{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T09:08:02Z","timestamp":1791018482406,"version":"4.1.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2002,6,1]],"date-time":"2002-06-01T00:00:00Z","timestamp":1022889600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Cancer"],"published-print":{"date-parts":[[2002,6]]},"DOI":"10.1038\/sj.bjc.6600368","type":"journal-article","created":{"date-parts":[[2002,9,3]],"date-time":"2002-09-03T17:28:41Z","timestamp":1031074121000},"page":"1937-1942","source":"Crossref","is-referenced-by-count":109,"title":["Induction of endothelial cell apoptosis by the antivascular agent 5,6-dimethylxanthenone-4-acetic acid"],"prefix":"10.1038","volume":"86","author":[{"given":"L-M","family":"Ching","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Kieda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Zwain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M B","family":"Jameson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B C","family":"Baguley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2002,6,11]]},"reference":[{"key":"BF6600368_CR1","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1084\/jem.182.1.155","volume":"182","author":"AL Angiolillo","year":"1995","unstructured":"Angiolillo AL, Sgadari C, Taub DD, Liao F, Farber JM, Maheshwari S, Kleinman HK, Reaman GH and Tosato G (1995) Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo. J Exp Med 182: 155\u2013162","journal-title":"J Exp Med"},{"key":"BF6600368_CR2","first-page":"967","volume":"2","author":"BC Baguley","year":"2001","unstructured":"Baguley BC (2001) Small-molecule cytokine inducers causing tumor necrosis. Curr Opin Investig Drugs 2: 967\u2013975","journal-title":"Curr Opin Investig Drugs"},{"key":"BF6600368_CR3","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/0277-5379(89)90018-7","volume":"25","author":"BC Baguley","year":"1989","unstructured":"Baguley BC, Calveley SB, Crowe KK, Fray LM, O'Rourke SA and Smith GP (1989) Comparison of the effects of flavone acetic acid, fostriecin, homoharringtonine and tumour necrosis factor alpha on Colon 38 tumors in mice. Eur J Cancer Clin Oncol 25: 263\u2013269","journal-title":"Eur J Cancer Clin Oncol"},{"key":"BF6600368_CR4","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/0248-4900(93)90259-H","volume":"79","author":"N Bizouarne","year":"1993","unstructured":"Bizouarne N, Mitterrand M, Monsigny M and Kieda C (1993) Characterization of membrane sugar-specific receptors in cultured high endothelial cells from mouse peripheral lymph nodes. Biol Cell 79: 27\u201335","journal-title":"Biol Cell"},{"key":"BF6600368_CR5","first-page":"4409","volume":"18","author":"WL Browne","year":"1998","unstructured":"Browne WL, Wilson WR, Baguley BC and Ching L-M (1998) Suppression of serum tumour necrosis factor-alpha by thalidomide does not lead to reversal of tumour vascular collapse and anti-tumour activity of 5,6-dimethylxanthenone-4-acetic acid. Anticancer Res 18: 4409\u20134414","journal-title":"Anticancer Res"},{"key":"BF6600368_CR6","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1038\/sj.bjc.6690415","volume":"80","author":"Z Cao","year":"1999","unstructured":"Cao Z, Joseph WR, Browne WL, Mountjoy KG, Palmer BD, Baguley BC and Ching LM (1999) Thalidomide increases both intra-tumoural tumour necrosis factor-alpha production and anti-tumour activity in response to 5,6-dimethylxanthenone-4-acetic acid. Br J Cancer 80: 716\u2013723","journal-title":"Br J Cancer"},{"key":"BF6600368_CR7","first-page":"1517","volume":"61","author":"Z Cao","year":"2001","unstructured":"Cao Z, Baguley BC and Ching L-M (2001) Interferon-inducible protein 10 induction and inhibition of angiogenesis in vivo by the antitumor agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA). Cancer Res 61: 1517\u20131521","journal-title":"Cancer Res"},{"key":"BF6600368_CR8","first-page":"2069","volume":"13","author":"LM Ching","year":"1993","unstructured":"Ching LM, Joseph WR and Baguley BC (1993) Effect of tumour growth on the macrophage response to the antitumour agent 5,6-dimethylxanthenone-4-acetic acid. Anticancer Res 13: 2069\u20132075","journal-title":"Anticancer Res"},{"key":"BF6600368_CR9","first-page":"870","volume":"54","author":"LM Ching","year":"1994","unstructured":"Ching LM, Joseph WR, Crosier KE and Baguley BC (1994) Induction of tumor necrosis factor-alpha messenger RNA in human and murine cells by the flavone acetic acid analogue 5,6-dimethylxanthenone-4-acetic acid (NSC 640488). Cancer Res 54: 870\u2013872","journal-title":"Cancer Res"},{"key":"BF6600368_CR10","first-page":"3304","volume":"59","author":"LM Ching","year":"1999","unstructured":"Ching LM, Goldsmith D, Joseph WR, Korner H, Sedgwick JD and Baguley BC (1999) Induction of intratumoral tumor necrosis factor (TNF) synthesis and hemorrhagic necrosis by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in TNF knockout mice. Cancer Res 59: 3304\u20133307","journal-title":"Cancer Res"},{"key":"BF6600368_CR11","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1080\/09553009114551951","volume":"60","author":"DJ Honess","year":"1991","unstructured":"Honess DJ and Bleehen NM (1991) Effects of two tumour blood flow modifiers, hydralazine and flavone acetic acid, on KHT tumours and normal tissues in mice. Int J Radiat Biol 60: 249\u2013253","journal-title":"Int J Radiat Biol"},{"key":"BF6600368_CR12","first-page":"182a","volume":"19","author":"MB Jameson","year":"2000","unstructured":"Jameson MB, Thompson PI, Baguley BC, Evans BD, Harvey VJ, Porter DJ, McCrystal MR and Kestell P (2000) Phase I pharmacokinetic and pharmacodynamic study of 5,6-dimethylxanthenone-4-acetic acid (DMXAA), a novel antivascular agent. Proc Am Soc Clin Oncol 19: 182a","journal-title":"Proc Am Soc Clin Oncol"},{"key":"BF6600368_CR13","first-page":"633","volume":"59","author":"WR Joseph","year":"1999","unstructured":"Joseph WR, Cao Z, Mountjoy KG, Marshall ES, Baguley BC and Ching L-M (1999) Stimulation of tumors to synthesize tumor necrosis factor-alpha in situ using 5,6-dimethylxanthenone-4-acetic acid: a novel approach to cancer therapy. Cancer Res 59: 633\u2013638","journal-title":"Cancer Res"},{"key":"BF6600368_CR14","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1038\/bjc.1998.512","volume":"78","author":"CJ Lash","year":"1998","unstructured":"Lash CJ, Li AE, Rutland M, Baguley BC, Zwi LJ and Wilson WR (1998) Enhancement of the anti-tumour effects of the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) by combination with 5-hydroxytryptamine and bioreductive drugs. Br J Cancer 78: 439\u2013445","journal-title":"Br J Cancer"},{"key":"BF6600368_CR15","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1038\/315672a0","volume":"315","author":"AD Luster","year":"1985","unstructured":"Luster AD, Unkeless JC and Ravetch JV (1985) Gamma-interferon transcriptionally regulates an early-response gene containing homology to platelet proteins. Nature 315: 672\u2013676","journal-title":"Nature"},{"key":"BF6600368_CR16","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1007\/BF00685815","volume":"28","author":"MJ McKeage","year":"1991","unstructured":"McKeage MJ, Kestell P, Denny WA and Baguley BC (1991) Plasma pharmacokinetics of the antitumour agents 5,6-dimethylxanthenone-4-acetic acid, xanthenone-4-acetic acid and flavone-8-acetic acid in mice. Cancer Chemother Pharmacol 28: 409\u2013413","journal-title":"Cancer Chemother Pharmacol"},{"key":"BF6600368_CR17","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/BF00689199","volume":"36","author":"M Philpott","year":"1995","unstructured":"Philpott M, Baguley BC and Ching L-M (1995) Induction of tumour necrosis factor-alpha by single and repeated doses of the antitumour agent 5,6-dimethylxanthenone-4-acetic acid. Cancer Chemother Pharmacol 36: 143\u2013148","journal-title":"Cancer Chemother Pharmacol"},{"key":"BF6600368_CR18","doi-asserted-by":"publisher","first-page":"1930","DOI":"10.1016\/S0959-8049(01)00210-6","volume":"37","author":"M Philpott","year":"2001","unstructured":"Philpott M, Ching LM and Baguley BC (2001) The antitumour agent 5,6-dimethylxanthenone-4-acetic acid acts in vitro on human mononuclear cells as a co-stimulator to other inducers of tumour necrosis factor. Eur J Cancer 37: 1930\u20131937","journal-title":"Eur J Cancer"},{"key":"BF6600368_CR19","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1021\/jm00105a034","volume":"34","author":"GW Rewcastle","year":"1991","unstructured":"Rewcastle GW, Atwell GJ, Zhuang L, Baguley BC and Denny WA (1991) Potential antitumor agents. 61. Structure-activity relationships for in vivo colon 38 activity among disubstituted 9-oxo-9H-xanthene-4-acetic acids. J Med Chem 34: 217\u2013222","journal-title":"J Med Chem"},{"key":"BF6600368_CR20","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1093\/oxfordjournals.annonc.a010960","volume":"9","author":"G Rustin","year":"1998","unstructured":"Rustin G, Galbraith S, Taylor N, Stratford M, Bradley C, Thompson P, Jameson M and Baguley B (1998) Impact on tumour perfusion measured by dynamic magnetic resonance imaging (MRI), in the phase 1 trial of 5,6-dimethylxanthenone-4-acetic acid (DMXAA). Ann Oncol 9: 126","journal-title":"Ann Oncol"},{"key":"BF6600368_CR21","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1084\/jem.177.6.1809","volume":"177","author":"DD Taub","year":"1993","unstructured":"Taub DD, Lloyd AR, Conlon K, Wang JM, Ortaldo JR, Harada A, Matsushima K, Kelvin DJ and Oppenheim JJ (1993) Recombinant human interferon-inducible protein 10 is a chemoattractant for human monocytes and T lymphocytes and promotes T cell adhesion to endothelial cells. J Exp Med 177: 1809\u20131814","journal-title":"J Exp Med"},{"key":"BF6600368_CR22","first-page":"247","volume":"63","author":"A Vecchi","year":"1994","unstructured":"Vecchi A, Garlanda C, Lampugnani MG, Resnati M, Matteucci C, Stoppacciaro A, Schnurch H, Risau W, Ruco L, Mantovani A and Dejana E (1994) Monoclonal antibodies specific for endothelial cells of mouse blood vessels. Their application in the identification of adult and embryonic endothelium. Eur J Cell Biol 63: 247\u2013254","journal-title":"Eur J Cell Biol"},{"key":"BF6600368_CR23","first-page":"S164","volume":"74","author":"ME Watts","year":"1996","unstructured":"Watts ME, Arnold S and Chaplin DJ (1996) Changes in coagulation and permeability properties of human endothelial cells in vitro induced by TNF-alpha or 5,6-MeXAA. Br J Cancer 74: S164\u2013S167","journal-title":"Br J Cancer"},{"key":"BF6600368_CR24","first-page":"1","volume":"77","author":"P Workman","year":"1998","unstructured":"Workman P, Twentyman P, Balkwill F, Balmain A, Chaplin D, Double J, Embleton J, Newell D, Raymond R, Stables J, Stephens T and Wallace J (1998) United Kingdom Co-ordinating Committee on Cancer Research (UKCCCR) Guidelines for the Welfare of Animals in Experimental Neoplasia (Second Edition). Br J Cancer 77: 1\u201310","journal-title":"Br J Cancer"},{"key":"BF6600368_CR25","first-page":"79","volume":"6","author":"LJ Zwi","year":"1994","unstructured":"Zwi LJ, Baguley BC, Gavin JB and Wilson WR (1994a) Correlation between immune and vascular activities of xanthenone acetic acid antitumor agents. Oncol Res 6: 79\u201385","journal-title":"Oncol Res"},{"key":"BF6600368_CR26","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1080\/00313029400169411","volume":"26","author":"LJ Zwi","year":"1994","unstructured":"Zwi LJ, Baguley BC, Gavin JB and Wilson WR (1994b) The morphological effects of the anti-tumour agents flavone acetic acid and 5,6-dimethylxanthenone acetic acid on the colon 38 mouse tumour. Pathology 26: 161\u2013169","journal-title":"Pathology"}],"container-title":["British Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/6600368.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/6600368","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/6600368.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T12:43:17Z","timestamp":1684413797000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/6600368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,6]]},"references-count":26,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2002,6]]}},"alternative-id":["BF6600368"],"URL":"https:\/\/doi.org\/10.1038\/sj.bjc.6600368","relation":{},"ISSN":["0007-0920","1532-1827"],"issn-type":[{"value":"0007-0920","type":"print"},{"value":"1532-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,6]]}}}