{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T11:18:21Z","timestamp":1785842301996,"version":"3.56.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1-2","license":[{"start":{"date-parts":[[1999,3,26]],"date-time":"1999-03-26T00:00:00Z","timestamp":922406400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Cancer"],"published-print":{"date-parts":[[1999,4]]},"DOI":"10.1038\/sj.bjc.6690318","type":"journal-article","created":{"date-parts":[[2002,9,4]],"date-time":"2002-09-04T15:04:50Z","timestamp":1031151890000},"page":"38-43","source":"Crossref","is-referenced-by-count":22,"title":["In squamous cell carcinoma of the vulva, overexpression of p53 is a late event and neither p53 nor mdm2 expression is a useful marker to predict lymph node metastases"],"prefix":"10.1038","volume":"80","author":[{"given":"A G","family":"Emanuels","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Koudstaal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M P M","family":"Burger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Hollema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[1999,3,26]]},"reference":[{"key":"BF6690318_CR1","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1002\/j.1460-2075.1993.tb05678.x","volume":"12","author":"Y Barak","year":"1993","unstructured":"Barak, Y., Juven, T., Haffner, R. & Oren, M. (1993) mdm2 expression is induced by wild type p53 activity. EMBO J 12: 461\u2013468.","journal-title":"EMBO J"},{"key":"BF6690318_CR2","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1007\/BF00203389","volume":"427","author":"S Bosari","year":"1995","unstructured":"Bosari, S. & Viale, G. (1995) The clinical significance of p53 aberrations in human tumors. Virchows Arch 427: 229\u2013241.","journal-title":"Virchows Arch"},{"key":"BF6690318_CR3","first-page":"790","volume":"147","author":"S Bosari","year":"1995","unstructured":"Bosari, S., Viale, G., Roncalli, M., Graziani, D., Borsani, G., Lee, A. K. & Coggi, G. (1995) p53 gene mutations, p53 protein accumulation and compartmentalization in colorectal adenocarcinoma. Am J Pathol 147: 790\u2013798.","journal-title":"Am J Pathol"},{"key":"BF6690318_CR4","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/0046-8177(95)90032-2","volume":"26","author":"C Charpin","year":"1995","unstructured":"Charpin, C., Devictor, B., Andrac, L., Amabile, J., Bergeret, D., Allasia, C. & Piana L and LaVaut, M. N. (1995) p53 quantitative immunocytochemical analysis in breast carcinomas. Hum Pathol 26: 159\u2013166.","journal-title":"Hum Pathol"},{"key":"BF6690318_CR5","first-page":"716","volume":"59","author":"J Chu","year":"1982","unstructured":"Chu, J., Tamimi, H., Ek, M. & Figge, D. (1982) Stage I vulvar cancer: criteria for microinvasion. Obstet Gynecol 59: 716\u2013719.","journal-title":"Obstet Gynecol"},{"key":"BF6690318_CR6","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/0046-8177(95)90249-X","volume":"26","author":"LK Coulter","year":"1995","unstructured":"Coulter, L. K., Wolber, R. & Tron, V. A. (1995) Site-specific comparison of p53 immunostaining in squamous cell carcinomas. Hum Pathol 26: 531\u2013533.","journal-title":"Hum Pathol"},{"key":"BF6690318_CR7","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1038\/sj.onc.1200922","volume":"14","author":"J Dazard","year":"1997","unstructured":"Dazard, J., Augias, D., Neel, H., Mils, V., Marechal, V., Basset-Seguin, N. & Piette, J. (1997) Mdm2 protein is expressed in different layers of normal human skin. Oncogene 14: 1123\u20131128.","journal-title":"Oncogene"},{"key":"BF6690318_CR8","first-page":"335","volume":"32","author":"A Emanuels","year":"1994","unstructured":"Emanuels, A., Hollema, H., Suurmeyer, A. & Koudstaal, J. (1994) A modified method for antigen retrieval MIB-1 staining of vulvar carcinoma. Eur J Morphol 32: 335\u2013337.","journal-title":"Eur J Morphol"},{"key":"BF6690318_CR9","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1056\/NEJM199411103311903","volume":"331","author":"D Esrig","year":"1994","unstructured":"Esrig, D., Elmajian, D., Groshen, S., Freeman, J. A., Stein, J. P., Chen, S. C., Nichols, P. W., Skinner, D. G., Jones, P. A. & Cote, R. J. (1994) Accumulation of nuclear p53 and tumor progression in bladder cancer [see comments]. N Engl J Med 331: 1259\u20131264.","journal-title":"N Engl J Med"},{"key":"BF6690318_CR10","first-page":"1389","volume":"143","author":"D Esrig","year":"1993","unstructured":"Esrig, D., Spruck, C. H., Nichols, P. W., Chaiwun, B., Steven, K., Groshen, S., Chen, S. C., Skinner, D. G., Jones, P. A. & Cote, R. J. (1993) p53 nuclear protein accumulation correlates with mutations in the p53 gene, tumor grade, and stage in bladder cancer. Am J Pathol 143: 1389\u20131397.","journal-title":"Am J Pathol"},{"key":"BF6690318_CR11","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1038\/bjc.1994.48","volume":"69","author":"VA Florenes","year":"1994","unstructured":"Florenes, V. A., Oyjord, T., Holm, R., Skrede, M., Borresen, A. L., Nesland, J. M. & Fodstad, O. (1994) TP53 allele loss, mutations and expression in malignant melanoma. Br J Cancer 69: 253\u2013259.","journal-title":"Br J Cancer"},{"key":"BF6690318_CR12","doi-asserted-by":"publisher","first-page":"1821","DOI":"10.1126\/science.7997877","volume":"266","author":"LH Hartwell","year":"1994","unstructured":"Hartwell, L. H. & Kastan, M. B. (1994) Cell cycle control and cancer. Science 266: 1821\u20131828.","journal-title":"Science"},{"key":"BF6690318_CR13","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1002\/(SICI)1097-0142(19971001)80:7<1228::AID-CNCR5>3.0.CO;2-G","volume":"80","author":"M Kagie","year":"1997","unstructured":"Kagie, M., Kenter, G., Tollenaar, R., Hermans, J., Baptist Trimbos, J. & Fleuren, G. (1997) p53 protein overexpression is common and independent of human papillomavirus infection in squamous cell carcinoma of the vulva. Cancer 80: 1228\u20131233.","journal-title":"Cancer"},{"key":"BF6690318_CR14","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/0046-8177(94)90114-7","volume":"25","author":"SM Kennedy","year":"1994","unstructured":"Kennedy, S. M., Macgeogh, C., Jaffe, R. & Spurr, N. K. (1994) Overexpression of the oncoprotein p53 in primary hepatic tumors of childhood does not correlate with gene mutations [see comments]. Hum Pathol 25: 438\u2013442.","journal-title":"Hum Pathol"},{"key":"BF6690318_CR15","first-page":"1398","volume":"143","author":"TD Kessis","year":"1993","unstructured":"Kessis, T. D., Slebos, R. J., Han, S. M., Shah, K., Bosch, X. F., Munoz, N., Hedrick, L. & Cho, K. R. (1993) p53 gene mutations and MDM2 amplification are uncommon in primary carcinomas of the uterine cervix. Am J Pathol 143: 1398\u20131405.","journal-title":"Am J Pathol"},{"key":"BF6690318_CR16","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1006\/gyno.1996.0130","volume":"61","author":"LA King","year":"1996","unstructured":"King, L. A., Okagaki, T., Gallup, D. G., Twiggs, L. B., Messing, M. J. & Carson, L. F. (1996) Mitotic count, nuclear atypia, and immunohistochemical determination of Ki-67, c-myc, p21-ras, c-erbB2, and p53 expression in granulosa cell tumors of the ovary: mitotic count and Ki-67 are indicators of poor prognosis. Gynecol Oncol 61: 227\u2013232.","journal-title":"Gynecol Oncol"},{"issue":"10","key":"BF6690318_CR17","doi-asserted-by":"publisher","first-page":"1786","DOI":"10.1002\/1097-0142(19951115)76:10<1786::AID-CNCR2820761016>3.0.CO;2-5","volume":"76","author":"Petra Kohlberger","year":"1995","unstructured":"Kohlberger, P., Kainz, C., Breitenecker, G., Gitsch, G., Sliutz, G., Kolbl, H., Tschachler, E. & Reinthaller, A. Prognostic value of immunohistochemically detected p53 expression in vulvar carcinoma. Cancer 76: 1786\u20131789.","journal-title":"Cancer"},{"key":"BF6690318_CR18","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/358015a0","volume":"358","author":"DP Lane","year":"1992","unstructured":"Lane, D. P. (1992) p53, guardian of the genome. Nature 358: 15\u201316.","journal-title":"Nature"},{"key":"BF6690318_CR19","first-page":"2235","volume":"53","author":"NJ Lassam","year":"1993","unstructured":"Lassam, N. J., From, L. & Kahn, H. J. (1993) Overexpression of p53 is a late event in the development of malignant melanoma. Cancer Res 53: 2235\u20132238.","journal-title":"Cancer Res"},{"key":"BF6690318_CR20","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1097\/00019606-199506000-00004","volume":"4","author":"A Marchetti","year":"1995","unstructured":"Marchetti, A., Buttitta, F., Pellegrini, S., Merlo, G., Chella, A., Angeletti, C. A. & Bevilacqua, G. (1995) mdm2 gene amplification and overexpression in non-small cell lung carcinomas with accumulation of the p53 protein in the absence of p53 gene mutations. Diagn Mol Pathol 4: 93\u201397.","journal-title":"Diagn Mol Pathol"},{"key":"BF6690318_CR21","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1038\/bjc.1995.189","volume":"71","author":"AH McCann","year":"1995","unstructured":"McCann, A. H., Kirley, A., Carney, D. N., Corbally, N., Magee, H. M., Keating, G. & Dervan, P. A. (1995) Amplification of the MDM2 gene in human breast cancer and its association with MDM2 and p53 protein status. Br J Cancer 71: 981\u2013985.","journal-title":"Br J Cancer"},{"key":"BF6690318_CR22","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1002\/ijc.2910630507","volume":"63","author":"K Milde-Langosch","year":"1995","unstructured":"Milde-Langosch, K., Albrecht, K., Joram, S., Schlechte, H., Giessing, M. & Loning, T. (1995) Presence and persistence of HPV infection and p53 mutation in cancer of the cervix and the vulva. Int J Cancer 63: 639\u2013645.","journal-title":"Int J Cancer"},{"key":"BF6690318_CR23","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1016\/0092-8674(92)90644-R","volume":"69","author":"J Momand","year":"1992","unstructured":"Momand, J., Zambetti, G. P., Olson, D. C., George, D. & Levine, A. J. (1992) The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 69: 1237\u20131245.","journal-title":"Cell"},{"key":"BF6690318_CR24","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1136\/mp.48.1.M12","volume":"48","author":"D Ofner","year":"1995","unstructured":"Ofner, D., Maier, H., Riedmann, B., Holzberger, P., Nogler, M., Totsch, M., Bankfalvi, A., Winde, G., Bocker, W. & Schmid, K. (1995) Immunohistochemically detectable p53 and mdm-2 oncoprotein expression in colorectal carcinoma: prognostic significance. J Clin Pathol Mol Pathol 48: 12\u201316.","journal-title":"J Clin Pathol Mol Pathol"},{"key":"BF6690318_CR25","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1038\/358080a0","volume":"358","author":"JD Oliner","year":"1992","unstructured":"Oliner, J. D., Kinzler, K. W., Meltzer, P. S., George, D. L. & Vogelstein, B. (1992) Amplification of a gene encoding a p53-associated protein in human sarcomas [see comments]. Nature 358: 80\u201383.","journal-title":"Nature"},{"key":"BF6690318_CR26","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1182\/blood.V84.8.2391.2391","volume":"84","author":"M Prokocimer","year":"1994","unstructured":"Prokocimer, M. & Rotter, V. (1994) Structure and function of p53 in normal cells and their aberrations in cancer cells: projection on the hematologic cell lineages. Blood 84: 2391\u20132411.","journal-title":"Blood"},{"key":"BF6690318_CR27","first-page":"1531","volume":"148","author":"RM Przygodzki","year":"1996","unstructured":"Przygodzki, R. M., Finkelstein, S. D., Langer, J. C., Swalsky, P. A., Fishback, N., Bakker, A., Guinee, D. G., Koss, M. & Travis, W. D. (1996) Analysis of p53, K-ras-2, and C-raf-1 in pulmonary neuroendocrine tumors. Correlation with histological subtype and clinical outcome. Am J Pathol 148: 1531\u20131541.","journal-title":"Am J Pathol"},{"key":"BF6690318_CR28","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1016\/0959-8049(94)90128-7","volume":"30A","author":"B Quesnel","year":"1994","unstructured":"Quesnel, B., Preudhomme, C., Fournier, J., Fenaux, P. & Peyrat, J. P. (1994) MDM2 gene amplification in human breast cancer. Eur J Cancer 30A: 982\u2013984.","journal-title":"Eur J Cancer"},{"key":"BF6690318_CR29","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/0046-8177(95)90122-1","volume":"26","author":"MS Shurbaji","year":"1995","unstructured":"Shurbaji, M. S., Kalbfleisch, J. H. & Thurmond, T. S. (1995) Immunohistochemical detection of p53 protein as a prognostic indicator in prostate cancer. Hum Pathol 26: 106\u2013109.","journal-title":"Hum Pathol"},{"key":"BF6690318_CR30","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1016\/0140-6736(92)92558-W","volume":"340","author":"XF Sun","year":"1992","unstructured":"Sun, X. F., Carstensen, J. M., Zhang, H., Stal, O., Wingren, S., Hatschek, T. & Nordenskjold, B. (1992) Prognostic significance of cytoplasmic p53 oncoprotein in colorectal adenocarcinoma. Lancet 340: 1369\u20131373.","journal-title":"Lancet"},{"key":"BF6690318_CR31","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1046\/j.1365-2559.1996.d01-558.x","volume":"30","author":"T Vogt","year":"1997","unstructured":"Vogt, T., Zipperer, K. H., Vogt, A., Holzel, D., Landthaler, M. & Stolz, W. (1997) p53-protein and Ki-67 antigen expression are both reliable biomarkers of prognosis in thick stage 1 nodular melanomas of the skin. Histopathology 30: 57\u201363.","journal-title":"Histopathology"},{"key":"BF6690318_CR32","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1101\/gad.7.7a.1126","volume":"7","author":"X Wu","year":"1993","unstructured":"Wu, X., Bayle, J., Olson, D. & Levine, A. (1993) The p53-mdm2 autoregulatory feedback loop. Genes Dev 7: 1126\u20131132.","journal-title":"Genes Dev"},{"key":"BF6690318_CR33","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/0046-8177(94)90116-3","volume":"25","author":"L Xerri","year":"1994","unstructured":"Xerri, L., Bouabdallah, R., Camerlo, J. & Hassoun, J. (1994) Expression of the p53 gene in Hodgkin\u2019s disease: dissociation between immunohistochemistry and clinicopathological data. Hum Pathol 25: 449\u2013454.","journal-title":"Hum Pathol"},{"key":"BF6690318_CR34","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/0046-8177(95)90031-4","volume":"26","author":"M Younes","year":"1995","unstructured":"Younes, M., Lebovitz, R. M., Bommer, K. E., Cagle, P. T., Morton, D., Khan, S. & Laucirica, R. (1995) p53 accumulation in benign breast biopsy specimens. Hum Pathol 26: 155\u2013158.","journal-title":"Hum Pathol"}],"container-title":["British Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/6690318.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/6690318","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/6690318.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T12:52:16Z","timestamp":1684414336000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/6690318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,3,26]]},"references-count":34,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[1999,4]]}},"alternative-id":["BF6690318"],"URL":"https:\/\/doi.org\/10.1038\/sj.bjc.6690318","relation":{},"ISSN":["0007-0920","1532-1827"],"issn-type":[{"value":"0007-0920","type":"print"},{"value":"1532-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,3,26]]}}}