{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:39:25Z","timestamp":1791301165057,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,2,10]],"date-time":"2009-02-10T00:00:00Z","timestamp":1234224000000},"content-version":"vor","delay-in-days":4392,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[1997,2]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>The present study was designed to investigate further the effects of the newly discovered orphanin FQ (OFQ)\u2010the endogenous ligand for the orphan opioid receptor (called, e.g., ORL<jats:sub>1<\/jats:sub> and LC132)\u2010on pain modulation in the rat. We used the tail\u2010flick assay as a nociceptive index.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>When injected into a cerebral ventricle, OFQ (4 fmol\u201010 nmol) has no effect on basal tail\u2010flick latency by itself at any dose, but dose\u2010dependently antagonizes systemic morphine analgesia (400 fmol\u201050 nmol).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Injected intrathecally, OFQ (3 and 10 nmol) displayed an analgesic effect without producing motor dysfunction, and potentiated morphine analgesia (1 and 10 nmol).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The anti\u2010opioid effect of OFQ in rat brain and the high level of expression of LC132\/ORL<jats:sub>1<\/jats:sub> receptor in the locus coeruleus indicated a possible role of OFQ in the precipitation of opiate withdrawal symptoms. However, no such precipitation was observed by OFQ in morphine\u2010dependent rats.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p>","DOI":"10.1038\/sj.bjp.0700942","type":"journal-article","created":{"date-parts":[[2006,8,25]],"date-time":"2006-08-25T16:10:13Z","timestamp":1156522213000},"page":"676-680","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":211,"title":["Bidirectional modulatory effect of orphanin FQ on morphine\u2010induced analgesia: antagonism in brain and potentiation in spinal cord of the rat"],"prefix":"10.1111","volume":"120","author":[{"given":"Jin\u2010Hua","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey S.","family":"Mogil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith E.","family":"Grisel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David K.","family":"Grandy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2010Sheng","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,2,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/276186a0"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19960429)368:2<229::AID-CNE5>3.0.CO;2-5"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.07.030184.001521"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(94)00561-3"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1996.tb15387.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199609020-00012"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-0348-7218-8_20"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(89)90982-7"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/377532a0"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(91)90671-H"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(96)00338-7"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(96)12917-7"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(94)80235-1"},{"key":"e_1_2_6_15_1","volume-title":"A Sterotaxic Atlas of Rat Brain","author":"Pellegrino L.J.","year":"1979"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.270.5237.792"},{"key":"e_1_2_6_17_1","first-page":"567","article-title":"Rat tail flick acupuncture analgesia model","volume":"92","author":"Ren M.F.","year":"1979","journal-title":"Chin. 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