{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T22:25:30Z","timestamp":1747779930591},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,2,10]],"date-time":"2009-02-10T00:00:00Z","timestamp":1234224000000},"content-version":"vor","delay-in-days":3999,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[1998,3]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Investigation with substances that are similar in structure, but different in anaesthetic properties, may lead to further understanding of the mechanisms of general anaesthesia.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>We have studied the effects of two cyclobutane derivatives, the anaesthetic, 1\u2010chloro\u20101,2,2\u2010trifluorocyclobutane (F3), and the non\u2010anaesthetic, 1,2\u2010dichlorohexafluorocyclobutane (F6), on K<jats:sup>+<\/jats:sup>\u2010evoked glutamate and \u03b3\u2010aminobutyric acid (GABA) release from isolated, superfused, cerebrocortical slices from mice, by use of h.p.l.c. with fluorescence detection for quantitative analysis.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>At clinically relevant concentrations, the anaesthetic, F3, inhibited 40\u2003m<jats:sc>M<\/jats:sc> K<jats:sup>+<\/jats:sup>\u2010evoked glutamate and GABA release by 72% and 47%, respectively, whereas the structurally similar non\u2010anaesthetic, F6, suppressed evoked glutamate release by 70% but had no significant effects on evoked GABA release. A second exposure to 40\u2003m<jats:sc>M<\/jats:sc> KCl after a \u223c30\u2003min washout of F3 or F6 showed recovery of K<jats:sup>+<\/jats:sup>\u2010evoked release, suggesting that F3 and F6 did not cause any non\u2010specific or irreversible changes in the brain slices.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Our findings suggest that suppression of excitatory neurotransmitter release may not be directly relevant to the primary action of general anaesthetics. A mechanism involving inhibitory postsynaptic action is implicated, in which a moderate suppression of depolarization\u2010evoked GABA release by the anaesthetic may be consistent with the enhancement of postsynaptic GABAergic activities.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (1998) <jats:bold>123<\/jats:bold>, 1274\u20131280; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0701728\">10.1038\/sj.bjp.0701728<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0701728","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T19:25:05Z","timestamp":1106940305000},"page":"1274-1280","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Comparison of anaesthetic and non\u2010anaesthetic effects on depolarization\u2010evoked glutamate and GABA release from mouse cerebrocortical slices"],"prefix":"10.1111","volume":"123","author":[{"given":"Serguei","family":"Liachenko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George T.","family":"Somogyi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199512000-00014"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(80)90293-0"},{"key":"e_1_2_6_5_1","first-page":"147","article-title":"Effects of pentobarbitone on the synapti\u2010cally evoked release of the amino acid neurotransmitter candidates aspartate and Gaba from rat olfactory cotex","volume":"27","author":"Collins G.G.S.","year":"1981","journal-title":"Adv. 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