{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:34:53Z","timestamp":1762144493813},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,2,10]],"date-time":"2009-02-10T00:00:00Z","timestamp":1234224000000},"content-version":"vor","delay-in-days":4242,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[1997,7]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>The resuscitating activity of melanocortin peptides (MSH\u2010ACTH peptides) was tested in an experimental model of prolonged respiratory arrest.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Anaesthetized, endotracheally intubated rats subjected to a 5 min period of ventilation interruption, invariably died from cardiac arrest within 6\u20139 min of resumption of ventilation.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>When resumption of ventilation was associated with the simultaneous intravenous (i.v.) injection of a melanocortin peptide (\u03b1\u2010MSH or ACTH\u2010(1\u201324)) (160 \u03bcg kg<jats:sup>\u22121<\/jats:sup>) there was an almost immediate (within 1 min), impressive increase in cardiac output, heart rate, mean arterial pressure (+560% of the before\u2010treatment value) and pulse pressure (+356% of the before\u2010treatment value), with full recovery of electroencephalogram after 30\u201345 min. Blood gases and pH were normalized within 15\u201360 min after treatment, and all treated animals eventually recovered completely and survived indefinitely (=more than 15 days).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The same response was observed in adrenalectomized animals, as well as in animals pretreated with a \u03b2<jats:sub>1<\/jats:sub>\u2010adrenoceptor blocking agent (atenolol, 3 mg kg<jats:sup>\u22121<\/jats:sup>, i.v.), or with an \u03b1<jats:sub>1<\/jats:sub>\u2010adrenoceptor blocking agent (prazosin, 0.1 mg kg<jats:sup>\u22121<\/jats:sup>, i.v.), or with an adrenergic neurone blocking agent (guanethidine, 10 mg kg<jats:sup>\u22121<\/jats:sup>, intraperitoneally).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>An effect quite similar to that produced by melanocortins was obtained with ouabain (0.1 mg kg<jats:sup>\u22121<\/jats:sup>, i.v.); the antioxidant drug, glutathione (75 mg kg<jats:sup>\u22121<\/jats:sup>, i.v.) also produced 100% resuscitation, but the effect was slower in onset. On the other hand, adrenaline (0.005 mg kg<jats:sup>\u22121<\/jats:sup>, i.v.) was able to resuscitate only 1 out of 8 rats and dobutamine (0.02 mg kg<jats:sup>\u22121<\/jats:sup>, i.v.) resuscitated 4 out of 8 rats; moreover, the effect of both catecholamines was much slower in onset than that of melanocortins and the initial, impressive stimulation of cardiovascular function was absent.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>These results show that melanocortin peptides have a resuscitating effect in a pre\u2010terminal condition produced in rats by prolonged asphyxia. This effect seems primarily due to the restoration of cardiac function, not mediated by catecholamines. These data also suggest that these peptides may have potential therapeutic value in conditions of transient cardiac hypoxia and re\u2010oxygenation such as occur in coronary artery disease.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p>","DOI":"10.1038\/sj.bjp.0701264","type":"journal-article","created":{"date-parts":[[2006,8,25]],"date-time":"2006-08-25T17:12:11Z","timestamp":1156525931000},"page":"1454-1460","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Resuscitating effect of melanocortin peptides after prolonged respiratory arrest"],"prefix":"10.1111","volume":"121","author":[{"given":"Salvatore","family":"Guarini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Bazzani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfio","family":"Bertolini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,10]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"1182","article-title":"Differential effects of melanocortin peptides on neural melanocortin receptors","volume":"46","author":"Adan R.A.H.","year":"1994","journal-title":"Mol. 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