{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:32:39Z","timestamp":1791073959238,"version":"4.1.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[1999,10,29]],"date-time":"1999-10-29T00:00:00Z","timestamp":941155200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Cancer"],"published-print":{"date-parts":[[1999,11]]},"DOI":"10.1038\/sj.bjc.6690790","type":"journal-article","created":{"date-parts":[[2002,9,5]],"date-time":"2002-09-05T18:11:19Z","timestamp":1031249479000},"page":"934-941","source":"Crossref","is-referenced-by-count":40,"title":["A comparative evaluation of various invasion assays testing colon carcinoma cell lines"],"prefix":"10.1038","volume":"81","author":[{"given":"N J de","family":"Both","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Vermey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W N","family":"Dinjens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F T","family":"Bosman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[1999,10,29]]},"reference":[{"key":"BF6690790_CR1","first-page":"3239","volume":"47","author":"A Albini","year":"1987","unstructured":"Albini, A, Iwamoto, Y, Kleinman, HK, Martin, GR, Aaronson, SA, Kozlowski, JM & McEwan, RN (1987). A rapid in vitro assay for quantitating the invasive potential of tumor cells. Cancer Res 47: 3239\u20133245.","journal-title":"Cancer Res"},{"key":"BF6690790_CR2","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1002\/(SICI)1097-0215(19970917)72:6<1137::AID-IJC32>3.0.CO;2-Z","volume":"72","author":"NJ de Both","year":"1997","unstructured":"de Both, NJ, Vermey, M, Groen, N, Dinjens, WN & Bosman, FT (1997). Clonal growth of colorectal carcinoma cell lines transplanted to nude mice. Int J Cancer 72: 1137\u20131141.","journal-title":"Int J Cancer"},{"key":"BF6690790_CR3","first-page":"179","volume":"213\/1","author":"B Boyer","year":"1996","unstructured":"Boyer, B, Valles, AM & Thiery, JP (1996). Model systems of carcinoma cell dispersion. Curr Topics Microbiol Immunol 213\/1: 179\u2013194.","journal-title":"Curr Topics Microbiol Immunol"},{"key":"BF6690790_CR4","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1002\/ijc.2910390514","volume":"39","author":"RS Bresalier","year":"1987","unstructured":"Bresalier, RS, Raper, SE, Hujanen, ES & Kim, YS (1987). A new model for human colon metastasis. Int J Cancer 39: 625\u2013630.","journal-title":"Int J Cancer"},{"key":"BF6690790_CR5","first-page":"4811","volume":"56","author":"C Chao","year":"1996","unstructured":"Chao, C, Lotz, ML, Clarke, AC & Mercurio, AM (1996). Function of the integrin \u03b16\u03b24 in the invasive properties of colorectal carcinoma cells. Cancer Res 56: 4811\u20134819.","journal-title":"Cancer Res"},{"key":"BF6690790_CR6","first-page":"2434","volume":"35","author":"TH Corbett","year":"1985","unstructured":"Corbett, TH, Giswold, DP, Roberts, BJ, Peckham, JC & Schnabel, FM (1985). Tumor induction relationships in development of transplantable cancer of the colon in mice for chemotherapy assays with a note on the carcinogen structure. Cancer Res 35: 2434\u20132439.","journal-title":"Cancer Res"},{"key":"BF6690790_CR7","first-page":"4813","volume":"55","author":"CM Ewing","year":"1995","unstructured":"Ewing, CM, Ru, N, Morton, RA, Robinson, JC, Wheelock, MJ, Johnson, KI, Barrett, JC & Isaacs, WB (1995). Chromosome 5 suppresses tumorigenicity of PC-3 prostate cancer cells: correlation with re-expression of \u03b1-catenin and restoration of E-cadherin function. Cancer Res 55: 4813\u20134817.","journal-title":"Cancer Res"},{"key":"BF6690790_CR8","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1111\/j.1432-0436.1992.tb00504.x","volume":"52","author":"A Fabra","year":"1992","unstructured":"Fabra, A, Nakajima, M, Bucana, CD & Fidler, IJ (1992). Modulation of the invasive phenotype of human colon carcinoma cells by organ specific fibroblasts of nude mice. Differentiation 52: 101\u2013110.","journal-title":"Differentiation"},{"key":"BF6690790_CR9","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1002\/(SICI)1096-9896(199610)180:2<175::AID-PATH630>3.0.CO;2-G","volume":"180","author":"C Gilles","year":"1998","unstructured":"Gilles, C, Polette, M, Piette, J, Delvigne, AC, Thompson, EU, Foidart, JM & Bierembaut, P (1998). Vimentin expression in cervical carcinomas: association with invasive and migratory potential. J Pathol 180: 175\u2013180.","journal-title":"J Pathol"},{"key":"BF6690790_CR10","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1128\/MCB.16.3.1115","volume":"16","author":"M Jeffers","year":"1996","unstructured":"Jeffers, M, Rong, S & van de Woude, GF (1996). Enhanced tumorigenicity and invasion-metastasis by hepatocyte growth factor\/scatter factor-met signalling in human cells concomitant with induction of the urokinase proteolysis network. Mol Cell Biol 16: 1115\u20131125.","journal-title":"Mol Cell Biol"},{"key":"BF6690790_CR11","first-page":"2205","volume":"51","author":"R Kath","year":"1991","unstructured":"Kath, R, Jambrosic, JA, Holland, L, Rodeck, U & Herlyn, M (1991). Development of invasive growth factor-independent cell variants from primary human melanomas. Cancer Res 51: 2205\u20132211.","journal-title":"Cancer Res"},{"key":"BF6690790_CR12","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/S0092-8674(00)81333-1","volume":"87","author":"KW Kinzler","year":"1996","unstructured":"Kinzler, KW & Vogelstein, B (1996). Lessons from hereditary colorectal cancer. Cell 87: 159\u2013170.","journal-title":"Cell"},{"key":"BF6690790_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1046\/j.1365-2613.1998.00051.x","volume":"79","author":"LA Kunz-Schughart","year":"1998","unstructured":"Kunz-Schughart, LA, Kruetz, M & Knuechel, R (1998). Multicellular spheroids: a three dimensional in vitro system to study tumour biology. Int J Exp Pathol 79: 1\u201323.","journal-title":"Int J Exp Pathol"},{"key":"BF6690790_CR14","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/BF02889094","volume":"30","author":"MM Mareel","year":"1979","unstructured":"Mareel, MM, Kint, J & Meyvisch, C (1979). Methods of study of the invasion of malignant C3H mouse fibroblasts into embryonic chick hearts in vitro. Virchows Arch B Cell Pathol 30: 95\u2013111.","journal-title":"Virchows Arch B Cell Pathol"},{"key":"BF6690790_CR15","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1002\/ijc.2910470623","volume":"47","author":"MM Mareel","year":"1991","unstructured":"Mareel, MM, Behrens, J, Birchmeier, W, de Bruyne, GK, Vleminckx, K, Hoogewijs, A, Fiers, WC & van Roy, FM (1991). Down regulation of E-cadherin expression in Madin-Darby canine kidney (MDCK) cells inside tumors of nude mice. Int J Cancer 47: 922\u2013928.","journal-title":"Int J Cancer"},{"key":"BF6690790_CR16","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/sj.onc.1201486","volume":"16","author":"S Meinders","year":"1998","unstructured":"Meinders, S, Brinkmann, V, Naundorf, H & Birchmeier, W (1998). Role of morphogenetic factors in metastasis of mammary carcinoma cells. Oncogene 16: 9\u201320.","journal-title":"Oncogene"},{"key":"BF6690790_CR17","first-page":"6863","volume":"48","author":"K Morikawa","year":"1988","unstructured":"Morikawa, K, Walker, SM, Nakajima, M, Pathak, S, Milburn Jessup, J & Fidler, IJ (1988). The influence of organ microenvironment on growth selection and metastasis of human colon cancer cells in nude mice. Cancer Res 48: 6863\u20136871.","journal-title":"Cancer Res"},{"key":"BF6690790_CR18","first-page":"3585","volume":"53","author":"RA Morton","year":"1993","unstructured":"Morton, RA, Ewing, CM, Nagafushi, A, Tsukita, S & Isaacs, WB (1993). Reduction of E-cadherin levels and deletion of the \u03b1-catenin gene in human prostate cancer cells. Cancer Res 53: 3585\u20133590.","journal-title":"Cancer Res"},{"key":"BF6690790_CR19","first-page":"405","volume":"51","author":"AC Noel","year":"1991","unstructured":"Noel, AC, Calle, A, Emonard, HP, Nusgens, BV, Simar, L, Foidart, J, Lapiere, CM & Foidart, JM (1991). Invasion of reconstituted basement membrane matrix is not correlated to the malignant metastatic cell phenotype. Cancer Res 51: 405\u2013414.","journal-title":"Cancer Res"},{"key":"BF6690790_CR20","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1023\/A:1006572204497","volume":"16","author":"M Polette","year":"1998","unstructured":"Polette, M, Gilles, C, de Bentzmann, S, Gruenert, D, Tournier, JM & Bierembaut, P (1998). Association of fibroblastoid features with the invasive phenotype in human bronchial cancer cell lines. Clin Exp Metastasis 16: 105\u2013112.","journal-title":"Clin Exp Metastasis"},{"key":"BF6690790_CR21","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1038\/370061a0","volume":"370","author":"H Sato","year":"1994","unstructured":"Sato, H, Takino, T, Okada, Y, Cao, J, Shinagawa, A, Yamamoto, E & Seiki, M (1994). A matrix metalloproteinase expressed on the surface of invasive tumour cells. Nature 370: 61\u201365.","journal-title":"Nature"},{"key":"BF6690790_CR22","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1023\/A:1018436407280","volume":"15","author":"AM Sieuwerts","year":"1997","unstructured":"Sieuwerts, AM, Klijn, JGM & Foekens, J (1997). Assessment of the invasive potential of human gynecological tumor cell lines with the in vitro Boyden chamber assay: influences of the ability of cells to migrate through the filter membrane. Clin and Exp Metastasis 15: 53\u201362.","journal-title":"Clin and Exp Metastasis"},{"key":"BF6690790_CR23","first-page":"5190","volume":"52","author":"C Sommers","year":"1992","unstructured":"Sommers, C, Heckford, SE, Skerker, JM, Worland, P, Torri, JA, Thompson, EW, Byers, SW & Gelmann, EP (1992). Loss of epithelial markers and acquisition of vimentin expression in adriamycin- and vinblastin-resistant human breast cancer cell lines. Cancer Res 52: 5190\u20135197.","journal-title":"Cancer Res"},{"key":"BF6690790_CR24","first-page":"1130","volume":"58","author":"AB Sparks","year":"1998","unstructured":"Sparks, AB, Morin, PJ, Vogelstein, B & Kinzler, KW (1998). Mutational analysis of the APC\/\u03b2-Catenin\/Tcf pathway in colorectal cancer. Cancer Res 58: 1130\u20131134.","journal-title":"Cancer Res"},{"key":"BF6690790_CR25","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/BF01753981","volume":"12","author":"I Sunitha","year":"1994","unstructured":"Sunitha, I, Meighen, DL, Hartman, DP, Thompson, EW, Byers, SW & Avigan, MI (1994). Hepatocyte growth factor stimulates invasion across reconstituted basement membranes by a new human small intestinal cell line. Clin Exp Metastasis 12: 143\u2013154.","journal-title":"Clin Exp Metastasis"},{"key":"BF6690790_CR26","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1002\/jcp.1041500314","volume":"150","author":"EW Thompson","year":"1992","unstructured":"Thompson, EW, Paik, S, Brunner, N, Sommers, CL, Zugmaier, G, Clarke, R, Shima, TB, Torri, J, Donahue, S, Lippman, ME, Martin, GR & Dickson, RB (1992). Association of increased basement membrane invasiveness with absence of estrogen receptor and expression of vimentin in human breast cancer cell lines. J Cell Physiol 150: 534\u2013544.","journal-title":"J Cell Physiol"},{"key":"BF6690790_CR27","first-page":"4722","volume":"55","author":"SJ Vermeulen","year":"1995","unstructured":"Vermeulen, SJ, Bruyneel, EA, Bracke, ME, De Bruyne, GK, Vennekens, KM, Vleminckx, KL, Berx, GJ, van Roy, FM & Mareel, MM (1995). Transition of the noninvasive to the invasive phenotype and loss of \u03b1-catenin in human colon cancer cells. Cancer Res 55: 4722\u20134728.","journal-title":"Cancer Res"},{"key":"BF6690790_CR28","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/0092-8674(91)90143-M","volume":"66","author":"K Vleminckx","year":"1991","unstructured":"Vleminckx, K, Vakaet, L, Mareel, MM, Fiers, W & van Roy, F (1991). Genetic manipulation of E-cadherin expression in epithelial tumor cells reveals an invasive suppressor role. Cell 66: 107\u2013119.","journal-title":"Cell"},{"key":"BF6690790_CR29","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1038\/bjc.1995.55","volume":"71","author":"JE de Vries","year":"1995","unstructured":"de Vries, JE, Dinjens, WNM, de Bruyne, GK, Verspaget, HW, van der Linden, EPM, de Bruine, AP, Mareel, MM, Bosman, FT & ten Kate, J (1995). In vivo and in vitro invasion in relation to phenotypic characteristics of human colorectal carcinoma cells. Br J Cancer 71: 271\u2013277.","journal-title":"Br J Cancer"},{"key":"BF6690790_CR30","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1111\/j.1440-1746.1994.tb01252.x","volume":"9","author":"G Webb","year":"1994","unstructured":"Webb, G, Baker, MS & Nicholl, J (1994). Chromosomal localisation of the human urokinase plasminogen activator receptor and plasminogen activator inhibitor type 2 genes: implications in colorectal cancer. Gastroenterol Hepatol 9: 340\u2013343.","journal-title":"Gastroenterol Hepatol"}],"container-title":["British Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/6690790.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/6690790","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/6690790.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T12:07:46Z","timestamp":1684411666000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/6690790"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,10,29]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1999,11]]}},"alternative-id":["BF6690790"],"URL":"https:\/\/doi.org\/10.1038\/sj.bjc.6690790","relation":{},"ISSN":["0007-0920","1532-1827"],"issn-type":[{"value":"0007-0920","type":"print"},{"value":"1532-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,10,29]]}}}