{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T08:35:31Z","timestamp":1765960531842},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,2,13]],"date-time":"2009-02-13T00:00:00Z","timestamp":1234483200000},"content-version":"vor","delay-in-days":4275,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[1997,6]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Effects of an orally active non\u2010peptide (BK) B<jats:sub>2<\/jats:sub> receptor antagonist, FR173657 ((E)\u20103\u2010(6\u2010acetamido\u20103\u2010pyridyl)\u2010 N\u2010[N\u2010[2,4\u2010dichloro\u20103\u2010[(2\u2010methyl\u20108\u2010quinolinyl)oxymethyl]phenyl]\u2010N\u2010methylaminocarbonylmethyl] acrylamide) on the plasma exudation in rat carrageenin\u2010induced pleurisy were investigated.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Plasma exudation induced by intrapleural injection of bradykinin (BK, 3 nmol per rat) into male SD strain rats (SPF, 8 weeks old) were significantly inhibited by oral administration of novel B<jats:sub>2<\/jats:sub> receptor antagonist FR173657 (3\u201330 mg kg<jats:sup>\u22121<\/jats:sup>, 1 h before BK injection) in a dose\u2010dependent manner, whereas that induced by histamine was not.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The inhibitory effect of 30 mg kg<jats:sup>\u22121<\/jats:sup> FR173657 persisted for more than 4 h.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Intrapleural injection of \u03bb\u2010carrageenin (2% (w\/v), 0.1 ml per rat) caused marked plasma exudation and accumulation of exudates from 1 h after carrageenin injection. The maximum plasma exudation response was observed 5 h after carrageenin. The oral administration of FR173657 to rats (30 mg kg<jats:sup>\u22121<\/jats:sup>, 1 h before carrageenin) significantly (by 50\u201377%) blunted the plasma exudation 1, 3, 5, and 7 h after carrageenin, causing a significant parallel reduction (by 42\u201357%) in the volume of exudates.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The anti\u2010inflammatory effect of FR173657 on rat carrageenin\u2010induced pleurisy was almost equipotent with that of the peptide B<jats:sub>2<\/jats:sub> antagonist Hoe140 (1 mg kg<jats:sup>\u22121<\/jats:sup>, i.v.), a plasma kallikrein inhibitor, soy bean trypsin inhibitor (0.3 mg per rat, intrapleural injection) and bromelain (10 mg kg<jats:sup>\u22121<\/jats:sup>, i.v.).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In pleurisy induced by intrapleural injection of a histamine releaser, compound 48\/80, the plasma exudation was observed only within 20 min after the injection. This plasma exudation was not affected by FR173657, although it was completely inhibited by a mixture of pyrilamine (5 mg kg<jats:sup>\u22121<\/jats:sup>, i.v.) and methysergide (3 mg kg<jats:sup>\u22121<\/jats:sup>, i.v.).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>These results indicate that FR173657 is an orally active, promising anti\u2010inflammatory agent for kinin\u2010dependent inflammation.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (1997) <jats:bold>121<\/jats:bold>, 723\u2013730; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0701194\">10.1038\/sj.bjp.0701194<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0701194","type":"journal-article","created":{"date-parts":[[2006,8,25]],"date-time":"2006-08-25T17:10:14Z","timestamp":1156525814000},"page":"723-730","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Effects of an orally active non\u2010peptide bradykinin B<sub>2<\/sub> receptor antagonist, FR173657, on plasma exudation in rat carrageenin\u2010induced pleurisy"],"prefix":"10.1111","volume":"121","author":[{"given":"Masataka","family":"Majima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriko","family":"Kawashima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ito","family":"Hiroshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Katori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0700955"},{"key":"e_1_2_6_3_1","first-page":"1","article-title":"Bioregulation of kinins: Kallikreins, kininogens, and kininases","volume":"44","author":"BHOOLA K.D.","year":"1992","journal-title":"Pharmacol. 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