{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T09:39:11Z","timestamp":1762249151175},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,2,10]],"date-time":"2009-02-10T00:00:00Z","timestamp":1234224000000},"content-version":"vor","delay-in-days":4242,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[1997,7]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>The present study concerns the possible relationship between glutamate excitotoxicity and 1\u2010methyl\u20104\u2010phenyl\u20101,2,3,6\u2010tetrahydropyridine\/1\u2010methyl\u20104\u2010phenylpyridinium (MPTP\/MPP<jats:sup>+<\/jats:sup>) neurotoxicity on striatal dopaminergic terminals.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>MPP<jats:sup>+<\/jats:sup> neurotoxicity has been studied by means of two MPP<jats:sup>+<\/jats:sup> perfusions separated by 24\u2003h. After the second MPP<jats:sup>+<\/jats:sup> 1\u2003m<jats:sc>M<\/jats:sc> perfusion, dopamine extracellular output, measured by microdialysis, was considered to be an index of the dopaminergic neurone damage produced by the first MPP<jats:sup>+<\/jats:sup> 1\u2003m<jats:sc>M<\/jats:sc> perfusion.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>High concentration (10\u2003m<jats:sc>M<\/jats:sc>) of glutamate uptake inhibitor <jats:sc>L<\/jats:sc>\u2010trans\u2010pyrrolidine\u20102,4\u2010dicarboxylic acid (PDC) stimulated basal release of dopamine and protected against the neurotoxic effect of MPP<jats:sup>+<\/jats:sup>.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>PDC 10\u2003m<jats:sc>M<\/jats:sc> perfusion produced an increase in the extracellular output of glutamate and aspartate, and a decrease in that of ascorbate.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The protective effect against MPP<jats:sup>+<\/jats:sup> toxicity observed with PDC 10\u2003m<jats:sc>M<\/jats:sc> was completely abolished when this glutamate uptake inhibitor was co\u2010perfused with ascorbate 0.5\u2003m<jats:sc>M<\/jats:sc>.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>These results suggest that glutamate\u2010induced neurotoxicity is not involved in MPP<jats:sup>+<\/jats:sup> toxicity. The protective effect found with the glutamate uptake inhibitor could be due to a decrease in extracellular ascorbate levels.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p>","DOI":"10.1038\/sj.bjp.0701216","type":"journal-article","created":{"date-parts":[[2006,8,25]],"date-time":"2006-08-25T17:11:32Z","timestamp":1156525892000},"page":"1038-1044","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Lack of involvement of glutamate\u2010induced excitotoxicity in MPP<sup>+<\/sup> toxicity in striatal dopaminergic terminals: possible involvement of ascorbate"],"prefix":"10.1111","volume":"121","author":[{"given":"Esperanza R","family":"Matarredona","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marti","family":"Santiago","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Machado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josefina","family":"Cano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,10]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm00106a037"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199304000-00011"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(91)91731-F"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(90)90131-R"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(91)91049-7"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1991.tb02134.x"},{"key":"e_1_2_5_8_1","first-page":"1515","article-title":"MK\u2010801 temporaly prevents MPTP\u2010induced acute dopamine depletion and MPP+ elimination in the mouse striatum","volume":"267","author":"Chan P.","year":"1993","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1995.tb13229.x"},{"key":"e_1_2_5_10_1","first-page":"722","article-title":"Characterization of L\u2010glutamate action on the release of endogenous dompamine from the rat caudade\u2010putamen","volume":"248","author":"Clow D.W.","year":"1989","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1994.62051847.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-0186(84)90120-7"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1993.tb13431.x"},{"key":"e_1_2_5_14_1","first-page":"317","article-title":"Neurochemical basis of neurotoxicity","volume":"11","author":"Gibb J.W.","year":"1990","journal-title":"Neurotoxicology"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0173(93)90010-W"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/10715769609149066"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/10408449309104073"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(92)91660-7"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199205000-00007"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(90)90269-A"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1006\/neur.1995.0018"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)90467-P"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1991.tb08299.x"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1995.64052262.x"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(94)90316-6"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(92)90492-K"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(89)90072-3"},{"key":"e_1_2_5_28_1","first-page":"153","volume-title":"Pharmacology of Cerebral Ischemia","author":"Olney J.W.","year":"1990"},{"key":"e_1_2_5_29_1","volume-title":"The Rat Brain in Sterotaxic Coordinates","author":"Paxinos G.","year":"1986"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(85)90267-X"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(92)90741-Q"},{"key":"e_1_2_5_32_1","doi-asserted-by":"crossref","first-page":"4272","DOI":"10.1523\/JNEUROSCI.13-10-04272.1993","article-title":"Intraneostriatal administration of glutamate antagonist increases behavioural activation and decreases neostriatal ascorbate via nondopaminergic mechanism","volume":"13","author":"Pierce R.C.","year":"1993","journal-title":"J. Neurosci."},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1991.tb11409.x"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(94)90052-3"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(96)00491-5"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1986.tb01747.x"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1997.68020732.x"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(92)91628-R"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00169457"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2563176"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1992.tb10081.x"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(93)90114-Q"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1992.tb10080.x"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/349414a0"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-0186(95)00163-8"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1995.65020725.x"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(87)90695-3"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1992.tb09429.x"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Fsj.bjp.0701216","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Fsj.bjp.0701216","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/sj.bjp.0701216","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T19:00:05Z","timestamp":1698433205000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1038\/sj.bjp.0701216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,7]]},"references-count":47,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1997,7]]}},"alternative-id":["10.1038\/sj.bjp.0701216"],"URL":"https:\/\/doi.org\/10.1038\/sj.bjp.0701216","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,7]]},"assertion":[{"value":"2009-02-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}