{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T21:00:51Z","timestamp":1773694851494,"version":"3.50.1"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[1998,12,11]],"date-time":"1998-12-11T00:00:00Z","timestamp":913334400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Cancer"],"published-print":{"date-parts":[[1999,1]]},"DOI":"10.1038\/sj.bjc.6690020","type":"journal-article","created":{"date-parts":[[2002,9,4]],"date-time":"2002-09-04T15:04:11Z","timestamp":1031151851000},"page":"114-118","source":"Crossref","is-referenced-by-count":59,"title":["Combination oral antiangiogenic therapy with thalidomide and sulindac inhibits tumour growth in rabbits"],"prefix":"10.1038","volume":"79","author":[{"given":"H M W","family":"Verheul","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Panigrahy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R J","family":"D\u2019Amato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[1998,12,11]]},"reference":[{"key":"BF6690020_CR1","first-page":"5049","volume":"55","author":"P Bossi","year":"1995","unstructured":"Bossi, P., Viale, G., Lee, A. K. C., Alfano, R. M., Coggi, G. & Bosari, S. (1995). Angiogenesis in colorectal tumors: microvessel quantitation in adenomas and carcinomas with clinicopathological correlations. Cancer Res 55: 5049\u20135053.","journal-title":"Cancer Res"},{"key":"BF6690020_CR2","first-page":"4267","volume":"57","author":"C Chiu","year":"1997","unstructured":"Chiu, C., McEntee, M. F. & Whelan, J. (1997). Sulindac causes rapid regression of preexisting tumors in Min\/+ mice, independent of prostaglandin biosynthesis. Cancer Res 57: 4267\u20134273.","journal-title":"Cancer Res"},{"key":"BF6690020_CR3","doi-asserted-by":"publisher","first-page":"4082","DOI":"10.1073\/pnas.91.9.4082","volume":"91","author":"RJ D\u2019Amato","year":"1994","unstructured":"D\u2019Amato, R. J., Loughnan, M. S., Flynn, E. & Folkman, J. (1994). Thalidomide is an inhibitor of angiogenesis. Proc Natl Acad Sci USA 91: 4082\u20134085.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF6690020_CR4","first-page":"8","volume":"201","author":"DE Duggan","year":"1977","unstructured":"Duggan, D. E., Hooke, K. F., Risley, E. A., Shen, T. Y. & Van Arman, C. G. (1977). Identification of the biologically active form of sulindac. J Pharm Exp Ther 201: 8\u201313.","journal-title":"J Pharm Exp Ther"},{"key":"BF6690020_CR5","first-page":"85","volume-title":"In Thalidomide: Potential Benefits and Risks, Open Public Scientific Workshop","author":"HA Fine","year":"1997","unstructured":"Fine, H. A. (1997). A phase II trial of the antiangiogenic agent thalidomide in patients with recurrent high-grade gliomas (abstract). In Thalidomide: Potential Benefits and Risks, Open Public Scientific Workshop, p. 85. National Institute of Health: Bethesda MD"},{"key":"BF6690020_CR6","doi-asserted-by":"publisher","first-page":"96","DOI":"10.7326\/0003-4819-82-1-96","volume":"82","author":"J Folkman","year":"1975","unstructured":"Folkman, J. (1975). Tumor angiogenesis: a possible control point in tumor growth. Ann Intern Med 82: 96\u2013100.","journal-title":"Ann Intern Med"},{"key":"BF6690020_CR7","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1093\/jnci\/82.1.4","volume":"82","author":"J Folkman","year":"1989","unstructured":"Folkman, J. (1989). What is the evidence that tumors are angiogenesis dependent?. J Natl Cancer Inst 82: 4\u20136.","journal-title":"J Natl Cancer Inst"},{"key":"BF6690020_CR8","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/nm0195-27","volume":"1","author":"J Folkman","year":"1995","unstructured":"Folkman, J. (1995). Angiogenesis in cancer, vascular, rheumatoid and other disease. Nature Med 1: 27\u201331.","journal-title":"Nature Med"},{"key":"BF6690020_CR9","first-page":"3075","volume-title":"Cancer, Principles and Practice of Oncology","author":"J Folkman","year":"1997","unstructured":"Folkman, J. (1997). Antiangiogenic therapy. Cancer, Principles and Practice of Oncology, DeVita Jr VT, Hellman S, Rosenberg SA (eds). pp. 3075\u20133086, Lipincott Raven: New York"},{"key":"BF6690020_CR10","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1097\/00000658-198709000-00016","volume":"206","author":"J Folkman","year":"1987","unstructured":"Folkman, J. & Ingber, D. E. (1987). Angiostatic steroids: method of discovery and mechanism of action. Ann Surg 206: 374\u2013384.","journal-title":"Ann Surg"},{"key":"BF6690020_CR11","first-page":"2419","volume":"44","author":"AM Fulton","year":"1984","unstructured":"Fulton, A. M. (1984). In vivo effects of indomethacin on the growth of murine mammary tumors. Cancer Res 44: 2419\u20132420.","journal-title":"Cancer Res"},{"key":"BF6690020_CR12","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1056\/NEJM199305063281805","volume":"328","author":"FM Giardiello","year":"1993","unstructured":"Giardiello, F. M., Hamilton, S. R., Krush, A. J., Piantodosi, S., Hylind, L. M., Cleano, P., Banker, S. V., Robinson, C. R. & Offerhaus, G. J. (1993). Treatment of colonic rectal adenomas with sulindac in familial adenomatous polyposis. N Engl J Med 328: 1313\u20131316.","journal-title":"N Engl J Med"},{"key":"BF6690020_CR13","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1073\/pnas.78.2.1176","volume":"78","author":"J Gross","year":"1981","unstructured":"Gross, J., Azizkhan, R. G., Biswas, C., Bruns, R. R., Hsieh, D. S. T. & Folkman, J. (1981). Inhibition of tumor growth, vasularization, and collagenolysis in the rabbit cornea by medroxyprogesterone. Proc Natl Acad Sci USA 78: 1176\u20131180.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF6690020_CR14","first-page":"3673","volume":"16","author":"M Gutman","year":"1996","unstructured":"Gutman, M., Szold, A., Ravid, A., Lazouskas, T., Merimsky, O. & Klausner, J. M. (1996). Failure of thalidomide to inhibit tumor growth and angiogenesis in vivo. Anticancer Res 16: 3673\u20133678.","journal-title":"Anticancer Res"},{"key":"BF6690020_CR15","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/0006-2952(96)00181-5","volume":"52","author":"R Hanif","year":"1996","unstructured":"Hanif, R., Pittas, A., Feng, Y., Koutsos, M. I., Qiao, L., Staiano-Coico, L., Shiff, S. I. & Rigos, B. (1996). Effects of nonsteroidal anti-inflammatory drugs on proliferation and on induction of apoptosis in colon cancer cells by a prostaglandin-independent pathway. Biochem Pharmacol 52: 237\u2013245.","journal-title":"Biochem Pharmacol"},{"key":"BF6690020_CR16","first-page":"1588","volume":"30","author":"WL Haynes","year":"1989","unstructured":"Haynes, W. L., Proia, A. D. & Klintworth, G. K. (1989). Effect of inhibitors of arachidonic acid metabolism on corneal neovascularization in the rat. Invest Ophthalmol Vis Sci 30: 1588\u20131593.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BF6690020_CR17","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1136\/gut.37.2.191","volume":"37","author":"N Hudson","year":"1995","unstructured":"Hudson, N., Balsitis, M., Everitt, S. & Hawkey, C. J. (1995). Angiogenesis in gastric ulcers: impaired in patients taking non-steroidal anti-inflammatory drugs. Gut 37: 191\u2013194.","journal-title":"Gut"},{"key":"BF6690020_CR18","first-page":"617","volume-title":"The Pharmacological Basis of Therapeutics","author":"PA Insel","year":"1996","unstructured":"Insel, P. A. (1996). Analgesic\u2013antipyretic and antiinflammatory agents and drugs employed in the treatment of gout. The Pharmacological Basis of Therapeutics, Hardman JG, Limbird LE (eds). 617\u2013658, The McGraw-Hill Companies: New York"},{"key":"BF6690020_CR19","first-page":"469","volume":"264","author":"S Kamei","year":"1993","unstructured":"Kamei, S., Okada, H., Inoue, Y., Yoshioka, T., Ogawa, Y. & Toguchi, H. (1993). Antitumor effects of angiogenesis inhibitor TNP-470 in rabbits bearing VX-2 carcinoma by arterial administration of microspheres and oil solution. J Pharm Exp Ther 264: 469\u2013474.","journal-title":"J Pharm Exp Ther"},{"key":"BF6690020_CR20","doi-asserted-by":"publisher","first-page":"12042","DOI":"10.1074\/jbc.271.20.12042","volume":"271","author":"S Karim","year":"1995","unstructured":"Karim, S., Habib, A., Levy-Toledano, S. & Maclouf, J. (1995). Cyclooxygenases-1 and -2 of endothelial cells utilize exogenous or endogenous arachidonic acid for transcellular production of thromboxane. J Biol Chem 271: 12042\u201312048.","journal-title":"J Biol Chem"},{"key":"BF6690020_CR21","first-page":"1625","volume":"37","author":"BM Kenyon","year":"1996","unstructured":"Kenyon, B. M., Voest, E. E., Chen, C., Flynn, E., Folkman, J. & D\u2019Amato, R. J. (1996). A model of angiogenesis in the mouse cornea. Invest Ophthalmol Vis Sci 37: 1625\u20131632.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BF6690020_CR22","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1006\/exer.1997.0292","volume":"64","author":"BM Kenyon","year":"1997","unstructured":"Kenyon, B. M., Browne, F. & D\u2019Amato, R. J. (1997). Effects of thalidomide and related metabolites in a mouse corneal model of neovascularization. Exp Eye Res 64: 971\u2013978.","journal-title":"Exp Eye Res"},{"key":"BF6690020_CR23","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1084\/jem.71.6.813","volume":"71","author":"JG Kidd","year":"1940","unstructured":"Kidd, J. G. & Rous, P. (1940). A transplantable rabbit carcinoma originating in a virus-induced papilloma and containing the virus in masked or altered form. J Exp Med 71: 813\u2013838.","journal-title":"J Exp Med"},{"key":"BF6690020_CR24","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/0016-5085(91)90519-Q","volume":"101","author":"D Labayle","year":"1991","unstructured":"Labayle, D., Fischer, D., Vielh, P., Drouhin, F., Pariente, A., Bories, C., Duhamel, A., Transset, M. & Attali, P. (1991). Sulindac causes regression of rectal polyps in familial adenomatous polyposis. Gastroenterology 101: 635\u2013639.","journal-title":"Gastroenterology"},{"key":"BF6690020_CR25","first-page":"91","volume-title":"Thalidomide: Potential Benefits and Risks, Open Public Scientific Workshop","author":"R Little","year":"1997","unstructured":"Little, R., Welles, L., Wyvill, K., Pluda, J., Figg, W., Tosato, G. & Yarchoan, R. (1997). Preliminary results of a phase II dose titration study of oral thalidomide in patients with HIV infection and Kaposi\u2019s sarcoma (abstract). Thalidomide: Potential Benefits and Risks, Open Public Scientific Workshop, 91. National Institute of Health: Bethesda"},{"key":"BF6690020_CR26","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1038\/bjc.1978.237","volume":"38","author":"NR Lynch","year":"1978","unstructured":"Lynch, N. R., Castes, M., Astoin, M. & Salomon, J. C. (1978). Mechanism of inhibition of tumour growth by aspirin and indomethacin. Br J Cancer 38: 503\u2013512.","journal-title":"Br J Cancer"},{"key":"BF6690020_CR27","first-page":"5575","volume":"52","author":"LJ Marnett","year":"1992","unstructured":"Marnett, L. J. (1992). Aspirin and the potential role of prostaglandins in colon cancer. Cancer Res 52: 5575\u20135589.","journal-title":"Cancer Res"},{"key":"BF6690020_CR28","doi-asserted-by":"crossref","first-page":"6610","DOI":"10.1016\/S0021-9258(18)53294-4","volume":"268","author":"EA Meade","year":"1993","unstructured":"Meade, E. A., Smith, W. L. & DeWitt, D. L. (1993). Differential inhibition of prostaglandin endoperoxide synthetase (cyclooygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs. J Biol Chem 268: 6610\u20136614.","journal-title":"J Biol Chem"},{"key":"BF6690020_CR29","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1097\/00001813-199605000-00015","volume":"7","author":"AI Minchinton","year":"1996","unstructured":"Minchinton, A. I., Fryer, K. H., Wendt, K. R., Clow, K. A. & Hayes, M. M. M. (1996). The effect of thalidomide on experimental tumors and metastases. Anticancer Drugs 7: 339\u2013343.","journal-title":"Anticancer Drugs"},{"key":"BF6690020_CR30","doi-asserted-by":"publisher","first-page":"11693","DOI":"10.1073\/pnas.90.24.11693","volume":"90","author":"JA Mitchell","year":"1993","unstructured":"Mitchell, J. A., Akarasereenont, P., Thiemermann, C., Flower, R. J. & Vane, J. R. (1993). Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc Natl Acad Sci USA 90: 11693\u201311697.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF6690020_CR31","first-page":"251","volume":"6","author":"H Peterson","year":"1996","unstructured":"Peterson, H. (1996). Tumor angiogenesis inhibition by prostaglandin synthetase inhibitors. Anticancer Res 6: 251\u2013254.","journal-title":"Anticancer Res"},{"key":"BF6690020_CR32","first-page":"3110","volume":"55","author":"GA Piazza","year":"1997","unstructured":"Piazza, G. A., Rahm, A. L., Krutzsch, M., Sperl, G., Paranka, N. S., Gross, P. H., Brendel, K., Burt, R. W., Alberts, O. S. & Paniukou, R. (1997). Antineoplastic drugs sulindac sulfide and sulfone inhibit cell growth by inducing apoptosis. Cancer Res 55: 3110\u20133116.","journal-title":"Cancer Res"},{"key":"BF6690020_CR33","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1016\/S0140-6736(62)92122-0","volume":"2","author":"G Pliess","year":"1962","unstructured":"Pliess, G. (1962). Thalidomide and congenital abnormalities. Lancet 2: 1128\u20131129.","journal-title":"Lancet"},{"key":"BF6690020_CR34","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1001\/archopht.1995.01100020106040","volume":"113","author":"T Sakamoto","year":"1995","unstructured":"Sakamoto, T., Soriano, D., Nassaralla, J., Murphy, T. L., Oganesian, A., Spee, C., Hinton, D. R. & Ryan, S. J. (1995). Effect of intravitreal administration of indomethacin on experimental subretinal neovascularization in the subhuman primate. Arch Ophthamol 113: 222\u2013226.","journal-title":"Arch Ophthamol"},{"key":"BF6690020_CR35","first-page":"338","volume":"25","author":"H Schumacher","year":"1965","unstructured":"Schumacher, H., Smith, R. L. & Williams, R. T. (1965). Metabolism of thalidomide: the fate of thalidomide and some of its hydrolysis products in various species. Br J Pharmacol 25: 338\u2013351.","journal-title":"Br J Pharmacol"},{"key":"BF6690020_CR36","first-page":"201","volume":"160","author":"H Schumacher","year":"1968","unstructured":"Schumacher, H., Blake, D. A. & Gilette, J. R. (1968). Disposition of thalidomide in rabbits and rats. J Pharm Exp Ther 160: 201\u2013211.","journal-title":"J Pharm Exp Ther"},{"key":"BF6690020_CR37","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/S0006-291X(88)81229-4","volume":"153","author":"KJ Silverman","year":"1988","unstructured":"Silverman, K. J., Lund, D. P., Zetter, B. R., Lainey, L. L., Shahood, J. A., Freiman, D. G., Folkman, J. & Burger, A. C. (1988). Angiogenic activity of adipose tissue. Biochem Biophys Res Commun 153: 347\u2013352.","journal-title":"Biochem Biophys Res Commun"},{"key":"BF6690020_CR38","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1111\/j.1749-6632.1994.tb52723.x","volume":"744","author":"WL Smith","year":"1994","unstructured":"Smith, W. L., Meade, E. A. & DeWitt, D. L. (1994). Interactions of PGH synthase isozymes-1 and -2 with NSAIDs. Ann NY Acad Sci 744: 50\u201357.","journal-title":"Ann NY Acad Sci"},{"key":"BF6690020_CR39","first-page":"1823","volume":"28","author":"KT Szabo","year":"1967","unstructured":"Szabo, K. T. & Steelman, R. L. (1967). Effects of maternal thalidomide treatment on pregnancy, fetal development, and mortality of the offspring in random-bred mice. Am J Vet Res 28: 1823\u20131828.","journal-title":"Am J Vet Res"},{"key":"BF6690020_CR40","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1161\/01.ATV.14.5.734","volume":"14","author":"H Tanaka","year":"1994","unstructured":"Tanaka, H., Sukhova, G. K. & Libby, P. (1994). Interaction of the allogeneic state and hypercholesterolemia in arterial lesion formation in experimental cardiac allografts. Arteriosclerosis Thromb 14: 734\u2013745.","journal-title":"Arteriosclerosis Thromb"},{"key":"BF6690020_CR41","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1007\/BF00686511","volume":"33","author":"BA Teicher","year":"1994","unstructured":"Teicher, B. A., Korbut, T. T., Menon, K., Holden, S. A. & Ara, G. (1994). Cyclooxygenase and lipoxygenase as modulators of cancer therapies. Cancer Chem Pharm 33: 515\u2013522.","journal-title":"Cancer Chem Pharm"},{"key":"BF6690020_CR42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1056\/NEJM199101033240101","volume":"324","author":"N Weidner","year":"1991","unstructured":"Weidner, N., Semple, J. P., Welch, W. R. & Folkman, J. (1991). Tumor angiogenesis and metastasis \u2013 correlation in invasive breast carcinoma. N Engl J Med 324: 1\u20138.","journal-title":"N Engl J Med"}],"container-title":["British Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/6690020.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/6690020","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/6690020.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T12:49:25Z","timestamp":1684414165000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/6690020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,12,11]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1999,1]]}},"alternative-id":["BF6690020"],"URL":"https:\/\/doi.org\/10.1038\/sj.bjc.6690020","relation":{},"ISSN":["0007-0920","1532-1827"],"issn-type":[{"value":"0007-0920","type":"print"},{"value":"1532-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,12,11]]}}}