{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:52:06Z","timestamp":1778633526591,"version":"3.51.4"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2006,12,19]],"date-time":"2006-12-19T00:00:00Z","timestamp":1166486400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Cancer"],"published-print":{"date-parts":[[2007,1]]},"DOI":"10.1038\/sj.bjc.6603517","type":"journal-article","created":{"date-parts":[[2006,12,19]],"date-time":"2006-12-19T04:31:52Z","timestamp":1166502712000},"page":"172-176","source":"Crossref","is-referenced-by-count":113,"title":["Helicobacter pylori and oesophageal and gastric cancers in a prospective study in China"],"prefix":"10.1038","volume":"96","author":[{"given":"F","family":"Kamangar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y-L","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M J","family":"Blaser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X-D","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Katki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J-H","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G I","family":"Perez-Perez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C C","family":"Abnet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S D","family":"Mark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P R","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S M","family":"Dawsey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2006,12,19]]},"reference":[{"key":"BF6603517_CR1","first-page":"2111","volume":"55","author":"MJ Blaser","year":"1995","unstructured":"Blaser MJ, Perez-Perez GI, Kleanthous H, Cover TL, Peek RM, Chyou PH, Stemmermann GN, Nomura A (1995) Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach. Cancer Res 55: 2111\u20132115","journal-title":"Cancer Res"},{"key":"BF6603517_CR2","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1093\/jnci\/85.18.1483","volume":"85","author":"WJ Blot","year":"1993","unstructured":"Blot WJ, Li JY, Taylor PR, Guo W, Dawsey S, Wang GQ, Yang CS, Zheng SF, Gail M, Li GY (1993) Nutrition intervention trials in Linxian, China: supplementation with specific vitamin\/mineral combinations, cancer incidence, and disease-specific mortality in the general population. J Natl Cancer Inst 85: 1483\u20131492","journal-title":"J Natl Cancer Inst"},{"key":"BF6603517_CR3","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1093\/jnci\/86.17.1340","volume":"86","author":"LM Brown","year":"1994","unstructured":"Brown LM, Hoover RN, Greenberg RS, Schoenberg JB, Schwartz AG, Swanson GM, Liff JM, Silverman DT, Hayes RB, Pottern LM (1994) Are racial differences in squamous cell esophageal cancer explained by alcohol and tobacco use? J Natl Cancer Inst 86: 1340\u20131345","journal-title":"J Natl Cancer Inst"},{"key":"BF6603517_CR4","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1093\/aje\/153.2.114","volume":"153","author":"LM Brown","year":"2001","unstructured":"Brown LM, Hoover R, Silverman D, Baris D, Hayes R, Swanson GM, Schoenberg J, Greenberg R, Liff J, Schwartz A, Dosemeci M, Pottern L, Fraumeni Jr JF (2001) Excess incidence of squamous cell esophageal cancer among US Black men: role of social class and other risk factors. Am J Epidemiol 153: 114\u2013122","journal-title":"Am J Epidemiol"},{"key":"BF6603517_CR5","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/bjc.1979.54","volume":"39","author":"PJ Cook-Mozaffari","year":"1979","unstructured":"Cook-Mozaffari PJ, Azordegan F, Day NE, Ressicaud A, Sabai C, Aramesh B (1979) Oesophageal cancer studies in the Caspian Littoral of Iran: results of a case\u2013control study. Br J Cancer 39: 293\u2013309","journal-title":"Br J Cancer"},{"key":"BF6603517_CR6","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1136\/gut.51.3.457","volume":"51","author":"SM Dawsey","year":"2002","unstructured":"Dawsey SM, Mark SD, Taylor PR, Limburg PJ (2002) Gastric cancer and H pylori. Gut 51: 457\u2013458","journal-title":"Gut"},{"key":"BF6603517_CR7","doi-asserted-by":"publisher","first-page":"2373","DOI":"10.1111\/j.1572-0241.1999.01360.x","volume":"94","author":"GD Eslick","year":"1999","unstructured":"Eslick GD, Lim LL, Byles JE, Xia HH, Talley NJ (1999) Association of Helicobacter pylori infection with gastric carcinoma: a meta-analysis. Am J Gastroenterol 94: 2373\u20132379","journal-title":"Am J Gastroenterol"},{"key":"BF6603517_CR8","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1080\/003655299750026353","volume":"34","author":"S Hansen","year":"1999","unstructured":"Hansen S, Melby KK, Aase S, Jellum E, Vollset SE (1999) Helicobacter pylori infection and risk of cardia cancer and non-cardia gastric cancer. A nested case\u2013control study. Scand J Gastroenterol 34: 353\u2013360","journal-title":"Scand J Gastroenterol"},{"key":"BF6603517_CR9","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1016\/0016-5085(93)90954-B","volume":"105","author":"LE Hansson","year":"1993","unstructured":"Hansson LE, Engstrand L, Nyren O, Evans Jr DJ, Lindgren A, Bergstrom R, Andersson B, Athlin L, Bendtsen O, Tracz P (1993) Helicobacter pylori infection: independent risk indicator of gastric adenocarcinoma. Gastroenterology 105: 1098\u20131103","journal-title":"Gastroenterology"},{"key":"BF6603517_CR10","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1038\/nrc1433","volume":"4","author":"M Hatakeyama","year":"2004","unstructured":"Hatakeyama M (2004) Oncogenic mechanisms of the Helicobacter pylori CagA protein. Nat Rev Cancer 4: 688\u2013694","journal-title":"Nat Rev Cancer"},{"issue":"3","key":"BF6603517_CR11","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1136\/gut.49.3.347","volume":"49","author":"Helicobacter and Cancer Collaborati","year":"2001","unstructured":"Helicobacter and Cancer Collaborative Group (2001) Gastric cancer and Helicobacter pylori: a combined analysis of 12 case control studies nested within prospective cohorts. Gut 49: 347\u2013353","journal-title":"Gut"},{"key":"BF6603517_CR12","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1016\/S0016-5085(98)70422-6","volume":"114","author":"JQ Huang","year":"1998","unstructured":"Huang JQ, Sridhar S, Chen Y, Hunt RH (1998) Meta-analysis of the relationship between Helicobacter pylori seropositivity and gastric cancer. Gastroenterology 114: 1169\u20131179","journal-title":"Gastroenterology"},{"key":"BF6603517_CR13","doi-asserted-by":"publisher","first-page":"1636","DOI":"10.1053\/j.gastro.2003.08.033","volume":"125","author":"JQ Huang","year":"2003","unstructured":"Huang JQ, Zheng GF, Sumanac K, Irvine EJ, Hunt RH (2003) Meta-analysis of the relationship between cagA seropositivity and gastric cancer. Gastroenterology 125: 1636\u20131644","journal-title":"Gastroenterology"},{"key":"BF6603517_CR14","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.1038\/sj.bjc.6601737","volume":"90","author":"F Islami","year":"2004","unstructured":"Islami F, Kamangar F, Aghcheli K, Fahimi S, Semnani S, Taghavi N, Marjani H, Merat S, Nasseri-Moghaddam S, Pourshams A, Nouraie M, Khatibian M, Abedi B, Barzandeh M, Ghaziani R, Sotoudeh M, Dawsey S, Abnet C, Taylor P, Malekzadeh R (2004) Epidemiologic features of upper gastrointestinal tract cancer in northeastern Iran. Br J Cancer 90: 1402\u20131406","journal-title":"Br J Cancer"},{"key":"BF6603517_CR15","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1093\/jnci\/djj393","volume":"98","author":"F Kamangar","year":"2006","unstructured":"Kamangar F, Dawsey SM, Blaser MJ, Perez-Perez GI, Pietinen P, Newschaffer CJ, Abnet CC, Albanes D, Virtamo J, Taylor PR (2006) Opposing risks of gastric cardia and non-cardia gastric adenocarcinomas associated with Helicobacter pylori seropositivity. J Natl Cancer Inst 98: 1445\u20131452","journal-title":"J Natl Cancer Inst"},{"issue":"Suppl 1:85-9","key":"BF6603517_CR16","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1111\/j.1365-2036.2004.01987.x","volume":"20","author":"M Kato","year":"2004","unstructured":"Kato M, Asaka M, Shimizu Y, Nobuta A, Takeda H, Sugiyama T (2004) Relationship between Helicobacter pylori infection and the prevalence, site and histological type of gastric cancer. Aliment Pharmacol Ther 20 (Suppl 1:85-9): 85\u201389","journal-title":"Aliment Pharmacol Ther"},{"key":"BF6603517_CR17","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/1047-2797(93)90078-I","volume":"3","author":"B Li","year":"1993","unstructured":"Li B, Taylor PR, Li JY, Dawsey SM, Wang W, Tangrea JA, Liu BQ, Ershow AG, Zheng SF, Fraumeni Jr JF (1993) Linxian nutrition intervention trials. Design, methods, participant characteristics, and compliance. Ann Epidemiol 3: 577\u2013585","journal-title":"Ann Epidemiol"},{"key":"BF6603517_CR18","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1093\/jnci\/93.3.226","volume":"93","author":"P Limburg","year":"2001","unstructured":"Limburg P, Qiao Y, Mark S, Wang G, Perez-Perez G, Blaser M, Wu Y, Zou X, Dong Z, Taylor P, Dawsey S (2001) Helicobacter pylori seropositivity and subsite-specific gastric cancer risks in Linxian, China. J Natl Cancer Inst 93: 226\u2013233","journal-title":"J Natl Cancer Inst"},{"key":"BF6603517_CR19","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1198\/016214505000000952","volume":"101","author":"SD Mark","year":"2006","unstructured":"Mark SD, Katki H (2006) Specifying and implementing nonparametric and semiparametric survival estimators in two-stage (sampled) cohort studies with missing case data. J Am Stat Assoc 101: 460\u2013471","journal-title":"J Am Stat Assoc"},{"key":"BF6603517_CR20","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1056\/NEJM199110173251604","volume":"325","author":"A Nomura","year":"1991","unstructured":"Nomura A, Stemmermann GN, Chyou PH, Kato I, Perez-Perez GI, Blaser MJ (1991) Helicobacter pylori infection and gastric carcinoma among Japanese Americans in Hawaii. N Engl J Med 325: 1132\u20131136","journal-title":"N Engl J Med"},{"key":"BF6603517_CR21","doi-asserted-by":"publisher","first-page":"2075","DOI":"10.1086\/430353","volume":"191","author":"AM Nomura","year":"2005","unstructured":"Nomura AM, Kolonel LN, Miki K, Stemmermann GN, Wilkens LR, Goodman MT, Perez-Perez GI, Blaser MJ (2005) Helicobacter pylori, pepsinogen, and gastric adenocarcinoma in Hawaii. J Infect Dis 191: 2075\u20132081","journal-title":"J Infect Dis"},{"key":"BF6603517_CR22","first-page":"1313","volume":"9","author":"J Romero-Gallo","year":"2002","unstructured":"Romero-Gallo J, Perez-Perez GI, Novick RP, Kamath P, Norbu T, Blaser MJ (2002) Responses of endoscopy patients in Ladakh, India, to Helicobacter pylori whole-cell and Cag A antigens. Clin Diagn Lab Immunol 9: 1313\u20131317","journal-title":"Clin Diagn Lab Immunol"},{"key":"BF6603517_CR23","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1046\/j.1523-5378.2001.00041.x","volume":"6","author":"JH Siman","year":"2001","unstructured":"Siman JH, Forsgren A, Berglund G, Floren CH (2001) Helicobacter pylori infection is associated with a decreased risk of developing oesophageal neoplasms. Helicobacter 6: 310\u2013316","journal-title":"Helicobacter"},{"key":"BF6603517_CR24","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1002\/ijc.20616","volume":"113","author":"GD Tran","year":"2005","unstructured":"Tran GD, Sun XD, Abnet CC, Fan JH, Dawsey SM, Dong ZW, Mark SD, Qiao YL, Taylor PR (2005) Prospective study of risk factors for esophageal and gastric cancers in the Linxian general population trial cohort in China. Int J Cancer 113: 456\u2013463","journal-title":"Int J Cancer"},{"key":"BF6603517_CR25","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1111\/j.1572-0241.2005.40623.x","volume":"100","author":"DC Wu","year":"2005","unstructured":"Wu DC, Wu IC, Lee JM, Hsu HK, Kao EL, Chou SH, Wu MT (2005) Helicobacter pylori infection: a protective factor for esophageal squamous cell carcinoma in a Taiwanese population. Am J Gastroenterol 100: 588\u2013593","journal-title":"Am J Gastroenterol"},{"key":"BF6603517_CR26","doi-asserted-by":"publisher","first-page":"801","DOI":"10.3748\/wjg.v7.i6.801","volume":"7","author":"FB Xue","year":"2001","unstructured":"Xue FB, Xu YY, Wan Y, Pan BR, Ren J, Fan DM (2001) Association of H. pylori infection with gastric carcinoma: a meta analysis. World J Gastroenterol 7: 801\u2013804","journal-title":"World J Gastroenterol"},{"key":"BF6603517_CR27","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1093\/jnci\/djh057","volume":"96","author":"W Ye","year":"2004","unstructured":"Ye W, Held M, Lagergren J, Engstrand L, Blot WJ, McLaughlin JK, Nyren O (2004) Helicobacter pylori infection and gastric atrophy: risk of adenocarcinoma and squamous-cell carcinoma of the esophagus and adenocarcinoma of the gastric cardia. J Natl Cancer Inst 96: 388\u2013396","journal-title":"J Natl Cancer Inst"}],"container-title":["British Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/6603517.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/6603517","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/6603517.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T08:25:01Z","timestamp":1684398301000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/6603517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12,19]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["BF6603517"],"URL":"https:\/\/doi.org\/10.1038\/sj.bjc.6603517","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1060787.512714","asserted-by":"object"}]},"ISSN":["0007-0920","1532-1827"],"issn-type":[{"value":"0007-0920","type":"print"},{"value":"1532-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,12,19]]}}}