{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:32:28Z","timestamp":1762144348044},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,2,3]],"date-time":"2009-02-03T00:00:00Z","timestamp":1233619200000},"content-version":"vor","delay-in-days":4112,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[1997,11]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>We have examined the role of extracellular chloride in the mast cell secretion process. The immunologically\u2010directed ligand, antibody to IgE (anti\u2010IgE) required extracellular chloride ions for optimum secretion from rat peritoneal mast cells. In contrast, replacement of extracellular chloride did not alter the mast cell secretory response to compound 48\/80, calcium ionophore A23187 or substance P.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Anti\u2010IgE\u2010stimulation of mast cells evoked a significant uptake of chloride ions compared to non\u2010stimulated cells. The magnitude of chloride uptake correlated with the magnitude of stimulated histamine secretion.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Compound 48\/80, substance P and A23187 did not alter the rate of chloride ion uptake, although these agents caused significant histamine secretion.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The Na<jats:sup>+<\/jats:sup>\/K<jats:sup>+<\/jats:sup>\/2Cl<jats:sup>\u2212<\/jats:sup> cotransport inhibitor, furosemide, reduced the rate of anti\u2010IgE\u2010stimulated chloride uptake at a relatively high concentration (700\u2003\u03bc<jats:sc>M<\/jats:sc>). However, the more potent Na<jats:sup>+<\/jats:sup>\/K<jats:sup>+<\/jats:sup>\/2Cl<jats:sup>\u2212<\/jats:sup> cotransport inhibitors, bumetanide (100\u2003\u03bc<jats:sc>M<\/jats:sc>) and piretanide (100\u2003\u03bc<jats:sc>M<\/jats:sc>) had no effect on the stimulated chloride uptake.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Furosemide inhibited anti\u2010IgE\u2010induced histamine secretion, bumetanide potentiated the response and piretanide had no effect. This suggests that their respective action on histamine secretion are unrelated to inhibition of the Na<jats:sup>+<\/jats:sup>\/K<jats:sup>+<\/jats:sup>\/2Cl<jats:sup>\u2212<\/jats:sup> carrier.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The chloride channel blocker, 5\u2010nitro\u20102\u2010((3\u2010phenylpropyl)\u2010amino)\u2010benzoic acid (NPPB), reduced both anti\u2010IgE\u2010stimulated chloride uptake and the corresponding histamine secretion in a dose\u2010dependent manner. The magnitude of the inhibitory action of the drug on these two cellular processes was comparable, implying that chloride channel activity is related to the mechanism of histamine secretion.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>It is concluded that chloride uptake has a role in the control of Fc<jats:sub>\u03b5<\/jats:sub>RI\u2010mediated histamine secretion from rodent mast cells.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (1997) <jats:bold>122<\/jats:bold>, 1188\u20131194; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0701418\">10.1038\/sj.bjp.0701418<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0701418","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T19:17:44Z","timestamp":1106939864000},"page":"1188-1194","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Fc<sub>\u03b5<\/sub>RI\u2010mediated chloride uptake by rat mast cells: modulation by chloride transport inhibitors in relation to histamine secretion"],"prefix":"10.1111","volume":"122","author":[{"given":"A. C.","family":"Redrup","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. C.","family":"Foreman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. A.","family":"Hayes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. L.","family":"Pearce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,3]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(90)91147-K"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.104.6.1099"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00582955"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/245249a0"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1994.tb14869.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.101.6.801"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1989.sp017831"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01993132"},{"key":"e_1_2_5_10_1","volume-title":"SPSS Advanced Statistics Users Guide","author":"Norusis M.J.","year":"1990"},{"key":"e_1_2_5_11_1","first-page":"F660","article-title":"Mode of inhibition of active chloride transport in the frog cornea by furosemide","volume":"245","author":"Patarca R.","year":"1983","journal-title":"Am. J. Physiol."},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/334499a0"},{"key":"e_1_2_5_13_1","first-page":"245","article-title":"Critical values for Spearman's rank order correlations","volume":"14","author":"Ramsey P.H.","year":"1989","journal-title":"J. Ed. Stat."},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(92)91325-K"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1991.tb04926.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00587857"},{"key":"e_1_2_5_17_1","first-page":"182","article-title":"A method for the fluorimetric assay of histamine in tissues","volume":"127","author":"Shore P.A.","year":"1959","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01982466"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Fsj.bjp.0701418","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Fsj.bjp.0701418","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/sj.bjp.0701418","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T13:25:27Z","timestamp":1698413127000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1038\/sj.bjp.0701418"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,11]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1997,11]]}},"alternative-id":["10.1038\/sj.bjp.0701418"],"URL":"https:\/\/doi.org\/10.1038\/sj.bjp.0701418","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,11]]},"assertion":[{"value":"2009-02-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}