{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T15:37:04Z","timestamp":1772897824262,"version":"3.50.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[1999,5,7]],"date-time":"1999-05-07T00:00:00Z","timestamp":926035200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Cancer"],"published-print":{"date-parts":[[1999,6]]},"DOI":"10.1038\/sj.bjc.6690447","type":"journal-article","created":{"date-parts":[[2002,9,5]],"date-time":"2002-09-05T18:05:47Z","timestamp":1031249147000},"page":"940-945","source":"Crossref","is-referenced-by-count":22,"title":["Expression levels of the DNA repair enzyme HAP1 do not correlate with the radiosensitivities of human or HAP1-transfected rat cell lines"],"prefix":"10.1038","volume":"80","author":[{"given":"C J","family":"Herring","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Deans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R H","family":"Elder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J A","family":"Rafferty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"MacKinnon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Barzilay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I D","family":"Hickson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J H","family":"Hendry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G P","family":"Margison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[1999,5,7]]},"reference":[{"key":"BF6690447_CR1","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1002\/bies.950170808","volume":"17","author":"G Barzilay","year":"1995","unstructured":"Barzilay, G. & Hickson, I. D. (1995). Structure and function of apurinic\/apyrimidinic endonucleases. Bioessays 17: 713\u2013719.","journal-title":"Bioessays"},{"key":"BF6690447_CR2","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1038\/nsb0795-561","volume":"2","author":"G Barzilay","year":"1995","unstructured":"Barzilay, G., Mol, C. D., Robson, C. N., Walker, L. J., Cunningham, R. P., Tainer, J. A. & Hickson, I. D. (1995a). Identification of critical active-site residues in the multifunctional human DNA repair enzyme HAP1. Nature Struct Biol 2: 561\u2013567.","journal-title":"Nature Struct Biol"},{"key":"BF6690447_CR3","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.1093\/nar\/23.9.1544","volume":"23","author":"G Barzilay","year":"1995","unstructured":"Barzilay, G., Walker, L. J., Robson, C. N. & Hickson, I. D. (1995b). Site-directed mutagenesis of the human DNA repair enzyme HAP1: identification of residues important for AP endonuclease and RNAase H activity. Nucl Acids Res 23: 1544\u20131550.","journal-title":"Nucl Acids Res"},{"key":"BF6690447_CR4","doi-asserted-by":"publisher","first-page":"S145","DOI":"10.1038\/bjc.1996.330","volume":"74","author":"G Barzilay","year":"1996","unstructured":"Barzilay, G., Walker, L. J., Rothwell, D. G. & Hickson, I. D. (1996). Role of HAP1 protein in repair of oxidative DNA damage and regulation of transcription factors. Br J Cancer 74: S145\u2013S150.","journal-title":"Br J Cancer"},{"key":"BF6690447_CR5","first-page":"306","volume-title":"Ann NY Acad Sci","author":"DS Chen","year":"1994","unstructured":"Chen, D. S. & Olkowski, Z. L. (1994). Biological responses of human apurinic endonuclease to radiation-induced DNA damage. In DNA Damage Effects in DNA Structure and Protein Recognition. Ann NY Acad Sci 726: Wallace SS, van Houten B and Kow YW (eds), pp. 306\u2013308."},{"key":"BF6690447_CR6","doi-asserted-by":"publisher","first-page":"5907","DOI":"10.1093\/nar\/19.21.5907","volume":"19","author":"DS Chen","year":"1991","unstructured":"Chen, D. S., Herman, T. & Demple, B. (1991). Two distinct human DNA diesterases that hydrolyse 3\u2032-blocking deoxyribose fragments from oxidised DNA. Nucleic Acids Res 19: 5907\u20135914.","journal-title":"Nucleic Acids Res"},{"key":"BF6690447_CR7","unstructured":"Chen, D. S., Herman, T. & Demple, B. (1992). Molecular basis for the radiosensitivity of two mouse mutant cell lines. Abstracts of the 40th Annual Meeting of the Radiation Research Society (USA): pp. 21\u201315"},{"key":"BF6690447_CR8","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1146\/annurev.bi.63.070194.004411","volume":"63","author":"B Demple","year":"1994","unstructured":"Demple, B. & Harrison, L. (1994). Repair of oxidative damage to DNA: enzymology and biology. Ann Rev Biochem 63: 915\u2013948.","journal-title":"Ann Rev Biochem"},{"key":"BF6690447_CR9","doi-asserted-by":"publisher","first-page":"7731","DOI":"10.1073\/pnas.83.20.7731","volume":"83","author":"B Demple","year":"1986","unstructured":"Demple, B., Johnson, A. & Fung, D. (1986). Exonuclease III and endonuclease IV remove 3\u2032 blocks from DNA synthesis primers in H2O2-damaged Escherichia coli. Proc Natl Acad Sci USA 83: 7731\u20137735.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF6690447_CR10","doi-asserted-by":"publisher","first-page":"11450","DOI":"10.1073\/pnas.88.24.11450","volume":"88","author":"B Demple","year":"1991","unstructured":"Demple, B., Herman, T. & Chen, D. S. (1991). Cloning and expression of APE, the cDNA encoding the major human apurinic endonuclease: definition of a family of DNA repair enzymes. Proc Natl Acad Sci USA 88: 11450\u201311454.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF6690447_CR11","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/0921-8777(90)90004-O","volume":"236","author":"PW Doetsch","year":"1990","unstructured":"Doetsch, P. W. & Cunningham, R. P. (1990). The enzymology of apurinic\/apyrimidinic endonucleases. Mutat Res 236: 173\u2013201.","journal-title":"Mutat Res"},{"key":"BF6690447_CR12","doi-asserted-by":"publisher","first-page":"30","DOI":"10.2307\/3578330","volume":"132","author":"L Harrison","year":"1992","unstructured":"Harrison, L., Skorvaga, M., Cunningham, R. P., Hendry, J. H. & Margison, G. P. (1992). Transfection of the E. coli nth gene into radiosensitive Chinese hamster cells: effects on sensitivity to radiation, hydrogen peroxide and bleomycin sulphate. Radiat Res 132: 30\u201339.","journal-title":"Radiat Res"},{"key":"BF6690447_CR13","doi-asserted-by":"crossref","first-page":"15198","DOI":"10.1016\/S0021-9258(17)43793-8","volume":"258","author":"WD Henner","year":"1983","unstructured":"Henner, W. D., Grunberg, S. M. & Haseltine, W. A. (1983). Enzyme action at 3\u2032 termini of ionizing radiation-induced DNA strand breaks. J Biol Chem 258: 15198\u201315205.","journal-title":"J Biol Chem"},{"key":"BF6690447_CR14","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1038\/bjc.1998.641","volume":"78","author":"CJ Herring","year":"1998","unstructured":"Herring, C. J., West, C. M. L., Wilks, D. P., Davidson, S. E., Hunter, R. D., Berry, P., Forster, G., McKinnon, J., Rafferty, J. A., Elder, R. H., Hendry, J. H. & Margison, G. P. (1998). Levels of the DNA repair enzyme HAP1(APE1,Apex, Ref-1) are associated with the intrinsic radiosensitivity of cervix cancers. Br J Cancer 78: 1128\u20131133.","journal-title":"Br J Cancer"},{"key":"BF6690447_CR15","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1101\/gad.11.5.558","volume":"11","author":"L Jayaraman","year":"1997","unstructured":"Jayaraman, L., Murthy, K. G., Zhu, C., Curran, T., Xanthoudakis, S. & Prives, C. (1997). Identification of redox\/repair protein Ref-1 as a potent activator of p53. Genes Dev 11: 558\u2013570.","journal-title":"Genes Dev"},{"key":"BF6690447_CR16","first-page":"51","volume":"132","author":"M LaBelle","year":"1984","unstructured":"LaBelle, M. & Linn, S. (1984). DNA repair in cultured mouse cells of increasing population doubling level. Mutat Res 132: 51\u201361.","journal-title":"Mutat Res"},{"key":"BF6690447_CR17","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/0165-1110(90)90022-4","volume":"238","author":"T Lindahl","year":"1990","unstructured":"Lindahl, T. (1990). Repair of intrinsic DNA lesions. Mutat Res 238: 305\u2013311.","journal-title":"Mutat Res"},{"key":"BF6690447_CR18","doi-asserted-by":"publisher","first-page":"3618","DOI":"10.1021\/bi00769a019","volume":"11","author":"T Lindahl","year":"1972","unstructured":"Lindahl, T. & Andersson, A. (1972). Rate of chain breakage at apurinic sites in double-stranded deoxyribonucleic acid. Biochemistry 11: 3618\u20133623.","journal-title":"Biochemistry"},{"key":"BF6690447_CR19","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1146\/annurev.ge.20.120186.001221","volume":"20","author":"LA Loeb","year":"1986","unstructured":"Loeb, L. A. & Preston, B. D. (1986). Mutagenesis by apurinic\/apyrimidinic sites. Ann Rev Genet 20: 201\u2013230.","journal-title":"Ann Rev Genet"},{"key":"BF6690447_CR20","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/0921-8777(94)90028-0","volume":"315","author":"Y Ono","year":"1994","unstructured":"Ono, Y., Furuta, T., Ohmoto, T., Akiyama, K. & Seki, S. (1994). Stable expression in rat glioma cells of sense and antisense nucleic acids to a human multifunctional DNA repair enzyme, APEX nuclease. Mutat Res DNA Repair 315: 55\u201363.","journal-title":"Mutat Res DNA Repair"},{"key":"BF6690447_CR21","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1007\/BF01053151","volume":"25","author":"Y Ono","year":"1995","unstructured":"Ono, Y., Matsumoto, K., Furuta, T., Ohmoto, T., Akiyama, K. & Seki, S. (1995). Relationship between expression of a major apurinic\/apyrimidinic endonuclease (APEX nuclease) and susceptibility to genotoxic agents in human glioma cell lines. J Neuro-Oncol 25: 183\u2013192.","journal-title":"J Neuro-Oncol"},{"key":"BF6690447_CR22","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1080\/09553009014551321","volume":"57","author":"SA Roberts","year":"1990","unstructured":"Roberts, S. A. (1990). DRFIT: a program for fitting radiation survival models. Int J Radiat Biol 57: 1243\u20131246.","journal-title":"Int J Radiat Biol"},{"key":"BF6690447_CR23","doi-asserted-by":"publisher","first-page":"5519","DOI":"10.1093\/nar\/19.20.5519","volume":"19","author":"CN Robson","year":"1991","unstructured":"Robson, C. N. & Hickson, I. D. (1991). Isolation of cDNA clones encoding a human apurinic\/apyrimidinic endonuclease that corrects DNA repair and mutagenesis defects in E. coli xth (exonuclease III) mutants. Nuceicl Acids Res 19: 5519\u20135523.","journal-title":"Nuceicl Acids Res"},{"key":"BF6690447_CR24","doi-asserted-by":"publisher","first-page":"4217","DOI":"10.1093\/nar\/24.21.4217","volume":"24","author":"DG Rothwell","year":"1996","unstructured":"Rothwell, D. G. & Hickson, I. D. (1996). Asparagine 212 is essential for abasic site recognition by the human DNA repair endonuclease HAP1. Nucleic Acids Res 24: 4217\u20134221.","journal-title":"Nucleic Acids Res"},{"key":"BF6690447_CR25","first-page":"275","volume":"9","author":"DG Rothwell","year":"1997","unstructured":"Rothwell, D. G., Barzilay, G., Gorman, M., Morera, S., Freemont, P. & Hickson, I. D. (1997). The structure and functions of the HAP1\/Ref-1 protein. Oncol Res 9: 275\u2013280.","journal-title":"Oncol Res"},{"key":"BF6690447_CR26","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/0167-4838(91)90024-T","volume":"1079","author":"S Seki","year":"1991","unstructured":"Seki, S., Ikdea, S., Watanabe, S., Hatsushika, M., Tsutsui, K., Akiyama, K. & Zhang, B. (1991). A mouse DNA repair enzyme (APEX nuclease), having exonuclease and apurinic\/apyrimidinic endonuclease activities: purification and characterisation. Biochim Biophys Acta 1079: 57\u201364.","journal-title":"Biochim Biophys Acta"},{"key":"BF6690447_CR27","first-page":"573","volume":"51","author":"R Teoule","year":"1987","unstructured":"Teoule, R. (1987). Radiation-induced DNA damage and its repair. Int J Radiat Biol 51: 573\u2013589.","journal-title":"Int J Radiat Biol"},{"key":"BF6690447_CR28","doi-asserted-by":"publisher","first-page":"5370","DOI":"10.1128\/MCB.13.9.5370","volume":"13","author":"LJ Walker","year":"1993","unstructured":"Walker, L. J., Robson, C. N., Black, E., Gillespie, D. & Hickson, I. D. (1993). Identification of residues in the human DNA repair enzyme HAP1 (Ref-1) that are essential for redox regulation of Jun DNA binding. Mol Cell Biol 13: 5370\u20135376.","journal-title":"Mol Cell Biol"},{"key":"BF6690447_CR29","doi-asserted-by":"publisher","first-page":"4884","DOI":"10.1093\/nar\/22.23.4884","volume":"22","author":"LJ Walker","year":"1994","unstructured":"Walker, L. J., Craig, R. B., Harris, A. L. & Hickson, I. D. (1994). A role for human DNA repair enzyme HAP1 in cellular protection against DNA damaging agents and hypoxic stress. Nucleic Acids Res 22: 4884\u20134889.","journal-title":"Nucleic Acids Res"},{"key":"BF6690447_CR30","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1093\/oxfordjournals.rpd.a082199","volume":"52","author":"JF Ward","year":"1994","unstructured":"Ward, J. F., Jones, G. D. D. & Milligan, J. R. (1994). Biological consequences of non-homogeneous energy deposition by ionising radiation. Radiat Prot Dosim 52: 271\u2013276.","journal-title":"Radiat Prot Dosim"},{"key":"BF6690447_CR31","doi-asserted-by":"publisher","first-page":"1866","DOI":"10.1093\/nar\/22.10.1866","volume":"22","author":"TA Winters","year":"1994","unstructured":"Winters, T. A., Henner, W. D., Russell, S. P., McCullough, A. & Jorgensen, T. J. (1994). Removal of 3\u2032-phosphoglycolate from DNA strand-break damage in an oligonucleotide substrate by recombinant human apurinic\/apyrimidinic endonuclease 1. Nucleic Acids Res 22: 1866\u20131873.","journal-title":"Nucleic Acids Res"},{"key":"BF6690447_CR32","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1002\/j.1460-2075.1992.tb05097.x","volume":"11","author":"S Xanthoudakis","year":"1992","unstructured":"Xanthoudakis, S. & Curran, T. (1992). Identification and characterisation of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity. EMBO J 11: 653\u2013665.","journal-title":"EMBO J"},{"key":"BF6690447_CR33","doi-asserted-by":"publisher","first-page":"3323","DOI":"10.1002\/j.1460-2075.1992.tb05411.x","volume":"11","author":"S Xanthoudakis","year":"1992","unstructured":"Xanthoudakis, S., Miao, G., Wang, F., E Pan, Y-C & Curran, T. (1992). Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme. EMBO J 11: 3323\u20133335.","journal-title":"EMBO J"},{"key":"BF6690447_CR34","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1073\/pnas.91.1.23","volume":"91","author":"S Xanthoudakis","year":"1994","unstructured":"Xanthoudakis, S., Miao, G. G. & Curran, T. (1994). The redox and DNA-repair activities of Ref-1 are encoded by nonoverlapping domains. Proc Natl Acad Sci USA 91: 23\u201327.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF6690447_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0167-8140(97)00049-2","volume":"44","author":"J Yarnold","year":"1997","unstructured":"Yarnold, J. (1997). Molecular aspects of cellular responses to radiotherapy. Radiother Oncol 44: 1\u20137.","journal-title":"Radiother Oncol"}],"container-title":["British Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/6690447.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/6690447","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/6690447.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T12:53:34Z","timestamp":1684414414000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/6690447"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,5,7]]},"references-count":35,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1999,6]]}},"alternative-id":["BF6690447"],"URL":"https:\/\/doi.org\/10.1038\/sj.bjc.6690447","relation":{},"ISSN":["0007-0920","1532-1827"],"issn-type":[{"value":"0007-0920","type":"print"},{"value":"1532-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,5,7]]}}}