{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:05:28Z","timestamp":1791155128820,"version":"4.1.0"},"reference-count":56,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,2,3]],"date-time":"2009-02-03T00:00:00Z","timestamp":1233619200000},"content-version":"vor","delay-in-days":4051,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[1998,1]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>The characterization of the B<jats:sub>1<\/jats:sub> kinin receptor, and some mediators involved in the inflammatory response elicited by intrathoracic (i.t.) administration of des\u2010Arg<jats:sup>9<\/jats:sup>\u2010bradykinin (BK) in the mouse model of pleurisy, was investigated.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>An i.t. injection of des\u2010Arg<jats:sup>9<\/jats:sup>\u2010BK (10\u2013100\u2003nmol per site), a selective B<jats:sub>1<\/jats:sub> agonist, caused a significant and dose\u2010related increase in the vascular permeability observed after 5\u2003min, which peaked at 1\u2003h, associated with an increase in cell influx, mainly neutrophils, and, to a lesser extent, mononuclear cell influx, peaking at 4\u2003h and lasting for up to 48\u2003h. The increase in fluid leakage caused by des\u2010Arg<jats:sup>9<\/jats:sup>\u2010BK was completely resolved 4\u2003h after peptide injection. I.t. injection of Lys\u2010des\u2010Arg<jats:sup>9<\/jats:sup>\u2010BK (30\u2003nmol per site) caused a similar inflammatory response.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Both the exudation and the neutrophil influx elicited by i.t. injection of des\u2010Arg<jats:sup>9<\/jats:sup>\u2010BK were significantly antagonized (<jats:italic>P<\/jats:italic>&lt;0.01) by an i.t. injection of the selective B<jats:sub>1<\/jats:sub> antagonists des\u2010Arg<jats:sup>9<\/jats:sup>\u2010[Leu<jats:sup>8<\/jats:sup>]\u2010BK (60 and 100\u2003nmol per site) or des\u2010Arg<jats:sup>9<\/jats:sup>\u2010NPC\u200317731 (5\u2003nmol per site), administered in association with des\u2010Arg<jats:sup>9<\/jats:sup>\u2010BK (<jats:italic>P<\/jats:italic>&lt;0.01), or 30 and 60\u2003min before the cellular peak, respectively. In contrast, an i.t. injection of the B<jats:sub>2<\/jats:sub> bradykinin selective receptor antagonist Hoe\u2003140 (30\u2003nmol per site), at a dose which consistently antagonized bradykinin (10\u2003nmol per site)\u2010induced pleurisy, had no significant effect on des\u2010Arg<jats:sup>9<\/jats:sup>\u2010BK\u2010induced pleurisy.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>An i.t. injection of the selective tachykinin receptor antagonists (NK<jats:sub>1<\/jats:sub>) FK\u2003888 (1\u2003nmol per site), (NK<jats:sub>2<\/jats:sub>) SR\u200348968 (20\u2003nmol per site) or (NK<jats:sub>3<\/jats:sub>) SR\u2003142801 (10\u2003nmol per site), administered 5\u2003min before pleurisy induction, significantly antagonized neutrophil migration caused by i.t. injection of des\u2010Arg<jats:sup>9<\/jats:sup>\u2010BK. In addition, FK\u2003888 and SR\u2003142801, but not SR\u200348968, also prevented the influx of mononuclear cells in response to i.t. injection of des\u2010Arg<jats:sup>9<\/jats:sup>\u2010BK (<jats:italic>P<\/jats:italic>&lt;0.01). However, the NK<jats:sub>3<\/jats:sub> receptor antagonist SR\u2003142801 (10\u2003nmol per site) also significantly inhibited des\u2010Arg<jats:sup>9<\/jats:sup>\u2010BK\u2010induced plasma extravasation. An i.t. injection of the calcitonin gene\u2010related peptide (CGRP) receptor antagonist CGRP<jats:sub>8\u201337<\/jats:sub> (1\u2003nmol per site), administered 5\u2003min before pleurisy induction, inhibited des\u2010Arg<jats:sup>9<\/jats:sup>\u2010BK\u2010induced plasma extravasation (<jats:italic>P<\/jats:italic>&lt;0.01), without significantly affecting the total and differential cell migration.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The nitric oxide synthase inhibitors <jats:sc>L<\/jats:sc>\u2010NOARG and <jats:sc>L<\/jats:sc>\u2010NAME (1\u2003pmol per site), administered 30\u2003min beforehand, almost completely prevented des\u2010Arg<jats:sup>9<\/jats:sup>\u2010BK (i.t.)\u2010induced neutrophil cell migration (<jats:italic>P<\/jats:italic>&lt;0.01), and, to a lesser extent, mononuclear cell migration (<jats:italic>P<\/jats:italic>&lt;0.01). The <jats:sc>D<\/jats:sc>\u2010enantiomer <jats:sc>D<\/jats:sc>\u2010NAME had no effect on des\u2010Arg<jats:sup>9<\/jats:sup>\u2010BK\u2010induced pleurisy. At the same dose range, <jats:sc>L<\/jats:sc>\u2010NOARG and <jats:sc>L<\/jats:sc>\u2010NAME inhibited the total cell migration (<jats:italic>P<\/jats:italic>&lt;0.01). <jats:sc>L<\/jats:sc>\u2010NAME, but not <jats:sc>L<\/jats:sc>\u2010NOARG caused significant inhibition of des\u2010Arg<jats:sup>9<\/jats:sup>\u2010BK\u2010induced fluid leakage. Indomethacin (1\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>, i.p.), administered 1\u2003h before des\u2010Arg<jats:sup>9<\/jats:sup>\u2010BK (30\u2003nmol per site), inhibited the mononuclear cell migration (<jats:italic>P<\/jats:italic>&lt;0.05), but, surprisingly, increased the neutrophil migration at 4\u2003h without interfering with plasma extravasation. The administration of terfenadine (50\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>, i.p.), 30\u2003min before des\u2010Arg<jats:sup>9<\/jats:sup>\u2010BK (30\u2003nmol per site), did not interfere significantly with the total cell migration or with the plasma extravasation in the mouse pleurisy caused by i.t. injection of des\u2010Arg<jats:sup>9<\/jats:sup>\u2010BK.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Pretreatment of animals with the lipopolysaccharide of <jats:italic>E. coli<\/jats:italic> (LPS; 10\u2003\u03bcg per animal, i.v.) for 24\u2003h did not result in any significant change of the inflammatory response induced by i.t. injection of des\u2010Arg<jats:sup>9<\/jats:sup>\u2010BK compared with the saline treated group. However, the identical treatment of mice with LPS resulted in a marked enhancement of des\u2010Arg<jats:sup>9<\/jats:sup>\u2010BK induced paw oedema (<jats:italic>P<\/jats:italic>&lt;0.01).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In conclusion, we have demonstrated that the inflammatory response induced by i.t. injection of des\u2010Arg<jats:sup>9<\/jats:sup>\u2010BK, in a murine model of pleurisy, is mediated by stimulation of constitutive B<jats:sub>1<\/jats:sub> receptors. These responses are largely mediated by release of neuropeptides such as substance\u2003P or CGRP and also by NO, but products derived from cyclo\u2010oxygenase pathway and histamine seem not to be involved. Therefore, these results further support the notion that the B<jats:sub>1<\/jats:sub> kinin receptor has an important role in modulating inflammatory responses, and it is suggested that selective B<jats:sub>1<\/jats:sub> antagonists may provide therapeutic benefit in the treatment of inflammatory and allergic conditions.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (1998) <jats:bold>123<\/jats:bold>, 281\u2013291; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0701590\">10.1038\/sj.bjp.0701590<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0701590","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T19:16:45Z","timestamp":1106939805000},"page":"281-291","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Characterization of the receptor and the mechanisms underlying the inflammatory response induced by des\u2010Arg<sup>9<\/sup>\u2010BK in mouse pleurisy"],"prefix":"10.1111","volume":"123","author":[{"given":"Rose M J","family":"Vianna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o B","family":"Calixto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,2,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/146.5_Pt_1.1177"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.47.11.979"},{"key":"e_1_2_6_4_1","first-page":"49","article-title":"Inflammatory mediators and asthma","volume":"40","author":"Barnes P.J.","year":"1988","journal-title":"Pharmacol. Rev."},{"key":"e_1_2_6_5_1","first-page":"384","article-title":"Regulation of kinin in human synovial cells and upregulation of receptor number by interleukin\u20101","volume":"260","author":"Bathon J.M.","year":"1992","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_6_6_1","first-page":"388","article-title":"Inhibitors of nitric oxide synthase attenuate human neutrophil Chemotaxis in vitro","volume":"122","author":"Belenky S.N.","year":"1993","journal-title":"J. Lab. Clin. Med."},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-6147(96)10027-4"},{"key":"e_1_2_6_8_1","first-page":"1","article-title":"Biorregulation of kinins: kallikreins, kininogens, and kininases","volume":"44","author":"Bhoola K.D.","year":"1992","journal-title":"Pharmacol. Rev."},{"key":"e_1_2_6_9_1","first-page":"299","article-title":"A pharmacological analysis of receptor subtypes and the mechanisms mediating the biphasic response induced by kinins in the rat stomach funds in vitro","volume":"277","author":"Cabrini D.A.","year":"1996","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02028275"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0700914"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1139\/y95-110"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1996.tb15262.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1993.tb13791.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(94)90107-4"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1994.tb16174.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1988.tb11487.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1991.tb12300.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(93)90133-7"},{"key":"e_1_2_6_20_1","first-page":"127","article-title":"SR 142801, the first potent non\u2010peptide antagonist of the tachykinin NK3 receptor","volume":"56","author":"Emonds\u2010Alt X.","year":"1995","journal-title":"Life Sci. Pharmacol. Lett."},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(92)90352-P"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1993.tb13878.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.32.040192.002455"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1992.tb14524.x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1994.tb17001.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-0115(93)90268-D"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7258(92)90016-S"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1990.tb14671.x"},{"key":"e_1_2_6_29_1","first-page":"1","article-title":"Differential pharmacology of cloned human and mouse B2 bradykinin receptors","volume":"45","author":"Hess J.F.","year":"1994","journal-title":"Mol Pharmacol"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(92)91187-U"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0162-3109(96)00074-4"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1990.tb12092.x"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1993.tb07176.x"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(92)91167-D"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01122798"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00923340"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1994.1512"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1995.tb13372.x"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0162-3109(95)00011-H"},{"key":"e_1_2_6_40_1","first-page":"33","volume-title":"Bradykinin Antagonists: Basic and Clinical Research","author":"Marceau F.","year":"1991"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.17.7724"},{"key":"e_1_2_6_42_1","doi-asserted-by":"crossref","first-page":"21583","DOI":"10.1016\/S0021-9258(17)31844-6","article-title":"Expression of cloning of a human B1 bradykinin receptor","volume":"269","author":"Menke J.G.","year":"1994","journal-title":"J. Biol. Chem."},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1996.tb15356.x"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-0115(93)90077-L"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1996.tb15205.x"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1993.tb13982.x"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1139\/y95-113"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1996.0384"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1980.tb12833.x"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1996.tb15472.x"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(97)01005-4"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1994.tb14027.x"},{"key":"e_1_2_6_53_1","first-page":"8","article-title":"Characterization and function of bradykinin receptors in vascular endothelial cells","volume":"247","author":"Sung C.P.","year":"1988","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(87)90681-9"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(89)81331-6"},{"key":"e_1_2_6_56_1","first-page":"729","article-title":"Production of cyclic GMP via activation of B1 and B2 kinin receptors in cultured bovine aortic endothelial cells","volume":"262","author":"Wiemer G.","year":"1992","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1993.265.1.C201"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Fsj.bjp.0701590","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Fsj.bjp.0701590","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/sj.bjp.0701590","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T07:00:50Z","timestamp":1698476450000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1038\/sj.bjp.0701590"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,1]]},"references-count":56,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1998,1]]}},"alternative-id":["10.1038\/sj.bjp.0701590"],"URL":"https:\/\/doi.org\/10.1038\/sj.bjp.0701590","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,1]]},"assertion":[{"value":"2009-02-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}