{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T03:46:08Z","timestamp":1768448768322,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,2,3]],"date-time":"2009-02-03T00:00:00Z","timestamp":1233619200000},"content-version":"vor","delay-in-days":4416,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[1997,1]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>The NK<jats:sub>1<\/jats:sub> receptor antagonist CP\u201099994 has been shown to prevent vomiting elicited by both peripherally and centrally acting emetogens in ferrets and dogs. These results have now been extended to another stimulus, provocative motion, and another species, the cat.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>CP\u201099994 displaced [<jats:sup>3<\/jats:sup>H]\u2010substance P from cat cortex with IC<jats:sub>50<\/jats:sub> of 0.52\u00b10.08 n<jats:sc>m<\/jats:sc>. Following s.c. administration, peak plasma drug levels were achieved at 30 min. The plasma drug half life was 1.4 h.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Subcutaneous administration of CP\u201099994 inhibited motion\u2010induced vomiting in the cat with an ED<jats:sub>50<\/jats:sub> of 144 \u03bcg kg<jats:sup>\u22121<\/jats:sup> but did not change the epiphenomena associated with provocative motion in the cat over the dose range of 30 to 300 \u03bcg kg<jats:sup>\u22121<\/jats:sup>. The antiemetic effect of CP\u201099994 can be attributed to antagonism of the NK<jats:sub>1<\/jats:sub> receptor because its enantiomer, CP\u2010100,263, which is 900 fold weaker as an NK<jats:sub>1<\/jats:sub> antagonist, had no effects on any response to provocative motion.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The inhibitory effect of CP\u201099994 on motion\u2010induced retching and vomiting is consistent with a central site of antiemetic action, potentially at the level of the motor nuclei responsible for these behaviours.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>An investigation into whether the failure of CP\u201099994 to alter the epiphenomena will also predict a lack of anti\u2010nausea effects in man will provide critical information on the neural organization of the emetic reflex.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p> <jats:italic>British Journal of Pharmacology<\/jats:italic> (1997) <jats:bold>120<\/jats:bold>, 116\u2013120; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0700888\">10.1038\/sj.bjp.0700888<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0700888","type":"journal-article","created":{"date-parts":[[2006,8,25]],"date-time":"2006-08-25T16:03:05Z","timestamp":1156521785000},"page":"116-120","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["The effect of CP\u201099994 on the responses to provocative motion in the cat"],"prefix":"10.1111","volume":"120","author":[{"given":"J B","family":"Lucot","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R S","family":"Obach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"McLean","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J W","family":"Watson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,3]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"255","volume-title":"5\u2010Ht\u20103 Receptor Antagonists","author":"Andrews P.L.R.","year":"1994"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(93)90189-A"},{"key":"e_1_2_6_4_1","first-page":"239","volume-title":"Mechanisms and Control of Emesis","author":"Bhandari P.","year":"1992"},{"key":"e_1_2_6_5_1","first-page":"6","volume-title":"Antiemetics and Cancer Chemotherapy","author":"Borison H.L.","year":"1983"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1949.12.5.305"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(93)90673-6"},{"key":"e_1_2_6_8_1","first-page":"9","volume-title":"Motion and Space Sickness","author":"Brizzee K.R.","year":"1990"},{"key":"e_1_2_6_9_1","first-page":"462","article-title":"A stimulator for laboratory studies of motion sickness in cats","volume":"56","author":"Crampton G.H.","year":"1985","journal-title":"Aviat. 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