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Pretreatment with a NK<jats:sub>2<\/jats:sub> receptor antagonist (SR48968, 1 m<jats:sc>m<\/jats:sc>) administered spinally through the microdialysis fibre prevented the heat hyperalgesia from developing in the early stages of the inflammation.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Post\u2010treatment through the microdialysis fibre with the NK<jats:sub>1<\/jats:sub> receptor antagonist (0.0110 m<jats:sc>m<\/jats:sc>) was effective in reversing the heat hyperalgesia. In contrast, post\u2010treatment spinally with the NK<jats:sub>2<\/jats:sub> receptor antagonist (0.011 m<jats:sc>m<\/jats:sc>) had no effect on the heat hyperalgesia. The inactive stereoisomers of the NK<jats:sub>1<\/jats:sub> receptor antagonist, CP100,263, or the NK<jats:sub>2<\/jats:sub> receptor antagonist, SR48965, administered at the same doses, had no effect on the joint inflammation or the heat hyperalgesia.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Pretreatment systemically with the NK<jats:sub>1<\/jats:sub> receptor antagonist (30 mg kg<jats:sup>\u22121<\/jats:sup>) had no effect on the heat hyperalgesia or pain\u2010related behaviour ratings where 0 is none and 5 is non weight bearing and complete avoidance of limb contact. Pretreatment with a NK<jats:sub>2<\/jats:sub> receptor antagonist (10 mg kg<jats:sup>\u22121<\/jats:sup>) systemically prevented the heat hyperalgesia and pain\u2010related behaviour ratings from developing in the early stages of the inflammation. The inactive stereoisomers of NK<jats:sub>1<\/jats:sub> receptor antagonist, CP100,263, or the NK<jats:sub>2<\/jats:sub> receptor antagonist, SR48965, administered at the same doses, had no effect on the joint inflammation or the heat hyperalgesia.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Post\u2010treatment systemically with either the NK<jats:sub>1<\/jats:sub> (0.130 mg kg<jats:sup>\u22121<\/jats:sup>) or the NK<jats:sub>2<\/jats:sub> (0.110 mg kg<jats:sup>\u22121<\/jats:sup>) receptor antagonist resulted in a dose\u2010dependent reversal of the heat hyperalgesia. Pain\u2010related behaviour ratings were reduced by post\u2010treatment only with the NK<jats:sub>1<\/jats:sub> receptor antagonist. The inactive stereoisomers of the NK<jats:sub>1<\/jats:sub> receptor antagonist, CP100,263, or the NK<jats:sub>2<\/jats:sub> receptor antagonist, SR48965, administered at the same doses, had no effect on the behavioural responses.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Direct pretreatment of the knee joint with either the NK<jats:sub>1<\/jats:sub> (30 mg) or the NK<jats:sub>2<\/jats:sub> (10 mg) receptor antagonist prevented the heat hyperalgesia from developing without affecting joint swelling. The inactive stereoisomers of the NK<jats:sub>1<\/jats:sub> receptor antagonist, CP100,263, or the NK<jats:sub>2<\/jats:sub> receptor antagonist, SR48965, administered at the same doses, had no effect on the joint inflammation or the heat hyperalgesia.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>There appears to be a differential role for the spinal tachykinin receptors in the development and maintenance of the heat hyperalgesia associated with acute joint inflammation. The NK<jats:sub>2<\/jats:sub> receptors appear to be activated early in the development of the heat hyperalgesia and NK<jats:sub>1<\/jats:sub> receptors are involved in the maintenance of the heat hyperalgesia.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Peripherally, both NK<jats:sub>1<\/jats:sub> and NK<jats:sub>2<\/jats:sub> receptors are involved in the development of heat hyperalgesia and pain\u2010related behaviour ratings induced by acute inflammation.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (1997) <jats:bold>120<\/jats:bold>, 1263\u20131273; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0701044\">10.1038\/sj.bjp.0701044<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0701044","type":"journal-article","created":{"date-parts":[[2006,8,25]],"date-time":"2006-08-25T16:13:16Z","timestamp":1156522396000},"page":"1263-1273","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Differential roles of neurokinin 1 and neurokinin 2 receptors in the development and maintenance of heat hyperalgesia induced by acute inflammation"],"prefix":"10.1111","volume":"120","author":[{"given":"K. 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