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Using a variety of neuropeptide Y (NPY) and PYY derivatives, we characterized the pharmacological profile of the receptor mediating the acid secretory response to PYY.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>[Pro<jats:sup>34<\/jats:sup>]rat(r)\/porcine(p)PYY and [Pro<jats:sup>34<\/jats:sup>]human(h)PYY (23\u2013117\u2003pmol), microinjected unilaterally into the DVC resulted in a similar maximal increase in net acid secretion reaching 68\u00b111 and 89\u00b131\u2003\u03bcmol 90\u2003min<jats:sup>\u22121<\/jats:sup> respectively.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Rat\/hNPY and pNPY (47\u2003pmol) microinjected into the DVC induced a similar net gastric acid secretion (27\u00b18 and 23\u00b18\u2003\u03bcmol 90\u2003min<jats:sup>\u22121<\/jats:sup> respectively) and a higher dose (116\u2003pmol) tended to reduce the response.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Pancreatic polypeptide (PP, 4\u201346\u2003pmol), [Leu<jats:sup>31<\/jats:sup>,Pro<jats:sup>34<\/jats:sup>]r\/hNPY (47 and 117\u2003pmol) and the Y2 selective agonists, hPYY<jats:sub>3\u201036<\/jats:sub>, pNPY<jats:sub>5\u201036<\/jats:sub> and pNPY<jats:sub>13\u201036<\/jats:sub> (25\u2013168\u2003pmol) microinjected into the DVC failed to influence basal gastric acid secretion.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The rank order of potency of PYY[Pro<jats:sup>34<\/jats:sup>]r\/pPYY=[Pro<jats:sup>34<\/jats:sup>]hPYY&gt;r\/hNPY=pNPY to stimulate gastric acid secretion upon injection into the DVC and the ineffectiveness of PP, [Leu<jats:sup>31<\/jats:sup>,Pro<jats:sup>34<\/jats:sup>]NPY and C\u2010terminal NPY\/PYY fragments suggest that a PYY\u2010preferring receptor subtype may be involved in mediating the stimulating effect.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (1998) <jats:bold>123<\/jats:bold>, 1549\u20131554; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0701767\">10.1038\/sj.bjp.0701767<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0701767","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T19:27:23Z","timestamp":1106940443000},"page":"1549-1554","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["PYY\u2010preferring receptor in the dorsal vagal complex and its involvement in PYY stimulation of gastric acid secretion in rats"],"prefix":"10.1111","volume":"123","author":[{"given":"H.","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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