{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:27:40Z","timestamp":1791412060075,"version":"4.3.3"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2008,5,27]],"date-time":"2008-05-27T00:00:00Z","timestamp":1211846400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Cancer"],"published-print":{"date-parts":[[2008,6]]},"DOI":"10.1038\/sj.bjc.6604383","type":"journal-article","created":{"date-parts":[[2008,5,28]],"date-time":"2008-05-28T13:51:40Z","timestamp":1211982700000},"page":"1731-1735","source":"Crossref","is-referenced-by-count":81,"title":["Circulating endothelial cells in oncology: pitfalls and promises"],"prefix":"10.1038","volume":"98","author":[{"given":"M H","family":"Strijbos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J W","family":"Gratama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Kraan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C H","family":"Lamers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MA den","family":"Bakker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Sleijfer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,5,27]]},"reference":[{"key":"BF6604383_CR1","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1200\/JCO.2005.02.7458","volume":"24","author":"LV Beerepoot","year":"2006","unstructured":"Beerepoot LV, Radema SA, Witteveen EO, Thomas T, Wheeler C, Kempin S, Voest EE (2006) Phase I clinical evaluation of weekly administration of the novel vascular-targetting agent, ZD6126, in patients with solid tumors. J Clin Oncol 24: 1491\u20131488","journal-title":"J Clin Oncol"},{"key":"BF6604383_CR2","doi-asserted-by":"publisher","first-page":"11044","DOI":"10.1158\/0008-5472.CAN-05-2617","volume":"65","author":"I Celik","year":"2005","unstructured":"Celik I, Surucu O, Dietz C, Heymach JV, Force J, Hoschele I, Becker CM, Folkman J, Kisker O (2005) Therapeutic efficacy of endostatin exhibits a biphasic dose-response curve. Cancer research 65: 11044\u201311050","journal-title":"Cancer research"},{"key":"BF6604383_CR3","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1111\/j.1399-6576.2006.00955.x","volume":"50","author":"TB Corcoran","year":"2006","unstructured":"Corcoran TB, O\u2019Shea A, Engel A, Shorten GD (2006) The influence of propofol on P-selectin expression and nitric oxide production in re-oxygenated human umbilical vein endothelial cells. Acta anaesthesiologica Scandinavica 50: 348\u2013354","journal-title":"Acta anaesthesiologica Scandinavica"},{"key":"BF6604383_CR4","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1200\/JCO.2006.07.7677","volume":"25","author":"F Dignat-George","year":"2007","unstructured":"Dignat-George F, Sabatier F, Blann A, Woywodt A (2007) Detection of circulating endothelial cells: CD146-based magnetic separation enrichment or flow cytometric assay? J Clin Oncol 25: e1\u2013e2; author reply e3\u20135","journal-title":"J Clin Oncol"},{"key":"BF6604383_CR5","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1111\/j.1365-2249.2004.02335.x","volume":"135","author":"GL Dixon","year":"2004","unstructured":"Dixon GL, Heyderman RS, van der Ley P, Klein NJ (2004) High-level endothelial E-selectin (CD62E) cell adhesion molecule expression by a lipopolysaccharide-deficient strain of Neisseria meningitidis despite poor activation of NF-kappaB transcription factor. Clin Exp Immunol 135: 85\u201393","journal-title":"Clin Exp Immunol"},{"key":"BF6604383_CR6","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1200\/JCO.2005.04.2861","volume":"24","author":"DG Duda","year":"2006","unstructured":"Duda DG, Cohen KS, di Tomaso E, Au P, Klein RJ, Scadden DT, Willett CG, Jain RK (2006) Differential CD146 expression on circulating vs tissue endothelial cells in rectal cancer patients: implications for circulating endothelial and progenitor cells as biomarkers for antiangiogenic therapy. J Clin Oncol 24: 1449\u20131453","journal-title":"J Clin Oncol"},{"key":"BF6604383_CR7","doi-asserted-by":"publisher","first-page":"2923","DOI":"10.1182\/blood-2005-06-2307","volume":"106","author":"MF Elshal","year":"2005","unstructured":"Elshal MF, Khan SS, Takahashi Y, Solomon MA, McCoy Jr JP (2005) CD146 (Mel-CAM), an adhesion marker of endothelial cells, is a novel marker of lymphocyte subset activation in normal peripheral blood. Blood 106: 2923\u20132924","journal-title":"Blood"},{"key":"BF6604383_CR8","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1038\/sj.bjc.6602952","volume":"94","author":"G Furstenberger","year":"2006","unstructured":"Furstenberger G, von Moos R, Lucas R, Thurlimann B, Senn HJ, Hamacher J, Boneberg EM (2006) Circulating endothelial cells and angiogenic serum factors during neoadjuvant chemotherapy of primary breast cancer. Br j cancer 94: 524\u2013531","journal-title":"Br j cancer"},{"key":"BF6604383_CR9","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1055\/s-0038-1648397","volume":"67","author":"F George","year":"1992","unstructured":"George F, Brisson C, Poncelet P, Laurent JC, Massot O, Arnoux D, Ambrosi P, Klein-Soyer C, Cazenave JP, Sampol J (1992) Rapid isolation of human endothelial cells from whole blood using S-Endo1 monoclonal antibody coupled to immuno-magnetic beads: demonstration of endothelial injury after angioplasty. Thrombosis and haemostasis 67: 147\u2013153","journal-title":"Thrombosis and haemostasis"},{"key":"BF6604383_CR10","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1160\/TH06-04-0185","volume":"96","author":"PK Goon","year":"2006","unstructured":"Goon PK, Boos CJ, Stonelake PS, Blann AD, Lip GY (2006) Detection and quantification of mature circulating endothelial cells using flow cytometry and immunomagnetic beads: a methodological comparison. Thrombosis and haemostasis 96: 45\u201352","journal-title":"Thrombosis and haemostasis"},{"key":"BF6604383_CR11","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1200\/JCO.2003.10.066","volume":"21","author":"F Kabbinavar","year":"2003","unstructured":"Kabbinavar F, Hurwitz HI, Fehrenbacher L, Meropol NJ, Novotny WF, Lieberman G, Griffing S, Bergsland E (2003) Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)\/leucovorin (LV) with FU\/LV alone in patients with metastatic colorectal cancer. J Clin Oncol 21: 60\u201365","journal-title":"J Clin Oncol"},{"issue":"7","key":"BF6604383_CR12","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1111\/j.1464-410X.2007.07342.x","volume":"101","author":"H Li","year":"2008","unstructured":"Li H, Raia V, Bertolini F, Price DK, Figg WD (2008) Circulating endothelial cells as a therapeutic marker for thalidomide in combined therapy with chemotherapy drugs in a human prostate cancer model. BJU Int 101 (7): 884\u2013888","journal-title":"BJU Int"},{"key":"BF6604383_CR13","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1038\/nm1101-1194","volume":"7","author":"D Lyden","year":"2001","unstructured":"Lyden D, Hattori K, Dias S, Costa C, Blaikie P, Butros L, Chadburn A, Heissig B, Marks W, Witte L, Wu Y, Hicklin D, Zhu Z, Hackett NR, Crystal RG, Moore MA, Hajjar KA, Manova K, Benezra R, Rafii S (2001) Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth. Nat Med 7: 1194\u20131201","journal-title":"Nat Med"},{"key":"BF6604383_CR14","doi-asserted-by":"publisher","first-page":"3658","DOI":"10.1182\/blood.V97.11.3658","volume":"97","author":"P Mancuso","year":"2001","unstructured":"Mancuso P, Burlini A, Pruneri G, Goldhirsch A, Martinelli G, Bertolini F (2001) Resting and activated endothelial cells are increased in the peripheral blood of cancer patients. Blood 97: 3658\u20133661","journal-title":"Blood"},{"key":"BF6604383_CR15","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1182\/blood-2005-11-4570","volume":"108","author":"P Mancuso","year":"2006","unstructured":"Mancuso P, Colleoni M, Calleri A, Orlando L, Maisonneuve P, Pruneri G, Agliano A, Goldhirsch A, Shaked Y, Kerbel RS, Bertolini F (2006) Circulating endothelial-cell kinetics and viability predict survival in breast cancer patients receiving metronomic chemotherapy. Blood 108: 452\u2013459","journal-title":"Blood"},{"key":"BF6604383_CR16","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1200\/JCO.2000.18.8.1725","volume":"18","author":"MT Meinardi","year":"2000","unstructured":"Meinardi MT, Gietema JA, van der Graaf WT, van Veldhuisen DJ, Runne MA, Sluiter WJ, de Vries EG, Willemse PB, Mulder NH, van den Berg MP, Koops HS, Sleijfer DT (2000) Cardiovascular morbidity in long-term survivors of metastatic testicular cancer. J Clin Oncol 18: 1725\u20131732","journal-title":"J Clin Oncol"},{"key":"BF6604383_CR17","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1111\/j.1523-1755.2005.00434.x","volume":"68","author":"G Moroni","year":"2005","unstructured":"Moroni G, Del Papa N, Moronetti LM, Vitali C, Maglione W, Comina DP, Urgnani F, Sandri S, Ponticelli C, Cortelezzi A (2005) Increased levels of circulating endothelial cells in chronic periaortitis as a marker of active disease. Kidney international 68: 562\u2013568","journal-title":"Kidney international"},{"key":"BF6604383_CR18","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1056\/NEJMoa065044","volume":"356","author":"RJ Motzer","year":"2007","unstructured":"Motzer RJ, Hutson TE, Tomczak P, Michaelson MD, Bukowski RM, Rixe O, Oudard S, Negrier S, Szczylik C, Kim ST, Chen I, Bycott PW, Baum CM, Figlin RA (2007) Sunitinib vs interferon alfa in metastatic renal-cell carcinoma. The New England journal of medicine 356: 115\u2013124","journal-title":"The New England journal of medicine"},{"key":"BF6604383_CR19","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1093\/jnci\/djj068","volume":"98","author":"GN Naumov","year":"2006","unstructured":"Naumov GN, Bender E, Zurakowski D, Kang SY, Sampson D, Flynn E, Watnick RS, Straume O, Akslen LA, Folkman J, Almog N (2006) A model of human tumor dormancy: an angiogenic switch from the nonangiogenic phenotype. Journal of the National Cancer Institute 98: 316\u2013325","journal-title":"Journal of the National Cancer Institute"},{"key":"BF6604383_CR20","doi-asserted-by":"publisher","first-page":"9130","DOI":"10.1200\/JCO.2005.01.4092","volume":"23","author":"J Nuver","year":"2005","unstructured":"Nuver J, Smit AJ, van der Meer J, van den Berg MP, van der Graaf WT, Meinardi MT, Sleijfer DT, Hoekstra HJ, van Gessel AI, van Roon AM, Gietema JA (2005) Acute chemotherapy-induced cardiovascular changes in patients with testicular cancer. J Clin Oncol 23: 9130\u20139137","journal-title":"J Clin Oncol"},{"key":"BF6604383_CR21","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1038\/nm1200","volume":"11","author":"BA Peters","year":"2005","unstructured":"Peters BA, Diaz LA, Polyak K, Meszler L, Romans K, Guinan EC, Antin JH, Myerson D, Hamilton SR, Vogelstein B, Kinzler KW, Lengauer C (2005) Contribution of bone marrow-derived endothelial cells to human tumor vasculature. Nat Med 11: 261\u2013262","journal-title":"Nat Med"},{"key":"BF6604383_CR22","doi-asserted-by":"publisher","first-page":"4474","DOI":"10.1158\/1078-0432.CCR-06-2912","volume":"13","author":"JM Rademaker-Lakhai","year":"2007","unstructured":"Rademaker-Lakhai JM, Beerepoot LV, Mehra N, Radema SA, van Maanen R, Vermaat JS, Witteveen EO, Visseren-Grul CM, Musib L, Enas N, van Hal G, Beijnen JH, Schellens JH, Voest EE (2007) Phase I pharmacokinetic and pharmacodynamic study of the oral protein kinase C beta-inhibitor enzastaurin in combination with gemcitabine and cisplatin in patients with advanced cancer. Clin Cancer Res 13: 4474\u20134481","journal-title":"Clin Cancer Res"},{"key":"BF6604383_CR23","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1002\/cyto.a.20364","volume":"71","author":"JL Rowand","year":"2007","unstructured":"Rowand JL, Martin G, Doyle GV, Miller MC, Pierce MS, Connelly MC, Rao C, Terstappen LW (2007) Endothelial cells in peripheral blood of healthy subjects and patients with metastatic carcinomas. Cytometry A 71: 105\u2013113","journal-title":"Cytometry A"},{"key":"BF6604383_CR24","doi-asserted-by":"publisher","first-page":"2542","DOI":"10.1056\/NEJMoa061884","volume":"355","author":"A Sandler","year":"2006","unstructured":"Sandler A, Gray R, Perry MC, Brahmer J, Schiller JH, Dowlati A, Lilenbaum R, Johnson DH (2006) Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. The New England journal of medicine 355: 2542\u20132550","journal-title":"The New England journal of medicine"},{"key":"BF6604383_CR25","first-page":"8345","volume":"63","author":"G Schuch","year":"2003","unstructured":"Schuch G, Heymach JV, Nomi M, Machluf M, Force J, Atala A, Eder Jr JP, Folkman J, Soker S (2003) Endostatin inhibits the vascular endothelial growth factor-induced mobilization of endothelial progenitor cells. Cancer research 63: 8345\u20138350","journal-title":"Cancer research"},{"key":"BF6604383_CR26","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.ccr.2007.04.017","volume":"11","author":"S Seaman","year":"2007","unstructured":"Seaman S, Stevens J, Yang MY, Logsdon D, Graff-Cherry C, St Croix B (2007) Genes that distinguish physiological and pathological angiogenesis. Cancer Cell 11: 539\u2013554","journal-title":"Cancer Cell"},{"key":"BF6604383_CR27","doi-asserted-by":"publisher","first-page":"2918","DOI":"10.1158\/0008-5472.CAN-05-4003","volume":"66","author":"DA Smirnov","year":"2006","unstructured":"Smirnov DA, Foulk BW, Doyle GV, Connelly MC, Terstappen LW, O\u2019Hara SM (2006) Global gene expression profiling of circulating endothelial cells in patients with metastatic carcinomas. Cancer research 66: 2918\u20132922","journal-title":"Cancer research"},{"key":"BF6604383_CR28","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1002\/cyto.b.20156","volume":"72","author":"MH Strijbos","year":"2007","unstructured":"Strijbos MH, Kraan J, den Bakker MA, Lambrecht BN, Sleijfer S, Gratama JW (2007) Cells meeting our immunophenotypic criteria of endothelial cells are large platelets. Cytometry 72: 86\u201393","journal-title":"Cytometry"},{"key":"BF6604383_CR29","doi-asserted-by":"publisher","first-page":"2034","DOI":"10.1083\/jcb.99.6.2034","volume":"99","author":"JC Voyta","year":"1984","unstructured":"Voyta JC, Via DP, Butterfield CE, Zetter BR (1984) Identification and isolation of endothelial cells based on their increased uptake of acetylated-low density lipoprotein. The Journal of cell biology 99: 2034\u20132040","journal-title":"The Journal of cell biology"},{"key":"BF6604383_CR30","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1111\/j.1538-7836.2006.01794.x","volume":"4","author":"A Woywodt","year":"2006","unstructured":"Woywodt A, Blann AD, Kirsch T, Erdbruegger U, Banzet N, Haubitz M, Dignat-George F (2006) Isolation and enumeration of circulating endothelial cells by immunomagnetic isolation: proposal of a definition and a consensus protocol. J Thromb Haemost 4: 671\u2013677","journal-title":"J Thromb Haemost"},{"key":"BF6604383_CR31","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1056\/NEJMoa021491","volume":"349","author":"JC Yang","year":"2003","unstructured":"Yang JC, Haworth L, Sherry RM, Hwu P, Schwartzentruber DJ, Topalian SL, Steinberg SM, Chen HX, Rosenberg SA (2003) A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. The New England journal of medicine 349: 427\u2013434","journal-title":"The New England journal of medicine"}],"container-title":["British Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/6604383.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/6604383","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/6604383.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T12:33:08Z","timestamp":1684413188000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/6604383"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5,27]]},"references-count":31,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["BF6604383"],"URL":"https:\/\/doi.org\/10.1038\/sj.bjc.6604383","relation":{},"ISSN":["0007-0920","1532-1827"],"issn-type":[{"value":"0007-0920","type":"print"},{"value":"1532-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,5,27]]}}}