{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T11:53:08Z","timestamp":1791028388233,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2009,2,11]],"date-time":"2009-02-11T00:00:00Z","timestamp":1234310400000},"content-version":"vor","delay-in-days":4212,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[1997,8]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>The effects of the potent 5\u2010hydroxytryptamine (5\u2010HT) and noradrenaline reuptake inhibitor (serotonin\u2010noradrenaline reuptake inhibitor, SNRI), sibutramine, on the cumulative food intake of freely\u2010feeding male Sprague\u2010Dawley rats during an 8\u2003h dark period were investigated and compared to those of the selective 5\u2010HT reuptake inhibitor (selective serotonin reuptake inhibitor, SSRI), fluoxetine; the selective noradrenaline reuptake inhibitor, nisoxetine; the 5\u2010HT and noradrenaline reuptake inhibitors, venlafaxine and duloxetine; and the 5\u2010HT releaser and 5\u2010HT reuptake inhibitor, (+)\u2010fenfluramine.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Sibutramine (3 and 10\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>, p.o.) and (+)\u2010fenfluramine (1 and 3\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>, p.o.) produced a significant, dose\u2010dependent decrease in food intake over the 8\u2003h dark period. These responses became apparent within the first 2\u2003h following drug administration.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Fluoxetine (3, 10 and 30\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>, p.o.), and nisoxetine (3, 10 and 30\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>, p.o.) had no significant effect on food intake during the 8\u2003h dark period. However, a combination of fluoxetine and nisoxetine (30\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>, p.o., of each) significantly decreased food intake 2 and 8\u2003h after drug administration.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Venlafaxine (100 and 300\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>, p.o.) and duloxetine (30\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>, p.o.) also significantly decreased food intake in the 2 and 8\u2003h following drug administration.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The results of this study demonstrate that inhibition of 5\u2010HT and noradrenaline reuptake by sibutramine, venlafaxine, duloxetine, or by a combination of fluoxetine and nisoxetine, markedly reduces food intake in freely\u2010feeding rats and suggest that this may be a novel approach for the treatment of obesity.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p> <jats:italic>British Journal of Pharmacology<\/jats:italic> (1997) <jats:bold>121<\/jats:bold>, 1758\u20131762; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0701312\">10.1038\/sj.bjp.0701312<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0701312","type":"journal-article","created":{"date-parts":[[2006,8,25]],"date-time":"2006-08-25T17:13:48Z","timestamp":1156526028000},"page":"1758-1762","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":113,"title":["Comparison of the effects of sibutramine and other monoamine reuptake inhibitors on food intake in the rat"],"prefix":"10.1111","volume":"121","author":[{"given":"Helen C.","family":"Jackson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M.","family":"Needham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa J.","family":"Hutchins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Mazurkiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Heal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,2,11]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(93)90194-8"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278-5846(88)90003-6"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(93)90181-2"},{"key":"e_1_2_5_5_1","first-page":"170P","article-title":"Role of \u03b2\u2010adrenoceptors in mediating the thermogenic effects of sibutramine","volume":"117","author":"Connoley I. P.","year":"1996","journal-title":"Br. J. Pharmacol."},{"key":"e_1_2_5_6_1","first-page":"388P","article-title":"A study in rats of the effects of sibutramine on food intake and thermogenesis","volume":"114","author":"Connoley I. P.","year":"1995","journal-title":"Br. J. Pharmacol."},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(96)01003-6"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199652050-00007"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(81)90302-7"},{"key":"e_1_2_5_10_1","first-page":"145","article-title":"Effects of Metabolites 1 and 2 of sibutramine on the short\u2010term control of food intake in the rat","volume":"19","author":"Fantino M.","year":"1995","journal-title":"Int. J. Obesity"},{"key":"e_1_2_5_11_1","first-page":"163","article-title":"Fluoxetine\u2010induced weight loss in overweight non\u2010depressed humans","volume":"11","author":"Ferguson J. M.","year":"1987","journal-title":"Int. J. Obesity"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000177857"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-199106000-00020"},{"key":"e_1_2_5_14_1","first-page":"455","article-title":"Blockade of amine depletion by nisoxetine in comparison to uptake inhibitors","volume":"1","author":"Fuller R. W.","year":"1975","journal-title":"Psychopharmacol. Commun."},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(88)90089-5"},{"key":"e_1_2_5_16_1","doi-asserted-by":"crossref","first-page":"160S","DOI":"10.1093\/ajcn\/55.1.160s","article-title":"Progress report on the anorexia induced by drugs believed to mimic some of the effects of serotonin on the central nervous system","volume":"55","author":"Garattini S.","year":"1992","journal-title":"Am. J. Clin. Nutr."},{"key":"e_1_2_5_17_1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1192\/S0007125000291757","article-title":"Reduction of food intake by manipulation of central serotonin: Current experimental results","volume":"155","author":"Garattini S.","year":"1989","journal-title":"Br. J. Psychiat."},{"key":"e_1_2_5_18_1","first-page":"129","article-title":"Fluoxetine: A randomised clinical trial in the treatment of obesity","volume":"18","author":"Goldstein D. J.","year":"1994","journal-title":"Int. J. Obesity"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1976.tb04165.x"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-199112000-00022"},{"key":"e_1_2_5_21_1","first-page":"612","article-title":"In vivo criteria to differentiate monoamine uptake inhibitors (MARIs) from serotonin releasing drugs: sibutramine is a MARI","volume":"22","author":"Gundlah C.","year":"1996","journal-title":"Soc. Neurosci. Abs."},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(95)02228-7"},{"key":"e_1_2_5_23_1","first-page":"387P","article-title":"Effects in the rat of sibutramine on food intake and the behavioural satiety sequence","volume":"114","author":"Halford J. C. G.","year":"1995","journal-title":"Br. J. Pharmacol."},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199549020-00010"},{"key":"e_1_2_5_25_1","first-page":"168P","article-title":"Investigation of the mechanisms underlying the hypophagic effects of the 5\u2010HT and NA reuptake inhibitor sibutramine in the rat","volume":"117","author":"Jackson H. C.","year":"1996","journal-title":"Br. J. Pharmacol."},{"key":"e_1_2_5_26_1","first-page":"391P","article-title":"The anxiolytic effects of selective 5\u2010HT reuptake inhibitors in the elevated plusmaze are not explained by reuptake inhibition or affinity for 5\u2010HT1A, 2A, 2C and 3 receptor subtypes","volume":"114","author":"Jackson H. C.","year":"1995","journal-title":"Br. J. Pharmacol."},{"key":"e_1_2_5_27_1","first-page":"323P","article-title":"Comparison of the effects of sibutramine and other monoamine reuptake inhibitors on food intake in the rat","volume":"117","author":"Jackson H. C.","year":"1996","journal-title":"Br. J. Pharmacol."},{"key":"e_1_2_5_28_1","first-page":"278","article-title":"Blockade of the serotonin and norepinephrine uptake processes by duloxetine: In vitro and in vivo studies in the rat brain","volume":"277","author":"Kasamo K.","year":"1996","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_5_29_1","first-page":"1067","article-title":"Behavioral and electroencephalographic properties of duloxetine (LY248686), a reuptake inhibitor of norepinephrine and serotonin, in mice and rats","volume":"272","author":"Katoh A.","year":"1995","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004850-199612005-00005"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1550-8528.1995.tb00160.x"},{"key":"e_1_2_5_32_1","first-page":"185","article-title":"Use of a serotonin reuptake inhibitor, fluoxetine, in the treatment of obesity","volume":"11","author":"Levine L. R.","year":"1987","journal-title":"Int. J. Obesity"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(95)00704-0"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(89)90048-8"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-0186(81)90015-2"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00427333"},{"key":"e_1_2_5_37_1","first-page":"997","article-title":"Neural adaptation in imipramine\u2010treated rats processed in forced swim test: Assessment of time course, handling, rat strain and amine uptake","volume":"252","author":"Paul I. A.","year":"1990","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_5_38_1","first-page":"237","article-title":"Effect of serotonin re\u2010uptake inhibition by fluoxetine on food intake and spontaneous food choice in obesity","volume":"15","author":"Pijl H.","year":"1991","journal-title":"Int. J. Obesity"},{"key":"e_1_2_5_39_1","first-page":"351P","article-title":"Comparison of the effects of sibutramine, fluoxetine and d\u2010fenfluramine on extracellular 5\u2010HT in rat anterior hypothalamus: An in vivo microdialysis study","volume":"120","author":"Prow M.R .","year":"1996","journal-title":"Br. J. Pharmacol."},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(96)00227-4"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1550-8528.1995.tb00227.x"},{"key":"e_1_2_5_42_1","first-page":"145","article-title":"Effects of sibutramine on feeding behaviour in obese and lean Zucker rats","volume":"19","author":"Stricker\u2010Krongrad A.","year":"1995","journal-title":"Int. J. Obesity"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1991.144"},{"key":"e_1_2_5_44_1","doi-asserted-by":"crossref","first-page":"181S","DOI":"10.1093\/ajcn\/55.1.181s","article-title":"Clinical studies with fluoxetine in obesity","volume":"55","author":"Wise S. D.","year":"1992","journal-title":"Am. J. Clin. Nutr."},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(76)90053-8"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(95)00209-O"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.1993.4"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(88)90376-0"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm00172a035"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Fsj.bjp.0701312","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Fsj.bjp.0701312","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/sj.bjp.0701312","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T19:45:33Z","timestamp":1698435933000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1038\/sj.bjp.0701312"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,8]]},"references-count":48,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1997,8]]}},"alternative-id":["10.1038\/sj.bjp.0701312"],"URL":"https:\/\/doi.org\/10.1038\/sj.bjp.0701312","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,8]]},"assertion":[{"value":"2009-02-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}