{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T08:50:48Z","timestamp":1768812648422,"version":"3.49.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2010,4,20]],"date-time":"2010-04-20T00:00:00Z","timestamp":1271721600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Cancer"],"published-print":{"date-parts":[[2010,5]]},"DOI":"10.1038\/sj.bjc.6605652","type":"journal-article","created":{"date-parts":[[2010,4,20]],"date-time":"2010-04-20T20:03:12Z","timestamp":1271793792000},"page":"1533-1540","source":"Crossref","is-referenced-by-count":23,"title":["Cellular and molecular phenotypes of proliferating stromal cells from human carcinomas"],"prefix":"10.1038","volume":"102","author":[{"given":"E P","family":"Kopantzev","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N A","family":"Vayshlya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M R","family":"Kopantseva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V I","family":"Egorov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Pikunov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M V","family":"Zinovyeva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T V","family":"Vinogradova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I B","family":"Zborovskaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E D","family":"Sverdlov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,4,20]]},"reference":[{"key":"BF6605652_CR1","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1038\/nrc2293","volume":"8","author":"DC Altieri","year":"2008","unstructured":"Altieri DC (2008) Survivin, cancer networks and pathway-directed drug discovery. Nat Rev Cancer 8: 61\u201370","journal-title":"Nat Rev Cancer"},{"key":"BF6605652_CR2","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1038\/nature03096","volume":"432","author":"NA Bhowmick","year":"2004","unstructured":"Bhowmick NA, Neilson EG, Moses HL (2004) Stromal fibroblasts in cancer initiation and progression. Nature 432: 332\u2013337","journal-title":"Nature"},{"key":"BF6605652_CR3","first-page":"S377","volume":"106","author":"DP Carbone","year":"1994","unstructured":"Carbone DP, Mitsudomi T, Chiba I, Piantadosi S, Rusch V, Nowak JA, McIntire D, Slamon D, Gazdar A, Minna J (1994) p53 immunostaining positivity is associated with reduced survival and is imperfectly correlated with gene mutations in resected non-small cell lung cancer. A preliminary report of LCSG 871. Chest 106: S377\u2013S381","journal-title":"Chest"},{"key":"BF6605652_CR4","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1006\/excr.2000.5133","volume":"264","author":"B Elenbaas","year":"2001","unstructured":"Elenbaas B, Weinberg RA (2001) Heterotypic signaling between epithelial tumor cells and fibroblasts in carcinoma formation. Exp Cell Res 264: 169\u2013184","journal-title":"Exp Cell Res"},{"key":"BF6605652_CR5","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1038\/nrm1175","volume":"4","author":"S Grunert","year":"2003","unstructured":"Grunert S, Jechlinger M, Beug H (2003) Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis. Nat Rev Mol Cell Biol 4: 657\u2013665","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BF6605652_CR6","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1196\/annals.1294.016","volume":"1014","author":"RB Hazan","year":"2004","unstructured":"Hazan RB, Qiao R, Keren R, Badano I, Suyama K (2004) Cadherin switch in tumor progression. Ann NY Acad Sci 1014: 155\u2013163","journal-title":"Ann NY Acad Sci"},{"key":"BF6605652_CR7","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1016\/j.cell.2005.09.030","volume":"123","author":"R Hill","year":"2005","unstructured":"Hill R, Song Y, Cardiff R, Van Dyke T (2005) Selective evolution of stromal mesenchyme with p53 loss in response to epithelial tumorigenesis. Cell 123: 1001\u20131011","journal-title":"Cell"},{"key":"BF6605652_CR8","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1172\/JCI0215518","volume":"110","author":"M Iwano","year":"2002","unstructured":"Iwano M, Plieth D, Danoff TM, Xue C, Okada H, Neilson EG (2002) Evidence that fibroblasts derive from epithelium during tissue fibrosis. J Clin Invest 110: 341\u2013350","journal-title":"J Clin Invest"},{"key":"BF6605652_CR9","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1038\/nrc1877","volume":"6","author":"R Kalluri","year":"2006","unstructured":"Kalluri R, Zeisberg M (2006) Fibroblasts in cancer. Nat Rev Cancer 6: 392\u2013401","journal-title":"Nat Rev Cancer"},{"key":"BF6605652_CR10","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1158\/0008-5472.CAN-04-3791","volume":"65","author":"H Kiaris","year":"2005","unstructured":"Kiaris H, Chatzistamou I, Trimis G, Frangou-Plemmenou M, Pafiti-Kondi A, Kalofoutis A (2005) Evidence for nonautonomous effect of p53 tumor suppressor in carcinogenesis. Cancer Res 65: 1627\u20131630","journal-title":"Cancer Res"},{"key":"BF6605652_CR11","doi-asserted-by":"publisher","first-page":"13180","DOI":"10.1073\/pnas.0605669103","volume":"103","author":"KK Kim","year":"2006","unstructured":"Kim KK, Kugler MC, Wolters PG, Robillard L, Galvez MG, Brumwell AN, Sheppard D, Chapman HA (2006) Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix. Proc Natl Acad Sci USA 103: 13180\u201313185","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF6605652_CR12","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1016\/j.cell.2008.03.027","volume":"133","author":"SA Mani","year":"2008","unstructured":"Mani SA, Guo W, Liao M-J, Eaton EN, Ayyanan A, Zhou AY, Brooks M, Reinhard F, Zhang CC, Shipitsin M, Campbell LL, Polyak K, Brisken C, Yang J, Weinberg RA (2008) The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 133: 704\u2013715","journal-title":"Cell"},{"key":"BF6605652_CR13","doi-asserted-by":"publisher","first-page":"2100","DOI":"10.1200\/JCO.1999.17.7.2100","volume":"17","author":"M Monzo","year":"1999","unstructured":"Monzo M, Rosell R, Felip E, Astudillo J, Sanchez JJ, Maestre J, Martin C, Font A, Barnadas A, Abad A (1999) A novel anti-apoptosis gene: reexpression of survivin messenger RNA as a prognosis marker in nonsmall-cell lung cancers. J Clin Oncol 17: 2100\u20132104","journal-title":"J Clin Oncol"},{"key":"BF6605652_CR14","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1038\/nrc1477","volume":"4","author":"MM Mueller","year":"2004","unstructured":"Mueller MM, Fusenig NE (2004) Friends or foes \u2013 bipolar effects of the tumour stroma in cancer. Nature Rev Cancer 4: 839\u2013849","journal-title":"Nature Rev Cancer"},{"key":"BF6605652_CR15","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/0014-4800(90)90007-Z","volume":"52","author":"D Oda","year":"1990","unstructured":"Oda D, Gown AM, Vande Berg JS, Stern R (1990) Instability of the myofibroblasts phenotype in culture. Exp Mol Pathol 52: 221\u2013234","journal-title":"Exp Mol Pathol"},{"key":"BF6605652_CR16","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1097\/01.coc.0000128864.15609.5b","volume":"27","author":"F Oshita","year":"2004","unstructured":"Oshita F, Ito H, Ikehara M, Ohgane N, Hamanaka N, Nakayama H, Saito H, Yamada K, Noda K, Mitsuda A, Kameda Y (2004) Prognostic impact of survivin, cyclin D1, Integrin beta1, and VEGF in patients with small adenocarcinoma of stage I lung cancer. Am J Clin Oncol 27: 425\u2013428","journal-title":"Am J Clin Oncol"},{"key":"BF6605652_CR17","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1242\/jcs.01635","volume":"118","author":"S Parrinello","year":"2005","unstructured":"Parrinello S, Coppe1 J-P, Krtolica1 A, Campisi J (2005) Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation. J Cell Sci 118: 485\u2013496","journal-title":"J Cell Sci"},{"key":"BF6605652_CR18","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/0003-2697(90)90382-J","volume":"191","author":"R Rago","year":"1990","unstructured":"Rago R, Mitchen J, Wilding G (1990) DNA fluorometric assay in 96-well tissue culture plates using Hoechst 33258 after cell lysis by freezing in distilled water. Anal Biochem 191: 31\u201334","journal-title":"Anal Biochem"},{"key":"BF6605652_CR19","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1083\/jcb.134.1.67","volume":"134","author":"L R\u00f8nnov-Jessen","year":"1996","unstructured":"R\u00f8nnov-Jessen L, Petersen OW (1996) A function for filamentous alpha-smooth muscle actin: retardation of motility in fibroblasts. J Cell Biol 134: 67\u201380","journal-title":"J Cell Biol"},{"key":"BF6605652_CR20","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1172\/JCI117736","volume":"95","author":"L R\u00f8nnov-Jessen","year":"1995","unstructured":"R\u00f8nnov-Jessen L, Petersen OW, Koteliansky VE, Bissel MJ (1995) The origin of the myofibroblasts in breast cancer. Recapitulation of tumor environment in culture unravels diversity and implicates converted fibroblasts and recruited smooth muscle cells. J Clin Invest 95: 859\u2013873","journal-title":"J Clin Invest"},{"key":"BF6605652_CR21","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1165\/rcmb.2007-0071OC","volume":"38","author":"Y Shintani","year":"2008","unstructured":"Shintani Y, Maeda M, Chaika N, Johnson KR, Wheelock MJ (2008) Collagen I promotes EMT in lung cancer cells via TGF-beta3 signaling. Am J Respir Cell Mol Biol 38: 95\u2013104","journal-title":"Am J Respir Cell Mol Biol"},{"key":"BF6605652_CR22","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1038\/nrc822","volume":"2","author":"JP Thiery","year":"2002","unstructured":"Thiery JP (2002) Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2: 442\u2013454","journal-title":"Nat Rev Cancer"},{"key":"BF6605652_CR23","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/S0959-437X(00)00156-8","volume":"11","author":"TD Tlsty","year":"2001","unstructured":"Tlsty TD, Hein PW (2001) Know thy neighbor: stromal cells can contribute oncogenic signals. Curr Opin Genet Dev 11: 54\u201359","journal-title":"Curr Opin Genet Dev"},{"key":"BF6605652_CR24","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1002\/humu.10177","volume":"21","author":"S Toyooka","year":"2003","unstructured":"Toyooka S, Tsuda T, Gazdar A (2003) The TP53 gene, tobacco exposure, and lung cancer. Hum Mutat 21: 229\u2013239","journal-title":"Hum Mutat"},{"key":"BF6605652_CR25","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1007\/s10585-008-9167-1","volume":"25","author":"A Wells","year":"2008","unstructured":"Wells A, Yates C, Shepard CK (2008) E-cadherin as an indicator of mesenchymal to epithelial reverting transitions during the metastatic seeding of disseminated carcinomas. Clin Exp Metastasis 25: 621\u2013628","journal-title":"Clin Exp Metastasis"},{"key":"BF6605652_CR26","first-page":"2931","volume":"4","author":"II Wistuba","year":"1998","unstructured":"Wistuba II, Behrens C, Milchgrub S, Syed S, Ahmadian M, Virmani AK, Kurvari V, Cunningham TH, Ashfaq R, Minna JD, Gazdar AF (1998) Comparison of features of human breast cancer cell lines and their corresponding tumors. Clin Cancer Res 4: 2931\u20132938","journal-title":"Clin Cancer Res"},{"key":"BF6605652_CR27","first-page":"991","volume":"5","author":"II Wistuba","year":"1999","unstructured":"Wistuba II, Bryant D, Behrens C, Milchgrub S, Virmani AK, Ashfaq R, Minna JD, Gazdar AF (1999) Comparison of features of human lung cancer cell lines and their corresponding tumors. Clin Cancer Res 5: 991\u20131000","journal-title":"Clin Cancer Res"},{"key":"BF6605652_CR28","first-page":"1527","volume":"4","author":"T Yamada","year":"1998","unstructured":"Yamada T, Nakamori S, Ohzato H, Oshima S, Aoki T, Higaki N, Sugimoto K, Akagi K, Fujiwara Y, Nishisho I, Sakon M, Gotoh M, Monden M (1998) Detection of K-ras gene mutations in plasma DNA of patients with pancreatic adenocarcinoma: correlation with clinicopathological features. Clin Cancer Res 4: 1527\u20131532","journal-title":"Clin Cancer Res"},{"key":"BF6605652_CR29","doi-asserted-by":"publisher","first-page":"3392","DOI":"10.1158\/0008-5472.CAN-05-4537","volume":"66","author":"F Xia","year":"2006","unstructured":"Xia F, Altieri DC (2006) Mitosis-independent Survivin gene expression in vivo and regulation by p53. Cancer Res 66: 3392\u20133395","journal-title":"Cancer Res"}],"container-title":["British Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/6605652.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/6605652","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/6605652.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T12:44:56Z","timestamp":1684413896000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/6605652"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4,20]]},"references-count":29,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["BF6605652"],"URL":"https:\/\/doi.org\/10.1038\/sj.bjc.6605652","relation":{},"ISSN":["0007-0920","1532-1827"],"issn-type":[{"value":"0007-0920","type":"print"},{"value":"1532-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,4,20]]}}}