{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T17:50:34Z","timestamp":1778953834471,"version":"3.51.4"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2010,12,21]],"date-time":"2010-12-21T00:00:00Z","timestamp":1292889600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Cancer"],"published-print":{"date-parts":[[2011,2]]},"DOI":"10.1038\/sj.bjc.6606057","type":"journal-article","created":{"date-parts":[[2010,12,21]],"date-time":"2010-12-21T20:57:25Z","timestamp":1292965045000},"page":"460-463","source":"Crossref","is-referenced-by-count":37,"title":["Toll-like receptor 2 is present in the microenvironment of oral squamous cell carcinoma"],"prefix":"10.1038","volume":"104","author":[{"given":"L K","family":"Ng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A M","family":"Rich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H M","family":"Hussaini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W M","family":"Thomson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A L","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L S","family":"Horne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G J","family":"Seymour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,12,21]]},"reference":[{"key":"BF6606057_CR1","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/nri1391","volume":"4","author":"S Akira","year":"2004","unstructured":"Akira S, Takeda K (2004) Toll-like receptor signalling. Nat Rev Immunol 4: 499\u2013511","journal-title":"Nat Rev Immunol"},{"key":"BF6606057_CR2","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1038\/90609","volume":"2","author":"S Akira","year":"2001","unstructured":"Akira S, Takeda K, Kaisho T (2001) Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol 2: 675\u2013680","journal-title":"Nat Immunol"},{"key":"BF6606057_CR3","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1038\/nm1622","volume":"13","author":"L Apetoh","year":"2007","unstructured":"Apetoh L, Ghiringhelli F, Tesniere A, Obeid M, Ortiz C, Criollo A, Mignot G, Maiuri MC, Ullrich E, Saulnier P, Yang H, Amigorena S, Ryffel B, Barrat FJ, Saftig P, Levi F, Lidereau R, Nogues C, Mira JP, Chompret A, Joulin V, Clavel-Chapelon F, Bourhis J, Andr\u00e9 F, Delaloge S, Tursz T, Kroemer G, Zitvogel L (2007) Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nat Med 13: 1050\u20131059","journal-title":"Nat Med"},{"key":"BF6606057_CR4","first-page":"2488","volume":"56","author":"J Califano","year":"1996","unstructured":"Califano J, Riet PVD, Westra W, Nawroz H, Clayman G, Piantadosi S, Corio R, Lee D, Greenberg B, Koch W, Sidransky D (1996) Genetic progression model for head and neck cancer: Implications for field cancerization. Cancer Research 56: 2488\u20132492","journal-title":"Cancer Research"},{"key":"BF6606057_CR5","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1111\/j.1600-0897.2006.00441.x","volume":"57","author":"R Chen","year":"2007","unstructured":"Chen R, Alvero AB, Silasi D, Mor G (2007) Inflammation, cancer and chemoresistance: taking advantage of the Toll-like receptor signalling pathway. Amer J Reprod Immunol 57: 93\u2013107","journal-title":"Amer J Reprod Immunol"},{"key":"BF6606057_CR6","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1038\/sj.onc.1210907","volume":"27","author":"R Chen","year":"2008","unstructured":"Chen R, Alvero AB, Silasi D, Steffensen KD, Mor G (2008) Cancers take their toll- the function and regulation of toll-like receptors in cancer cells. Oncogene 27: 225\u2013233","journal-title":"Oncogene"},{"key":"BF6606057_CR7","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1038\/sj.onc.1210910","volume":"27","author":"H Conroy","year":"2008","unstructured":"Conroy H, Marshall NA, Mills KHG (2008) TLR ligand suppression or enhancement of Treg cells? A double-edged sword in immunity to tumours. Oncogene 27: 168\u2013180","journal-title":"Oncogene"},{"key":"BF6606057_CR8","doi-asserted-by":"publisher","first-page":"2836","DOI":"10.1158\/1078-0432.CCR-06-1953","volume":"13","author":"JE Ellerman","year":"2007","unstructured":"Ellerman JE, Brown CK, de Vera M, Zeh HJ, Billiar T, Rubartelli A, Lotze MT (2007) Masquerader: high mobility group box-1 and cancer. Clin Cancer Res 13: 2836\u20132848","journal-title":"Clin Cancer Res"},{"key":"BF6606057_CR9","doi-asserted-by":"publisher","first-page":"3642","DOI":"10.1158\/1535-7163.MCT-08-0582","volume":"7","author":"Y Goto","year":"2008","unstructured":"Goto Y, Arigami T, Kitago M, Nguyen SL, Narita N, Ferrone S, Morton DL, Irie RF, Hoon DS (2008) Activation of Toll-like receptors 2, 3, and 4 on human melanoma cells induces inflammatory factors. Mol Cancer Ther 7: 3642\u20133653","journal-title":"Mol Cancer Ther"},{"key":"BF6606057_CR10","doi-asserted-by":"publisher","first-page":"2850","DOI":"10.1016\/j.molimm.2007.01.022","volume":"44","author":"W He","year":"2007","unstructured":"He W, Liu Q, Wang L, Chen W, Li N, Cao X (2007) TLR4 signalling promotes immune escape of human lung cancer cells by inducing immunosuppressive cytokines and apoptosis resistance. Mol Immunol 44: 2850\u20132859","journal-title":"Mol Immunol"},{"key":"BF6606057_CR11","doi-asserted-by":"publisher","first-page":"5009","DOI":"10.1158\/0008-5472.CAN-05-0784","volume":"65","author":"B Huang","year":"2005","unstructured":"Huang B, Zhao J, Li H, He KL, Chen Y, Mayer L, Unkeless JC, Xiong H (2005) Toll-like receptors on tumour cells facilitate evasion of immune surveillance. Cancer Res 65: 5009\u20135014","journal-title":"Cancer Res"},{"key":"BF6606057_CR12","doi-asserted-by":"publisher","first-page":"4346","DOI":"10.1158\/0008-5472.CAN-06-4067","volume":"67","author":"B Huang","year":"2007","unstructured":"Huang B, Zhao J, Shen S, Li H, He KL, Shen GX, Mayer L, Unkeless J, Li D, Yuan Y, Zhang G, Xiong H, Feng Z (2007) Listeria monocytogenes promotes tumour growth via tumour cell toll-like receptor 2 signalling. Cancer Res 67: 4346\u20134352","journal-title":"Cancer Res"},{"key":"BF6606057_CR13","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1038\/sj.onc.1210904","volume":"27","author":"B Huang","year":"2008","unstructured":"Huang B, Zhao J, Unkeless JC, Feng ZH, Xiong H (2008) TLR signalling by tumor and immune cells: A double-edged sword. Oncogene 27: 218\u2013224","journal-title":"Oncogene"},{"key":"BF6606057_CR14","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1111\/j.1601-0825.1997.tb00018.x","volume":"3","author":"D Kerdpon","year":"1997","unstructured":"Kerdpon D, Rich AM, Reade PC (1997) Expression of p53 in oral mucosal hyperplasia, dysplasia and squamous cell carcinoma. Oral Diseases 3: 86\u201392","journal-title":"Oral Diseases"},{"key":"BF6606057_CR15","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1038\/sj.bjc.6603275","volume":"95","author":"SD Killeen","year":"2006","unstructured":"Killeen SD, Wang JH, Andrews EJ, Redmond HP (2006) Exploitation of the toll-like receptor system in cancer: a double-edged sword? Brit J Cancer 95: 247\u2013252","journal-title":"Brit J Cancer"},{"key":"BF6606057_CR16","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1007\/s10156-008-0596-1","volume":"14","author":"Y Kumagai","year":"2008","unstructured":"Kumagai Y, Takeuchi O, Akira S (2008) Pathogen recognition by innate receptors. J Infect Chemother 14: 86\u201392","journal-title":"J Infect Chemother"},{"key":"BF6606057_CR17","first-page":"213","volume":"2","author":"K Liu","year":"2006","unstructured":"Liu K (2006) Dendritic cell, toll-like receptor and the immune system. J Cancer Molecules 2: 213\u2013215","journal-title":"J Cancer Molecules"},{"key":"BF6606057_CR18","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1111\/j.1600-065X.2007.00579.x","volume":"220","author":"MT Lotze","year":"2007","unstructured":"Lotze MT, Zeh HJ, Rubartelli A, Sparvero LJ, Amoscato AA, Washburn NR, Devera ME, Liang X, Tor M, Billiar T (2007) The grateful dead: damage-associated molecular pattern molecules and reduction\/oxidation regulate immunity. Immunol Rev 220: 60\u201381","journal-title":"Immunol Rev"},{"key":"BF6606057_CR19","doi-asserted-by":"publisher","first-page":"S205","DOI":"10.1007\/s12307-009-0022-y","volume":"2","author":"Y Sato","year":"2009","unstructured":"Sato Y, Goto Y, Narita N, Hoon DSB (2009) Cancer cells expressing toll-like receptors and the tumor microenvironment. Cancer Microenviron 2: S205\u2013S214","journal-title":"Cancer Microenviron"},{"key":"BF6606057_CR20","doi-asserted-by":"publisher","first-page":"2568","DOI":"10.1158\/0008-5472.CAN-08-3199","volume":"69","author":"JJ Sheu","year":"2009","unstructured":"Sheu JJ, Hua CH, Wan L, Lin WJ, Lai MT, Tseng HC, Jinawath N, Tsai MH, Chang NW, Lin CF, Lin CC, Hsieh LJ, Wang TL, Shih IeM, Tsai FJ (2009) Functional genomic analysis identified epidermal growth factor receptor activation as the most common genetic event in oral squamous cell carcinoma. Cancer Res 69: 2568\u20132576","journal-title":"Cancer Res"},{"key":"BF6606057_CR21","doi-asserted-by":"publisher","first-page":"3105","DOI":"10.1158\/0008-5472.CAN-08-3838","volume":"69","author":"MJ Szczepanski","year":"2009","unstructured":"Szczepanski MJ, Czystowska M, Szajnik M, Harasymczuk M, Boyiadzis M, Kruk-Zagajewska A, Szyfter W, Zeromski J, Whiteside TL (2009) Triggering of toll-like receptor 4 expressed on human head and neck squamous cell carcinoma promotes tumor development and protects the tumor from immune attack. Cancer Res 69: 3105\u20133113","journal-title":"Cancer Res"},{"key":"BF6606057_CR22","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1007\/s00405-006-0215-7","volume":"264","author":"MJ Szczepanski","year":"2007","unstructured":"Szczepanski MJ, Stelmachowska M, Stryczynski L, Golusinski W, Samara H, Mozer-Lisewska I, Zeromski J (2007) Assessment of expression of toll-like receptors 2, 3 and 4 in laryngeal carcinoma. Eur Arch Otorhinolaryngol 264: 525\u2013530","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"BF6606057_CR23","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1158\/1940-6207.CAPR-08-0123","volume":"1","author":"IFL Tsui","year":"2008","unstructured":"Tsui IFL, Rosin MP, Zhang L, Ng RT, Lam WL (2008) Multiple aberrations of chromosome 3p detected in oral premalignant lesions. Cancer Prev Res 1: 424\u2013429","journal-title":"Cancer Prev Res"},{"key":"BF6606057_CR24","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1038\/sj.onc.1210906","volume":"27","author":"R-F Wang","year":"2008","unstructured":"Wang R-F, Miyahara Y, Wang HY (2008) Toll-like receptors and immune regulation: Implications for cancer therapy. Oncogene 27: 181\u2013189","journal-title":"Oncogene"},{"key":"BF6606057_CR25","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1016\/j.bbrc.2009.01.009","volume":"379","author":"W Xie","year":"2009","unstructured":"Xie W, Wang Y, Huang Y, Yang H, Wang J, Hu Z (2009) Toll-like receptor 2 mediates invasion via activating NF-kappaB in MDA-MB-231 breast cancer cells. Biochem Biophys Res Commun 379: 1027\u20131032","journal-title":"Biochem Biophys Res Commun"}],"container-title":["British Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/6606057.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/6606057","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/6606057.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T12:48:51Z","timestamp":1684414131000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/6606057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12,21]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["BF6606057"],"URL":"https:\/\/doi.org\/10.1038\/sj.bjc.6606057","relation":{},"ISSN":["0007-0920","1532-1827"],"issn-type":[{"value":"0007-0920","type":"print"},{"value":"1532-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,21]]}}}