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It also reduced the onset of action of disinhibition following treatment with the 5\u2010HT synthesis inhibitor parachlorophenylalanine. Ritanserin failed to enhance the disinhibitory effects of the CCK<jats:sub>B<\/jats:sub>receptor antagonist CI\u2010988, the angiotensin AT<jats:sub>1<\/jats:sub>receptor antagonist losarten or the angiotensin converting enzyme inhibitor ceranapril.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>The 5\u2010HT<jats:sub>4<\/jats:sub>receptor antagonists SDZ205\u2010557, GR113808 and SB204070 caused dose\u2010related reductions in the disinhibitory effect of diazepam, returning values to those shown in vehicle treated controls. The antagonists failed to modify mouse behaviour when administered alone.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>GR113808 was also shown to cause a dose\u2010related antagonism of the disinhibitory effects of chlordiazepoxide, lorazepam, 8\u2010OH\u2010DPAT, buspirone, lesopitron, ondansetron,<jats:bold>R<\/jats:bold>(+)\u2010zacopride, sulpiride, tiapride, devazepide, CI\u2010988, losarten, ceranapril and parachlorophenylalanine.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>It was concluded that in BKW mice (a) the failure of 5\u2010HT<jats:sub>2<\/jats:sub>and 5\u2010HT<jats:sub>4<\/jats:sub>receptor antagonists when administered alone to modify behaviour in the light\/dark test indicates an absence of an endogenous 5\u2010HT tone at the 5\u2010HT<jats:sub>2<\/jats:sub>and 5\u2010HT<jats:sub>4<\/jats:sub>receptors and (b) the enhancement by the 5\u2010HT<jats:sub>2<\/jats:sub>receptor antagonists and attenuation by the 5\u2010HT<jats:sub>4<\/jats:sub>receptor antagonists of drug\u2010induced disinhibition indicates a plurality of 5\u2010HT receptor involvement in the mediation of drug\u2010induced disinhibitory profiles in the mouse.<\/jats:p><\/jats:list-item><\/jats:list><\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic>(1997)<jats:bold>122<\/jats:bold>, 1105\u20131118; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0701513\">10.1038\/sj.bjp.0701513<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0701513","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T19:17:44Z","timestamp":1106939864000},"page":"1105-1118","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["The influence of 5\u2010HT<sub>2<\/sub>and 5\u2010HT<sub>4<\/sub>receptor antagonists to modify drug induced disinhibitory effects in the mouse light\/dark test"],"prefix":"10.1111","volume":"122","author":[{"given":"Brenda","family":"Costall","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Naylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,2,3]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1990.01810160095016"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(94)90119-8"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(93)90827-5"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(92)90151-S"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1992.tb14492.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199009000-00006"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02247357"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(87)90565-X"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(00)88991-9"},{"key":"e_1_2_5_11_1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1093\/oso\/9780198577560.003.0015","volume-title":"Multiple Cholecystokinin Receptors in the CNS","author":"Belleroche J.","year":"1992"},{"key":"e_1_2_5_12_1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/978-94-011-1920-7_7","volume-title":"Serotonin from Cell Biology to Pharmacology and Therapeutics","author":"Blier P.","year":"1993"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/312363a0"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/070674379003500115"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(90)94806-9"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1957.tb40753.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(94)90080-9"},{"key":"e_1_2_5_18_1","first-page":"398P","article-title":"Comparison of in vivo and in vitro actions of tiapride in rodents","volume":"79","author":"Chivers J.K.","year":"1983","journal-title":"Br. 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