{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T14:40:00Z","timestamp":1759588800148},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[1999,9,24]],"date-time":"1999-09-24T00:00:00Z","timestamp":938131200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Cancer"],"published-print":{"date-parts":[[1999,10]]},"DOI":"10.1038\/sj.bjc.6690749","type":"journal-article","created":{"date-parts":[[2002,9,5]],"date-time":"2002-09-05T18:10:15Z","timestamp":1031249415000},"page":"690-695","source":"Crossref","is-referenced-by-count":23,"title":["In vivo and in vitro expression of steroid-converting enzymes in human breast tumours: associations with interleukin-6"],"prefix":"10.1038","volume":"81","author":[{"given":"V","family":"Speirs","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D S","family":"Walton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M-C","family":"Hall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S L","family":"Atkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[1999,9,24]]},"reference":[{"key":"BF6690749_CR1","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1002\/ijc.2910490122","volume":"49","author":"EF Adams","year":"1991","unstructured":"Adams, EF, Rafferty, B & White, MC (1991) Interleukin 6 is secreted by breast fibroblasts and stimulates 17\u03b2-oestradiol oxidoreductase activity in MCF-7 cells: possible paracrine regulation of 17\u03b2-oestradiol levels. Int J Cancer 49: 118\u2013121","journal-title":"Int J Cancer"},{"key":"BF6690749_CR2","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1042\/bj3110437","volume":"311","author":"J Adamski","year":"1992","unstructured":"Adamski, J, Normand, T, Leenders, F, Monte, D, Begue, A, Stehelin, D, Jungblut, PW & de Launoit, Y (1992) Molecular cloning of a novel widely expressed human 80 kDa 17\u03b2-hydroxysteroid dehydrogenase IV. Biochem J 311: 437\u2013443","journal-title":"Biochem J"},{"key":"BF6690749_CR3","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1677\/joe.0.1460197","volume":"146","author":"S Andersson","year":"1995","unstructured":"Andersson, S (1995) 17\u03b2-hydroxysteroid dehydrogenase: isozymes and mutations. J Endocrinol 146: 197\u2013200","journal-title":"J Endocrinol"},{"key":"BF6690749_CR4","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1002\/(SICI)1096-9896(199604)178:4<442::AID-PATH521>3.0.CO;2-I","volume":"178","author":"E Boyle-Walsh","year":"1996","unstructured":"Boyle-Walsh, E, Birch, MA, Gallagher, J, Speirs, V, White, MC, Shenkin, A & Fraser, WD (1996) RT-PCR detection of cytokine transcripts in a series of cultured human meningiomas. J Pathol 178: 442\u2013446","journal-title":"J Pathol"},{"key":"BF6690749_CR5","doi-asserted-by":"publisher","first-page":"2135","DOI":"10.1172\/JCI117569","volume":"94","author":"ML Casey","year":"1994","unstructured":"Casey, ML, Macdonald, PC & Andersson, S (1994) 17\u03b2-hydroxysteroid dehydrogenase type 2: chromosomal assignment and progestin regulation of gene expression in human endometrium. J Clin Invest 94: 2135\u20132141","journal-title":"J Clin Invest"},{"key":"BF6690749_CR6","doi-asserted-by":"publisher","first-page":"4876","DOI":"10.1210\/endo.138.11.5497","volume":"138","author":"LAM Castagnetta","year":"1997","unstructured":"Castagnetta, LAM, Carruba, G, Traina, A, Granata, OM, Markus, M, Pavone-Macaluso, M, Blomquist, CH & Adamski, J (1997) Expression of different 17\u03b2-hydroxysteroid dehydrogenase types and their activities in human prostate cancer cells. Endocrinology 138: 4876\u20134882","journal-title":"Endocrinology"},{"key":"BF6690749_CR7","first-page":"187","volume":"83","author":"AM Corbould","year":"1998","unstructured":"Corbould, AM, Judd, SJ & Rodgers, RJ (1998) Expression of types 1, 2 and 3 17\u03b2-hydroxysteroid dehydrogenase in subcutaneous abdominal and intra-abdominal adipose tissue of women. J Clin Endo Metab 83: 187\u2013194","journal-title":"J Clin Endo Metab"},{"key":"BF6690749_CR8","doi-asserted-by":"publisher","first-page":"10461","DOI":"10.1074\/jbc.270.18.10461","volume":"270","author":"Y Deyashiki","year":"1995","unstructured":"Deyashiki, Y, Ohshima, K, Nakanishi, M, Sato, K, Matsuura, K & Hara, A (1995) Molecular cloning and characterisation of mouse estradiol 17\u03b2-dehydrogenase (A-specific), a member of the aldoketoreductase family. J Biol Chem 270: 10461\u201310467","journal-title":"J Biol Chem"},{"key":"BF6690749_CR9","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1002\/(SICI)1097-0215(19960328)66:1<37::AID-IJC7>3.0.CO;2-#","volume":"66","author":"JP Elo","year":"1996","unstructured":"Elo, JP, Akinola, LA, Poutanen, M, Vihko, P, Kyllonen, AP, Lukkarinen, O & Vihko, R (1996) Characterisation of 17\u03b2-hydroxysteroid dehydrogenase isoenzyme expression in benign and malignant human prostate. Int J Cancer 66: 37\u201341","journal-title":"Int J Cancer"},{"key":"BF6690749_CR10","first-page":"P95","volume":"152","author":"M English","year":"1997","unstructured":"English, M, Robinson, E, Hughes, SV, Morton, D, Langman, MJ, Stewart, PM & Hewison, M (1997) Demonstration in vitro and in vivo of oestrogen metabolism in colonic cancer tissue. J Endocrinol Suppl 152: P95","journal-title":"J Endocrinol Suppl"},{"key":"BF6690749_CR11","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1002\/(SICI)1097-0215(19970917)72:6<937::AID-IJC3>3.0.CO;2-Q","volume":"72","author":"AR Green","year":"1997","unstructured":"Green, AR, Green, VL, White, MC & Speirs, V (1997) Expression of cytokine messenger RNA in normal and neoplastic human breast tissue: identification of interleukin-8 as a potential regulatory factor in breast tumours. Int J Cancer 72: 937\u2013941","journal-title":"Int J Cancer"},{"key":"BF6690749_CR12","first-page":"1340","volume":"84","author":"VL Green","year":"1999","unstructured":"Green, VL, Speirs, V, Jeffreys, RV, Foy, P, Landolt, AM & Atkin, SL (1999) 17\u03b2-hydroxysteroid dehydrogenase type 1, 2, 3 and 4 expression and enzyme activity in human anterior pituitary adenomas. J Clin Endo Metab 84: 1340\u20131345","journal-title":"J Clin Endo Metab"},{"key":"BF6690749_CR13","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1096\/fasebj.6.2.1537465","volume":"6","author":"FP Guengerich","year":"1992","unstructured":"Guengerich, FP (1992) Characterisation of human cytochrome P450 enzymes. FASEB J 6: 745\u2013748","journal-title":"FASEB J"},{"key":"BF6690749_CR14","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/0039-128X(83)90077-6","volume":"50","author":"VHT James","year":"1987","unstructured":"James, VHT, McNeill, JM, Lai, LC, Newton, CJ, Ghilchik, MW & Reed, MJ (1987) Aromatase activity in normal breast and breast tumour tissue: in vivo and in vitro studies. Steroids 50: 269\u2013279","journal-title":"Steroids"},{"key":"BF6690749_CR15","doi-asserted-by":"publisher","first-page":"6003","DOI":"10.1021\/bi00018a001","volume":"34","author":"H Jornvall","year":"1995","unstructured":"Jornvall, H, Person, B, Krook, M, Atrain, S, Gonzalez-Duatre, R, Jeffrey, J & Ghosh, D (1995) Short-chain dehydrogenases\/reductases (SDR). Biochem 34: 6003\u20136013","journal-title":"Biochem"},{"key":"BF6690749_CR16","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/S0960-0760(96)00175-6","volume":"60","author":"S Kurebayashi","year":"1997","unstructured":"Kurebayashi, S, Miyashita, Y, Hirose, T, Kasayama, S, Akira, S & Kishimoto, T (1997) Characterisation of mechanisms of interleukin-6 repression by estrogen receptor. J Steroid Biochem Mol Biol 60: 11\u201317","journal-title":"J Steroid Biochem Mol Biol"},{"key":"BF6690749_CR17","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/S0039-128X(96)00174-2","volume":"62","author":"F Labrie","year":"1997","unstructured":"Labrie, F, Luu-The, V, Lin, S-X, Labrie, C, Simard, J, Breton, R & Belanger, A (1997) The key role of 17\u03b2-hydroxysteroid dehydrogenases in sex steroid biology. Steroids 62: 148\u2013158","journal-title":"Steroids"},{"key":"BF6690749_CR18","doi-asserted-by":"publisher","first-page":"3061","DOI":"10.1210\/endo.137.7.8770932","volume":"137","author":"Q Lu","year":"1996","unstructured":"Lu, Q, Nakmura, J, Savinov, A, Yue, W, Weisz, J, Dabbs, DJ, Wolz, G & Brodie, A (1996) Expression of aromatase protein and messenger ribonucleic acid in tumour epithelial cells and evidence of functional significance of locally produced estrogen in human breast cancers. Endocrinology 137: 3061\u20133068","journal-title":"Endocrinology"},{"key":"BF6690749_CR19","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/0960-0760(95)00209-X","volume":"55","author":"V Luu-The","year":"1995","unstructured":"Luu-The, V, Zhang, Y, Poirier, D & Labrie, F (1995) Characteristics of human types 1, 2 and 3 17\u03b2-hydroxysteroid dehydrogenase activities: oxidation\/reduction and inhibition. J Steroid Biochem Molec Biol 55: 581\u2013587","journal-title":"J Steroid Biochem Molec Biol"},{"key":"BF6690749_CR20","unstructured":"Nokelainen, PA, Peltoketo, H, Vihko, RK & Vihko, PT (1998) Expression cloning of a novel mouse 17\u03b2-hydroxysteroid dehydrogenase\/17-ketosteroid reductase, an enzyme of estradiol biosynthesis in the corpus luteum. Proc Am Endo Soc, P1\u2013279"},{"key":"BF6690749_CR21","first-page":"1460","volume":"81","author":"JR Pasqualini","year":"1996","unstructured":"Pasqualini, JR, Chetrite, G, Blacker, C, Feinstein, MC, Delonde, L, Talbi, M & Maloche, C (1996a) Concentrations of estrone, estradiol and estrone sulfate and evaluation of sulfatase and aromatase activities in pre- and post-menopausal breast cancer patients. J Clin Endocrinol Metab 81: 1460\u20131464","journal-title":"J Clin Endocrinol Metab"},{"key":"BF6690749_CR22","doi-asserted-by":"publisher","first-page":"S99","DOI":"10.1677\/joe.0.1500099","volume":"150","author":"JR Pasqualini","year":"1996","unstructured":"Pasqualini, JR, Chetrite, G & Le Nestour, E (1996b) Control and expression of oestrone sulphatase activities in human breast cancer. J Endocrinol 150: S99\u2013S105","journal-title":"J Endocrinol"},{"key":"BF6690749_CR23","first-page":"S21","volume":"150","author":"H Peltoketo","year":"1996","unstructured":"Peltoketo, H, Isomaa, V & Vihko, R (1996) Expression and regulation of 17\u03b2-hydroxysteroid dehydrogenase type I. J Endocrinol 150: S21\u2013S30","journal-title":"J Endocrinol"},{"key":"BF6690749_CR24","first-page":"281","volume":"18","author":"TM Penning","year":"1996","unstructured":"Penning, TM (1996) Molecular endocrinology of hydroxysteroid dehydrogenases. Endocrine Rev 18: 281\u2013305","journal-title":"Endocrine Rev"},{"key":"BF6690749_CR25","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1677\/erc.0.0040323","volume":"4","author":"A Purohit","year":"1997","unstructured":"Purohit, A, Duncan, LJ, Wang, DY, Coldham, NG, Ghilchik, MW & Reed, MJ (1997) Paracrine control of oestrogen production in breast cancer. Endocrine Rel Cancer 4: 323\u2013330","journal-title":"Endocrine Rel Cancer"},{"key":"BF6690749_CR26","doi-asserted-by":"crossref","first-page":"12940","DOI":"10.1016\/S0021-9258(18)99966-7","volume":"269","author":"A Ray","year":"1994","unstructured":"Ray, A, Prefontaine, KE & Ray, P (1994) Down-modulation of interleukin-6 gene by 17\u03b2-estradiol in the absence of high affinity DNA binding by the estrogen receptor. J Biol Chem 269: 12940\u201312946","journal-title":"J Biol Chem"},{"key":"BF6690749_CR27","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1210\/edrv.18.5.0314","volume":"18","author":"MJ Reed","year":"1997","unstructured":"Reed, MJ & Purohit, A (1997) Breast cancer and the role of cytokines in regulating estrogen synthesis: An emerging hypothesis. Endo Rev 18: 701\u2013705","journal-title":"Endo Rev"},{"key":"BF6690749_CR28","first-page":"673","volume":"19","author":"MJ Reed","year":"1994","unstructured":"Reed, MJ, Purohit, A, Howarth, NM & Potter, BVL (1994) Steroid sulphatase inhibitors: a new endocrine therapy. Drugs Future 19: 673\u2013680","journal-title":"Drugs Future"},{"key":"BF6690749_CR29","first-page":"627","volume":"79","author":"RJ Santen","year":"1994","unstructured":"Santen, RJ, Martel, J, Hoahland, F, Naftolin, F, Roa, L, Harada, N, Hafer, L, Zaino, R & Santer, SJ (1994) Stromal spindle cells contain aromatase in human breast tumours. J Clin Endo Metab 79: 627\u2013632","journal-title":"J Clin Endo Metab"},{"key":"BF6690749_CR30","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1210\/jcem-59-1-29","volume":"59","author":"SJ Santer","year":"1984","unstructured":"Santer, SJ, Feil, PD & Santen, RJ (1984) In situ estrogen production via the estrone sulphatase pathway in breast tumours: relative importance versus the aromatase pathway. J Clin Endo Metab 59: 29\u201333","journal-title":"J Clin Endo Metab"},{"key":"BF6690749_CR31","first-page":"4042","volume":"81","author":"H Sasano","year":"1996","unstructured":"Sasano, H, Frost, AR, Saitoh, R, Harada, N, Poutanen, M, Vihko, R, Bulun, SE, Silverberg, SG & Nagura, H (1996) Aromatase and 17\u03b2-hydroxysteroid dehydrogenase type I in human breast carcinoma. J Clin Endo Metab 81: 4042\u20134045","journal-title":"J Clin Endo Metab"},{"key":"BF6690749_CR32","first-page":"342","volume":"15","author":"ER Simpson","year":"1994","unstructured":"Simpson, ER, Mahendroo, MS, Means, GD, Kilgore, MW, Hinshelwood, MM, Graham-Lorence, S, Amarneh, B, Ito, Y, Fisher, CR, Michael, MD, Mendelson, CR & Bulun, SE (1994) Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis. Endo Rev 15: 342\u2013355","journal-title":"Endo Rev"},{"key":"BF6690749_CR33","doi-asserted-by":"publisher","first-page":"2952","DOI":"10.1172\/JCI119848","volume":"100","author":"MA Sovak","year":"1997","unstructured":"Sovak, MA, Bellas, RE, Kim, DW, Zanieski, GJ, Rogers, AE, Traish, AM & Sonenshein, GE (1997) Aberrant nuclear factor-kappaB\/Rel expression and the pathogenesis of breast cancer. J Clin Invest 100: 2952\u20132960","journal-title":"J Clin Invest"},{"key":"BF6690749_CR34","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/0960-0760(93)90203-9","volume":"46","author":"V Speirs","year":"1993","unstructured":"Speirs, V, Adams, EF, Rafferty, B & White, MC (1993) Interactive effects of interleukin-6, 17\u03b2-estradiol and progesterone on growth and 17\u03b2-hydroxysteroid dehydrogenase activity of human breast carcinoma cells. J Steroid Biochem Mol Biol 46: 11\u201315","journal-title":"J Steroid Biochem Mol Biol"},{"key":"BF6690749_CR35","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1007\/BF02723036","volume":"32","author":"V Speirs","year":"1996","unstructured":"Speirs, V, Green, AR & White, MC (1996a) Collagenase III: a superior enzyme for complete disaggregation and improved viability of normal and malignant human breast tissue. InVitro Cell Dev Biol 32: 72\u201374","journal-title":"Vitro Cell Dev Biol"},{"key":"BF6690749_CR36","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1002\/(SICI)1097-0215(19960516)66:4<551::AID-IJC21>3.0.CO;2-9","volume":"66","author":"V Speirs","year":"1996","unstructured":"Speirs, V, Green, AR & White, MC (1996b) A comparative study of cytokine gene transcripts in normal and malignant human breast tissue and primary cell cultures derived from the same tissue samples. Int J Cancer 66: 551\u2013556","journal-title":"Int J Cancer"},{"key":"BF6690749_CR37","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1038\/bjc.1998.702","volume":"78","author":"V Speirs","year":"1998","unstructured":"Speirs, V, Green, AR, Walton, DS, Kerin, MJ, Fox, JN, Carleton, PJ, Desai, SB & Atkin, SL (1998a) Short-term primary culture of epithelial cells derived from breast tumours. Br J Cancer 78: 1421\u20131429","journal-title":"Br J Cancer"},{"key":"BF6690749_CR38","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/S0960-0760(98)00119-8","volume":"67","author":"V Speirs","year":"1998","unstructured":"Speirs, V, Green, AR & Atkin, SL (1998b) Expression and activity of 17\u03b2-hydroxysteroid dehydrogenase type I in primary cultures of epithelial and stromal cells derived from normal and tumourous human breast tissue: The role of IL-8. J Steroid Biochem Mol Biol 67: 267\u2013274","journal-title":"J Steroid Biochem Mol Biol"},{"key":"BF6690749_CR39","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1210\/jcem-57-6-1125","volume":"57","author":"N Tilson-Mallet","year":"1983","unstructured":"Tilson-Mallet, N, Santer, SJ, Feil, PD & Santen, RJ (1983) Biological significance of aromatase activity in human breast tumours. J Clin Endo Metab 57: 1125\u20131128","journal-title":"J Clin Endo Metab"},{"key":"BF6690749_CR40","first-page":"3594","volume":"81","author":"Y Zhang","year":"1996","unstructured":"Zhang, Y, Word, RA, Fesmire, S, Carr, BR & Rainey, WE (1996) Human ovarian expression of 17\u03b2-hydroxysteroid dehydrogenase types 1, 2 and 3. J Clin Endo Metab 81: 3594\u20133598","journal-title":"J Clin Endo Metab"}],"container-title":["British Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/6690749.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/6690749","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/6690749.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T12:56:22Z","timestamp":1684414582000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/6690749"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,9,24]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1999,10]]}},"alternative-id":["BF6690749"],"URL":"https:\/\/doi.org\/10.1038\/sj.bjc.6690749","relation":{},"ISSN":["0007-0920","1532-1827"],"issn-type":[{"value":"0007-0920","type":"print"},{"value":"1532-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,9,24]]}}}