{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T01:43:20Z","timestamp":1792547000873,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,2,10]],"date-time":"2009-02-10T00:00:00Z","timestamp":1234224000000},"content-version":"vor","delay-in-days":4392,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[1997,2]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>The effect of amylin on gastric ulcers induced by oral administration of indomethacin (Indo, 20 mg kg<jats:sup>\u22121<\/jats:sup> at a dosing volume of 5 ml) or ethanol 50% (EtOH, 1 ml\/rat) was investigated in conscious rats.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Amylin given intracerebroventricularly (0.22, 0.66 and 2.2 \u03bcg\/rat, i.c.v.) demonstrated a dose\u2010dependent cytoprotective effect against both Indo and EtOH\u2010induced ulcers. In contrast, amylin, given subcutaneously at doses effective in inhibiting acid gastric secretion (2.5, 10 and 40 \u03bcg kg<jats:sup>\u22121<\/jats:sup>, s.c), did not show any cytoprotective effect.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The interaction between amylin and endogenous nitric oxide (NO) in the maintenance of gastric mucosal integrity was investigated by pretreating the rats with a selective inhibitor of NO\u2010synthesis, N<jats:sup>G<\/jats:sup>\u2010nitro\u2010L\u2010arginine methyl ester (l\u2010NAME, 25 and 70 mg kg<jats:sup>\u22121<\/jats:sup>, s.c). Administration of L\u2010NAME to rats did not significantly increase the degree of the Indo\u2010induced ulcer index and was not able to remove the protective effect of amylin on Indo\u2010induced ulcers, thus excluding a role for endogenous NO in mediating the protective effect of this peptide.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>To determine whether the cytoprotective effect of amylin was mediated by endogenous prostaglandins, we studied the effect of amylin (2.2 \u03bcg\/rat, i.c.v.) on EtOH\u2010induced ulcers in rats pretreated with Indo (10 mg kg<jats:sup>\u22121<\/jats:sup>, s.c.) to inhibit prostanoid biosynthesis; Indo was injected 30 min before amylin and EtOH after a further 30 min. Pretreatment with Indo did not significantly increase the ulcer index induced by EtOH but counteracted the ability of amylin to prevent the ulcer formation.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>These findings suggest that amylin exerts a gastroprotective activity that is not strictly related to inhibition of acid gastric secretion and can be partly explained through a prostaglandin\u2010dependent mechanism mediated by receptors for the peptide in the brain. Amylin might be considered as a new brain\u2010gut peptide.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p>","DOI":"10.1038\/sj.bjp.0700941","type":"journal-article","created":{"date-parts":[[2006,8,25]],"date-time":"2006-08-25T16:10:13Z","timestamp":1156522213000},"page":"581-586","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Protection by amylin of gastric erosions induced by indomethacin or ethanol in rats"],"prefix":"10.1111","volume":"120","author":[{"given":"F.","family":"Guidobono","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Pagani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Ticozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Sibilia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Pecile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Netti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,2,10]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"113","article-title":"Pharmacological research on gefarnate, a new synthetic isoprenoid with antiulceration activity","volume":"147","author":"Adami R.","year":"1964","journal-title":"Int. Pharmacodyn. Ther."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1139\/y95-144"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.130.2.906"},{"key":"e_1_2_6_5_1","first-page":"487","article-title":"The demonstration of vasodilator activity of amylin amide in the rat","volume":"136","author":"Brain S.D.","year":"1990","journal-title":"Am. J. Pathol."},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.39.6.752"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(93)90511-F"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(94)90252-6"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/edrv-15-2-163"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.23.8628"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(89)92391-7"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(91)91476-S"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1991.tb12142.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-3623(87)90039-5"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1677\/jme.0.003R001"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0196-9781(94)90098-1"},{"key":"e_1_2_6_17_1","first-page":"555","article-title":"Effect of unmodified eel calcitonin on gastric acid secretion and gastric ulcers in the rat","volume":"46","author":"Guidobono F.","year":"1991","journal-title":"Il Farmaco"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/1043-6618(90)90726-T"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1993.tb13824.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1139\/y95-138"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000138750"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/335632a0"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000139228"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.39.5.639"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(05)81416-0"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0196-9781(91)90148-I"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1139\/y95-147"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.240550004"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(00)89093-8"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-6147(93)90081-T"},{"key":"e_1_2_6_31_1","first-page":"433","article-title":"Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl and thermal injury","volume":"77","author":"Robert A.","year":"1979","journal-title":"Gastroenterology"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-192304000-00006"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(88)90093-7"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1139\/y95-131"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02088352"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-0101-1"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00305236"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1139\/y95-155"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.11.3881"},{"key":"e_1_2_6_40_1","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1007\/BF00274799","article-title":"Islet Amyloid polypeptide\u2010like immunor\u2010eactivity in the islet B cells of type 2 (non\u2010insulin\u2010dependent) diabetic and non\u2010diabetic individuals","volume":"30","author":"Westermark P.","year":"1987","journal-title":"Diabetologia"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1990.259.3.E457"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Fsj.bjp.0700941","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Fsj.bjp.0700941","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/sj.bjp.0700941","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T19:52:48Z","timestamp":1698436368000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1038\/sj.bjp.0700941"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,2]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1997,2]]}},"alternative-id":["10.1038\/sj.bjp.0700941"],"URL":"https:\/\/doi.org\/10.1038\/sj.bjp.0700941","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,2]]},"assertion":[{"value":"2009-02-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}