{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T21:37:43Z","timestamp":1789767463863,"version":"4.0.1"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2004,6,22]],"date-time":"2004-06-22T00:00:00Z","timestamp":1087862400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Cancer"],"published-print":{"date-parts":[[2004,7]]},"DOI":"10.1038\/sj.bjc.6601953","type":"journal-article","created":{"date-parts":[[2004,6,22]],"date-time":"2004-06-22T19:13:06Z","timestamp":1087931586000},"page":"219-224","source":"Crossref","is-referenced-by-count":64,"title":["Vascular endothelial growth factor (VEGF) in leptomeningeal metastasis: diagnostic and prognostic value"],"prefix":"10.1038","volume":"91","author":[{"given":"U","family":"Herrlinger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Wiendl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Renninger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"F\u00f6rschler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Dichgans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Weller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2004,6,22]]},"reference":[{"key":"BF6601953_CR1","doi-asserted-by":"publisher","first-page":"2376","DOI":"10.1002\/1097-0142(19931015)72:8<2376::AID-CNCR2820720814>3.0.CO;2-6","volume":"72","author":"F Bach","year":"1993","unstructured":"Bach F, Bjerregaard B, Soletormos G, Bach FW, Horn T (1993) Diagnostic value of cerebrospinal fluid cytology in comparison with tumor marker activity in central nervous system metastases secondary to breast cancer. Cancer 72: 2376\u20132382","journal-title":"Cancer"},{"key":"BF6601953_CR2","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1001\/archneur.1996.00550070064013","volume":"53","author":"M Balm","year":"1996","unstructured":"Balm M, Hammack J (1996) Leptomeningeal carcinomatosis. Presenting features and prognostic factors. Arch Neurol 53: 626\u2013632","journal-title":"Arch Neurol"},{"key":"BF6601953_CR3","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1172\/JCI116165","volume":"91","author":"RA Berkman","year":"1993","unstructured":"Berkman RA, Merrill MJ, Reinhold WC, Monacci WT, Saxena A, Clark WC, Robertson JT, Ali IU, Oldfield EH (1993) Expression of the vascular permeability factor\/vascular endothelial growth factor gene in central nervous system neoplasms. J Clin Invest 91: 153\u2013159","journal-title":"J Clin Invest"},{"key":"BF6601953_CR4","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1002\/1097-0142(19910315)67:6<1685::AID-CNCR2820670635>3.0.CO;2-M","volume":"67","author":"W Boogerd","year":"1991","unstructured":"Boogerd W, Hart AAM, Sande JJ, Engelsman E (1991) Meningeal carcinomatosis in breast cancer: prognostic factors and influence of treatment. Cancer 67: 1685\u20131695","journal-title":"Cancer"},{"key":"BF6601953_CR5","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1002\/(SICI)1097-0142(19960401)77:7<1315::AID-CNCR14>3.0.CO;2-4","volume":"77","author":"K Fizazi","year":"1996","unstructured":"Fizazi K, Asselain B, Vincent-Salomon A, Jouve M, Dieras V, Palangie T, Beuzeboc P, Dorval T, Pouillart P (1996) Meningeal carcinomatosis in patients with breast carcinoma. Clinical features, prognostic factors, and results of a high-dose intrathecal methotrexate regimen. Cancer 77: 1315\u20131323","journal-title":"Cancer"},{"key":"BF6601953_CR6","first-page":"6020","volume":"61","author":"D Fukumura","year":"2001","unstructured":"Fukumura D, Xu L, Chen Y, Gohongi T, Seed B, Jain RK (2001) Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo. Cancer Res 61: 6020\u20136024","journal-title":"Cancer Res"},{"key":"BF6601953_CR7","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","volume":"53","author":"EL Kaplan","year":"1958","unstructured":"Kaplan EL, Meier P (1958) Non-parametric estimations from incomplete observations. J Am Stat Assoc 53: 457\u2013481","journal-title":"J Am Stat Assoc"},{"key":"BF6601953_CR8","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/S0025-6196(12)61391-3","volume":"61","author":"GG Klee","year":"1986","unstructured":"Klee GG, Tallman RD, Goellner JR, Yanagihara T (1986) Elevation of carcinoembryonic antigen in cerebrospinal fluid among patients with meningeal carcinomatosis. Mayo Clin Proc 61: 9\u201313","journal-title":"Mayo Clin Proc"},{"key":"BF6601953_CR9","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1002\/ijc.2910440310","volume":"44","author":"RP Moseley","year":"1989","unstructured":"Moseley RP, Oge K, Shafqat S, Moseley CM, Sullivan NM, Badley RA, Burchell J, Taylor-Papadimitriou J, Coakham HB (1989) HMFG1 antigen: a new marker for carcinomatous meningitis. Int J Cancer 44: 440\u2013444","journal-title":"Int J Cancer"},{"key":"BF6601953_CR10","first-page":"1411","volume":"2","author":"Y Ohta","year":"1996","unstructured":"Ohta Y, Endo Y, Tanaka M, Shimizu J, Oda M, Hayashi Y, Watanabe Y, Sasaki T (1996) Significance of vascular endothelial growth factor messenger RNA expression in primary lung cancer. Clin Cancer Res 2: 1411\u20131416","journal-title":"Clin Cancer Res"},{"key":"BF6601953_CR11","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1159\/000411630","volume":"29","author":"BW Ongerboer de Visser","year":"1985","unstructured":"Ongerboer de Visser BW, van Zanten AP, Twijnstra A, Nooyen WJ, Hart AA (1985) Sensitivity and specificity of cerebrospinal fluid biochemical markers of central nervous system metastases. Prog Exp Tumor Res 29: 105\u2013115","journal-title":"Prog Exp Tumor Res"},{"key":"BF6601953_CR12","first-page":"919","volume":"63","author":"J Seidenfeld","year":"1979","unstructured":"Seidenfeld J, Marton LJ (1979) Biochemical markers of central nervous system tumors measured in cerebrospinal fluid and their potential use in diagnosis and patient management: a review. J Natl Cancer Inst 63: 919\u2013931","journal-title":"J Natl Cancer Inst"},{"key":"BF6601953_CR13","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1073\/pnas.92.3.768","volume":"92","author":"D Shweiki","year":"1995","unstructured":"Shweiki D, Neeman M, Itin A, Keshet E (1995) Induction of vascular endothelial growth factor expression by hypoxia and by glucose deficiency in multicell spheroids: implications for tumor angiogenesis. Proc Natl Acad Sci USA 92: 768\u2013772","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF6601953_CR14","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1212\/WNL.54.8.1670","volume":"54","author":"G Stockhammer","year":"2000","unstructured":"Stockhammer G, Poewe W, Burgstaller S, Deisenhammer F, Muigg A, Kiechl S, Schmutzhard E, Maier H, Felber S, Schumacher P, Gunsilius E, Gastl G (2000) Vascular endothelial growth factor in CSF: a biological marker for carcinomatous meningitis. Neurology 54: 1670\u20131676","journal-title":"Neurology"},{"key":"BF6601953_CR15","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/0009-8981(86)90009-4","volume":"161","author":"AP Van Zanten","year":"1986","unstructured":"Van Zanten AP, Twijnstra A, Hart AA, Ongerboer de Visser BW (1986) Cerebrospinal fluid lactate dehydrogenase activities in patients with central nervous system metastases. Clin Chim Acta 161: 259\u2013268","journal-title":"Clin Chim Acta"},{"key":"BF6601953_CR16","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.1002\/(SICI)1097-4598(199811)21:11<1390::AID-MUS5>3.0.CO;2-4","volume":"21","author":"O Watanabe","year":"1998","unstructured":"Watanabe O, Maruyama I, Arimura K, Kitajima I, Arimura H, Hanatani M, Matsuo K, Arisato T, Osame M (1998) Overproduction of vascular endothelial growth factor\/vascular permeability factor is causative in Crow\u2013Fukase (POEMS) syndrome. Muscle Nerve 21: 1390\u20131397","journal-title":"Muscle Nerve"},{"key":"BF6601953_CR17","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1111\/j.1600-0404.1990.tb01604.x","volume":"82","author":"M Weller","year":"1990","unstructured":"Weller M, Sommer N, Stevens A, Wietholter H (1990) Increased intrathecal synthesis of fibronectin in bacterial and carcinomatous meningitis. Acta Neurol Scand 82: 138\u2013142","journal-title":"Acta Neurol Scand"},{"key":"BF6601953_CR18","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1038\/sj.neo.7900195","volume":"3","author":"LS Ziemer","year":"2001","unstructured":"Ziemer LS, Koch CJ, Maity A, Magarelli DP, Horan AM, Evans SM (2001) Hypoxia and VEGF mRNA expression in human tumors. Neoplasia 3: 500\u2013508","journal-title":"Neoplasia"}],"container-title":["British Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/6601953.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/6601953","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/6601953.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T12:09:53Z","timestamp":1684411793000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/6601953"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,6,22]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,7]]}},"alternative-id":["BF6601953"],"URL":"https:\/\/doi.org\/10.1038\/sj.bjc.6601953","relation":{},"ISSN":["0007-0920","1532-1827"],"issn-type":[{"value":"0007-0920","type":"print"},{"value":"1532-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,6,22]]}}}