res 1996; 75: 1346\u20131352.","journal-title":"J Dent Res"},{"key":"BF4809925_CR10","first-page":"291","volume":"22","author":"M Lapter","year":"1998","unstructured":"Lapter M, Slaj M, Skrinjaric I, Muretic Z Inheritance of hypodontia in twins. Collegioum Antropol 1998; 22: 291\u2013298.","journal-title":"Collegioum Antropol"},{"key":"BF4809925_CR11","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/ng0896-417","volume":"13","author":"H Vastardis","year":"1996","unstructured":"Vastardis H, Karimbux N, Guthua SW, Seidman JG, Seidman CE A human MSZ1 homeodomain missence mutation causes selective tooth agenesis. Nature Genetics 1996; 13: 417\u2013421.","journal-title":"Nature Genetics"},{"key":"BF4809925_CR12","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0011-8532(22)00661-9","volume":"19","author":"HL Bailit","year":"1975","unstructured":"Bailit HL Dental variations among populations, an anthropologic view. Dent Clin N Am 1975; 19: 125\u2013139.","journal-title":"Dent Clin N Am"},{"key":"BF4809925_CR13","first-page":"133","volume":"59","author":"Y Schalk-vander Weide","year":"1992","unstructured":"Schalk-vander Weide Y, Steen WHA, Bosman F Distribution of missing teeth and tooth morphology in patients with oligodontia. J Dent Child 1992; 59: 133\u2013140.","journal-title":"J Dent Child"},{"key":"BF4809925_CR14","first-page":"285","volume":"26","author":"A Kupietzky","year":"1995","unstructured":"Kupietzky A, Houpt M Hypohidrotic ectodermal dysplasia: characteristic and treatment. Quintessence Int 1995; 26: 285\u2013291.","journal-title":"Quintessence Int"},{"key":"BF4809925_CR15","first-page":"37","volume":"5","author":"AH Brook","year":"1974","unstructured":"Brook AH Dental anomalies of number, form and size: their prevalence in British schoolchildren. J Int Assoc Dent Child 1974; 5: 37\u201353.","journal-title":"J Int Assoc Dent Child"},{"key":"BF4809925_CR16","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1365-263X.1997.tb00265.x","volume":"7","author":"J Daugaard-Jensen","year":"1997","unstructured":"Daugaard-Jensen J, Nodal M, Kjaer I Pattern of agenesis in the primary dentition: a radiographic study of 193 cases. Int J Paed Dent 1997(a); 7: 3\u20137.","journal-title":"Int J Paed Dent"},{"issue":"Suppl","key":"BF4809925_CR17","first-page":"3","volume":"7","author":"H Grahnen","year":"1956","unstructured":"Grahnen H Hypodontia in the permanent dentition. Clinical and genetic investigations. Thesis. Odont Revy 1956 (Suppl) 7: 3.","journal-title":"Odont Revy"},{"key":"BF4809925_CR18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1834-7819.1996.tb05645.x","volume":"41","author":"J Cameron","year":"1996","unstructured":"Cameron J, Sampson WJ Hypodontia of the permanent dentition. Case reports. Aust Dent J 1996; 41: 1\u20135.","journal-title":"Aust Dent J"},{"key":"BF4809925_CR19","volume-title":"Studies on the serial observations of dentofacial regions in Japanese children","author":"M Arita","year":"1963","unstructured":"Arita M, Iwagaki H Studies on the serial observations of dentofacial regions in Japanese children Monographs Tokyo: Nikon University School of dentistry 1963."},{"key":"BF4809925_CR20","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1046\/j.1365-263X.1997.00230.x","volume":"7","author":"J Daugaard-Jensen","year":"1997","unstructured":"Daugaard-Jensen J, Nodal M, Skovgaard LT, Kjaer I Comparison of the pattern of agenesis in the primary and permanent dentitions in a population characterised by agenesis in the primary dentition. Int J Paed Dent 1997(b); 7: 143\u2013148.","journal-title":"Int J Paed Dent"},{"key":"BF4809925_CR21","first-page":"4","volume":"92","author":"BR Whittington","year":"1996","unstructured":"Whittington BR, Durward CS Survey of anomalies in primary teeth and their correlation with the permanent dentition. N Z Dent J 1996; 92: 4\u20138.","journal-title":"N Z Dent J"},{"key":"BF4809925_CR22","first-page":"69","volume":"22","author":"SR Mestrovic","year":"1998","unstructured":"Mestrovic SR, Rajic Z, Papic JS Hypodontia in patients with Down's syndrome. Collegium Antropologicum 1998; 22: 69\u201372.","journal-title":"Collegium Antropologicum"},{"key":"BF4809925_CR23","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/S0889-5406(99)70258-1","volume":"115","author":"Y Shapira","year":"1999","unstructured":"Shapira Y, Lubit E, Kuftinee MM Congenitally missing second premolars in cleft lip and cleft palate children. Am J Orthodont Dentofacial Orthopedics 1999; 115: 396\u2013400.","journal-title":"Am J Orthodont Dentofacial Orthopedics"},{"key":"BF4809925_CR24","first-page":"269","volume":"21","author":"JM Stimson","year":"1997","unstructured":"Stimson JM, Stivers JE, Hava GL Features of oligodontia in three generations. J Clin Ped Dent 1997; 21: 269\u2013275.","journal-title":"J Clin Ped Dent"},{"key":"BF4809925_CR25","first-page":"278","volume":"20","author":"AD Guckes","year":"1998","unstructured":"Guckes AD, Roberts MW, McCarthy GR Pattern of permanent teeth present in individuals with ectodermal dysplasia and severe hypodontia suggests treatment with dental implants. Ped Dent 1998; 20: 278\u2013280.","journal-title":"Ped Dent"},{"key":"BF4809925_CR26","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/ipd.1991.1.2.99","volume":"2","author":"WS McLaughlin","year":"1991","unstructured":"McLaughlin WS Congenital absence of all primary and permanent lateral incisors in a carrier of x-linked hypohidrotic ectodermal dysplasia. Int J Paed Dent 1991; 2: 99\u2013103.","journal-title":"Int J Paed Dent"},{"key":"BF4809925_CR27","first-page":"447","volume":"20","author":"SGS Ellis","year":"1993","unstructured":"Ellis SGS, Ahmed H Hypohidrotic ectodermal dysplasia affecting a female patient. Dent Update 1993; 20: 447\u2013450.","journal-title":"Dent Update"},{"key":"BF4809925_CR28","first-page":"127","volume":"43","author":"H Ziada","year":"1997","unstructured":"Ziada H, Holland T Ectodermal dysplasia: a case report. J Irish Dent Assoc 1997; 43: 127\u2013130.","journal-title":"J Irish Dent Assoc"},{"key":"BF4809925_CR29","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/j.1525-1470.1997.tb00233.x","volume":"14","author":"P Hummel","year":"1997","unstructured":"Hummel P, Guddack S Psychosocial stress and adaptive functioning in children and adolescents suffering from hypohidrotic ectodermal dysplasia. Ped Dermatol 1997; 14: 180\u2013185.","journal-title":"Ped Dermatol"},{"key":"BF4809925_CR30","unstructured":"Lagerheim B Why me? \u2013 A depressive crisis at the age of nine in handicapped children. In: Gyllensvard A, Lauren K (Eds). Psychosomatic disease in childhood. Stockholm: Sven Jerring Foundation."},{"key":"BF4809925_CR31","first-page":"255","volume":"43","author":"B Nussbaum","year":"1976","unstructured":"Nussbaum B, Carrel R The behaviour modification of a dentally disabled child. J Dent Child 1976; 43: 255\u2013261.","journal-title":"J Dent Child"},{"key":"BF4809925_CR32","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1365-263X.1996.tb00227.x","volume":"6","author":"RD Holt","year":"1996","unstructured":"Holt RD, Nunn JH, Rock WP, Page J Fluoride dietary supplements and fluoride toothpastes for children: a policy document. Int J Paed Dent 1996 6: 139\u2013142.","journal-title":"Int J Paed Dent"},{"key":"BF4809925_CR33","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1046\/j.1365-263x.2000.010002174.x","volume":"10","author":"JH Nunn","year":"2000","unstructured":"Nunn JH, Murray JJ, Smallridge J British Society of Paediatric Dentistry: a policy document on fissure sealants in paediatric dentistry. Int J Paed Dent 2000; 10: 174\u2013177.","journal-title":"Int J Paed Dent"},{"key":"BF4809925_CR34","unstructured":"Royal College of Surgeons of England Faculty of Dental Surgery. Prevention of dental caries in children. In: National Clinical Guidelines 1997."},{"key":"BF4809925_CR35","unstructured":"Royal College of Surgeons of England Faculty of Dental Surgery. Continuing oral care \u2013 review and recall. In: National Clinical Guidelines 1997."},{"key":"BF4809925_CR36","first-page":"1","volume":"2","author":"JH Nunn","year":"2002","unstructured":"Nunn JH Ectodermal Dysplasia and oral health. EDLines 2002; 2: 1\u20133.","journal-title":"EDLines"},{"issue":"Suppl","key":"BF4809925_CR37","first-page":"85","volume":"9","author":"BM McGivern","year":"1999","unstructured":"McGivern BM, Nunn JH, Carter NE A review of the outcome of infraoccluded primary teeth in a population of referred young people. Int J Paed Dent 1999; 9 (Suppl) 85.","journal-title":"Int J Paed Dent"},{"key":"BF4809925_CR38","first-page":"63","volume":"22","author":"AY Saad","year":"1997","unstructured":"Saad AY Regressive changes of the dental pulp complex in retained primary molars with congenitally missing successor teeth. J Clin Ped Dent 1997; 22: 63\u201367.","journal-title":"J Clin Ped Dent"},{"key":"BF4809925_CR39","first-page":"52","volume":"23","author":"RD Evans","year":"1996","unstructured":"Evans RD, Briggs PF Restoration of an infraoccluded primary molar with an indirect composite onlay: a case report and literature review. Dent Update 1996; 23: 52\u201354.","journal-title":"Dent Update"},{"key":"BF4809925_CR40","first-page":"589","volume":"18","author":"A Mamopoulou","year":"1996","unstructured":"Mamopoulou A, Hagg U, Schroder U, Hansen K Agenesis of mandibular second premolars. Spontaneous space closure after extraction therapy. A 4-year follow-up. Eur J Orthodont 1996; 18: 589\u2013600.","journal-title":"Eur J Orthodont"},{"key":"BF4809925_CR41","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1046\/j.1365-263X.2001.00257.x","volume":"11","author":"K Haselden","year":"2001","unstructured":"Haselden K, Hobkirk JA, Goodman JR, Jones SP, Hemmings KW Root resorption in retained deciduous canine and molar teeth without permanent successors in patients with severe hypodontia. Int J Paed Dent 2001; 11: 171\u2013178.","journal-title":"Int J Paed Dent"},{"key":"BF4809925_CR42","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0022-3913(05)80148-9","volume":"73","author":"TE Miller","year":"1995","unstructured":"Miller TE Implications of congenitally missing teeth: orthodontic and restorative procedures in the adult patient. J Pros Dent 1995; 73: 115\u2013122.","journal-title":"J Pros Dent"},{"key":"BF4809925_CR43","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1093\/ejo\/20.4.427","volume":"20","author":"E Levander","year":"1998","unstructured":"Levander E, Malmgren O, Stenback K Apical root resorption during orthodontic treatment of patients with multiple aplasia: a study of maxillary incisors. Eur J Orthodont 1998; 20: 427\u2013434.","journal-title":"Eur J Orthodont"},{"key":"BF4809925_CR44","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/ejo\/19.1.71","volume":"19","author":"S Yuksel","year":"1997","unstructured":"Yuksel S, Ucem T The effect of tooth agenesis on dentofacial structures. Eur J Orthodont 1997; 19: 71\u201378.","journal-title":"Eur J Orthodont"},{"key":"BF4809925_CR45","first-page":"57","volume":"4","author":"RP Renner","year":"1980","unstructured":"Renner RP, Kleinerman V Overdenture techniques in management of oligodontia \u2013 a case report. Quintessence Int 1980; 4: 57\u201365.","journal-title":"Quintessence Int"},{"key":"BF4809925_CR46","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.1365-2842.1980.tb00447.x","volume":"7","author":"J Hobkirk","year":"1980","unstructured":"Hobkirk J, Brook AH The management of patients with severe hypodontia. J Oral Rehab 1980; 7: 289\u2013298.","journal-title":"J Oral Rehab"},{"key":"BF4809925_CR47","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1093\/ejo\/16.2.84","volume":"16","author":"B Thilander","year":"1994","unstructured":"Thilander B, Odman J, Grondhal K, Friberg B Osseointegrated implants in adolescents. An alternative in replacing teeth? Eur J Orthodont 1994; 16: 84\u201395.","journal-title":"Eur J Orthodont"},{"key":"BF4809925_CR48","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/S0889-5406(95)70009-9","volume":"108","author":"HU Paulsen","year":"1995","unstructured":"Paulsen HU, Andreasen JO, Scwartz O Pulp and periodontal healing, root development and root resorption subsequent to transplantation and orthodontic rotation: a long-term study of autotransplanted premolars. Am J Orthod Dentofac Orthop 1995; 108: 630\u2013640.","journal-title":"Am J Orthod Dentofac Orthop"},{"key":"BF4809925_CR49","first-page":"149","volume":"41","author":"T Bergendal","year":"1991","unstructured":"Bergendal T, Eckerdal O, Hallonsten A-L, Koch G, Kurol J, Kvint S Osseointegrated implants in the oral rehabilitation of a boy with ectodermal dysplasia: a case report. Int Dent J 1991; 41: 149\u2013156.","journal-title":"Int Dent J"},{"key":"BF4809925_CR50","first-page":"282","volume":"19","author":"AD Guckes","year":"1997","unstructured":"Guckes AD, McCarthy GR, Brahim J Use of endosseous implants in a 3-year-old child with ectodermal dysplasia:case report and 5-year follow-up. Ped Dent 1997; 19: 282\u2013285.","journal-title":"Ped Dent"},{"key":"BF4809925_CR51","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1046\/j.1365-263X.1998.00065.x","volume":"8","author":"AS McMillan","year":"1998","unstructured":"McMillan AS, Nunn JH, Postlethwaite K Implant supported prosthesis in a child with hereditary mandibular anodontia: the role of ball attachments. Int J Paed Dent 1998; 8: 65\u201370.","journal-title":"Int J Paed Dent"},{"key":"BF4809925_CR52","unstructured":"Andreasen J Personal communication 1997."}],"container-title":["British Dental Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/4809925.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/4809925","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/4809925.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T14:52:16Z","timestamp":1704811936000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/4809925"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,3]]},"references-count":52,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2003,3]]}},"alternative-id":["BF4809925"],"URL":"https:\/\/doi.org\/10.1038\/sj.bdj.4809925","relation":{},"ISSN":["0007-0610","1476-5373"],"issn-type":[{"value":"0007-0610","type":"print"},{"value":"1476-5373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,3]]}}}