{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:47:45Z","timestamp":1791179265498,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2009,2,11]],"date-time":"2009-02-11T00:00:00Z","timestamp":1234310400000},"content-version":"vor","delay-in-days":4212,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[1997,8]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Sibutramine is a novel 5\u2010hydroxytryptamine (5\u2010HT) and noradrenaline reuptake inhibitor (serotonin\u2010 noradrenaline reuptake inhibitor, SNRI) which is currently being developed as a treatment for obesity. Sibutramine has been shown to decrease food intake in the rat. In this study we have used a variety of monoamine receptor antagonists to examine the pharmacological mechanisms underlying sibutramine\u2010induced hypophagia.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Individually\u2010housed male Sprague\u2010Dawley rats were maintained on reversed phase lighting with free access to food and water. Drugs were administered at 09\u2003h 00\u2003min and food intake was monitored over the following 8\u2003h dark period.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Sibutramine (10\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>, p.o.) produced a significant decrease in food intake during the 8\u2003h following drug administration. This hypophagic response was fully antagonized by the \u03b1<jats:sub>1<\/jats:sub>\u2010adrenoceptor antagonist, prazosin (0.3 and 1\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>, i.p.), and partially antagonized by the \u03b2<jats:sub>1<\/jats:sub>\u2010adrenoceptor antagonist, metoprolol (3 and 10\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>, i.p.) and the 5\u2010HT receptor antagonists, metergoline (non\u2010selective; 0.3\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>, i.p.); ritanserin (5\u2010HT<jats:sub>2A\/2C<\/jats:sub>; 0.1 and 0.5\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>, i.p.) and SB200646 (5\u2010HT<jats:sub>2B\/2C<\/jats:sub>; 20 and 40\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>, p.o.).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>By contrast, the \u03b1<jats:sub>2<\/jats:sub>\u2010adrenoceptor antagonist, RX821002 (0.3 and 1\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>, i.p.) and the \u03b2<jats:sub>2<\/jats:sub>\u2010adrenoceptor antagonist, ICI 118,551 (3 and 10\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>, i.p.) did not reduce the decrease in food intake induced by sibutramine.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>These results demonstrate that \u03b2<jats:sub>1<\/jats:sub>\u2010adrenoceptors, 5\u2010HT<jats:sub>2A\/2C<\/jats:sub>\u2010receptors and particularly \u03b1<jats:sub>1<\/jats:sub>\u2010adrenoceptors, are involved in the effects of sibutramine on food intake and are consistent with the hypothesis that sibutramine\u2010induced hypophagia is related to its ability to inhibit the reuptake of both noradrenaline and 5\u2010HT, with the subsequent activation of a variety of noradrenaline and 5\u2010HT receptor systems.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p> <jats:italic>British Journal of Pharmacology<\/jats:italic> (1997) <jats:bold>121<\/jats:bold>, 1613\u20131618; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0701311\">10.1038\/sj.bjp.0701311<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0701311","type":"journal-article","created":{"date-parts":[[2006,8,25]],"date-time":"2006-08-25T17:13:48Z","timestamp":1156526028000},"page":"1613-1618","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":136,"title":["Investigation of the mechanisms underlying the hypophagic effects of the 5\u2010HT and noradrenaline reuptake inhibitor, sibutramine, in the rat"],"prefix":"10.1111","volume":"121","author":[{"given":"Helen C.","family":"Jackson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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