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Consistently, PMN homotypic aggregation and formation of mixed cell\u2010conjugates between PMN and thrombin\u2010stimulated fixed platelets in a dynamic system were also prevented by <jats:italic>trans<\/jats:italic>\u2010resveratrol.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>These results, indicating that <jats:italic>trans<\/jats:italic>\u2010resveratrol interferes with the release of inflammatory mediators by activated PMN and down\u2010regulates adhesion\u2010dependent thrombogenic PMN functions, may provide some biological plausibility to the protective effect of red wine consumption against CHD.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (1998) <jats:bold>123<\/jats:bold>, 1691\u20131699; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0701784\">10.1038\/sj.bjp.0701784<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0701784","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T19:27:23Z","timestamp":1106940443000},"page":"1691-1699","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":192,"title":["Effect of <i>trans<\/i>\u2010resveratrol, a natural polyphenolic compound, on human polymorphonuclear leukocyte function"],"prefix":"10.1111","volume":"123","author":[{"given":"Serenella","family":"Rotondo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grazyna","family":"Rajtar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Manarini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Celardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Rotilio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"De Gaetano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virgilio","family":"Evangelista","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Cerletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,2,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.75.1.282"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.4049\/jimmunol.137.1.15","article-title":"Contribution of the MAC\u20101 glycoprotein family to adherence\u2010dependent granulocyte functions: structure\u2010function assessments employing subunit\u2010specific monoclonal antibodies","volume":"137","author":"Anderson D.C.","year":"1986","journal-title":"J. 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