{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T10:53:25Z","timestamp":1769684005301,"version":"3.49.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2004,6,8]],"date-time":"2004-06-08T00:00:00Z","timestamp":1086652800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Cancer"],"published-print":{"date-parts":[[2004,7]]},"DOI":"10.1038\/sj.bjc.6601913","type":"journal-article","created":{"date-parts":[[2004,6,9]],"date-time":"2004-06-09T08:31:57Z","timestamp":1086769917000},"page":"381-388","source":"Crossref","is-referenced-by-count":85,"title":["Evidence for colorectal cancer cell specificity of aspirin effects on NF\u03baB signalling and apoptosis"],"prefix":"10.1038","volume":"91","author":[{"given":"F V N","family":"Din","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M G","family":"Dunlop","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L A","family":"Stark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2004,6,8]]},"reference":[{"key":"BF6601913_CR1","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1002\/jcb.240590804","volume":"22","author":"DS Alberts","year":"1995","unstructured":"Alberts DS, Hixson L, Ahnen D, Bogert C, Einspahr J, Paranka N, Brendel K, Gross PH, Pamukcu R, Burt RW (1995) Do NSAIDs exert their colon cancer chemoprevention activities through the inhibition of mucosal prostaglandin synthetase? J Cell Biochem Suppl 22: 18\u201323","journal-title":"J Cell Biochem Suppl"},{"key":"BF6601913_CR2","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1136\/gut.48.2.238","volume":"48","author":"M Anti","year":"2001","unstructured":"Anti M, Armuzzi A, Morini S, Iascone E, Pignataro G, Coco C, Lorenzetti R, Paolucci M, Covino M, Gasbarrini A, Vecchio F, Gasbarrini G (2001) Severe imbalance of cell proliferation and apoptosis in the left colon and in the rectosigmoid tract in subjects with a history of large adenomas. Gut 48: 238\u2013246","journal-title":"Gut"},{"key":"BF6601913_CR3","first-page":"423","volume":"97","author":"HA Arango","year":"2001","unstructured":"Arango HA, Icely S, Roberts WS, Cavanagh D, Becker JL (2001) Aspirin effects on endometrial cancer cell growth. Obstet Gynecol 97: 423\u2013427","journal-title":"Obstet Gynecol"},{"key":"BF6601913_CR4","first-page":"2556","volume":"56","author":"SK Boolbol","year":"1996","unstructured":"Boolbol SK, Dannenberg AJ, Chadburn A, Martucci C, Guo XJ, Ramonetti JT, Abreu-Goris M, Newmark HL, Lipkin ML, DeCosse JJ, Bertagnolli MM (1996) Cyclooxygenase-2 overexpression and tumor formation are blocked by sulindac in a murine model of familial adenomatous polyposis. Cancer Res 56: 2556\u20132560","journal-title":"Cancer Res"},{"key":"BF6601913_CR5","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/0006-2952(94)90448-0","volume":"47","author":"V Bours","year":"1994","unstructured":"Bours V, Dejardin E, Goujon-Letawe F, Merville MP, Castronovo V (1994) The NF-kappa B transcription factor and cancer: high expression of NF-kappa B- and I kappa B-related proteins in tumor cell lines. Biochem Pharmacol 47: 145\u2013149","journal-title":"Biochem Pharmacol"},{"key":"BF6601913_CR6","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1038\/sj.bjc.6690690","volume":"81","author":"E Castano","year":"1999","unstructured":"Castano E, Dalmau M, Barragan M, Pueyo G, Bartrons R, Gil J (1999) Aspirin induces cell death and caspase-dependent phosphatidylserine externalization in HT-29 human colon adenocarcinoma cells (in process citation). Br J Cancer 81: 294\u2013299","journal-title":"Br J Cancer"},{"key":"BF6601913_CR7","doi-asserted-by":"publisher","first-page":"1598","DOI":"10.1038\/sj.bjc.6600927","volume":"88","author":"MP Charalambous","year":"2003","unstructured":"Charalambous MP, Maihofner C, Bhambra U, Lightfoot T, Gooderham NJ (2003) Upregulation of cyclooxygenase-2 is accompanied by increased expression of nuclear factor-kappa B and I kappa B kinase-alpha in human colorectal cancer epithelial cells. Br J Cancer 88: 1598\u20131604","journal-title":"Br J Cancer"},{"key":"BF6601913_CR8","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1038\/sj.bjc.6690651","volume":"81","author":"JP Collet","year":"1999","unstructured":"Collet JP, Sharpe C, Belzile E, Boivin JF, Hanley J, Abenhaim L (1999) Colorectal cancer prevention by non-steroidal anti-inflammatory drugs: effects of dosage and timing (in process citation). Br J Cancer 81: 62\u201368","journal-title":"Br J Cancer"},{"key":"BF6601913_CR9","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/S0140-6736(97)08064-1","volume":"351","author":"DW Cramer","year":"1998","unstructured":"Cramer DW, Harlow BL, Titus-Ernstoff L, Bohlke K, Welch WR, Greenberg ER (1998) Over-the-counter analgesics and risk of ovarian cancer. Lancet 351: 104\u2013107","journal-title":"Lancet"},{"key":"BF6601913_CR10","doi-asserted-by":"publisher","first-page":"2567","DOI":"10.1038\/sj.onc.1202599","volume":"18","author":"E Dejardin","year":"1999","unstructured":"Dejardin E, Deregowski V, Chapelier M, Jacobs N, Gielen J, Merville MP, Bours V (1999) Regulation of NF-kappaB activity by I kappaB-related proteins in adenocarcinoma cells. Oncogene 18: 2567\u20132577","journal-title":"Oncogene"},{"key":"BF6601913_CR11","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1016\/0016-5085(94)90246-1","volume":"107","author":"CE Eberhart","year":"1994","unstructured":"Eberhart CE, Coffey RJ, Radhika A, Giardiello FM, Ferrenbach S, DuBois RN (1994) Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas. Gastroenterology 107: 1183\u20131188","journal-title":"Gastroenterology"},{"key":"BF6601913_CR12","first-page":"1679","volume":"3","author":"DJ Elder","year":"1997","unstructured":"Elder DJ, Halton DE, Hague A, Paraskeva C (1997) Induction of apoptotic cell death in human colorectal carcinoma cell lines by a cyclooxygenase-2 (COX-2)-selective nonsteroidal anti-inflammatory drug: independence from COX-2 protein expression. Clin Cancer Res 3: 1679\u20131683","journal-title":"Clin Cancer Res"},{"key":"BF6601913_CR13","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1023\/A:1016380917625","volume":"13","author":"KM Fairfield","year":"2002","unstructured":"Fairfield KM, Hunter DJ, Fuchs CS, Colditz GA, Hankinson SE (2002) Aspirin, other NSAIDs, and ovarian cancer risk (United States). Cancer Causes Control 13: 535\u2013542","journal-title":"Cancer Causes Control"},{"key":"BF6601913_CR14","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1023\/A:1005924730450","volume":"48","author":"EK Han","year":"1998","unstructured":"Han EK, Arber N, Yamamoto H, Lim JT, Delohery T, Pamukcu R, Piazza GA, Xing WQ, Weinstein IB (1998) Effects of sulindac and its metabolites on growth and apoptosis in human mammary epithelial and breast carcinoma cell lines. Breast Cancer Res Treat 48: 195\u2013203","journal-title":"Breast Cancer Res Treat"},{"key":"BF6601913_CR15","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/0006-2952(96)00181-5","volume":"52","author":"R Hanif","year":"1996","unstructured":"Hanif R, Pittas A, Feng Y, Koutsos MI, Qiao L, Staiano-Coico L, Shiff SI, Rigas B (1996) Effects of nonsteroidal anti-inflammatory drugs on proliferation and on induction of apoptosis in colon cancer cells by a prostaglandin-independent pathway. Biochem Pharmacol 52: 237\u2013245","journal-title":"Biochem Pharmacol"},{"key":"BF6601913_CR16","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1038\/sj.onc.1204162","volume":"20","author":"JC Hardwick","year":"2001","unstructured":"Hardwick JC, van den Brink GR, Offerhaus GJ, van Deventer SJ, Peppelenbosch MP (2001) NF-kappaB, p38 MAPK and JNK are highly expressed and active in the stroma of human colonic adenomatous polyps. Oncogene 20: 819\u2013827","journal-title":"Oncogene"},{"key":"BF6601913_CR17","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1677\/erc.0.0080097","volume":"8","author":"LR Howe","year":"2001","unstructured":"Howe LR, Subbaramaiah K, Brown AM, Dannenberg AJ (2001) Cyclooxygenase-2: a target for the prevention and treatment of breast cancer. Endocr Relat Cancer 8: 97\u2013114","journal-title":"Endocr Relat Cancer"},{"key":"BF6601913_CR18","doi-asserted-by":"publisher","first-page":"G1282","DOI":"10.1152\/ajpgi.2000.279.6.G1282","volume":"279","author":"MS Inan","year":"2000","unstructured":"Inan MS, Tolmacheva V, Wang QS, Rosenberg DW, Giardina C (2000) Transcription factor NF-kappaB participates in regulation of epithelial cell turnover in the colon. Am J Physiol Gastrointest Liver Physiol 279: G1282\u2013G1291","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"BF6601913_CR19","first-page":"617","volume-title":"The Pharmacological Basis of Therapeutics","author":"P Insel","year":"1996","unstructured":"Insel P (1996) Analgesic\u2013antipyretic and anti-inflammatory agents and drugs employed in the treatment of gout. In The Pharmacological Basis of Therapeutics, Hardman JG, Limberd LE, Molinoff PB, Rudden RW, Gilman AG (eds) pp 617\u2013659. New York: McGraw-Hill"},{"key":"BF6601913_CR20","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1124\/jpet.102.042754","volume":"303","author":"K Kashfi","year":"2002","unstructured":"Kashfi K, Ryann Y, Qiao LL, Williams JL, Chen J, Del Soldato P, Traganos F, Rigas B (2002) Nitric oxide-donating nonsteroidal anti-inflammatory drugs inhibit the growth of various cultured human cancer cells: evidence of a tissue type-independent effect. J Pharmacol Exp Ther 303: 1273\u20131282","journal-title":"J Pharmacol Exp Ther"},{"key":"BF6601913_CR21","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1054\/bjoc.2000.1709","volume":"84","author":"SA Khuder","year":"2001","unstructured":"Khuder SA, Mutgi AB (2001) Breast cancer and NSAID use: a meta-analysis. Br J Cancer 84: 1188\u20131192","journal-title":"Br J Cancer"},{"key":"BF6601913_CR22","doi-asserted-by":"publisher","first-page":"1642","DOI":"10.1136\/bmj.320.7250.1642","volume":"320","author":"MJ Langman","year":"2000","unstructured":"Langman MJ, Cheng KK, Gilman EA, Lancashire RJ (2000) Effect of anti-inflammatory drugs on overall risk of common cancer: case\u2013control study in general practice research database. BMJ 320: 1642\u20131646","journal-title":"BMJ"},{"key":"BF6601913_CR23","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1067\/msy.2001.116672","volume":"130","author":"DS Lind","year":"2001","unstructured":"Lind DS, Hochwald SN, Malaty J, Rekkas S, Hebig P, Mishra G, Moldawer LL, Copeland III EM, Mackay S (2001) Nuclear factor-kappa B is upregulated in colorectal cancer. Surgery 130: 363\u2013369","journal-title":"Surgery"},{"key":"BF6601913_CR24","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1592\/phco.22.5.303.33189","volume":"22","author":"CR Meier","year":"2002","unstructured":"Meier CR, Schmitz S, Jick H (2002) Association between acetaminophen or nonsteroidal antiinflammatory drugs and risk of developing ovarian, breast, or colon cancer. Pharmacotherapy 22: 303\u2013309","journal-title":"Pharmacotherapy"},{"key":"BF6601913_CR25","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1038\/sj.bjc.6600541","volume":"87","author":"LM Mooney","year":"2002","unstructured":"Mooney LM, Al Sakkaf KA, Brown BL, Dobson PR (2002) Apoptotic mechanisms in T47D and MCF-7 human breast cancer cells. Br J Cancer 87: 909\u2013917","journal-title":"Br J Cancer"},{"key":"BF6601913_CR26","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/0952-3278(95)90051-9","volume":"53","author":"M Noguchi","year":"1995","unstructured":"Noguchi M, Earashi M, Minami M, Miyazaki I, Tanaka M, Sasaki T (1995) Effects of piroxicam and esculetin on the MDA-MB-231 human breast cancer cell line. Prostagland Leukotr Essent Fatty Acids 53: 325\u2013329","journal-title":"Prostagland Leukotr Essent Fatty Acids"},{"key":"BF6601913_CR27","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1002\/art.1780220804","volume":"22","author":"LM Pachman","year":"1979","unstructured":"Pachman LM, Olufs R, Procknal JA, Levy G (1979) Pharmacokinetic monitoring of salicylate therapy in children with juvenile rheumatoid arthritis. Arthritis Rheum 22: 826\u2013831","journal-title":"Arthritis Rheum"},{"key":"BF6601913_CR28","doi-asserted-by":"publisher","first-page":"6853","DOI":"10.1038\/sj.onc.1203239","volume":"18","author":"HL Pahl","year":"1999","unstructured":"Pahl HL (1999) Activators and target genes of Rel\/NF-kappaB transcription factors. Oncogene 18: 6853\u20136866","journal-title":"Oncogene"},{"key":"BF6601913_CR29","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1002\/(SICI)1097-0215(19990315)80:6<827::AID-IJC6>3.0.CO;2-P","volume":"80","author":"DM Parkin","year":"1999","unstructured":"Parkin DM, Pisani P, Ferlay J (1999) Estimates of the worldwide incidence of 25 major cancers in 1990. Int J Cancer 80: 827\u2013841","journal-title":"Int J Cancer"},{"key":"BF6601913_CR30","first-page":"2452","volume":"57","author":"GA Piazza","year":"1997","unstructured":"Piazza GA, Rahm AK, Finn TS, Fryer BH, Li H, Stoumen AL, Pamukcu R, Ahnen DJ (1997) Apoptosis primarily accounts for the growth-inhibitory properties of sulindac metabolites and involves a mechanism that is independent of cyclooxygenase inhibition, cell cycle arrest, and p53 induction. Cancer Res 57: 2452\u20132459","journal-title":"Cancer Res"},{"key":"BF6601913_CR31","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1016\/0024-3205(95)02069-U","volume":"57","author":"P Planchon","year":"1995","unstructured":"Planchon P, Veber N, Magnien V, Prevost G, Starzec AB, Israel L (1995) Evidence for separate mechanisms of antiproliferative action of indomethacin and prostaglandin on MCF-7 breast cancer cells. Life Sci 57: 1233\u20131240","journal-title":"Life Sci"},{"key":"BF6601913_CR32","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/S0163-7258(96)00102-7","volume":"72","author":"DM Pritchard","year":"1996","unstructured":"Pritchard DM, Watson AJ (1996) Apoptosis and gastrointestinal pharmacology. Pharmacol Ther 72: 149\u2013169","journal-title":"Pharmacol Ther"},{"key":"BF6601913_CR33","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/S0006-2952(97)00400-0","volume":"55","author":"L Qiao","year":"1998","unstructured":"Qiao L, Hanif R, Sphicas E, Shiff SJ, Rigas B (1998) Effect of aspirin on induction of apoptosis in HT-29 human colon adenocarcinoma cells. Biochem Pharmacol 55: 53\u201364","journal-title":"Biochem Pharmacol"},{"key":"BF6601913_CR34","doi-asserted-by":"publisher","first-page":"6938","DOI":"10.1038\/sj.onc.1203221","volume":"18","author":"B Rayet","year":"1999","unstructured":"Rayet B, Gelinas C (1999) Aberrant rel\/nfkb genes and activity in human cancer. Oncogene 18: 6938\u20136947","journal-title":"Oncogene"},{"key":"BF6601913_CR35","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1054\/mehy.1999.0023","volume":"54","author":"B Rigas","year":"2000","unstructured":"Rigas B, Shiff SJ (2000) Is inhibition of cyclooxygenase required for the chemopreventive effect of NSAIDs in colon cancer? A model reconciling the current contradiction. Med Hypotheses 54: 210\u2013215","journal-title":"Med Hypotheses"},{"key":"BF6601913_CR36","first-page":"933","volume":"9","author":"L Rosenberg","year":"2000","unstructured":"Rosenberg L, Palmer JR, Rao RS, Coogan PF, Strom BL, Zauber AG, Stolley PD, Shapiro S (2000) A case\u2013control study of analgesic use and ovarian cancer. Cancer Epidemiol Biomarkers Prev 9: 933\u2013937","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"BF6601913_CR37","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1097\/00001648-199403000-00003","volume":"5","author":"DM Schreinemachers","year":"1994","unstructured":"Schreinemachers DM, Everson RB (1994) Aspirin use and lung, colon, and breast cancer incidence in a prospective study. Epidemiology 5: 138\u2013146","journal-title":"Epidemiology"},{"key":"BF6601913_CR38","first-page":"2997","volume":"19","author":"C Sotiriou","year":"1999","unstructured":"Sotiriou C, Lacroix M, Lagneaux L, Berchem G, Body JJ (1999) The aspirin metabolite salicylate inhibits breast cancer cells growth and their synthesis of the osteolytic cytokines interleukins-6 and -11. Anticancer Res 19: 2997\u20133006","journal-title":"Anticancer Res"},{"key":"BF6601913_CR39","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1096\/fj.00-0529fje","volume":"15","author":"LA Stark","year":"2001","unstructured":"Stark LA, Din FV, Zwacka RM, Dunlop MG (2001) Aspirin-induced activation of the NF-kappaB signaling pathway: a novel mechanism for aspirin-mediated apoptosis in colon cancer cells. FASEB J 15: 1273\u20131275","journal-title":"FASEB J"},{"key":"BF6601913_CR40","doi-asserted-by":"publisher","first-page":"8571","DOI":"10.1128\/MCB.22.24.8571-8579.2002","volume":"22","author":"F Tang","year":"2002","unstructured":"Tang F, Tang G, Xiang J, Dai Q, Rosner MR, Lin A (2002) The absence of NF-kappaB-mediated inhibition of c-Jun N-terminal kinase activation contributes to tumor necrosis factor alpha-induced apoptosis. Mol Cell Biol 22: 8571\u20138579","journal-title":"Mol Cell Biol"},{"key":"BF6601913_CR41","first-page":"1322","volume":"53","author":"MJ Thun","year":"1993","unstructured":"Thun MJ, Namboodiri MM, Calle EE, Flanders WD, Heath CWJ (1993) Aspirin use and risk of fatal cancer (see comments). Cancer Res 53: 1322\u20131327","journal-title":"Cancer Res"},{"key":"BF6601913_CR42","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1038\/newbio231232a0","volume":"231","author":"JR Vane","year":"1971","unstructured":"Vane JR (1971) Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat New Biol 231: 232\u2013235","journal-title":"Nat New Biol"}],"container-title":["British Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/6601913.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/6601913","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/6601913.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T12:09:24Z","timestamp":1684411764000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/6601913"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,6,8]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,7]]}},"alternative-id":["BF6601913"],"URL":"https:\/\/doi.org\/10.1038\/sj.bjc.6601913","relation":{},"ISSN":["0007-0920","1532-1827"],"issn-type":[{"value":"0007-0920","type":"print"},{"value":"1532-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,6,8]]}}}