{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T03:26:24Z","timestamp":1791084384997,"version":"4.1.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"5-6","license":[{"start":{"date-parts":[[1999,4,23]],"date-time":"1999-04-23T00:00:00Z","timestamp":924825600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Cancer"],"published-print":{"date-parts":[[1999,5]]},"DOI":"10.1038\/sj.bjc.6690419","type":"journal-article","created":{"date-parts":[[2002,9,17]],"date-time":"2002-09-17T14:24:08Z","timestamp":1032272648000},"page":"756-765","source":"Crossref","is-referenced-by-count":134,"title":["Boswellic acids and malignant glioma: induction of apoptosis but no modulation of drug sensitivity"],"prefix":"10.1038","volume":"80","author":[{"given":"T","family":"Glaser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Winter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Groscurth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Safayhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E-R","family":"Sailer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H P T","family":"Ammon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Schabet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Weller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[1999,4,23]]},"reference":[{"key":"BF6690419_CR1","first-page":"369","volume":"1","author":"HPT Ammon","year":"1996","unstructured":"Ammon, H. P. T. (1996). Salai Guggal-Boswellia serrata: From a herbal medicine to a non redox inhibitor of leukotriene biosynthesis. Eur J Med Res 1: 369\u2013370.","journal-title":"Eur J Med Res"},{"key":"BF6690419_CR2","first-page":"B958","volume":"94","author":"DK B\u00f6ker","year":"1997","unstructured":"B\u00f6ker, D. K. & Winking, M. (1997). Die Rolle von Boswellia-S\u00e4uren in der Therapie maligner Gliome. Deutsches \u00c4rzteblatt 94: B958\u2013B960.","journal-title":"Deutsches \u00c4rzteblatt"},{"key":"BF6690419_CR3","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1093\/jnci\/89.14.1036","volume":"89","author":"C Gomez-Manzano","year":"1997","unstructured":"Gomez-Manzano, C., Fueyo, J., Kyritsis, A. P., McDonnell, T. J., Steck, P. A., Levin, V. A. & Yung, W. K. A. (1997). Characterization of p53 and p21 functional interactions in glioma cells en route to apoptosis. J Natl Cancer Inst 89: 1036\u20131044.","journal-title":"J Natl Cancer Inst"},{"key":"BF6690419_CR4","first-page":"37","volume":"2","author":"I Gupta","year":"1997","unstructured":"Gupta, I., Parihar, A., Malhotra, P., Singh, G. B., L\u00fcdtke, R., Safayhi, H. & Ammon, H. P. T. (1997). Effects of boswellia serrata gum resin in patients with ulcerative colitis. Eur J Med Res 2: 37\u201343.","journal-title":"Eur J Med Res"},{"key":"BF6690419_CR5","unstructured":"Heldt, R. M., Syrovets, T., Winking, M., Sailer, E. R., Safayhi, H., Ammon, H. P. T. & Simmet, T. H. (1997). Boswellic acids exhibit cytotoxic effects on brain tumor cells independent from 5-lipoxygenase inhibition. Naunyn-S-Arch Pharmacol 355: 30 (Abstract)"},{"key":"BF6690419_CR6","unstructured":"Hoernlein, R. F., Orlikowsky, T. H., Niethammer, D., Sailer, E-R, Dannecker, G. E. & Ammon, H. P. T. (1997). Acetyl-11-keto-\u03b2-boswellic acid (AKBA) induces apoptosis in HL60 and CCRF-CEM cells and inhibits topoisomerase I. Soc Cancer Res 1291: (Abstract)"},{"key":"BF6690419_CR7","first-page":"2021","volume":"11","author":"JM Jung","year":"1995","unstructured":"Jung, J. M., Bruner, J. M., Ruan, S., Langford, L. A., Kyritsis, A. P., Kobayashi, T., Levin, V. A. & Zhang, W. (1995). Increased levels of p21WAF1\/Cip1 in human brain tumors. Oncogene 11: 2021\u20132028.","journal-title":"Oncogene"},{"key":"BF6690419_CR8","first-page":"674","volume":"62","author":"D Michalowitz","year":"1990","unstructured":"Michalowitz, D., Halevy, O. & Oren, M. (1990). Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53. Cell 62: 674\u2013680.","journal-title":"Cell"},{"key":"BF6690419_CR9","first-page":"3391","volume":"54","author":"P Michieli","year":"1994","unstructured":"Michieli, P., Chedid, M., Lin, D., Pierce, J. H., Mercer, W. E. & Givol, D. (1994). Induction of WAF1\/CIP1 by a p53-independent pathway. Cancer Res 54: 3391\u20133395.","journal-title":"Cancer Res"},{"key":"BF6690419_CR10","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1038\/sj.onc.1202071","volume":"17","author":"U Naumann","year":"1998","unstructured":"Naumann, U., Durka, S. & Weller, M. (1998). Dexamethasone-mediated protection from drug toxicity linked to p21WAF\/CIP1 protein accumulation. Oncogene 17: 1567\u20131575.","journal-title":"Oncogene"},{"key":"BF6690419_CR11","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s002620050355","volume":"44","author":"W Roth","year":"1997","unstructured":"Roth, W., Fontana, A., Trepel, M., Dichgans, J., Reed, J. C. & Weller, M. (1997). Immunochemotherapy of malignant glioma: synergistic activity of CD95 ligand and chemotherapeutics. Cancer Immunol Immunother 44: 55\u201363.","journal-title":"Cancer Immunol Immunother"},{"key":"BF6690419_CR12","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/S0006-2952(97)00480-2","volume":"55","author":"U Reber","year":"1998","unstructured":"Reber, U., W\u00fcllner, U., Trepel, M., Baumgart, J., Seyfried, J., Klockgether, T., Dichgans, J. & Weller, M. (1998). Potentiation of treosulfan toxicity by the glutathione-depleting agent, buthionine sulfoximine, in human malignant glioma cells: the role of bcl-2. Biochem Pharmacol 55: 349\u2013359.","journal-title":"Biochem Pharmacol"},{"key":"BF6690419_CR13","first-page":"2021","volume":"46","author":"TC Rowe","year":"1986","unstructured":"Rowe, T. C., Chen, G. L., Hsiang, Y. H. & Liu, L. F. (1986). DNA damage by antitumor acridines mediated by mammalian DNA topoisomerase II. Cancer Res 46: 2021\u20132026.","journal-title":"Cancer Res"},{"key":"BF6690419_CR14","first-page":"1538","volume":"58","author":"S Ruan","year":"1998","unstructured":"Ruan, S., Okcu, M. F., Ren, J. P., Chiao, P., Andreeff, Levin, V. & Zhang, W. (1998). Overexpressed WAF1\/Cip1 renders glioblastoma cells resistant to chemotherapy agents 1,3-bis(2-chloroethyl)-1-nitrosourea and cisplatin. Cancer Res 58: 1538\u20131543.","journal-title":"Cancer Res"},{"key":"BF6690419_CR15","first-page":"1143","volume":"261","author":"H Safayhi","year":"1992","unstructured":"Safayhi, H., Mack, T., Sabieraj, J. & Ammon, H. P. T. (1992). Boswellic acids: novel, specific non-redox inhibitors of 5-lipoxygenase. J Pharmacol Exp Ther 261: 1143\u20131146.","journal-title":"J Pharmacol Exp Ther"},{"key":"BF6690419_CR16","first-page":"1212","volume":"47","author":"H Safayhi","year":"1995","unstructured":"Safayhi, H., Sailer, E. R. & Ammon, H. P. T. (1995). Mechanism of 5-lipoxygenase inhibition by acetyl-11-keto-\u03b2-boswellic acids. Mol Pharmacol 47: 1212\u20131216.","journal-title":"Mol Pharmacol"},{"key":"BF6690419_CR17","first-page":"460","volume":"281","author":"H Safayhi","year":"1997","unstructured":"Safayhi, H., Rall, B., Sailer, E. R. & Ammon, H. P. T. (1997). Inhibition by boswellic acids of human leukocyte elastase. J Pharmocol Exp Ther 281: 460\u2013463.","journal-title":"J Pharmocol Exp Ther"},{"key":"BF6690419_CR18","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1111\/j.1476-5381.1996.tb15235.x","volume":"117","author":"ER Sailer","year":"1996","unstructured":"Sailer, E. R., Subramanian, L. R., Rall, B., Hoernlein, R. F., Ammon, H. P. T. & Safayhi, H. (1996). Acetyl-11-keto-\u03b2-boswellic acid (AKBA): structure requirements for binding and 5-lipoxygenase inhibitory activity. Br J Pharmacol 117: 615\u2013618.","journal-title":"Br J Pharmacol"},{"key":"BF6690419_CR19","doi-asserted-by":"publisher","first-page":"4696","DOI":"10.1523\/JNEUROSCI.16-15-04696.1996","volume":"16","author":"JB Schulz","year":"1996","unstructured":"Schulz, J. B., Weller, M. & Klockgether, T. (1996). A sequential requirement for new mRNA and protein synthesis, ICE-like protease activity, and free radicals in potassium deprivation-induced apoptosis of cerebellar granule cells. J Neurosci 16: 4696\u20134706.","journal-title":"J Neurosci"},{"key":"BF6690419_CR20","doi-asserted-by":"publisher","first-page":"1875","DOI":"10.1038\/sj.onc.1201004","volume":"14","author":"M Sheikh","year":"1997","unstructured":"Sheikh, M., Chen, Y. Q., Smith, M. L. & Fornace, A. J. (1997). Role of p21Waf1\/Cip1\/Sdi1 in cell death and DNA repair as studied using a tetracycline-inducible system in p53-deficient cells. Oncogene 14: 1875\u20131882.","journal-title":"Oncogene"},{"key":"BF6690419_CR21","doi-asserted-by":"publisher","first-page":"6136","DOI":"10.1002\/j.1460-2075.1995.tb00304.x","volume":"14","author":"A Strasser","year":"1995","unstructured":"Strasser, A., Harris, A. W., Huang, D. C., Krammer, P. H. & Cory, S. (1995). Bcl-2 and Fas\/Apo-1 regulate distinct pathways to lymphocyte apoptosis. EMBO J 14: 6136\u20136147.","journal-title":"EMBO J"},{"key":"BF6690419_CR22","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1023\/A:1005910323338","volume":"39","author":"M Trepel","year":"1998","unstructured":"Trepel, M., Groscurth, P., Malipiero, U., Gulbins, E., Dichgans, J. & Weller, M. (1998). Chemosensitivity of human malignant glioma: modulation by p53 gene transfer. J Neuro-Oncol 39: 19\u201332.","journal-title":"J Neuro-Oncol"},{"key":"BF6690419_CR23","first-page":"649","volume":"54","author":"EG Van Meir","year":"1994","unstructured":"Van Meir, E. G., Kikuchi, T., Tada, M., Li, H., Diserens, A. C., Wojcik, B. E., Huang, H. J. S., Friedmann, T., De Tribolet, N. & Cavenee, W. K. (1994). Analysis of the p53 gene and its expression in human glioblastoma cells. Cancer Res 54: 649\u2013652.","journal-title":"Cancer Res"},{"key":"BF6690419_CR24","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/S0014-5793(97)00468-7","volume":"409","author":"B Wagenknecht","year":"1997","unstructured":"Wagenknecht, B., Gulbins, E., Lang, F., Dichgans, J. & Weller, M. (1997a). Lipoxygenase inhibitors block CD95 ligand-mediated apoptosis of human malignant glioma cells. FEBS Lett 409: 17\u201323.","journal-title":"FEBS Lett"},{"key":"BF6690419_CR25","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1159\/000154888","volume":"7","author":"B Wagenknecht","year":"1997","unstructured":"Wagenknecht, B., Trepel, M., von Deimling, A., Grimmel, C., Rollbrocker, B., Hayashi, Y., Lang, F., Dichgans, J., Gulbins, E. & Weller, M. (1997b). p53 accumulation promotes dephosphorylation and proteolytic cleavage of retinoblastoma protein in human malignant glioma cells. Cell Physiol Biochem 7: 304\u2013311.","journal-title":"Cell Physiol Biochem"},{"key":"BF6690419_CR26","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1038\/sj.cdd.4400435","volume":"5","author":"B Wagenknecht","year":"1998","unstructured":"Wagenknecht, B., Schulz, J. B., Gulbins, E. & Weller, M. (1998). CD95L-induced apoptosis of malignant glioma cells: inhibition of the cascade by crm-A, bcl-2, and NDGA. Cell Death Differ 5: 894\u2013900.","journal-title":"Cell Death Differ"},{"key":"BF6690419_CR27","first-page":"5187","volume":"55","author":"T Waldman","year":"1995","unstructured":"Waldman, T., Kinzler, K. W. & Vogelstein, B. (1995). p21 is necessary for the p53-mediated G1 arrest in human cancer cells. Cancer Res 55: 5187\u20135190.","journal-title":"Cancer Res"},{"key":"BF6690419_CR28","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1038\/381713a0","volume":"381","author":"T Waldman","year":"1996","unstructured":"Waldman, T., Lengauer, C., Kinzler, K. W. & Vogelstein, B. (1996). Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21. Nature 381: 713\u2013716.","journal-title":"Nature"},{"key":"BF6690419_CR29","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1172\/JCI117462","volume":"94","author":"M Weller","year":"1994","unstructured":"Weller, M., Frei, K., Groscurth, P., Krammer, P. H., Yonekawa, Y. & Fontana, A. (1994). Anti-Fas\/APO-1 antibody-mediated apoptosis of cultured human malignant glioma cells. Induction and modulation of sensitivity by cytokines. J Clin Invest 94: 954\u2013964.","journal-title":"J Clin Invest"},{"key":"BF6690419_CR30","doi-asserted-by":"publisher","first-page":"2633","DOI":"10.1172\/JCI117965","volume":"95","author":"M Weller","year":"1995","unstructured":"Weller, M., Malipiero, U. V., Aguzzi, A., Reed, J. C. & Fontana, A. (1995a). Protooncogene bcl-2 gene transfer abrogates Fas\/APO-1 antibody-mediated apoptosis of human malignant glioma cells and confers resistance to chemotherapeutic drugs and therapeutic irradiation. J Clin Invest 95: 2633\u20132643.","journal-title":"J Clin Invest"},{"key":"BF6690419_CR31","first-page":"2936","volume":"55","author":"M Weller","year":"1995","unstructured":"Weller, M., Malipiero, U., Rensing-Ehl, A., Barr, P. & Fontana, A. (1995b). Fas\/APO-1 gene transfer for human malignant glioma. Cancer Res 55: 2936\u20132944.","journal-title":"Cancer Res"},{"key":"BF6690419_CR32","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1212\/WNL.48.6.1704","volume":"48","author":"M Weller","year":"1997","unstructured":"Weller, M., Schmidt, C., Roth, W. & Dichgans, J. (1997a). Chemotherapy of human malignant glioma: prevention of efficacy by dexamethasone?. Neurology 48: 1704\u20131709.","journal-title":"Neurology"},{"key":"BF6690419_CR33","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1080\/01616412.1997.11740843","volume":"19","author":"M Weller","year":"1997","unstructured":"Weller, M., Trepel, M., Grimmel, C., Schabet, M., Bremen, D., Krajewski, S. & Reed, J. C. (1997b). Hypericin-induced apoptosis of human malignant glioma cells is light-dependent, independent of bcl-2 expression, and does not require wild-type p53. Neurol Res 19: 459\u2013470.","journal-title":"Neurol Res"},{"key":"BF6690419_CR34","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1002\/(SICI)1097-0215(19971127)73:5<707::AID-IJC16>3.0.CO;2-2","volume":"73","author":"M Weller","year":"1997","unstructured":"Weller, M., Winter, S., Schmidt, C., Esser, P., Fontana, A., Dichgans, J. & Groscurth, P. (1997c). Topoisomerase I inhibitors for human malignant glioma. Differential modulation of p53, p21, bax and bcl-2 expression and of CD95-mediated apoptosis by camptothecin and \u03b2-lapachone. Int J Cancer 73: 707\u2013714.","journal-title":"Int J Cancer"},{"key":"BF6690419_CR35","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1002\/(SICI)1097-0215(19981218)79:6<640::AID-IJC15>3.0.CO;2-Z","volume":"79","author":"M Weller","year":"1998","unstructured":"Weller, M., Rieger, J., Grimmel, C., Van Meir, E. G., De Tribolet, N., Krajewski, S., Reed, J. C., von Deimling, A. & Dichgans, J. (1998). Predicting chemoresistence in human malignant glioma cells: the role of molecular genetic analyses. Int J Cancer 79: 640\u2013644.","journal-title":"Int J Cancer"},{"key":"BF6690419_CR36","unstructured":"Winking, M., Sarikya, S., J\u00f6dicke, A. & B\u00f6ker, D. K. (1998). Boswellic acids inhibit glioma growth. J Cancer Res Clin Oncol 124: R141 (Abstr.)"},{"key":"BF6690419_CR37","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/S0014-2999(97)01478-7","volume":"341","author":"S Winter","year":"1998","unstructured":"Winter, S., Roth, W., Dichgans, J. & Weller, M. (1998). Synergy of CD95 ligand and teniposide: no role of cleavable complex formation and enhanced CD95 expression. Eur J Pharmacol 341: 323\u2013328.","journal-title":"Eur J Pharmacol"},{"key":"BF6690419_CR38","first-page":"1374","volume":"286","author":"S Winter","year":"1998","unstructured":"Winter, S. & Weller, M. (1998). Potentiation of CD95L-induced apoptosis of human malignant glioma cells by topotecan involves inhibition of RNA synthesis but not changes in CD95 or CD95L expression. J Pharmacol Exp Ther 286: 1374\u20131382.","journal-title":"J Pharmacol Exp Ther"}],"container-title":["British Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/6690419.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/6690419","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/6690419.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T12:53:20Z","timestamp":1684414400000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/6690419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,4,23]]},"references-count":38,"journal-issue":{"issue":"5-6","published-print":{"date-parts":[[1999,5]]}},"alternative-id":["BF6690419"],"URL":"https:\/\/doi.org\/10.1038\/sj.bjc.6690419","relation":{},"ISSN":["0007-0920","1532-1827"],"issn-type":[{"value":"0007-0920","type":"print"},{"value":"1532-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,4,23]]}}}