{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:08:05Z","timestamp":1762520885139},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2004,3,2]],"date-time":"2004-03-02T00:00:00Z","timestamp":1078185600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Cancer"],"published-print":{"date-parts":[[2004,4]]},"DOI":"10.1038\/sj.bjc.6601691","type":"journal-article","created":{"date-parts":[[2004,3,30]],"date-time":"2004-03-30T17:14:03Z","timestamp":1080666843000},"page":"1407-1413","source":"Crossref","is-referenced-by-count":50,"title":["Human papillomavirus oncogenic expression in the dysplastic portio; an investigation of biopsies from 190 cervical cones"],"prefix":"10.1038","volume":"90","author":[{"given":"I","family":"Kraus","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Molden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L E","family":"Ern\u00f8","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Skomedal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Karlsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Hagmar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2004,3,2]]},"reference":[{"key":"BF6601691_CR1","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1128\/JCM.28.3.495-503.1990","volume":"28","author":"R Boom","year":"1990","unstructured":"Boom R, Sol CJ, Salimans MM, Jansen CL, Wertheim-van Dillen PM, van der NJ (1990) Rapid and simple method for purification of nucleic acids. J Clin Microbiol 28: 495\u2013503","journal-title":"J Clin Microbiol"},{"key":"BF6601691_CR2","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1136\/jcp.55.4.244","volume":"55","author":"FX Bosch","year":"2002","unstructured":"Bosch FX, Lorincz A, Munoz N, Meijer CJ, Shah KV (2002) The causal relation between human papillomavirus and cervical cancer. J Clin Pathol 55: 244\u2013265","journal-title":"J Clin Pathol"},{"key":"BF6601691_CR3","first-page":"796","volume":"87","author":"FX Bosch","year":"1995","unstructured":"Bosch FX, Manos MM, Munoz N, Sherman M, Jansen AM, Peto J, Schiffman MH, Moreno V, Kurman R, Shah KV (1995) Prevalence of human papillomavirus in cervical cancer: a worldwide perspective. International Biological Study on Cervical Cancer (IBSCC) Study Group. J Natl Cancer Inst 87: 796\u2013802","journal-title":"International Biological Study on Cervical Cancer (IBSCC) Study Group. J Natl Cancer Inst"},{"key":"BF6601691_CR4","first-page":"185","volume":"10","author":"AB Chan","year":"1999","unstructured":"Chan AB, Fox JD (1999) NASBA and other transcription-based amplification methods for research and diagnostic microbiology. Med Microbiol 10: 185\u2013196","journal-title":"Med Microbiol"},{"key":"BF6601691_CR5","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/350091a0","volume":"350","author":"J Compton","year":"1991","unstructured":"Compton J (1991) Nucleic acid sequence-based amplification. Nature 350: 91\u201392","journal-title":"Nature"},{"key":"BF6601691_CR6","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1093\/ajcp\/112.3.384","volume":"112","author":"CP Crum","year":"1999","unstructured":"Crum CP, Genest DR, Krane JF, Hogan C, Sun D, Bellerose B, Kostopoulou E, Lee KR (1999) Subclassifying atypical squamous cells in thin-prep cervical cytology correlates with detection of high-risk human papillomavirus DNA. Am J Clin Pathol 112: 384\u2013390","journal-title":"Am J Clin Pathol"},{"key":"BF6601691_CR7","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1385\/MB:20:2:163","volume":"20","author":"B Deiman","year":"2002","unstructured":"Deiman B, van Aarle P, Sillekens P (2002) Characteristics and applications of nucleic acid sequence-based amplification (NASBA). Mol Biotechnol 20: 163\u2013179","journal-title":"Mol Biotechnol"},{"key":"BF6601691_CR8","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1136\/jcp.56.7.532","volume":"56","author":"G Gallo","year":"2003","unstructured":"Gallo G, Bibbo M, Bagella L, Zamparelli A, Sanseverino F, Giovagnoli MR, Vecchione A, Giordano A (2003) Study of viral integration of HPV-16 in young patients with LSIL. J Clin Pathol 56: 532\u2013536","journal-title":"J Clin Pathol"},{"key":"BF6601691_CR9","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/S0046-8177(99)90015-1","volume":"30","author":"L Geng","year":"1999","unstructured":"Geng L, Connolly DC, Isacson C, Ronnett BM, Cho KR (1999) A typical immature metaplasia (AIM) of the cervix: is it related to high-grade squamous intraepithelial lesion (HSIL)? Hum Pathol 30: 345\u2013351","journal-title":"Hum Pathol"},{"key":"BF6601691_CR10","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1056\/NEJM199802123380703","volume":"338","author":"GY Ho","year":"1998","unstructured":"Ho GY, Bierman R, Beardsley L, Chang CJ, Burk RD (1998) Natural history of cervicovaginal papillomavirus infection in young women. N Engl J Med 338: 423\u2013428","journal-title":"N Engl J Med"},{"key":"BF6601691_CR11","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1097\/00004347-199804000-00009","volume":"17","author":"M Kalantari","year":"1998","unstructured":"Kalantari M, Karlsen F, Kristensen G, Holm R, Hagmar B, Johansson B (1998) Disruption of the E1 and E2 reading frames of HPV 16 in cervical carcinoma is associated with poor prognosis. Int J Gynecol Pathol 17: 146\u2013153","journal-title":"Int J Gynecol Pathol"},{"key":"BF6601691_CR12","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1128\/JCM.34.9.2095-2100.1996","volume":"34","author":"F Karlsen","year":"1996","unstructured":"Karlsen F, Kalantari M, Jenkins A, Pettersen E, Kristensen G, Holm R, Johansson B, Hagmar B (1996) Use of multiple PCR primer sets for optimal detection of human papillomavirus. J Clin Microbiol 34: 2095\u20132100","journal-title":"J Clin Microbiol"},{"key":"BF6601691_CR13","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1046\/j.1365-2559.1998.00436.x","volume":"33","author":"CJ Meijer","year":"1998","unstructured":"Meijer CJ, Helmerhorst TJ, Rozendaal L, van der Linden JC, Voorhorst FJ, Walboomers JM (1998) HPV typing and testing in gynaecological pathology: has the time come? Histopathology 33: 83\u201386","journal-title":"Histopathology"},{"key":"BF6601691_CR14","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1002\/(SICI)1097-0142(19990425)87:2<56::AID-CNCR3>3.0.CO;2-9","volume":"87","author":"MA Montes","year":"1999","unstructured":"Montes MA, Cibas ES, DiNisco SA, Lee KR (1999) Cytologic characteristics of abnormal cells in prior \u2018normal\u2019 cervical\/vaginal papanicolaou smears from women with a high grade squamous intraepithelial lesion. Cancer 87: 56\u201359","journal-title":"Cancer"},{"key":"BF6601691_CR15","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/S0022-3476(98)70445-7","volume":"132","author":"AB Moscicki","year":"1998","unstructured":"Moscicki AB, Shiboski S, Broering J, Powell K, Clayton L, Jay N, Darragh TM, Brescia R, Kanowitz S, Miller SB, Stone J, Hanson E, Palefsky J (1998) The natural history of human papillomavirus infection as measured by repeated DNA testing in adolescent and young women. J Pediatr 132: 277\u2013284","journal-title":"J Pediatr"},{"key":"BF6601691_CR16","doi-asserted-by":"crossref","first-page":"4417","DOI":"10.1128\/JVI.63.10.4417-4421.1989","volume":"63","author":"K Munger","year":"1989","unstructured":"Munger K, Phelps WC, Bubb V, Howley PM, Schlegel R (1989) The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes. J Virol 63: 4417\u20134421","journal-title":"J Virol"},{"key":"BF6601691_CR17","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1056\/NEJMoa021641","volume":"348","author":"N Munoz","year":"2003","unstructured":"Munoz N, Bosch FX, de Sanjose S, Herrero R, Castellsague X, Shah KV, Snijders PJ, Meijer CJ (2003) Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med 348: 518\u2013527","journal-title":"N Engl J Med"},{"key":"BF6601691_CR18","first-page":"1249","volume":"45","author":"JM Mwenda","year":"1999","unstructured":"Mwenda JM, Shotake T, Yamamoto T, Uchihi R, Bambra CS, Katsumata Y (1999) DNA typing of primate major histocompatibility complex (Mhc)-DQA1 locus by PCR and dot blot hybridization. Cell Mol Biol (Noisy -le-grand) 45: 1249\u20131256","journal-title":"Cell Mol Biol (Noisy -le-grand)"},{"key":"BF6601691_CR19","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1128\/JCM.40.3.863-867.2002","volume":"40","author":"S Nagao","year":"2002","unstructured":"Nagao S, Yoshinouchi M, Miyagi Y, Hongo A, Kodama J, Itoh S, Kudo T (2002) Rapid and sensitive detection of physical status of human papillomavirus type 16 DNA by quantitative real-time PCR. J Clin Microbiol 40: 863\u2013867","journal-title":"J Clin Microbiol"},{"key":"BF6601691_CR20","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1002\/1096-9071(200010)62:2<251::AID-JMV18>3.0.CO;2-V","volume":"62","author":"S Nakagawa","year":"2000","unstructured":"Nakagawa S, Yoshikawa H, Yasugi T, Kimura M, Kawana K, Matsumoto K, Yamada M, Onda T, Taketani Y (2000) Ubiquitous presence of E6 and E7 transcripts in human papillomavirus-positive cervical carcinomas regardless of its type. J Med Virol 62: 251\u2013258","journal-title":"J Med Virol"},{"key":"BF6601691_CR21","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/0378-1119(91)90077-O","volume":"102","author":"RL Nelissen","year":"1991","unstructured":"Nelissen RL, Sillekens PT, Beijer RP, Geurts van Kessel AH, van Venrooij WJ (1991) Structure, chromosomal localization and evolutionary conservation of the gene encoding human U1 snRNP-specific A protein. Gene 102: 189\u2013196","journal-title":"Gene"},{"key":"BF6601691_CR22","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1002\/cncr.10722","volume":"96","author":"WK Ng","year":"2002","unstructured":"Ng WK, Cheung LK, Li AS, Cheung FM, Chow JC (2002) Transitional cell metaplasia of the uterine cervix is related to human papillomavirus: molecular analysis in seven patients with cytohistologic correlation. Cancer 96: 250\u2013258","journal-title":"Cancer"},{"key":"BF6601691_CR23","doi-asserted-by":"publisher","first-page":"1782","DOI":"10.1016\/S0140-6736(01)06809-X","volume":"358","author":"MA Nobbenhuis","year":"2001","unstructured":"Nobbenhuis MA, Helmerhorst TJ, van den Brule AJ, Rozendaal L, Voorhorst FJ, Bezemer PD, Verheijen RH, Meijer CJ (2001) Cytological regression and clearance of high-risk human papillomavirus in women with an abnormal cervical smear. Lancet 358: 1782\u20131783","journal-title":"Lancet"},{"key":"BF6601691_CR24","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1006\/gyno.1996.4596","volume":"65","author":"JS Park","year":"1997","unstructured":"Park JS, Hwang ES, Park SN, Ahn HK, Um SJ, Kim CJ, Kim SJ, Namkoong SE (1997) Physical status and expression of HPV genes in cervical cancers. Gynecol Oncol 65: 121\u2013129","journal-title":"Gynecol Oncol"},{"issue":"Part 4","key":"BF6601691_CR25","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1099\/0022-1317-76-4-1057","volume":"76","author":"AM Roda Husman","year":"1995","unstructured":"Roda Husman AM, Walboomers JM, van den Brule AJ, Meijer CJ, Snijders PJ (1995) The use of general primers GP5 and GP6 elongated at their 3\u2019 ends with adjacent highly conserved sequences improves human papillomavirus detection by PCR. J Gen Virol 76(Part 4): 1057\u20131062","journal-title":"J Gen Virol"},{"key":"BF6601691_CR26","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1006\/gyno.1998.4994","volume":"69","author":"K Sotlar","year":"1998","unstructured":"Sotlar K, Selinka HC, Menton M, Kandolf R, Bultmann B (1998) Detection of human papillomavirus type 16 E6\/E7 oncogene transcripts in dysplastic and nondysplastic cervical scrapes by nested RT\u2013PCR. Gynecol Oncol 69: 114\u2013121","journal-title":"Gynecol Oncol"},{"key":"BF6601691_CR27","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/0046-8177(92)90232-R","volume":"23","author":"MH Stoler","year":"1992","unstructured":"Stoler MH, Rhodes CR, Whitbeck A, Wolinsky SM, Chow LT, Broker TR (1992) Human papillomavirus type 16 and 18 gene expression in cervical neoplasias. Hum Pathol 23: 117\u2013128","journal-title":"Hum Pathol"},{"key":"BF6601691_CR28","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1002\/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F","volume":"189","author":"JM Walboomers","year":"1999","unstructured":"Walboomers JM, Jacobs MV, Manos MM, Bosch FX, Kummer JA, Shah KV, Snijders PJ, Peto J, Meijer CJ, Munoz N (1999) Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol 189: 12\u201319","journal-title":"J Pathol"},{"key":"BF6601691_CR29","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1002\/cncr.10718","volume":"96","author":"RE Zuna","year":"2002","unstructured":"Zuna RE, Sienko A, Lightfoot S, Gaiser M (2002) Cervical smear interpretations in women with a histologic diagnosis of severe dysplasia: factors associated with discrepant interpretations. Cancer 96: 218\u2013224","journal-title":"Cancer"},{"key":"BF6601691_CR30","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1002\/mc.2940010302","volume":"1","author":"H zur Hausen","year":"1988","unstructured":"zur Hausen H (1988) Papillomaviruses in human cancers. Mol Carcinog 1: 147\u2013150","journal-title":"Mol Carcinog"},{"key":"BF6601691_CR31","first-page":"207","volume":"20","author":"H zur Hausen","year":"1989","unstructured":"zur Hausen H (1989) Host cell regulation of HPV transforming gene expression. Princess Takamatsu Symp 20: 207\u2013219","journal-title":"Princess Takamatsu Symp"},{"key":"BF6601691_CR32","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/0042-6822(91)90816-T","volume":"184","author":"H zur Hausen","year":"1991","unstructured":"zur Hausen H (1991) Human papillomaviruses in the pathogenesis of anogenital cancer. Virology 184: 9\u201313","journal-title":"Virology"},{"key":"BF6601691_CR33","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1038\/nrc798","volume":"2","author":"H zur Hausen","year":"2002","unstructured":"zur Hausen H (2002) Papillomaviruses and cancer: from basic studies to clinical application. Nat Rev Cancer 2: 342\u2013350","journal-title":"Nat Rev Cancer"}],"container-title":["British Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/6601691.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/6601691","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/6601691.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T12:56:35Z","timestamp":1684414595000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/6601691"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,3,2]]},"references-count":33,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2004,4]]}},"alternative-id":["BF6601691"],"URL":"https:\/\/doi.org\/10.1038\/sj.bjc.6601691","relation":{},"ISSN":["0007-0920","1532-1827"],"issn-type":[{"value":"0007-0920","type":"print"},{"value":"1532-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,3,2]]}}}