{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T15:48:42Z","timestamp":1770738522764,"version":"3.49.0"},"reference-count":61,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,2,11]],"date-time":"2009-02-11T00:00:00Z","timestamp":1234310400000},"content-version":"vor","delay-in-days":4151,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[1997,10]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>The production of chemokines by vascular smooth muscle cells (SMC) is implicated in the pathogenesis of atherosclerosis, although the factors regulating chemokine production by these cells are incompletely characterized.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>We describe the differential stimulation of interleukin\u2010(IL)\u20108, monocyte chemoattractant protein (MCP)\u20101 and regulated on activation normal T\u2010cell expressed and secreted (RANTES) synthesis following treatment of human vascular SMC with IL\u20101\u03b1 or tumour necrosis factor \u03b1 (TNF\u03b1). Under basal conditions, cultured SMC release very low amounts of IL\u20108, MCP\u20101 and RANTES as assessed by specific ELISA. Concentration\u2010response studies with IL\u20101\u03b1 or TNF\u03b1 revealed that each stimulus induced a similar amount of MCP\u20101. In contrast approximately three fold more IL\u20108 was induced by IL\u20101\u03b1 than by TNF\u03b1 whereas significant RANTES production was induced only by TNF\u03b1. These findings point to a divergence in the regulation of synthesis of the different chemokines in response to IL\u20101\u03b1 or TNF\u03b1 stimulation.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The T\u2010cell derived cytokines IL\u201010 and IL\u201013 were also found to have differential effects on chemokine production by SMC. IL\u201013, but not IL\u201010, significantly enhanced IL\u20108 and MCP\u20101 release in response to IL\u20101\u03b1 or TNF\u03b1. This increase in chemokine release appeared to be accounted for by increased mRNA expression.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>These findings provide support for the concept that smooth muscle cells can have an active role in a local immune response via the production of chemokines which can be selectively modulated by T\u2010cell derived cytokines.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (1997) <jats:bold>122<\/jats:bold>, 749\u2013757; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0701433\">10.1038\/sj.bjp.0701433<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0701433","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T19:14:06Z","timestamp":1106939646000},"page":"749-757","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Chemokine production by human vascular smooth muscle cells: modulation by IL\u201013"],"prefix":"10.1111","volume":"122","author":[{"given":"Nicola J.","family":"Jordan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malcolm L.","family":"Watson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan G.","family":"Roach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teizo","family":"Yoshimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Westwick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,11]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(89)91076-0"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.1996.477579.x"},{"key":"e_1_2_4_4_1","doi-asserted-by":"crossref","first-page":"799","DOI":"10.4049\/jimmunol.154.2.799","article-title":"IL\u201013 selectively induces vascular cell adhesion molecule\u20101 expression in human endothelial cells","volume":"154","author":"Bochner B.S.","year":"1995","journal-title":"J. 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