{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T11:57:52Z","timestamp":1791115072064,"version":"4.1.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2004,6,29]],"date-time":"2004-06-29T00:00:00Z","timestamp":1088467200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Cancer"],"published-print":{"date-parts":[[2004,8]]},"DOI":"10.1038\/sj.bjc.6602008","type":"journal-article","created":{"date-parts":[[2004,6,30]],"date-time":"2004-06-30T10:22:13Z","timestamp":1088590933000},"page":"707-713","source":"Crossref","is-referenced-by-count":84,"title":["Transcriptional silencing of the Dickkopfs-3 (Dkk-3) gene by CpG hypermethylation in acute lymphoblastic leukaemia"],"prefix":"10.1038","volume":"91","author":[{"given":"J","family":"Roman-Gomez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Jimenez-Velasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X","family":"Agirre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J A","family":"Castillejo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Navarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Barrios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E J","family":"Andreu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Prosper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Heiniger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2004,6,29]]},"reference":[{"key":"BF6602008_CR1","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1038\/sj.onc.1206236","volume":"22","author":"X Agirre","year":"2003","unstructured":"Agirre X, Vizmanos JL, Calasanz MJ, Garcia-Delgado M, Larrayoz MJ, Novo FJ (2003) Methylation of CpG dinucleotides and\/or CCWGG motifs at the promoter of TP53 correlates with decreased gene expression in a subset of acute lymphoblastic leukemia patients. Oncogene 22: 1070\u20131072","journal-title":"Oncogene"},{"key":"BF6602008_CR2","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1101\/gad.947102","volume":"16","author":"A Bird","year":"2002","unstructured":"Bird A (2002) DNA methylation patterns and epigenetic memory. Genes Dev 16: 6\u201321","journal-title":"Genes Dev"},{"key":"BF6602008_CR3","doi-asserted-by":"crossref","first-page":"4132","DOI":"10.1182\/blood.V96.13.4132","volume":"96","author":"C Brandon","year":"2000","unstructured":"Brandon C, Eisemberg LM, Eisemberg CA (2000) WNT signaling modulates the diversification of hematopoietic cells. Blood 96: 4132\u20134141","journal-title":"Blood"},{"key":"BF6602008_CR4","doi-asserted-by":"publisher","first-page":"37024","DOI":"10.1074\/jbc.M300191200","volume":"278","author":"A Caricasole","year":"2003","unstructured":"Caricasole A, Ferraro T, Iacovelli L, Barletta E, Caruso A, Melchiorri D, Terstappen GC, Nicoletti (2003) Functional characterization of Wnt7a signalling in PC12 cells: interaction with a FZD5\/LRP6 receptor complex and modulation by DKK proteins. J Biol Chem 278: 37024\u201337031","journal-title":"J Biol Chem"},{"key":"BF6602008_CR5","first-page":"2217","volume":"8","author":"G Garcia-Manero","year":"2002","unstructured":"Garcia-Manero G, Daniel J, Smith TL, Kornblau SM, Lee MS, Kantarjian HM, Issa JP (2002) DNA methylation of multiple promoter-associated CpG islands in adult acute lymphoblastic leukemia. Clin Cancer Res 8: 2217\u20132224","journal-title":"Clin Cancer Res"},{"key":"BF6602008_CR6","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/S0092-8674(00)81683-9","volume":"100","author":"D Hanahan","year":"2000","unstructured":"Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100: 57\u201370","journal-title":"Cell"},{"key":"BF6602008_CR7","first-page":"1180","volume":"62","author":"L Hayflick","year":"1997","unstructured":"Hayflick L (1997) Mortality and immortality at the cellular level: a review. Biochemistry 62: 1180\u20131190","journal-title":"Biochemistry"},{"key":"BF6602008_CR8","doi-asserted-by":"publisher","first-page":"9821","DOI":"10.1073\/pnas.93.18.9821","volume":"93","author":"JG Herman","year":"1996","unstructured":"Herman JG, Graff JR, Myohanen S, Nelkin BD, Baylin SB (1996) Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci USA 93: 9821\u20139826","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF6602008_CR9","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1038\/nrg816","volume":"3","author":"PA Jones","year":"2002","unstructured":"Jones PA, Baylin SB (2002) The fundamental role of epigenetic events in cancer. Nat Rev 3: 415\u2013428","journal-title":"Nat Rev"},{"key":"BF6602008_CR10","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/S0378-1119(01)00838-1","volume":"282","author":"K Kobayashi","year":"2002","unstructured":"Kobayashi K, Ouchida M, Tsuji T, Hanafusa H, Miyazaki M, Namba M, Shimizu N, Shimizu K (2002) Reduced expression of the REIC\/Dkk-3 gene by promoter-hypermethylation in human tumor cells. Gene 282: 151\u2013158","journal-title":"Gene"},{"key":"BF6602008_CR11","doi-asserted-by":"publisher","first-page":"2572","DOI":"10.1182\/blood-2001-11-0026","volume":"100","author":"Y Li","year":"2002","unstructured":"Li Y, Nagai H, Ohno T, Yuge M, Hatano S, Ito E, Mori N, Saito H, Kinoshita T (2002) Aberrant DNA methylation of p57kip2 gene in the promoter region in lymphoid malignancies of B-cell phenotype. Blood 100: 2572\u20132577","journal-title":"Blood"},{"key":"BF6602008_CR12","doi-asserted-by":"crossref","unstructured":"McWhirter JR, Neuteboom ST, Wancewicz EV, Monia BP, Downing JR, Murre C (1999) Proc Natl Acad Sci USA 96: 11464\u201311469","DOI":"10.1073\/pnas.96.20.11464"},{"key":"BF6602008_CR13","first-page":"163","volume":"5","author":"JJ Ortega","year":"1998","unstructured":"Ortega JJ (1998) Spanish acute lymphoblastic leukemia trials. Int J Pediat Hemat Oncol 5: 163\u2013176","journal-title":"Int J Pediat Hemat Oncol"},{"key":"BF6602008_CR14","first-page":"586","volume":"86","author":"JJ Ortega","year":"2001","unstructured":"Ortega JJ, Ribera JM, Oriol A, Bastida P, Gonzalez ME, Calvo C, Egurbide I, Hernandez Rivas JM, Rivas C, Alcala A, Besalduch J, Macia J, Gardella S, Carnero M, Lite JM, Casanova F, Martinez M, Fontanillas M, Feliu E, San Miguel JF, PETHEMA Group, Spanish Society of Hematology. Programa para el Estudio y Tratamiento de las Hemopatias Malignas (2001) Early and delayed consolidation chemotherapy significantly improves the outcome of children with intermediate-risk acute lymphoblastic leukemia. Final results of the prospective randomized PETHEMA ALL-89 TRIAL. Haematologica 86: 586\u2013595","journal-title":"Haematologica"},{"key":"BF6602008_CR15","doi-asserted-by":"publisher","first-page":"1536","DOI":"10.1038\/sj.onc.1206239","volume":"22","author":"Y-W Qiang","year":"2003","unstructured":"Qiang Y-W, Endo Y, Rubin JS, Rudikoff S (2003) Wnt signaling in B-cell neoplasia. Oncogene 22: 1536\u20131545","journal-title":"Oncogene"},{"key":"BF6602008_CR16","first-page":"222","volume":"83","author":"JM Ribera","year":"1998","unstructured":"Ribera JM, Ortega JJ, Oriol A, Fontanillas M, Hernandez-Rivas JM, Brunet S, Garcia-Conde J, Maldonado J, Zuazu J, Gardella S, Besalduch J, Leon P, Macia J, Domingo-Albos A, Feliu E, San Miguel JF (1998) Late intensification chemotherapy has not improved the results of intensive chemotherapy in adult acute lymphoblastic leukemia. Results of a prospective multicenter randomized trial (PETHEMA ALL-89). Haematologica 83: 222\u2013230","journal-title":"Haematologica"},{"key":"BF6602008_CR17","first-page":"154","volume":"87","author":"JM Ribera","year":"2002","unstructured":"Ribera JM, Ortega JJ, Oriol A, Granada I, Hernandez-Rivas JM, Parody R, Bethencourt C, Rivas C, Bastida P, del Potro E, Gonzalez-Valentin ME, Moreno MJ, Besalduch J, Fernandez-Calvo J, Tormo M, Arias J, Molines A, Sanz MA, Maldonado J, Milla F, Feliu E, San Miguel JF, PETHEMA Group, Spanish Society of Hematology (2002) Prognostic value of karyotypic analysis in children and adults with high-risk acute lymphoblastic leukemia included in the PETHEMA ALL-93 trial. Haematologica 87: 154\u2013166","journal-title":"Haematologica"},{"key":"BF6602008_CR18","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1046\/j.1365-2141.2001.02764.x","volume":"113","author":"J Roman-Gomez","year":"2001","unstructured":"Roman-Gomez J, Castillejo JA, Jimenez A, Bornstein R, Gonzalez MG, del Carmen Rodriguez M, Barrios M, Maldonado J, Torres A (2001) Hypermethylation of the calcitonin gene in acute lymphoblastic leukaemia is associated with unfavourable clinical outcome. Br J Haematol 113: 329\u2013338","journal-title":"Br J Haematol"},{"key":"BF6602008_CR19","doi-asserted-by":"publisher","first-page":"2291","DOI":"10.1182\/blood.V99.7.2291","volume":"99","author":"J Roman-Gomez","year":"2002","unstructured":"Roman-Gomez J, Castillejo JA, Jimenez A, Gonzalez MG, Moreno F, Rodriguez Mdel C, Barrios M, Maldonado J, Torres A (2002) 5\u2032 CpG island hypermethylation is associated with transcriptional silencing of the p21CIP1\/WAF1\/SDI1 gene and confers poor prognosis in acute lymphoblastic leukemia. Blood 99: 2291\u20132296","journal-title":"Blood"},{"key":"BF6602008_CR20","doi-asserted-by":"publisher","first-page":"1855","DOI":"10.1080\/1042819031000116689","volume":"44","author":"J Roman-Gomez","year":"2003","unstructured":"Roman-Gomez J, Jimenez A, Castillejo JA, Barrios M, Heiniger A, Torres A (2003) The role of DNA methylation in the pathogenesis and prognosis of acute lymphoblastic leukemia. Leuk Lymphoma 44: 1855\u20131864","journal-title":"Leuk Lymphoma"},{"key":"BF6602008_CR21","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/S0092-8674(00)81902-9","volume":"88","author":"M Serrano","year":"1997","unstructured":"Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SE (1997) Oncogenic Ras provokes premature cell senescence associated with accumulation of p53 and p16. Cell 88: 593\u2013602","journal-title":"Cell"},{"key":"BF6602008_CR22","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/S0960-9822(99)80310-8","volume":"9","author":"LC Sheldahl","year":"1999","unstructured":"Sheldahl LC, Park M, Malbon CC, Moon RT (1999) Protein kinase C is differentially stimulated by Wnt and Frizzled homologs in a G-protein-dependent manner. Curr Biol 9: 695\u2013698","journal-title":"Curr Biol"},{"key":"BF6602008_CR23","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1200\/JCO.1996.14.1.18","volume":"14","author":"M Smith","year":"1996","unstructured":"Smith M, Arthur D, Camitta B, Carroll AJ, Crist W, Gaynon P, Gelber R, Heerema N, Korn EL, Link M, Murphy S, Pui CH, Pullen J, Reamon G, Sallan SE, Sather H, Shuster J, Simon R, Trigg M, Tubergen D, Uckun F, Ungerleider R (1996) Uniform approach to risk classification and treatment assignment for children with acute lymphoblastic leukemia. J Clin Oncol 14: 18\u201324","journal-title":"J Clin Oncol"},{"key":"BF6602008_CR24","doi-asserted-by":"publisher","first-page":"2109","DOI":"10.1128\/MCB.19.3.2109","volume":"19","author":"GH Stein","year":"1999","unstructured":"Stein GH, Drullinger LF, Soulard A, Dulic V (1999) Differential roles for cyclin-dependent kinase inhibitors p16 and p21 in the mechanism of senescence and differentiation in human fibroblasts. Mol Cell Biol 19: 2109\u20132117","journal-title":"Mol Cell Biol"},{"key":"BF6602008_CR25","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/35077219","volume":"411","author":"J Taipale","year":"2001","unstructured":"Taipale J, Beachy PA (2001) The Hedgehog and Wnt signaling pathways in cancer. Nature 411: 349\u2013354","journal-title":"Nature"},{"key":"BF6602008_CR26","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1006\/bbrc.1999.2067","volume":"268","author":"T Tsuji","year":"2000","unstructured":"Tsuji T, Miyazaki M, Sakaguchi M, Inoue Y, Namba M (2000) A REIC gene shows down-regulation in human immortalized cells and human tumor-derived cell lines. Biochem Biophys Res Commun 268: 20\u201324","journal-title":"Biochem Biophys Res Commun"},{"key":"BF6602008_CR27","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1006\/bbrc.2001.5972","volume":"289","author":"T Tsuji","year":"2001","unstructured":"Tsuji T, Nozaki I, Miyazaki M, Sakaguchi M, Pu H, Hamazaki Y, Iijima O, Namba M (2001) Antiproliferative activity of REIC\/Dkk-3 and its significant down-regulation in non-small-cell lung carcinomas. Biochem Biophys Res Commun 289: 257\u2013263","journal-title":"Biochem Biophys Res Commun"}],"container-title":["British Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/6602008.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/6602008","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/6602008.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T12:10:37Z","timestamp":1684411837000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/6602008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,6,29]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,8]]}},"alternative-id":["BF6602008"],"URL":"https:\/\/doi.org\/10.1038\/sj.bjc.6602008","relation":{},"ISSN":["0007-0920","1532-1827"],"issn-type":[{"value":"0007-0920","type":"print"},{"value":"1532-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,6,29]]}}}