{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:40:31Z","timestamp":1791902431392,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,2,10]],"date-time":"2009-02-10T00:00:00Z","timestamp":1234224000000},"content-version":"vor","delay-in-days":3999,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[1998,3]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>The effect of antidromic stimulation of the sensory fibres of the sciatic nerve on inflammatory plasma extravasation in various tissues and on cutaneous vasodilatation elicited in distant parts of the body was investigated in rats pretreated with guanethidine (8\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>, i.p.) and pipecuronium (200\u2003\u03bcg\u2003kg<jats:sup>\u22121<\/jats:sup>, i.v.).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Antidromic sciatic nerve stimulation with C\u2010fibre strength (20\u2003V, 0.5\u2003ms) at 5\u2003Hz for 5\u2003min elicited neurogenic inflammation in the innervated area and inhibited by 50.3\u00b14.67% the development of a subsequent plasma extravasation in response to similar stimulation of the contralateral sciatic nerve. Stimulation at 0.5\u2003Hz for 1\u2003h also evoked local plasma extravasation and inhibited the carrageenin\u2010induced (1%, 100\u2003\u03bcl\u2003s.c.) cutaneous inflammation by 38.5\u00b110.0% in the contralateral paw. Excitation at 0.1\u2003Hz for 4\u2003h elicited no local plasma extravasation in the stimulated hindleg but still reduced the carrageenin\u2010induced oedema by 52.1\u00b19.7% in the paw on the contralateral side.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Plasma extravasation in the knee joint in response to carrageenin (2%, 200\u2003\u03bcl intra\u2010articular injection) was diminished by 46.1\u00b112.69% and 40.9\u00b14.93% when the sciatic nerve was stimulated in the contralateral leg at 0.5\u2003Hz for 1\u2003h or 0.1\u2003Hz for 4\u2003h, respectively.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Stimulation of the peripheral stump of the left vagal nerve (20\u2003V, 1\u2003ms, 8\u2003Hz, 10\u2003min) elicited plasma extravasation in the trachea, oesophagus and mediastinal connective tissue in rats pretreated with atropine (2\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>, i.v.), guanethidine (8\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>, i.p.) and pipecuronium (200\u2003\u03bcg\u2003kg<jats:sup>\u22121<\/jats:sup>, i.v.). These responses were inhibited by 37.8\u00b15.1%, 49.7\u00b19.9% and 37.6\u00b14.2%, respectively by antidromic sciatic nerve excitation (5\u2003Hz, 5\u2003min) applied 5\u2003min earlier.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Pretreatment with polyclonal somatostatin antiserum (0.5\u2003ml\/rat, i.v.) or the selective somatostatin depleting agent cysteamine (280\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>, s.c.) prevented the anti\u2010inflammatory effect of sciatic nerve stimulation (5\u2003Hz, 5\u2003min) on a subsequent neurogenic plasma extravasation of the contralateral paw skin. The inhibitory effect of antidromic sciatic nerve excitation on plasma extravasation in response to vagal nerve stimulation was also prevented by somatostatin antiserum pretreatment.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Cutaneous blood flow assessment by laser Doppler flowmetry indicated that antidromic vasodilatation induced by sciatic nerve stimulation was not inhibited by excitation of the sciatic nerve of the contralateral leg (1\u2003Hz, 30\u2003min) or by somatostatin (10\u2003\u03bcg\/rat, i.v.) injection.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Plasma levels of somatostatin increased more than 4 fold after stimulation of both sciatic nerves (5\u2003Hz, 5\u2003min) but the stimulus\u2010evoked increase was not observed in cysteamine (280\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>, s.c.) pretreated rats.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>These results suggest that somatostatin released from the activated sensory nerve terminals mediates the systemic anti\u2010inflammatory effect evoked by stimulating the peripheral stump of the sciatic nerve.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (1998) <jats:bold>123<\/jats:bold>, 936\u2013942; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0701685\">10.1038\/sj.bjp.0701685<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0701685","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T19:24:26Z","timestamp":1106940266000},"page":"936-942","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":116,"title":["Release of somatostatin and its role in the mediation of the anti\u2010inflammatory effect induced by antidromic stimulation of sensory fibres of rat sciatic nerve"],"prefix":"10.1111","volume":"123","author":[{"given":"J\u00e1nos","family":"Szolcs\u00e1nyi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsuzsanna","family":"Helyes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e1bor","family":"Oroszi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f3zsef","family":"N\u00e9meth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Pint\u00e9r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,2,10]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"The Vaso\u2010motor System","author":"Bayliss W.M.","year":"1923"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1993.tb13878.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00507224"},{"key":"e_1_2_6_5_1","volume-title":"Neurogenic Inflammation","author":"Geppetti P.","year":"1996"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0196-9781(83)90016-5"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BFb0033194"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1994.tb13208.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1967.tb01984.x"},{"key":"e_1_2_6_10_1","first-page":"369","volume-title":"Progress in Brain Research","author":"Lawson S.N.","year":"1996"},{"key":"e_1_2_6_11_1","volume-title":"The Blood Vessels of the Human Skin and their Responses","author":"Lewis L.","year":"1927"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-115-4-1492"},{"key":"e_1_2_6_13_1","first-page":"113","article-title":"Pharmacology of cotransmission in the autonomic nervous system: Integrative aspects on amines, neuropeptides, adenosine triphosphate, amino acids and nitric oxide","volume":"48","author":"Lundberg J.M.","year":"1996","journal-title":"Pharmacol. 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