{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T04:54:38Z","timestamp":1698468878534},"reference-count":7,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,2,5]],"date-time":"2009-02-05T00:00:00Z","timestamp":1233792000000},"content-version":"vor","delay-in-days":4114,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[1997,11]]},"abstract":"<jats:p>Epithelioid cells in the chicken thoracic aorta are shown to contain 5\u2010hydroxytryptamine (5\u2010HT) in immunocytochemical studies. To determine whether these cells act as chemoreceptors, as do type I cells of the carotid body, we examined the effects of hypoxia and acidosis on the release of 5\u2010HT from the chicken thoracic aorta. Hypoxia caused the output of 5\u2010HT in incubation medium. A reduction of pH to 6.8 failed to evoke 5\u2010HT release. The response to hypoxia was inhibited by the removal of extracellular Ca<jats:sup>2+<\/jats:sup> and by nifedipine and \u03c9\u2010conotoxin GVIA. These results suggest that epithelioid cells in the chicken thoracic aorta are chemoreceptors which sense a decrease in <jats:italic>P<\/jats:italic><jats:sc>O<\/jats:sc><jats:sub>2<\/jats:sub> and then release 5\u2010HT by Ca<jats:sup>2+<\/jats:sup> influx through voltage\u2010dependent L\u2010 and N\u2010type Ca<jats:sup>2+<\/jats:sup> channels. The epithelioid cells in the chicken aorta may be a useful model for pharmacological and physiological studies of 5\u2010HT\u2010containing cells.<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (1997) <jats:bold>122<\/jats:bold>, 799\u2013801; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0701489\">10.1038\/sj.bjp.0701489<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0701489","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T19:15:39Z","timestamp":1106939739000},"page":"799-801","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Release of 5\u2010hydroxytryptamine by hypoxia from epithelioid cells of chicken thoracic aorta"],"prefix":"10.1111","volume":"122","author":[{"given":"Shigeo","family":"Ito","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshio","family":"Ohta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshikazu","family":"Nakazato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,5]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1994.sp020239"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1995.sp021083"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1994.74.4.829"},{"key":"e_1_2_5_5_1","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1152\/jappl.1991.70.6.2539","article-title":"Respiratory responses to aortic and carotid chemoreceptor activation in the dog","volume":"70","author":"Hopp F.A.","year":"1991","journal-title":"J. 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