{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:40:13Z","timestamp":1792291213681,"version":"4.4.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2004,12,14]],"date-time":"2004-12-14T00:00:00Z","timestamp":1102982400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Cancer"],"published-print":{"date-parts":[[2005,1]]},"DOI":"10.1038\/sj.bjc.6602302","type":"journal-article","created":{"date-parts":[[2004,12,14]],"date-time":"2004-12-14T05:20:31Z","timestamp":1103001631000},"page":"167-175","source":"Crossref","is-referenced-by-count":265,"title":["Breast cancer risk by age at birth, time since birth and time intervals between births: exploring interaction effects"],"prefix":"10.1038","volume":"92","author":[{"given":"G","family":"Albrektsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Heuch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Kv\u00e5le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2004,12,14]]},"reference":[{"key":"BF6602302_CR1","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1097\/00001648-199411000-00008","volume":"5","author":"G Albrektsen","year":"1994","unstructured":"Albrektsen G, Heuch I, Tretli S, Kv\u00e5le G (1994) Breast cancer incidence before age 55 in relation to parity and age at first and last births: a prospective study of one million Norwegian women. Epidemiology 5: 604\u2013611","journal-title":"Epidemiology"},{"key":"BF6602302_CR2","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1038\/bjc.1995.359","volume":"72","author":"G Albrektsen","year":"1995","unstructured":"Albrektsen G, Heuch I, Kv\u00e5le G (1995) The short-term and long-term effect of a pregnancy on breast cancer risk: a prospective study of 802,457 parous Norwegian women. Br J Cancer 72: 480\u2013484","journal-title":"Br J Cancer"},{"key":"BF6602302_CR3","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1002\/(SICI)1097-0258(19990530)18:10<1261::AID-SIM119>3.0.CO;2-A","volume":"18","author":"G Albrektsen","year":"1999","unstructured":"Albrektsen G, Heuch I, Kv\u00e5le G (1999) Joint effects on cancer risk of age at childbirth, time since birth and attained age: circumventing the problem of collinearity. Stat Med 18: 1261\u20131277","journal-title":"Stat Med"},{"key":"BF6602302_CR4","first-page":"1035","volume":"76","author":"L Bernstein","year":"1986","unstructured":"Bernstein L, Depue RH, Ross RK, Judd HL, Pike MC, Henderson BE (1986) Higher maternal levels of free estradiol in first compared to second pregnancy: early gestational differences. J Natl Cancer Inst 76: 1035\u20131039","journal-title":"J Natl Cancer Inst"},{"key":"BF6602302_CR5","volume-title":"Statistical Methods in Cancer Research","author":"NE Breslow","year":"1987","unstructured":"Breslow NE, Day NE (1987) Statistical Methods in Cancer Research Vol. 2, The Design and Analysis of Cohort Studies. IARC Scientific Publications No. 82, Lyon: IARC"},{"key":"BF6602302_CR6","unstructured":"Brunborg H, Kravdal \u00d8 (1986) Fertility by birth order in Norway. A register based analysis (tables, figures and summary in English). Central Bureau of Statistics of Norway, Report No. 86\/27, Oslo-Kongsvinger"},{"key":"BF6602302_CR7","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1093\/oxfordjournals.aje.a010266","volume":"151","author":"W-C Chie","year":"2000","unstructured":"Chie W-C, Hsieh C-c, Newcomb PA, Longnecker MP, Mittendorf R, Greenberg ER, Clapp RW, Burke KP, Titus-Ernstoff L, Trentham-Dietz A, MacMahon B (2000) Age at any full-term pregnancy and breast cancer risk. Am J Epidemiol 151: 715\u2013722","journal-title":"Am J Epidemiol"},{"key":"BF6602302_CR8","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1093\/aje\/152.10.950","volume":"152","author":"GA Colditz","year":"2000","unstructured":"Colditz GA, Rosner B (2000) Cumulative risk of breast cancer to age 70 years according to risk factor status: data from the Nurses' Health study. Am J Epidemiol 152: 950\u2013964","journal-title":"Am J Epidemiol"},{"key":"BF6602302_CR9","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1093\/jnci\/djh025","volume":"96","author":"GA Colditz","year":"2004","unstructured":"Colditz GA, Rosner BA, Chen WY, Holmes MD, Hankinson SE (2004) Risk factors for breast cancer according to estrogen and progesteron receptor status. J Natl Cancer Inst 96: 218\u2013228","journal-title":"J Natl Cancer Inst"},{"key":"BF6602302_CR10","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1097\/00001648-199709000-00003","volume":"8","author":"P Cummings","year":"1997","unstructured":"Cummings P, Weiss NS, McKnight B, Stanford JL (1997) Estimating the risk of breast cancer in relation to the interval since last term pregnancy. Epidemiology 8: 488\u2013494","journal-title":"Epidemiology"},{"key":"BF6602302_CR11","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1002\/(SICI)1097-0215(19960717)67:2<187::AID-IJC6>3.0.CO;2-P","volume":"67","author":"A Decarli","year":"1996","unstructured":"Decarli A, La Vecchia C, Negri E, Franceschi S (1996) Age at any birth and breast cancer in Italy. Int J Cancer 67: 187\u2013189","journal-title":"Int J Cancer"},{"key":"BF6602302_CR12","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1002\/sim.4780080504","volume":"8","author":"S Durrleman","year":"1989","unstructured":"Durrleman S, Simon R (1989) Flexible regression models with cubic splines. Stat Med 8: 551\u2013561","journal-title":"Stat Med"},{"key":"BF6602302_CR13","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1093\/oxfordjournals.epirev.a036107","volume":"15","author":"LA Habel","year":"1993","unstructured":"Habel LA, Stanford JL (1993) Hormone receptors and breast cancer. Epidemiol Rev 15: 209\u2013219","journal-title":"Epidemiol Rev"},{"key":"BF6602302_CR14","doi-asserted-by":"publisher","first-page":"S11","DOI":"10.1007\/BF02633520","volume":"18","author":"BE Henderson","year":"1991","unstructured":"Henderson BE, Bernstein L (1991) The international variation in breast cancer rates: An epidemiological assessment. Breast Cancer Res Treat 18: S11\u2013S17","journal-title":"Breast Cancer Res Treat"},{"key":"BF6602302_CR15","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1097\/00001648-199911000-00015","volume":"10","author":"I Heuch","year":"1999","unstructured":"Heuch I, Albrektsen G, Kv\u00e5le G (1999) Modeling effects of age at and time since delivery on subsequent risk of cancer. Epidemiology 10: 739\u2013746","journal-title":"Epidemiology"},{"key":"BF6602302_CR16","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1097\/00001648-200007000-00025","volume":"11","author":"I Heuch","year":"2000","unstructured":"Heuch I, Albrektsen G, Kv\u00e5le G (2000) Modeling effects of age and time since delivery on subsequent cancer risk. The authors reply. Epidemiology 11: 481","journal-title":"Epidemiology"},{"key":"BF6602302_CR17","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1002\/(SICI)1097-0258(19960730)15:14<1545::AID-SIM292>3.0.CO;2-7","volume":"15","author":"C-C Hsieh","year":"1996","unstructured":"Hsieh C-C, Lan S-J (1996) Assessment of postpartum time-dependent disease risk in case-control studies: an application for examining age-specific effect estimates. Stat Med 15: 1545\u20131556","journal-title":"Stat Med"},{"key":"BF6602302_CR18","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1016\/0959-8049(94)90125-2","volume":"30A","author":"C Hsieh","year":"1994","unstructured":"Hsieh C, Pavia M, Lambe M, Lan S-J, Colditz GA, Ekbom A, Adami H-O, Trichopoulos D, Willett WC (1994) Dual effect of parity on breast cancer risk. Eur J Cancer 30A: 969\u2013973","journal-title":"Eur J Cancer"},{"key":"BF6602302_CR19","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1056\/NEJM199407073310102","volume":"331","author":"M Lambe","year":"1994","unstructured":"Lambe M, Hsieh C-C, Trichopoulos D, Ekbom A, Pavia M, Adami H-O (1994) Transient increase in the risk of breast cancer after giving birth. N Engl J Med 331: 5\u20139","journal-title":"N Engl J Med"},{"key":"BF6602302_CR20","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/S0002-9610(03)00272-1","volume":"186","author":"SH Lee","year":"2003","unstructured":"Lee SH, Akuete K, Fulton J, Chelmow D, Chung MA, Cady B (2003) An increased risk of breast cancer after delayed first parity. Am J Surg 186: 409\u2013412","journal-title":"Am J Surg"},{"key":"BF6602302_CR21","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/BF00051403","volume":"6","author":"DA Leon","year":"1995","unstructured":"Leon DA, Carpenter LM, Broeders MJM, Gunnarskog J, Murphy MFG (1995) Breast cancer in Swedish women before age 50: evidence of a dual effect of completed pregnancy. Cancer Causes Control 6: 283\u2013291","journal-title":"Cancer Causes Control"},{"key":"BF6602302_CR22","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1023\/A:1015287208222","volume":"13","author":"Q Liu","year":"2002","unstructured":"Liu Q, Wuu J, Lambe M, Hsieh S-F, Ekbom A, Hsieh C-C (2002) Transient increase in breast cancer risk after giving birth: postpartum period with the highest risk (Sweden). Cancer Causes Control 13: 299\u2013305","journal-title":"Cancer Causes Control"},{"key":"BF6602302_CR23","first-page":"1035","volume":"69","author":"B MacMahon","year":"1982","unstructured":"MacMahon B, Purde M, Cramer D, Hint E (1982) Association of breast cancer risk with age at first and subsequent births: a study in the population of Estonian republic. J Natl Cancer Inst 69: 1035\u20131038","journal-title":"J Natl Cancer Inst"},{"key":"BF6602302_CR24","unstructured":"National Cancer Institute (2003) Summary report: early reproductive events and breast cancer workshop ( \n                    http:\/\/cancer.gov\/cancerinfo\/ere-workshop-report\n                    \n                   )"},{"key":"BF6602302_CR25","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1002\/ijc.2910450308","volume":"45","author":"E Negri","year":"1990","unstructured":"Negri E, La Vecchia C, Duffy SF, Bruzzi P, Parazzini F, Day NE (1990) Age at first and second births and breast cancer risk in biparous women. Int J Cancer 45: 428\u2013430","journal-title":"Int J Cancer"},{"key":"BF6602302_CR26","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1023\/A:1015282916368","volume":"13","author":"DR Pathak","year":"2002","unstructured":"Pathak DR (2002) Dual effect of first full term pregnancy on breast cancer risk: empirical evidence and postulated underlying biology. Cancer Causes Control 13: 295\u2013298","journal-title":"Cancer Causes Control"},{"key":"BF6602302_CR27","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1200\/JCO.2004.07.062","volume":"22","author":"K-A Phillips","year":"2004","unstructured":"Phillips K-A, Milne RL, Friedlander ML, Jenkins MA, McCredie MRE, Giles GG, Hopper JL (2004) Prognosis of premenopausal breast cancer and childbirth prior to diagnosis. J Clin Oncol 22: 699\u2013705","journal-title":"J Clin Oncol"},{"key":"BF6602302_CR28","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1038\/303767a0","volume":"303","author":"MC Pike","year":"1983","unstructured":"Pike MC, Krailo MD, Henderson BE, Casagrande JT, Hoel DG (1983) Hormonal' risk factors, \u2018breast tissue age\u2019 and the age-incidence of breast cancer. Nature 303: 767\u2013770","journal-title":"Nature"},{"key":"BF6602302_CR29","volume-title":"EPICURE \u2013 Programs for Generalized Risk Modeling and Person-year Computation","author":"DL Preston","year":"1996","unstructured":"Preston DL, Lubin JH, Pierce DA, McConney ME (1996) EPICURE \u2013 Programs for Generalized Risk Modeling and Person-year Computation. Seattle, USA: Hirosoft International Corporation"},{"key":"BF6602302_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/(SICI)1097-0215(19970926)73:1<1::AID-IJC1>3.0.CO;2-U","volume":"73","author":"C Robertson","year":"1997","unstructured":"Robertson C, Primic-Zakelj M, Boyle P, Hsieh C-C (1997) Effect of parity and age at delivery on breast cancer risk in Slovenian women aged 25\u201354 years. Int J Cancer 73: 1\u20139","journal-title":"Int J Cancer"},{"key":"BF6602302_CR31","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1093\/jnci\/88.6.359","volume":"88","author":"B Rosner","year":"1996","unstructured":"Rosner B, Colditz GA (1996) Nurses' Health study: log-incidence mathematical model of breast cancer incidence. J Natl Cancer Inst 88: 359\u2013364","journal-title":"J Natl Cancer Inst"},{"key":"BF6602302_CR32","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1002\/ijc.2910310604","volume":"31","author":"D Trichopoulos","year":"1983","unstructured":"Trichopoulos D, Hsieh C-C, MacMahon B, Lin T-M, Lowe CR, Mirra AP, Ravnihar B, Salber EJ, Valaoras VG, Yuasa S (1983) Age at any birth and breast cancer risk. Int J Cancer 31: 701\u2013704","journal-title":"Int J Cancer"},{"key":"BF6602302_CR33","doi-asserted-by":"publisher","first-page":"1796","DOI":"10.1038\/bjc.1996.632","volume":"74","author":"RA Walker","year":"1996","unstructured":"Walker RA, Lees E, Webb MB, Dearing SJ (1996) Breast carcinomas occurring in young women (&lt;35 years) are different. Br J Cancer 74: 1796\u20131800","journal-title":"Br J Cancer"},{"key":"BF6602302_CR34","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1097\/00001648-200101000-00012","volume":"12","author":"J Wohlfahrt","year":"2001","unstructured":"Wohlfahrt J, Melbye M (2001) Age at any birth is associated with breast cancer risk. Epidemiology 12: 68\u201373","journal-title":"Epidemiology"}],"container-title":["British Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/6602302.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/6602302","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/6602302.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T08:13:49Z","timestamp":1684397629000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/6602302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12,14]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,1]]}},"alternative-id":["BF6602302"],"URL":"https:\/\/doi.org\/10.1038\/sj.bjc.6602302","relation":{},"ISSN":["0007-0920","1532-1827"],"issn-type":[{"value":"0007-0920","type":"print"},{"value":"1532-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,12,14]]}}}