{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T11:06:20Z","timestamp":1759057580482},"reference-count":9,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,2,17]],"date-time":"2009-02-17T00:00:00Z","timestamp":1234828800000},"content-version":"vor","delay-in-days":4371,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[1997,3]]},"abstract":"<jats:p>Mammalian hearts possess an atypical \u03b2\u2010adrenoceptor (non\u2010\u03b2<jats:sub>1<\/jats:sub>, non\u2010\u03b2<jats:sub>2<\/jats:sub>, non\u2010\u03b2<jats:sub>3<\/jats:sub>) through which (\u2013)\u20104\u2010(3\u2010t\u2010butylamino\u20102\u2010hydroxypropoxy)benzimidazol\u20102\u2010one ((\u2013)\u2010CGP 12177) causes cardiostimulant effects. Here we showed that (\u2013)\u2010CGP 12177 increased the activity of adenosine 3\u2032 : 5\u2032\u2010cyclic monophosphate (cyclic AMP)\u2010dependent protein kinase in the presence of 200 n<jats:sc>m<\/jats:sc> (\u2013)\u2010propranolol in rat atria at a concentration (10 \u03bc<jats:sc>m<\/jats:sc>) that elicits maximum positive chronotropic and inotropic effects. The phosphodiesterase inhibitor 3\u2010isobutyl\u2010l\u2010methylxanthine (IBMX) potentiated the positive chronotropic and inotropic effects of (\u2013)\u2010CGP 12177. We suggest that the atypical \u03b2\u2010adrenoceptor is coupled positively to the Gs protein\u2010adenylyl cyclase system.<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (1997) <jats:bold>120<\/jats:bold>, 1187\u20131189; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0701053\">10.1038\/sj.bjp.0701053<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0701053","type":"journal-article","created":{"date-parts":[[2006,8,25]],"date-time":"2006-08-25T16:13:16Z","timestamp":1156522396000},"page":"1187-1189","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Stimulation of cyclic AMP\u2010dependent protein kinase in rat atria by (\u2013;)\u2010CGP 12177 through an atypical \u03b2\u2010adrenoceptor"],"prefix":"10.1111","volume":"120","author":[{"given":"Alberto J.","family":"Kaumann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James A.","family":"Lynham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,17]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118823"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00500096"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-6147(89)90065-5"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1996.tb15159.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00165555"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1996.tb15648.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1996.tb15285.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00167185"},{"key":"e_1_2_5_10_1","unstructured":"SARSERO D. MOLENAAR P.&KAUMANN A.J.(1997). (\u2212)\u2010[3H]\u2010CGP 12177 labels the atypical \u03b2\u2010adrenoceptor in rat atrium. In Proc. ASPET Meeting San Diego March 7\u201311."}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Fsj.bjp.0701053","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Fsj.bjp.0701053","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/sj.bjp.0701053","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T14:27:20Z","timestamp":1698416840000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1038\/sj.bjp.0701053"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,3]]},"references-count":9,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1997,3]]}},"alternative-id":["10.1038\/sj.bjp.0701053"],"URL":"https:\/\/doi.org\/10.1038\/sj.bjp.0701053","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,3]]},"assertion":[{"value":"2009-02-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}