{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:34:44Z","timestamp":1762144484263},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,2,17]],"date-time":"2009-02-17T00:00:00Z","timestamp":1234828800000},"content-version":"vor","delay-in-days":4371,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[1997,3]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>We investigated the effect of the non\u2010peptide neurotensin (NT) antagonist SR 48692 on renal function in rats and the involvement of nitric oxide (NO) in the diuretic action of this compound.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In fed animals, SR 48692 dose\u2010dependently (0.5 to 12.5 mg kg<jats:sup>\u22121<\/jats:sup>, p.o., 0.03 to 1 mg kg<jats:sup>\u22121<\/jats:sup>, i.p. and 0.1 to 1 \u03bcg\/rat, i.c.v.) increased urine output and urinary excretion of Na<jats:sup>+<\/jats:sup>, K<jats:sup>+<\/jats:sup> and Cl<jats:sup>\u2212<\/jats:sup> and reduced urine osmolality. The diuretic activity was also evident in water\u2010deprived, fasted animals and in fasted, water\u2010loaded rats.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>NT (0.1 \u03bcg\/rat, i.c.v.) had no effect on urine output in fed rats, but reduced the diuretic action of SR 48692 (1 \u03bcg\/rat, i.c.v.). The opposite result was obtained in fasted, water\u2010loaded animals: NT dose\u2010dependently (0.01 and 0.1 \u03bcg\/rat, i.c.v.) inhibited diuresis and this effect was significantly inhibited by i.c.v. SR 48692. In this experimental condition, SR 48692 did not further increase the on\u2010going diuresis.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The NO synthesis inhibitor N<jats:sup>\u03c9<\/jats:sup>\u2010nitro\u2010<jats:sc>l<\/jats:sc>\u2010arginine methyl ester (<jats:sc>l<\/jats:sc>\u2010NAME; 30 mg kg<jats:sup>\u22121<\/jats:sup>, i.p.) alone had no effect on urine output in fed rats but prevented the diuretic action of i.c.v. or i.p. SR 48692; <jats:sc>l<\/jats:sc>\u2010arginine (1 g kg<jats:sup>\u22121<\/jats:sup>, i.p.) but not <jats:sc>d<\/jats:sc>\u2010arginine (1 g kg<jats:sup>\u22121<\/jats:sup>, i.p.) restored the SR 48692\u2010dependent increase in diuresis. <jats:sc>l<\/jats:sc>\u2010NAME had no effect on furosemide\u2010stimulated diuresis.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Systemically administered <jats:sc>l<\/jats:sc>\u2010NAME or i.c.v. NT in fasted, water\u2010loaded rats significantly reduced water diuresis but this effect was no longer seen in animals given i.p. <jats:sc>l<\/jats:sc>\u2010arginine. Rats receiving i.c.v. NT, whose diuresis was significantly reduced, also excreted less nitrates and nitrites in urine.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Increased diuresis after central or systemic administration of SR 48692 to fed rats was paralleled by increased urinary excretion of nitrates and nitrites, this being consistent with peripheral enhancement of NO production after NT\u2010receptor blockade by SR 48692. The increase in diuresis after furosemide also involved an increase of nitrates and nitrites in urine, but this effect was about half that attained with an equipotent diuretic dose of SR 48692.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In fed rats, the NO donor isosorbide\u2010dinitrate, reduced systolic blood pressure (unlike SR 48692 which did not affect blood pressure) but also dose\u2010dependently (1 and 5 mg kg<jats:sup>\u22121<\/jats:sup>, i.p.) stimulated urine output.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The overall effects of SR 48692 strongly support a link between the actions of endogenous NT, AVP and peripheral NO production in the modulation of renal excretion of water, Na<jats:sup>+<\/jats:sup>, K<jats:sup>+<\/jats:sup> and Cl<jats:sup>\u2212<\/jats:sup>.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (1997) <jats:bold>120<\/jats:bold>, 1312\u20131318; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0701016\">10.1038\/sj.bjp.0701016<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0701016","type":"journal-article","created":{"date-parts":[[2006,8,25]],"date-time":"2006-08-25T16:13:16Z","timestamp":1156522396000},"page":"1312-1318","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Negative modulation of nitric oxide production by neurotensin as a putative mechanism of the diuretic action of SR 48692 in rats"],"prefix":"10.1111","volume":"120","author":[{"given":"Tiziano","family":"Croci","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Landi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Gully","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Pierre","family":"Maffrand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e9rard","family":"Le Fur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciano","family":"Manara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,17]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(94)90095-7"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(12)80170-3"},{"key":"e_1_2_5_4_1","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1681\/ASN.V16875","article-title":"Endothelial derived relaxing factor controls renal hemodynamics in the normal rat kidney","volume":"1","author":"BAYLIS C.","year":"1990","journal-title":"J. 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