{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:57:31Z","timestamp":1787003851391,"version":"build-2736575974"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2004,8,1]],"date-time":"2004-08-01T00:00:00Z","timestamp":1091318400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Dent J"],"published-print":{"date-parts":[[2004,8]]},"DOI":"10.1038\/sj.bdj.4811530","type":"journal-article","created":{"date-parts":[[2004,8,13]],"date-time":"2004-08-13T09:56:42Z","timestamp":1092391002000},"page":"141-143","source":"Crossref","is-referenced-by-count":11,"title":["Azithromycin and dentistry \u2014 a useful agent?"],"prefix":"10.1038","volume":"197","author":[{"given":"L D","family":"Addy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M V","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2004,8,14]]},"reference":[{"key":"BF4811530_CR1","first-page":"407","volume":"190","author":"WA Littler","year":"2001","unstructured":"Littler WA . Clindamycin suspension and endocarditis prophylaxis. Br Dent J 2001; 190: 407.","journal-title":"Br Dent J"},{"key":"BF4811530_CR2","doi-asserted-by":"publisher","first-page":"703","DOI":"10.2165\/00128072-200103100-00001","volume":"3","author":"B Capitano","year":"2001","unstructured":"Capitano B, Quintiliani R, Nightingale CH, Nicolau DP . Antibacterials for the prophylaxis and treatment of bacterial endocarditis in children. Paediatr Drugs 2001; 3: 703\u2013 718.","journal-title":"Paediatr Drugs"},{"key":"BF4811530_CR3","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1161\/01.CIR.96.1.358","volume":"96","author":"AS Dajani","year":"1997","unstructured":"Dajani AS, Taubert KA, Wilson W, et al. Prevention of bacterial endocarditis. Recommendations by the American Heart Association. Circulation 1997; 96: 358\u2013 366.","journal-title":"Circulation"},{"key":"BF4811530_CR4","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1159\/000401062","volume":"25","author":"JT Wilson","year":"1978","unstructured":"Wilson JT, van Boxtel CJ . Pharmacokinetics of Erythromycin in man. Antibiot Chemother 1978; 25: 181\u2013 203.","journal-title":"Antibiot Chemother"},{"key":"BF4811530_CR5","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/S0025-6196(12)60322-X","volume":"60","author":"JA Washington 2nd","year":"1985","unstructured":"Washington JA 2nd, Wilson WR . Erythromycin: a microbial and clinical perspective after 30 years of clinical use (2). Mayo Clin Proc 1985; 60: 271\u2013 278.","journal-title":"Mayo Clin Proc"},{"key":"BF4811530_CR6","doi-asserted-by":"crossref","unstructured":"Chun A, Seitz J . Pharmokinetics and biological availability of erythromycin. Infection 1977; 5(Suppl 1): 14\u2013 22.","DOI":"10.1007\/BF01639131"},{"issue":"Suppl C","key":"BF4811530_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/jac\/37.suppl_C.1","volume":"37","author":"H Lode","year":"1996","unstructured":"Lode H, Borner K, Koeppe P, Scaberg T . Azithromycin- review of key chemical, pharmokinetic and microbiological features. J Antimicrob Chemother 1996; 37 (Suppl C): 1\u2013 8.","journal-title":"J Antimicrob Chemother"},{"issue":"Suppl A","key":"BF4811530_CR8","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1093\/jac\/25.suppl_A.39","volume":"25","author":"EF Fiese","year":"1990","unstructured":"Fiese EF, Steffen SH . Comparison of the acid stability of azithromycin and erythromycin A. J Antimicrob Chemother 1990; 25 Suppl A: 39\u2013 47.","journal-title":"J Antimicrob Chemother"},{"key":"BF4811530_CR9","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1016\/S1079-2104(05)80247-1","volume":"80","author":"WA Coulter","year":"1995","unstructured":"Coulter WA, McGimpsey JG, Coffey A, Strawbridge J, Linden GJ . Dental anxiety and the absorption of orally administered erythromycin stearate. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1995; 80: 660\u2013 665.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"BF4811530_CR10","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1093\/jac\/25.6.975","volume":"25","author":"AM Sefton","year":"1990","unstructured":"Sefton AM, Maskell JP, Kerawala C, et al. Comparative efficacy and tolerance of erythromycin and josamycin in the prevention of bacteraemia following dental extraction. J Antimicrob Chemother 1990; 25: 975\u2013 984.","journal-title":"J Antimicrob Chemother"},{"key":"BF4811530_CR11","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/S0140-6736(83)91713-0","volume":"1","author":"DC Shanson","year":"1983","unstructured":"Shanson DC, McNabb WR, Ruby K . High dose oral erythromycin for preventing endocarditis. Lancet 1983; 1: 299\u2013 300.","journal-title":"Lancet"},{"key":"BF4811530_CR12","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1128\/AAC.33.3.277","volume":"33","author":"RP Gladue","year":"1989","unstructured":"Gladue RP, Bright GM, Isaacson RE, Newborg MF . In vitro and in vivo uptake of azithromycin (CP-62,993) by phagocytic cells: possible mechanism of delivery and release at sites of infection. Antimicrob Agents Chemother 1989; 33: 277\u2013 282.","journal-title":"Antimicrob Agents Chemother"},{"key":"BF4811530_CR13","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1128\/AAC.34.6.1056","volume":"34","author":"RP Gladue","year":"1990","unstructured":"Gladue RP, Snider ME . Intracellular accumulation of azithromycin by cultured human fibroblasts. Antimicrob Agents Chemother 1990; 34: 1056\u2013 1060.","journal-title":"Antimicrob Agents Chemother"},{"key":"BF4811530_CR14","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1128\/AAC.36.6.1302","volume":"36","author":"M Bonnet","year":"1992","unstructured":"Bonnet M, Van der Auwera P . In vitro and in vivo intraleukocytic accumulation of azithromycin (CP- 62, 993) and its influence on ex vivo leukocyte chemiluminescence. Antimicrob Agents Chemother 1992; 36: 1302\u2013 1309.","journal-title":"Antimicrob Agents Chemother"},{"issue":"Suppl A","key":"BF4811530_CR15","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1093\/jac\/25.suppl_A.73","volume":"25","author":"G Foulds","year":"1990","unstructured":"Foulds G, Shepard RM, Johnson RB . The pharmacokinetics of azithromycin in human serum and tissues. J Antimicrob Chemother 1990; 25 (Suppl A): 73\u2013 82.","journal-title":"J Antimicrob Chemother"},{"issue":"Suppl E","key":"BF4811530_CR16","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1093\/jac\/31.suppl_E.39","volume":"31","author":"G Foulds","year":"1993","unstructured":"Foulds G, Johnson RB . Selection of dose regimens of azithromycin. J Antimicrob Chemother 1993; 31 (Suppl E): 39\u2013 50.","journal-title":"J Antimicrob Chemother"},{"issue":"Suppl C","key":"BF4811530_CR17","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1093\/jac\/37.suppl_C.37","volume":"37","author":"G Foulds","year":"1996","unstructured":"Foulds G, Luke DR, Teng R, Willavize SA, Friedman H, Curatolo WJ . The absence of an effect of food on the bioavailability of azithromycin administered as tablets, sachet or suspension. J Antimicrob Chemother 1996; 37 (Suppl C): 37\u2013 44.","journal-title":"J Antimicrob Chemother"},{"key":"BF4811530_CR18","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1128\/AAC.44.6.1754-1756.2000","volume":"44","author":"A Tsitasika","year":"2000","unstructured":"Tsitasika A, Pefanis A, Perdikaris GS, Donta I, Karayiannakos P, Giamarellou H . Single-oral dose azithromycin prophylaxis against experimental streptococcal or staphylococcal aortic valve endocarditis. Antimicrob Agents Chemother 2000; 44: 1754\u2013 1756.","journal-title":"Antimicrob Agents Chemother"},{"issue":"Suppl E","key":"BF4811530_CR19","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1093\/jac\/31.suppl_E.29","volume":"31","author":"AE Girard","year":"1993","unstructured":"Girard AE, Cimochowski CR, Faiella JA . The comparative activity of azithromycin, macrolides and amoxycillin against streptococci in experimental infections. J Antimicrob Chemother 1993; 31 (Suppl E): 29\u2013 37.","journal-title":"J Antimicrob Chemother"},{"key":"BF4811530_CR20","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.1128\/AAC.41.8.1673","volume":"41","author":"MS Rouse","year":"1997","unstructured":"Rouse MS, Steckelberg JM, Brandt CM, Patel R, Miro JM, Wilson WR . Efficacy of azithromycin or clarithromycin for prophylaxis of viridans group streptococcus experimental endocarditis. Antimicrob Agents Chemother 1997; 41: 1673\u2013 1676.","journal-title":"Antimicrob Agents Chemother"},{"key":"BF4811530_CR21","volume-title":"Oral Microbiology","author":"P Marsh","year":"1999","unstructured":"Marsh P, Martin M . Oral Microbiology. 4th ed. Oxford: Wright, 1999."},{"key":"BF4811530_CR22","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1038\/sj.bdj.4800845","volume":"189","author":"RA Seymour","year":"2000","unstructured":"Seymour RA, Lowry R, Whitworth JM, Martin MV . Infective endocarditis, dentistry and antibiotic prophylaxis; time for a rethink? Br Dent J 2000; 189: 610\u2013 616.","journal-title":"Br Dent J"},{"issue":"Suppl E","key":"BF4811530_CR23","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1093\/jac\/31.suppl_E.119","volume":"31","author":"AM Lo Bue","year":"1993","unstructured":"Lo Bue AM, Sammartino R, Chisari G, Gismondo MR, Nicoletti G . Efficacy of azithromycin compared with spiramycin in the treatment of odontogenic infections. J Antimicrob Chemother 1993; 31 (Suppl E): 119\u2013 127.","journal-title":"J Antimicrob Chemother"},{"key":"BF4811530_CR24","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1177\/030006059802600202","volume":"26","author":"PA Clement","year":"1998","unstructured":"Clement PA, de Gandt JB . A comparison of the efficacy, tolerability and safety of azithromycin and co-amoxiclav in the treatment of sinusitis in adults. J Int Med Res 1998; 26: 66\u2013 75.","journal-title":"J Int Med Res"},{"key":"BF4811530_CR25","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1111\/j.1600-051X.1996.tb00527.x","volume":"23","author":"AM Sefton","year":"1996","unstructured":"Sefton AM, Maskell JP, Beighton D, et al. Azithromycin in the treatment of periodontal disease. Effect on microbial flora. J Clin Periodontol 1996; 23: 998\u2013 1003.","journal-title":"J Clin Periodontol"},{"key":"BF4811530_CR26","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1902\/jop.1997.68.12.1206","volume":"68","author":"T Malizia","year":"1997","unstructured":"Malizia T, Tejada MR, Ghelardi E, et al. Periodontal tissue disposition of azithromycin. J Periodontol 1997; 68: 1206\u2013 1209.","journal-title":"J Periodontol"},{"key":"BF4811530_CR27","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1902\/jop.2000.72.9.1151","volume":"72","author":"T Malizia","year":"2001","unstructured":"Malizia T, Batoni G, Ghelardi E, et al. Interaction between piroxicam and azithromycin during distribution to human periodontal tissues. J Periodontol 2001; 72: 1151\u2013 1156.","journal-title":"J Periodontol"},{"key":"BF4811530_CR28","first-page":"57","volume":"47","author":"G Varvara","year":"1998","unstructured":"Varvara G, D'Arcangelo C . [The evaluation of the clinical efficacy and tolerance of azithromycin in odontostomatological infections]. Minerva Stomatol 1998; 47: 57\u2013 62.","journal-title":"Minerva Stomatol"},{"key":"BF4811530_CR29","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1902\/jop.1999.70.9.960","volume":"70","author":"C Blandizzi","year":"1999","unstructured":"Blandizzi C, Malizia T, Lupetti A, et al. Periodontal tissue disposition of azithromycin in patients affected by chronic inflammatory periodontal diseases. J Periodontol 1999; 70: 960\u2013 966.","journal-title":"J Periodontol"},{"key":"BF4811530_CR30","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/jac\/30.1.27","volume":"30","author":"JD Williams","year":"1992","unstructured":"Williams JD, Maskell JP, Shain H, et al. Comparative in-vitro activity of azithromycin, macrolides (erythromycin, clarithromycin and spiramycin) and streptogramin RP 59500 against oral organisms. J Antimicrob Chemother 1992; 30: 27\u2013 37.","journal-title":"J Antimicrob Chemother"},{"key":"BF4811530_CR31","doi-asserted-by":"publisher","first-page":"750","DOI":"10.2165\/00003495-199244050-00007","volume":"44","author":"DH Peters","year":"1992","unstructured":"Peters DH, Friedel HA, McTavish D . Azithromycin. A review of its antimicrobial activity, pharmacokinetic properties and clinical efficacy. Drugs 1992; 44: 750\u2013 799.","journal-title":"Drugs"},{"issue":"Suppl E","key":"BF4811530_CR32","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1093\/jac\/31.suppl_E.111","volume":"31","author":"S Hopkins","year":"1993","unstructured":"Hopkins S . Clinical safety and tolerance of azithromycin in children. J Antimicrob Chemother 1993; 31 (Suppl E): 111\u2013 117.","journal-title":"J Antimicrob Chemother"},{"key":"BF4811530_CR33","doi-asserted-by":"publisher","first-page":"40S","DOI":"10.1016\/0002-9343(91)90401-I","volume":"91","author":"S Hopkins","year":"1991","unstructured":"Hopkins S . Clinical toleration and safety of azithromycin. Am J Med 1991; 91: 40S\u2013 45S.","journal-title":"Am J Med"},{"key":"BF4811530_CR34","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1034\/j.1600-051x.2002.290109.x","volume":"29","author":"SR Smith","year":"2002","unstructured":"Smith SR, Foyle DM, Daniels J, et al. A double-blind placebo-controlled trial of azithromycin as an adjunct to non-surgical treatment of periodontitis in adults: clinical results. J Clin Periodontol 2002; 29: 54\u2013 61.","journal-title":"J Clin Periodontol"},{"key":"BF4811530_CR35","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1093\/jac\/26.4.539","volume":"26","author":"JP Maskell","year":"1990","unstructured":"Maskell JP, Sefton AM, Cannell H, et al. Predominance of resistant oral streptococci in saliva and the effect of a single course of josamycin or erythromycin. J Antimicrob Chemother 1990; 26: 539\u2013 548.","journal-title":"J Antimicrob Chemother"},{"key":"BF4811530_CR36","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1093\/jac\/15.4.471","volume":"15","author":"GA Harrison","year":"1985","unstructured":"Harrison GA, Stross WP, Rubin MP, Davies RM, Speller DC . Resistance in oral streptococci after repeated three-dose erythromycin prophylaxis. J Antimicrob Chemother 1985; 15: 471\u2013 479.","journal-title":"J Antimicrob Chemother"},{"key":"BF4811530_CR37","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1542\/peds.46.1.84","volume":"46","author":"K Sprunt","year":"1970","unstructured":"Sprunt K, Leidy G, Redman W . Cross resistance between lincomycin and erythromycin in viridans streptococci. Pediatrics 1970; 46: 84\u2013 88.","journal-title":"Pediatrics"},{"key":"BF4811530_CR38","doi-asserted-by":"publisher","first-page":"3484","DOI":"10.1073\/pnas.75.7.3484","volume":"75","author":"DJ LeBlanc","year":"1978","unstructured":"LeBlanc DJ, Hawley RJ, Lee LN, St MartinEJ . 'Conjugal' transfer of plasmid DNA among oral streptococci. Proc Natl Acad Sci USA 1978; 75: 3484\u2013 3487.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF4811530_CR39","unstructured":"Dental Practitioners' Formulary. 2002-2004. British National Formulary Number 44. London: The Royal Pharmaceutical Society of Great Britain and The British Medical Association, 2002."}],"container-title":["British Dental Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/4811530.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/4811530","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/4811530.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T21:25:21Z","timestamp":1684358721000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/4811530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,8]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,8]]}},"alternative-id":["BF4811530"],"URL":"https:\/\/doi.org\/10.1038\/sj.bdj.4811530","relation":{},"ISSN":["0007-0610","1476-5373"],"issn-type":[{"value":"0007-0610","type":"print"},{"value":"1476-5373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,8]]}}}